Order and Disorder at the Surface of Biological Membranes.

Informazioni relative al progetto

BioDisOrder

ID dell’accordo di sovvenzione: 819644

DOI

10.3030/819644

Progetto chiuso

Data della firma CE 19 Marzo 2019

Data di avvio 1 Giugno 2019

Data di completamento 30 Novembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 945,00

Contributo UE

€ 1 999 945,00

Coordinato da

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (25)

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

Autori: Daniel K Weber, U Venkateswara Reddy, Songlin Wang, Erik K Larsen, Tata Gopinath, Martin B Gustavsson, Razvan L Cornea, David D Thomas, Alfonso De Simone, Gianluigi Veglia
Pubblicato in: eLife, Numero 10, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.66226

Stimuli-Responsive Hydrogels from Liquid–Liquid Phase Separations of FUS-Derived Peptides

Autori: Elisabetta Rosa, Mariantonietta Pizzella, Luca Cimmino, Valeria Castelletto, Ian W. Hamley, Luigi Vitagliano, Alfonso De Simone, Antonella Accardo
Pubblicato in: ACS Applied Materials & Interfaces, 2025, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.5c15249

Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease‐associated T183A variant

Autori: Mario Sanz-Hernández, Alfonso De Simone
Pubblicato in: Biomolecular NMR assignments, 2021, ISSN 1874-2718
Editore: Springer Verlag
DOI: 10.1007/s12104-021-10005-y

Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

Autori: Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R. Carta
Pubblicato in: International Journal of Molecular Sciences, Numero 21/22, 2020, Pagina/e 8535, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228535

Immune responses to oligomeric α-synuclein in Parkinson’s disease peripheral blood mononuclear cells

Autori: Ana Florencia Vega-Benedetti, Clara Porcedda, Tommaso Ercoli, Giuliana Fusco, Chiara Burgaletto, Rita Pillai, Francesca Palmas, Anna Flavia Cantone, Fabrizio Angius, Paolo Solla, Alfonso De Simone, Giuseppina Cantarella, Cesarina Giallongo, Valeria Sogos, Giovanni Defazio, Anna R. Carta
Pubblicato in: Journal of Neurology, Numero 271, 2024, Pagina/e 5916-5929, ISSN 0340-5354
Editore: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-024-12554-3

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

Autori: Wing K. Man, Bogachan Tahirbegi, Michail D. Vrettas, Swapan Preet, Liming Ying, Michele Vendruscolo, Alfonso De Simone, Giuliana Fusco
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21027-4

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

Autori: Matteo Runfola, Alfonso De Simone, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Pubblicato in: Scientific Reports, Numero 10, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-57023-4

Membrane Interactions and Toxicity by Misfolded Protein Oligomers

Autori: Mario Gonzalez-Garcia, Giuliana Fusco, Alfonso De Simone
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2021.642623

Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates

Autori: Serene W. Chen, Joseph D. Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A. Jarvis, Fabrizio Chiti, Christopher M. Dobson, Giuliana Fusco, Alfonso De Simone
Pubblicato in: Journal of the American Chemical Society, Numero 146, 2024, Pagina/e 10537-10549, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c14703

In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes

Autori: Carlos Navarro-Paya, Maximo Sanz-Hernandez, Alfonso De Simone
Pubblicato in: Life, Numero 10/6, 2020, Pagina/e 98, ISSN 2075-1729
Editore: MDPI
DOI: 10.3390/life10060098

Plasticity of Membrane Binding by the Central Region of α-Synuclein

Autori: Navarro-Paya C, Sanz-Hernandez M, De Simone A.
Pubblicato in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editore: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.857217

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

Autori: Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-16564-3

Enhancing Biomolecular Simulations with Hybrid Potentials Incorporating NMR Data

Autori: Qi G, Michail D. Vrettas, Biancaniello C, Sanz-Hernandez M, Cafolla CT, Morgan JWR, Wang Y, De Simone A, Wales DJ.
Pubblicato in: Journal of Chemical Theory and Computations, 2022, ISSN 1549-9618
Editore: American Chemical Society
DOI: 10.1021/acs.jctc.2c00657

α-Synuclein and biological membranes: the danger of loving too much

Autori: Silvia Mansueto, Giuliana Fusco, Alfonso De Simone
Pubblicato in: Chemical Communications, Numero 59, 2024, Pagina/e 8769-8778, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cc01682j

Mechanism of misfolding of the human prion protein revealed by a pathological mutation

Autori: Máximo Sanz-Hernández, Joseph D. Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/12, 2021, Pagina/e e2019631118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2019631118

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Autori: Phuong H. Nguyen, Ayyalusamy Ramamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez, Joan-Emma Shea, Nikolay V. Dokholyan, Alfonso De Simone, Buyong Ma, Ruth Nussinov, Saeed Najafi, Son Tung Ngo, Antoine Loquet, Mara Chiricotto, Pritam Ganguly, James McCarty, Mai Suan Li, Carol Hall, Yiming Wang, Yifat Miller, Simone Melchionna, Birgit Habenstein, Stepan Timr, Jiaxi
Pubblicato in: Chemical Reviews, Numero 121/4, 2021, Pagina/e 2545-2647, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.0c01122

Thermal tuning of protein hydration in a hyperthermophilic enzyme

Autori: Giuliana Fusco, Carmen Biancaniello, Michail Vrettas, Alfonso De Simone
Pubblicato in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editore: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.1037445

Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein

Autori: Maria Zacharopoulou, Neeleema Seetaloo, James Ross, Amberley D. Stephens, Giuliana Fusco, Thomas M. McCoy, Wenyue Dai, Ioanna Mela, Ana Fernandez-Villegas, Anne Martel, Alexander F. Routh, Alfonso De Simone, Jonathan J. Phillips, Gabriele S. Kaminski Schierle
Pubblicato in: Journal of the American Chemical Society, Numero 147, 2025, Pagina/e 13131-13145, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.4c13473

α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance

Autori: Angelo Gallo, Silvia Mansueto, Alessandro Emendato, Giuliana Fusco, Alfonso De Simone
Pubblicato in: JACS Au, Numero 4, 2024, Pagina/e 2372-2380, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacsau.4c00323

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

Autori: Wing K. Man, Alfonso De Simone, Joseph D. Barritt, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Pubblicato in: Frontiers in Neuroscience, Numero 14, 2020, ISSN 1662-453X
Editore: Frontiers
DOI: 10.3389/fnins.2020.00018

Structure and Dynamics of the Misfolding Intermediate in the Pathogenic T183A Prion Protein Mutant

Autori: Carmen Biancaniello, Alessandro Emendato, Alfonso De Simone
Pubblicato in: Journal of Chemical Theory and Computation, 2025, ISSN 1549-9618
Editore: American Chemical Society
DOI: 10.1021/acs.jctc.5c00742

Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson's Disease

Autori: Maria Francesca Palmas, Anna Ena, Chiara Burgaletto, Maria Antonietta Casu, Giuseppina Cantarella, Ezio Carboni, Michela Etzi, Alfonso De Simone, Giuliana Fusco, Maria Cristina Cardia, Francesco Lai, Luca Picci, David Tweedie, Michael T. Scerba, Valentina Coroneo, Renato Bernardini, Nigel H. Greig, Augusta Pisanu, Anna R. Carta
Pubblicato in: Neurotherapeutics, Numero 19, 2024, Pagina/e 305-324, ISSN 1878-7479
Editore: Springer Nature
DOI: 10.1007/s13311-022-01182-2

Editorial: Oligomers in amyloid-associated diseases—structural properties and toxicity

Autori: Neville Vassallo, Sandrine Ongeri, Alfonso De Simone
Pubblicato in: Frontiers in Molecular Biosciences, Numero 10, 2023, ISSN 2296-889X
Editore: Frontiers Media
DOI: 10.3389/fmolb.2023.1215340

Metal interactions of α-synuclein probed by NMR amide-proton exchange

Autori: Mario Gonzalez-Garcia, Giuliana Fusco, Alfonso De Simone
Pubblicato in: Frontiers in Chemistry, Numero 11, 2023, ISSN 2296-2646
Editore: Frontiers Media
DOI: 10.3389/fchem.2023.1167766

The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes

Autori: Fusco G, Bemporad F, Chiti F, Dobson CM, De Simone A.
Pubblicato in: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editore: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.981312