Biocatalysis for Sustainable Chemistry – Understanding Oxidation/Reduction of Small Molecules by Redox Metalloenzymes via a Suite of Steady State and Transient Infrared Electrochemical Methods

Informazioni relative al progetto

BiocatSusChem

ID dell’accordo di sovvenzione: 819580

DOI

10.3030/819580

Progetto chiuso

Data della firma CE 11 Febbraio 2019

Data di avvio 1 Marzo 2019

Data di completamento 28 Febbraio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 997 286,00

Contributo UE

€ 1 997 286,00

Coordinato da

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Other (2)

Cofactor-free biocatalytic hydrogenation of nitro compounds for synthesis of amines

Autori: Daria Sokolova, Tara Lurshay, Jack Rowbotham, Georgia Stonadge, Holly Reeve, Sarah Cleary, Tim Sudmeier, Kylie Vincent
Pubblicato in: ChemXRIV, 2024
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-vqfc1

Glutamate “flick” enables proton tunneling during fast redox biocatalysis

Autori: Stephen B. Carr, Wangzhe Li, Kin Long Wong, Rhiannon M. Evans, Sophie E. T. Kendall-Price, Kylie A. Vincent, Philip A. Ash
Pubblicato in: ChemXRIV, 2024
Editore: American Chemical Society (ACS)
DOI: 10.26434/chemrxiv-2024-mn36l

Peer reviewed articles (17)

The 2022 solar fuels roadmap

Autori: Gideon Segev; Jakob Kibsgaard; Christopher Hahn; Zhichuan J Xu; Wen-Hui (Sophia) Cheng; Todd G Deutsch; Chengxiang Xiang; Jenny Z Zhang; Leif Hammarström; Daniel G Nocera; Adam Z Weber; Peter Agbo; Takashi Hisatomi; Frank E Osterloh; Kazunari Domen; Fatwa F Abdi; Sophia Haussener; Daniel J Miller; Shane Ardo; Paul C McIntyre; Thomas Hannappel; Shu Hu; Harry Atwater; John M Gregoire; Mehmed Z Erte
Pubblicato in: Journal of Physics D: Applied Physics, Numero Vol 55, Iss 32, 2022, Pagina/e 323003, ISSN 1361-6463
Editore: IOPScience
DOI: 10.1088/1361-6463/ac6f97

H2-Driven Reduction of Flavin by Hydrogenase Enables Cleaner Operation of Nitroreductases for Nitro-Group to Amine Reductions

Autori: Miguel A. Ramirez, Shiny Joseph Srinivasan, Sarah E. Cleary, Peter M. T. Todd, Holly A. Reeve, Kylie A. Vincent
Pubblicato in: Frontiers in Catalysis, Numero Vol 2, 2022, Pagina/e https://doi.org/10.3389/fctls.2022.906694, ISSN 2673-7841
Editore: Frontiers
DOI: 10.3389/fctls.2022.906694

E. coli Nickel‐Iron Hydrogenase 1 Catalyses Non‐native Reduction of Flavins: Demonstration for Alkene Hydrogenation by Old Yellow Enzyme Ene‐reductases**

Autori: Shiny Joseph Srinivasan; Sarah E. Cleary; Miguel A. Ramirez; Holly A. Reeve; Caroline E. Paul; Kylie A. Vincent
Pubblicato in: Angewandte Chemie (International Ed. in English), Numero Vol 60, 2021, Pagina/e 13824-13828, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202101186

Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR

Autori: Jack S. Rowbotham, Jake H. Nicholson, Miguel A. Ramirez, Kouji Urata, Peter M. T. Todd, Gogulan Karunanithy, Lars Lauterbach, Holly A. Reeve, Andrew J. Baldwin, Kylie A. Vincent
Pubblicato in: Chemical Science, Numero 14, 2024, Pagina/e 12160-12165, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc01718d

The crystalline state as a dynamic system: IR microspectroscopy under electrochemical control for a [NiFe] hydrogenase

Autori: Philip A. Ash; Sophie E. T. Kendall-Price; Rhiannon M. Evans; Stephen B. Carr; Amelia R. Brasnett; Simone Morra; Jack S. Rowbotham; Ricardo Hidalgo; Adam J. Healy; Gianfelice Cinque; Mark D. Frogley; Fraser A. Armstrong; Kylie A. Vincent
Pubblicato in: Chemical Science, Numero Vol 12, 2021, Pagina/e 12959-12970, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d1sc01734a

Controlled Biocatalytic Synthesis of a Metal Nanoparticle‐Enzyme Hybrid: Demonstration for Catalytic H₂‐driven NADH Recycling

Autori: Lucy B. F. Browne, Tim Sudmeier, Maya A. Landis, Christopher S. Allen, Kylie A. Vincent
Pubblicato in: Angewandte Chemie, Numero 136, 2024, Pagina/e e202404024, ISSN 0044-8249
Editore: Wiley
DOI: 10.1002/ange.202404024

Replacing a Cysteine Ligand by Selenocysteine in a [NiFe]-Hydrogenase Unlocks Hydrogen Production Activity and Addresses the Role of Concerted Proton-Coupled Electron Transfer in Electrocatalytic Reversibility

Autori: Rhiannon M. Evans, Natalie Krahn, Joshua Weiss, Kylie A. Vincent, Dieter Söll, Fraser A. Armstrong
Pubblicato in: Journal of the American Chemical Society, Numero 146, 2024, Pagina/e 16971-16976, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c03489

Stability of the H-cluster under whole-cell conditions—formation of an Htrans-like state and its reactivity towards oxygen

Autori: Marco Lorenzi; Pierre Ceccaldi; Patricia Rodríguez-Maciá; Holly Jayne Redman; Afridi Zamader; James A. Birrell; Livia S. Mészáros; Gustav Berggren
Pubblicato in: Journal of Biological Inorganic Chemistry, Numero 1, 2022, ISSN 0949-8257
Editore: Springer Verlag
DOI: 10.1007/s00775-022-01928-5

Exploiting hydrogenases for biocatalytic hydrogenations

Autori: Daria Sokolova, Kylie A. Vincent
Pubblicato in: Chemical Communications, Numero 60, 2024, Pagina/e 13667-13677, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d4cc04525d

The Nonphysiological Reductant Sodium Dithionite and [FeFe] Hydrogenase: Influence on the Enzyme Mechanism.

Autori: Maria Alessandra Martini; Olaf Rüdiger; Nina Breuer; Birgit Nöring; Serena DeBeer; Patricia Rodríguez-Maciá; James A. Birrell
Pubblicato in: Journal of the American Chemical Society, Numero 1, 2021, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c07322

Binuclear Lanthanide Complexes as Magnetic Resonance and Optical Imaging Probes for Redox Sensing

Autori: Charlie H. Simms, Daniel Kovacs, Lina Hacker, Euan T. Sarson, Daria Sokolova, Kirsten E. Christensen, Alexandr Khrapichev, Louise A. W. Martin, Kylie Vincent, Stuart J. Conway, Ester M. Hammond, Matthew J. Langton, Stephen Faulkner
Pubblicato in: Chemistry – A European Journal, Numero 31, 2025, Pagina/e e202404748, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202404748

Electrochemical experiments define potentials associated with binding of substrates and inhibitors to nitrogenase MoFe protein

Autori: Ting Chen; Philip A. Ash; Lance C. Seefeldt; Kylie A. Vincent
Pubblicato in: Faraday Discussions, Numero 243, 2023, Pagina/e 270-286, ISSN 1364-5498
Editore: Royal Society of Chemistry
DOI: 10.1039/d2fd00170e

Riboflavin with H₂‐Driven or Electrochemical Recycling: A Cheap Cofactor System for Supporting Biocatalytic Alkene Reduction

Autori: Lucy B. F. Browne, Charlotte C. Hancox, Sofia M. Helin, Peter M. T. Todd, Kylie A. Vincent
Pubblicato in: ChemCatChem, Numero 17, 2025, ISSN 1867-3880
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202401578

Cyanophenylalanine as an Infrared Probe for Iron–Sulfur Cluster Redox State in Multicenter Metalloenzymes

Autori: Zehui Duan, Jiaao Wei, Stephen B. Carr, Miguel Ramirez, Rhiannon M. Evans, Philip A. Ash, Patricia Rodriguez‐Macia, Amit Sachdeva, Kylie A. Vincent
Pubblicato in: ChemBioChem, Numero doi:10.1002/cbic.202500251, 2025, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202500251

Electrochemical control of [FeFe]-hydrogenase single crystals reveals complex redox populations at the catalytic site

Autori: Simone Morra; Jifu Duan; Martin Winkler; Philip A. Ash; Thomas Happe; Kylie A. Vincent
Pubblicato in: Dalton Transactions, Numero Vol 50, 2021, Pagina/e 12655-12663, ISSN 1477-9226
Editore: Royal Society of Chemistry
DOI: 10.1039/d1dt02219a

Selective hydrogenation of nitro compounds to amines by coupled redox reactions over a heterogeneous biocatalyst

Autori: Daria Sokolova, Tara C. Lurshay, Jack S. Rowbotham, Georgia Stonadge, Holly A. Reeve, Sarah E. Cleary, Tim Sudmeier, Kylie A. Vincent
Pubblicato in: Nature Communications, Numero 15, 2024, Pagina/e 7297, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51531-2

A Beginner’s Guide to Thermodynamic Modelling of [FeFe] Hydrogenase

Autori: James A. Birrell; Patricia Rodríguez-Maciá; Adrian Hery-Barranco
Pubblicato in: Catalysts, Numero Vol 11, 2021, Pagina/e 238, ISSN 2073-4344
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal11020238

Diritti di proprietà intellettuale

Patent (1)

METHOD OF REDUCING AND RECYCLING OXIDIZED FLAVIN COFACTORS

Numero candidatura/pubblicazione: 20 21051000
Data: 2021-04-23
Candidato/i: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD