Order and Disorder at the Surface of Biological Membranes.

Project Information

BioDisOrder

Grant agreement ID: 819644

DOI

10.3030/819644

Project closed

EC signature date 19 March 2019

Start date 1 June 2019

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 945,00

EU contribution

€ 1 999 945,00

Coordinated by

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

Author(s): Daniel K Weber, U Venkateswara Reddy, Songlin Wang, Erik K Larsen, Tata Gopinath, Martin B Gustavsson, Razvan L Cornea, David D Thomas, Alfonso De Simone, Gianluigi Veglia
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.66226

Stimuli-Responsive Hydrogels from Liquid–Liquid Phase Separations of FUS-Derived Peptides

Author(s): Elisabetta Rosa, Mariantonietta Pizzella, Luca Cimmino, Valeria Castelletto, Ian W. Hamley, Luigi Vitagliano, Alfonso De Simone, Antonella Accardo
Published in: ACS Applied Materials & Interfaces, 2025, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.5c15249

Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease‐associated T183A variant

Author(s): Mario Sanz-Hernández, Alfonso De Simone
Published in: Biomolecular NMR assignments, 2021, ISSN 1874-2718
Publisher: Springer Verlag
DOI: 10.1007/s12104-021-10005-y

Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

Author(s): Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R. Carta
Published in: International Journal of Molecular Sciences, Issue 21/22, 2020, Page(s) 8535, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228535

Immune responses to oligomeric α-synuclein in Parkinson’s disease peripheral blood mononuclear cells

Author(s): Ana Florencia Vega-Benedetti, Clara Porcedda, Tommaso Ercoli, Giuliana Fusco, Chiara Burgaletto, Rita Pillai, Francesca Palmas, Anna Flavia Cantone, Fabrizio Angius, Paolo Solla, Alfonso De Simone, Giuseppina Cantarella, Cesarina Giallongo, Valeria Sogos, Giovanni Defazio, Anna R. Carta
Published in: Journal of Neurology, Issue 271, 2024, Page(s) 5916-5929, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-024-12554-3

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

Author(s): Wing K. Man, Bogachan Tahirbegi, Michail D. Vrettas, Swapan Preet, Liming Ying, Michele Vendruscolo, Alfonso De Simone, Giuliana Fusco
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21027-4

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

Author(s): Matteo Runfola, Alfonso De Simone, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Published in: Scientific Reports, Issue 10, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-57023-4

Membrane Interactions and Toxicity by Misfolded Protein Oligomers

Author(s): Mario Gonzalez-Garcia, Giuliana Fusco, Alfonso De Simone
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2021.642623

Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates

Author(s): Serene W. Chen, Joseph D. Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A. Jarvis, Fabrizio Chiti, Christopher M. Dobson, Giuliana Fusco, Alfonso De Simone
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 10537-10549, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c14703

In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes

Author(s): Carlos Navarro-Paya, Maximo Sanz-Hernandez, Alfonso De Simone
Published in: Life, Issue 10/6, 2020, Page(s) 98, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life10060098

Plasticity of Membrane Binding by the Central Region of α-Synuclein

Author(s): Navarro-Paya C, Sanz-Hernandez M, De Simone A.
Published in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Publisher: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.857217

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

Author(s): Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16564-3

Enhancing Biomolecular Simulations with Hybrid Potentials Incorporating NMR Data

Author(s): Qi G, Michail D. Vrettas, Biancaniello C, Sanz-Hernandez M, Cafolla CT, Morgan JWR, Wang Y, De Simone A, Wales DJ.
Published in: Journal of Chemical Theory and Computations, 2022, ISSN 1549-9618
Publisher: American Chemical Society
DOI: 10.1021/acs.jctc.2c00657

α-Synuclein and biological membranes: the danger of loving too much

Author(s): Silvia Mansueto, Giuliana Fusco, Alfonso De Simone
Published in: Chemical Communications, Issue 59, 2024, Page(s) 8769-8778, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cc01682j

Mechanism of misfolding of the human prion protein revealed by a pathological mutation

Author(s): Máximo Sanz-Hernández, Joseph D. Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone
Published in: Proceedings of the National Academy of Sciences, Issue 118/12, 2021, Page(s) e2019631118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2019631118

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Author(s): Phuong H. Nguyen, Ayyalusamy Ramamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez, Joan-Emma Shea, Nikolay V. Dokholyan, Alfonso De Simone, Buyong Ma, Ruth Nussinov, Saeed Najafi, Son Tung Ngo, Antoine Loquet, Mara Chiricotto, Pritam Ganguly, James McCarty, Mai Suan Li, Carol Hall, Yiming Wang, Yifat Miller, Simone Melchionna, Birgit Habenstein, Stepan Timr, Jiaxi
Published in: Chemical Reviews, Issue 121/4, 2021, Page(s) 2545-2647, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.0c01122

Thermal tuning of protein hydration in a hyperthermophilic enzyme

Author(s): Giuliana Fusco, Carmen Biancaniello, Michail Vrettas, Alfonso De Simone
Published in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Publisher: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.1037445

Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein

Author(s): Maria Zacharopoulou, Neeleema Seetaloo, James Ross, Amberley D. Stephens, Giuliana Fusco, Thomas M. McCoy, Wenyue Dai, Ioanna Mela, Ana Fernandez-Villegas, Anne Martel, Alexander F. Routh, Alfonso De Simone, Jonathan J. Phillips, Gabriele S. Kaminski Schierle
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 13131-13145, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c13473

α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance

Author(s): Angelo Gallo, Silvia Mansueto, Alessandro Emendato, Giuliana Fusco, Alfonso De Simone
Published in: JACS Au, Issue 4, 2024, Page(s) 2372-2380, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.4c00323

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

Author(s): Wing K. Man, Alfonso De Simone, Joseph D. Barritt, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Published in: Frontiers in Neuroscience, Issue 14, 2020, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2020.00018

Structure and Dynamics of the Misfolding Intermediate in the Pathogenic T183A Prion Protein Mutant

Author(s): Carmen Biancaniello, Alessandro Emendato, Alfonso De Simone
Published in: Journal of Chemical Theory and Computation, 2025, ISSN 1549-9618
Publisher: American Chemical Society
DOI: 10.1021/acs.jctc.5c00742

Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson's Disease

Author(s): Maria Francesca Palmas, Anna Ena, Chiara Burgaletto, Maria Antonietta Casu, Giuseppina Cantarella, Ezio Carboni, Michela Etzi, Alfonso De Simone, Giuliana Fusco, Maria Cristina Cardia, Francesco Lai, Luca Picci, David Tweedie, Michael T. Scerba, Valentina Coroneo, Renato Bernardini, Nigel H. Greig, Augusta Pisanu, Anna R. Carta
Published in: Neurotherapeutics, Issue 19, 2024, Page(s) 305-324, ISSN 1878-7479
Publisher: Springer Nature
DOI: 10.1007/s13311-022-01182-2

Editorial: Oligomers in amyloid-associated diseases—structural properties and toxicity

Author(s): Neville Vassallo, Sandrine Ongeri, Alfonso De Simone
Published in: Frontiers in Molecular Biosciences, Issue 10, 2023, ISSN 2296-889X
Publisher: Frontiers Media
DOI: 10.3389/fmolb.2023.1215340

Metal interactions of α-synuclein probed by NMR amide-proton exchange

Author(s): Mario Gonzalez-Garcia, Giuliana Fusco, Alfonso De Simone
Published in: Frontiers in Chemistry, Issue 11, 2023, ISSN 2296-2646
Publisher: Frontiers Media
DOI: 10.3389/fchem.2023.1167766

The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes

Author(s): Fusco G, Bemporad F, Chiti F, Dobson CM, De Simone A.
Published in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Publisher: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.981312