Biocatalysis for Sustainable Chemistry – Understanding Oxidation/Reduction of Small Molecules by Redox Metalloenzymes via a Suite of Steady State and Transient Infrared Electrochemical Methods

Información del proyecto

BiocatSusChem

Identificador del acuerdo de subvención: 819580

DOI

10.3030/819580

Proyecto cerrado

Fecha de la firma de la CE 11 Febrero 2019

Fecha de inicio 1 Marzo 2019

Fecha de finalización 28 Febrero 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 997 286,00

Aportación de la UE

€ 1 997 286,00

Coordinado por

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Other (2)

Cofactor-free biocatalytic hydrogenation of nitro compounds for synthesis of amines

Autores: Daria Sokolova, Tara Lurshay, Jack Rowbotham, Georgia Stonadge, Holly Reeve, Sarah Cleary, Tim Sudmeier, Kylie Vincent
Publicado en: ChemXRIV, 2024
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-vqfc1

Glutamate “flick” enables proton tunneling during fast redox biocatalysis

Autores: Stephen B. Carr, Wangzhe Li, Kin Long Wong, Rhiannon M. Evans, Sophie E. T. Kendall-Price, Kylie A. Vincent, Philip A. Ash
Publicado en: ChemXRIV, 2024
Editor: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-mn36l

Peer reviewed articles (17)

The 2022 solar fuels roadmap

Autores: Gideon Segev; Jakob Kibsgaard; Christopher Hahn; Zhichuan J Xu; Wen-Hui (Sophia) Cheng; Todd G Deutsch; Chengxiang Xiang; Jenny Z Zhang; Leif Hammarström; Daniel G Nocera; Adam Z Weber; Peter Agbo; Takashi Hisatomi; Frank E Osterloh; Kazunari Domen; Fatwa F Abdi; Sophia Haussener; Daniel J Miller; Shane Ardo; Paul C McIntyre; Thomas Hannappel; Shu Hu; Harry Atwater; John M Gregoire; Mehmed Z Erte
Publicado en: Journal of Physics D: Applied Physics, Edición Vol 55, Iss 32, 2022, Página(s) 323003, ISSN 1361-6463
Editor: IOPScience
DOI: 10.1088/1361-6463/ac6f97

H2-Driven Reduction of Flavin by Hydrogenase Enables Cleaner Operation of Nitroreductases for Nitro-Group to Amine Reductions

Autores: Miguel A. Ramirez, Shiny Joseph Srinivasan, Sarah E. Cleary, Peter M. T. Todd, Holly A. Reeve, Kylie A. Vincent
Publicado en: Frontiers in Catalysis, Edición Vol 2, 2022, Página(s) https://doi.org/10.3389/fctls.2022.906694, ISSN 2673-7841
Editor: Frontiers
DOI: 10.3389/fctls.2022.906694

E. coli Nickel‐Iron Hydrogenase 1 Catalyses Non‐native Reduction of Flavins: Demonstration for Alkene Hydrogenation by Old Yellow Enzyme Ene‐reductases**

Autores: Shiny Joseph Srinivasan; Sarah E. Cleary; Miguel A. Ramirez; Holly A. Reeve; Caroline E. Paul; Kylie A. Vincent
Publicado en: Angewandte Chemie (International Ed. in English), Edición Vol 60, 2021, Página(s) 13824-13828, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202101186

Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR

Autores: Jack S. Rowbotham, Jake H. Nicholson, Miguel A. Ramirez, Kouji Urata, Peter M. T. Todd, Gogulan Karunanithy, Lars Lauterbach, Holly A. Reeve, Andrew J. Baldwin, Kylie A. Vincent
Publicado en: Chemical Science, Edición 14, 2024, Página(s) 12160-12165, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d3sc01718d

The crystalline state as a dynamic system: IR microspectroscopy under electrochemical control for a [NiFe] hydrogenase

Autores: Philip A. Ash; Sophie E. T. Kendall-Price; Rhiannon M. Evans; Stephen B. Carr; Amelia R. Brasnett; Simone Morra; Jack S. Rowbotham; Ricardo Hidalgo; Adam J. Healy; Gianfelice Cinque; Mark D. Frogley; Fraser A. Armstrong; Kylie A. Vincent
Publicado en: Chemical Science, Edición Vol 12, 2021, Página(s) 12959-12970, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d1sc01734a

Controlled Biocatalytic Synthesis of a Metal Nanoparticle‐Enzyme Hybrid: Demonstration for Catalytic H₂‐driven NADH Recycling

Autores: Lucy B. F. Browne, Tim Sudmeier, Maya A. Landis, Christopher S. Allen, Kylie A. Vincent
Publicado en: Angewandte Chemie, Edición 136, 2024, Página(s) e202404024, ISSN 0044-8249
Editor: Wiley
DOI: 10.1002/ange.202404024

Replacing a Cysteine Ligand by Selenocysteine in a [NiFe]-Hydrogenase Unlocks Hydrogen Production Activity and Addresses the Role of Concerted Proton-Coupled Electron Transfer in Electrocatalytic Reversibility

Autores: Rhiannon M. Evans, Natalie Krahn, Joshua Weiss, Kylie A. Vincent, Dieter Söll, Fraser A. Armstrong
Publicado en: Journal of the American Chemical Society, Edición 146, 2024, Página(s) 16971-16976, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.4c03489

Stability of the H-cluster under whole-cell conditions—formation of an Htrans-like state and its reactivity towards oxygen

Autores: Marco Lorenzi; Pierre Ceccaldi; Patricia Rodríguez-Maciá; Holly Jayne Redman; Afridi Zamader; James A. Birrell; Livia S. Mészáros; Gustav Berggren
Publicado en: Journal of Biological Inorganic Chemistry, Edición 1, 2022, ISSN 0949-8257
Editor: Springer Verlag
DOI: 10.1007/s00775-022-01928-5

Exploiting hydrogenases for biocatalytic hydrogenations

Autores: Daria Sokolova, Kylie A. Vincent
Publicado en: Chemical Communications, Edición 60, 2024, Página(s) 13667-13677, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d4cc04525d

The Nonphysiological Reductant Sodium Dithionite and [FeFe] Hydrogenase: Influence on the Enzyme Mechanism.

Autores: Maria Alessandra Martini; Olaf Rüdiger; Nina Breuer; Birgit Nöring; Serena DeBeer; Patricia Rodríguez-Maciá; James A. Birrell
Publicado en: Journal of the American Chemical Society, Edición 1, 2021, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c07322

Binuclear Lanthanide Complexes as Magnetic Resonance and Optical Imaging Probes for Redox Sensing

Autores: Charlie H. Simms, Daniel Kovacs, Lina Hacker, Euan T. Sarson, Daria Sokolova, Kirsten E. Christensen, Alexandr Khrapichev, Louise A. W. Martin, Kylie Vincent, Stuart J. Conway, Ester M. Hammond, Matthew J. Langton, Stephen Faulkner
Publicado en: Chemistry – A European Journal, Edición 31, 2025, Página(s) e202404748, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202404748

Electrochemical experiments define potentials associated with binding of substrates and inhibitors to nitrogenase MoFe protein

Autores: Ting Chen; Philip A. Ash; Lance C. Seefeldt; Kylie A. Vincent
Publicado en: Faraday Discussions, Edición 243, 2023, Página(s) 270-286, ISSN 1364-5498
Editor: Royal Society of Chemistry
DOI: 10.1039/d2fd00170e

Riboflavin with H₂‐Driven or Electrochemical Recycling: A Cheap Cofactor System for Supporting Biocatalytic Alkene Reduction

Autores: Lucy B. F. Browne, Charlotte C. Hancox, Sofia M. Helin, Peter M. T. Todd, Kylie A. Vincent
Publicado en: ChemCatChem, Edición 17, 2025, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202401578

Cyanophenylalanine as an Infrared Probe for Iron–Sulfur Cluster Redox State in Multicenter Metalloenzymes

Autores: Zehui Duan, Jiaao Wei, Stephen B. Carr, Miguel Ramirez, Rhiannon M. Evans, Philip A. Ash, Patricia Rodriguez‐Macia, Amit Sachdeva, Kylie A. Vincent
Publicado en: ChemBioChem, Edición doi:10.1002/cbic.202500251, 2025, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202500251

Electrochemical control of [FeFe]-hydrogenase single crystals reveals complex redox populations at the catalytic site

Autores: Simone Morra; Jifu Duan; Martin Winkler; Philip A. Ash; Thomas Happe; Kylie A. Vincent
Publicado en: Dalton Transactions, Edición Vol 50, 2021, Página(s) 12655-12663, ISSN 1477-9226
Editor: Royal Society of Chemistry
DOI: 10.1039/d1dt02219a

Selective hydrogenation of nitro compounds to amines by coupled redox reactions over a heterogeneous biocatalyst

Autores: Daria Sokolova, Tara C. Lurshay, Jack S. Rowbotham, Georgia Stonadge, Holly A. Reeve, Sarah E. Cleary, Tim Sudmeier, Kylie A. Vincent
Publicado en: Nature Communications, Edición 15, 2024, Página(s) 7297, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-51531-2

A Beginner’s Guide to Thermodynamic Modelling of [FeFe] Hydrogenase

Autores: James A. Birrell; Patricia Rodríguez-Maciá; Adrian Hery-Barranco
Publicado en: Catalysts, Edición Vol 11, 2021, Página(s) 238, ISSN 2073-4344
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal11020238

Derechos de propiedad intelectual

Patent (1)

METHOD OF REDUCING AND RECYCLING OXIDIZED FLAVIN COFACTORS

Número de solicitud/publicación: 20 21051000
Fecha: 2021-04-23
Solicitante(s): THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD