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The value of diagnostics to combat antimicrobial resistance by optimising antibiotic use

Objective

Antimicrobial resistance (AMR) is of great public health concern, causing numerous losses of lives worldwide and threatening to reverse many of the considerable strides modern medicine has made over the last century. There is a need to stratify antibiotic and alternative treatments in terms of the actual benefit for the patient, improving patient outcome and limit the impact on AMR. High quality, effective and appropriate diagnostic tests to steer appropriate use of antibiotics are available. However, implementation of these tests into daily healthcare practice is hampered due to lack of insight in the medical, technological and health economical value and limited knowledge about psychosocial, ethical, regulatory and organisational barriers to their implementation into clinical practice.

VALUE-Dx will define and understand these value indicators and barriers to adoption of diagnostics of Community-Acquired Acute Respiratory Tract Infections (CA-ARTI) in order to develop and improve health economic models to generate insight in the whole value of diagnostics and develop policy and regulatory recommendations. In addition, efficient clinical algorithms and user requirement specifications of tests will be developed fuelling the medical and technological value of CA-ARTI diagnostics. The value of diagnostics will be tested and demonstrated in a unique pan-European clinical and laboratory research infrastructure allowing for innovative adaptive trial designs to evaluate novel CA-ARTI diagnostics. Close and continuous interaction with the VALUE-Dx multi-stakeholder platform provides for optimal alignment of VALUE-Dx activities with stakeholder opinions, expert knowledge and interests.

A variety of dissemination and advocacy measures will promote wide-spread adoption of clinical and cost-effective innovative diagnostics to achieve more personalized, evidence-based antibiotic prescription in order to transform clinical practice, improve patient outcomes and combat AMR.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

H2020-JTI-IMI2-2017-13-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

UNIVERSITEIT ANTWERPEN
Address
Prinsstraat 13
2000 Antwerpen
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 282 957

Participants (25)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 716 160
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 730 458
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS
Italy
EU contribution
€ 189 444
Address
Corso Stati Uniti 4
35127 Padova
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 275 409
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 75 765
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 305 596
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
THE HEALTH CORPORATION - RAMBAM
Israel
EU contribution
€ 226 444
Address
Haaliya 8
31096 Haifa
Activity type
Research Organisations
UNIVERSIDAD DE LA RIOJA
Spain
EU contribution
€ 136 693
Address
Avenida De La Paz 93
26006 La Rioja
Activity type
Higher or Secondary Education Establishments
THE TRUSTEES OF BOSTON UNIVERSITY
United States
EU contribution
€ 15 641
Address
Commonwealth Avenue 881
02215 Boston Ma
Activity type
Higher or Secondary Education Establishments
BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE
France
EU contribution
€ 66 337
Address
40 Avenue Tony Garnier
69007 Lyon
Activity type
Research Organisations
FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS
Switzerland
EU contribution
€ 77 858
Address
Campus Biotech, Chemin Des Mines 9
1202 Geneve
Activity type
Other
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE
United Kingdom
EU contribution
€ 137 793
Address
Level 1A City Tower Piccadilly Plaza
M1 4BT Manchester
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
GESUNDHEIT OSTERREICH GMBH
Austria
EU contribution
€ 88 520
Address
Stubenring 6
1010 Wien
Activity type
Other
EUROPEAN SOCIETY CLINICAL MICROBIOLOGY INFECTIOUS DISEASES (EUROPAISCHE GESELLSCHAFT FUR KLINISCHE MIKROBIOLOGIE INFEKTIONSKRANKHEITEN)
Switzerland
EU contribution
€ 184 649
Address
Gerbergasse 14
4001 Basel
Activity type
Other
EUROPEAN RESPIRATORY SOCIETY
Switzerland
EU contribution
€ 144 902
Address
Avenue Sainte Luce 4
1003 Lausanne
Activity type
Other
BERRY CONSULTANTS LLP
United Kingdom
EU contribution
€ 72 411
Address
Merchant House 5 East Saint Helen Street
OX14 5EG Abingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LUXEMBOURG INSTITUTE OF HEALTH
Luxembourg
EU contribution
€ 37 365
Address
Val Fleuri 84
1526 Luxembourg
Activity type
Research Organisations
ZORGONDERZOEK NEDERLAND ZON
Netherlands
EU contribution
€ 34 698
Address
Laan Van Nieuw Oost Indie 334
2593CE Den Haag
Activity type
Research Organisations
BIOMERIEUX SA
France
EU contribution
€ 0
Address
Chemin De L'orme
69280 Marcy L'etoile
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACCELERATE DIAGNOSTICS SL
Spain
EU contribution
€ 0
Address
Cl Esteve Terrades 1 3 Edif. Rdit Parc Pmt-upc
08860 Castelldefels
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALERE INTERNATIONAL LIMITED
Ireland
EU contribution
€ 0
Address
Parkmore East Business Park Ballybrit
Galway
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIO-RAD
France
EU contribution
€ 0
Address
3 Blv Raymond Poincare
92430 Marnes-la-coquette
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BD SWITZERLAND SARL
Switzerland
EU contribution
€ 0
Address
Route De Crassier 17, Business Park Terre-bonne, B
1262 Eysins
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE WELLCOME TRUST LIMITED
United Kingdom
EU contribution
€ 0
Address
Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)