Order and Disorder at the Surface of Biological Membranes.

Información del proyecto

BioDisOrder

Identificador del acuerdo de subvención: 819644

DOI

10.3030/819644

Proyecto cerrado

Fecha de la firma de la CE 19 Marzo 2019

Fecha de inicio 1 Junio 2019

Fecha de finalización 30 Noviembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 945,00

Aportación de la UE

€ 1 999 945,00

Coordinado por

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (25)

Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation

Autores: Daniel K Weber, U Venkateswara Reddy, Songlin Wang, Erik K Larsen, Tata Gopinath, Martin B Gustavsson, Razvan L Cornea, David D Thomas, Alfonso De Simone, Gianluigi Veglia
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.66226

Stimuli-Responsive Hydrogels from Liquid–Liquid Phase Separations of FUS-Derived Peptides

Autores: Elisabetta Rosa, Mariantonietta Pizzella, Luca Cimmino, Valeria Castelletto, Ian W. Hamley, Luigi Vitagliano, Alfonso De Simone, Antonella Accardo
Publicado en: ACS Applied Materials & Interfaces, 2025, ISSN 1944-8244
Editor: American Chemical Society
DOI: 10.1021/acsami.5c15249

Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease‐associated T183A variant

Autores: Mario Sanz-Hernández, Alfonso De Simone
Publicado en: Biomolecular NMR assignments, 2021, ISSN 1874-2718
Editor: Springer Verlag
DOI: 10.1007/s12104-021-10005-y

Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

Autores: Laura Boi, Augusta Pisanu, Maria Francesca Palmas, Giuliana Fusco, Ezio Carboni, Maria Antonietta Casu, Valentina Satta, Maria Scherma, Elzbieta Janda, Ignazia Mocci, Giovanna Mulas, Anna Ena, Saturnino Spiga, Paola Fadda, Alfonso De Simone, Anna R. Carta
Publicado en: International Journal of Molecular Sciences, Edición 21/22, 2020, Página(s) 8535, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228535

Immune responses to oligomeric α-synuclein in Parkinson’s disease peripheral blood mononuclear cells

Autores: Ana Florencia Vega-Benedetti, Clara Porcedda, Tommaso Ercoli, Giuliana Fusco, Chiara Burgaletto, Rita Pillai, Francesca Palmas, Anna Flavia Cantone, Fabrizio Angius, Paolo Solla, Alfonso De Simone, Giuseppina Cantarella, Cesarina Giallongo, Valeria Sogos, Giovanni Defazio, Anna R. Carta
Publicado en: Journal of Neurology, Edición 271, 2024, Página(s) 5916-5929, ISSN 0340-5354
Editor: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-024-12554-3

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

Autores: Wing K. Man, Bogachan Tahirbegi, Michail D. Vrettas, Swapan Preet, Liming Ying, Michele Vendruscolo, Alfonso De Simone, Giuliana Fusco
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-21027-4

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

Autores: Matteo Runfola, Alfonso De Simone, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Publicado en: Scientific Reports, Edición 10, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-57023-4

Membrane Interactions and Toxicity by Misfolded Protein Oligomers

Autores: Mario Gonzalez-Garcia, Giuliana Fusco, Alfonso De Simone
Publicado en: Frontiers in Cell and Developmental Biology, Edición 9, 2021, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2021.642623

Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates

Autores: Serene W. Chen, Joseph D. Barritt, Roberta Cascella, Alessandra Bigi, Cristina Cecchi, Martina Banchelli, Angelo Gallo, James A. Jarvis, Fabrizio Chiti, Christopher M. Dobson, Giuliana Fusco, Alfonso De Simone
Publicado en: Journal of the American Chemical Society, Edición 146, 2024, Página(s) 10537-10549, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c14703

In Silico Study of the Mechanism of Binding of the N-Terminal Region of α Synuclein to Synaptic-Like Membranes

Autores: Carlos Navarro-Paya, Maximo Sanz-Hernandez, Alfonso De Simone
Publicado en: Life, Edición 10/6, 2020, Página(s) 98, ISSN 2075-1729
Editor: MDPI
DOI: 10.3390/life10060098

Plasticity of Membrane Binding by the Central Region of α-Synuclein

Autores: Navarro-Paya C, Sanz-Hernandez M, De Simone A.
Publicado en: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editor: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.857217

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

Autores: Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16564-3

Enhancing Biomolecular Simulations with Hybrid Potentials Incorporating NMR Data

Autores: Qi G, Michail D. Vrettas, Biancaniello C, Sanz-Hernandez M, Cafolla CT, Morgan JWR, Wang Y, De Simone A, Wales DJ.
Publicado en: Journal of Chemical Theory and Computations, 2022, ISSN 1549-9618
Editor: American Chemical Society
DOI: 10.1021/acs.jctc.2c00657

α-Synuclein and biological membranes: the danger of loving too much

Autores: Silvia Mansueto, Giuliana Fusco, Alfonso De Simone
Publicado en: Chemical Communications, Edición 59, 2024, Página(s) 8769-8778, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d3cc01682j

Mechanism of misfolding of the human prion protein revealed by a pathological mutation

Autores: Máximo Sanz-Hernández, Joseph D. Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone
Publicado en: Proceedings of the National Academy of Sciences, Edición 118/12, 2021, Página(s) e2019631118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2019631118

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Autores: Phuong H. Nguyen, Ayyalusamy Ramamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez, Joan-Emma Shea, Nikolay V. Dokholyan, Alfonso De Simone, Buyong Ma, Ruth Nussinov, Saeed Najafi, Son Tung Ngo, Antoine Loquet, Mara Chiricotto, Pritam Ganguly, James McCarty, Mai Suan Li, Carol Hall, Yiming Wang, Yifat Miller, Simone Melchionna, Birgit Habenstein, Stepan Timr, Jiaxi
Publicado en: Chemical Reviews, Edición 121/4, 2021, Página(s) 2545-2647, ISSN 0009-2665
Editor: American Chemical Society
DOI: 10.1021/acs.chemrev.0c01122

Thermal tuning of protein hydration in a hyperthermophilic enzyme

Autores: Giuliana Fusco, Carmen Biancaniello, Michail Vrettas, Alfonso De Simone
Publicado en: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editor: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.1037445

Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein

Autores: Maria Zacharopoulou, Neeleema Seetaloo, James Ross, Amberley D. Stephens, Giuliana Fusco, Thomas M. McCoy, Wenyue Dai, Ioanna Mela, Ana Fernandez-Villegas, Anne Martel, Alexander F. Routh, Alfonso De Simone, Jonathan J. Phillips, Gabriele S. Kaminski Schierle
Publicado en: Journal of the American Chemical Society, Edición 147, 2025, Página(s) 13131-13145, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.4c13473

α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance

Autores: Angelo Gallo, Silvia Mansueto, Alessandro Emendato, Giuliana Fusco, Alfonso De Simone
Publicado en: JACS Au, Edición 4, 2024, Página(s) 2372-2380, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/jacsau.4c00323

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles

Autores: Wing K. Man, Alfonso De Simone, Joseph D. Barritt, Michele Vendruscolo, Christopher M. Dobson, Giuliana Fusco
Publicado en: Frontiers in Neuroscience, Edición 14, 2020, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2020.00018

Structure and Dynamics of the Misfolding Intermediate in the Pathogenic T183A Prion Protein Mutant

Autores: Carmen Biancaniello, Alessandro Emendato, Alfonso De Simone
Publicado en: Journal of Chemical Theory and Computation, 2025, ISSN 1549-9618
Editor: American Chemical Society
DOI: 10.1021/acs.jctc.5c00742

Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson's Disease

Autores: Maria Francesca Palmas, Anna Ena, Chiara Burgaletto, Maria Antonietta Casu, Giuseppina Cantarella, Ezio Carboni, Michela Etzi, Alfonso De Simone, Giuliana Fusco, Maria Cristina Cardia, Francesco Lai, Luca Picci, David Tweedie, Michael T. Scerba, Valentina Coroneo, Renato Bernardini, Nigel H. Greig, Augusta Pisanu, Anna R. Carta
Publicado en: Neurotherapeutics, Edición 19, 2024, Página(s) 305-324, ISSN 1878-7479
Editor: Springer Nature
DOI: 10.1007/s13311-022-01182-2

Editorial: Oligomers in amyloid-associated diseases—structural properties and toxicity

Autores: Neville Vassallo, Sandrine Ongeri, Alfonso De Simone
Publicado en: Frontiers in Molecular Biosciences, Edición 10, 2023, ISSN 2296-889X
Editor: Frontiers Media
DOI: 10.3389/fmolb.2023.1215340

Metal interactions of α-synuclein probed by NMR amide-proton exchange

Autores: Mario Gonzalez-Garcia, Giuliana Fusco, Alfonso De Simone
Publicado en: Frontiers in Chemistry, Edición 11, 2023, ISSN 2296-2646
Editor: Frontiers Media
DOI: 10.3389/fchem.2023.1167766

The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes

Autores: Fusco G, Bemporad F, Chiti F, Dobson CM, De Simone A.
Publicado en: Frontiers in Molecular Biosciences, 2022, ISSN 2296-889X
Editor: Lausanne: Frontiers Media S.A., 2014-
DOI: 10.3389/fmolb.2022.981312