Project description DEENESFRITPL Digital sensors to monitor mobility, disease progression Clinicians, scientists, prominent academic centres, businesses, and the world’s largest pharmaceutical and medical industries are working together to develop a revolutionary sensor system to monitor gait in daily life. Mobility is considered the ‘sixth vital sign’ of health, with poor gait such as walking slowly being associated with greater risk of disease, cognitive decline, risk of falls, and even earlier death. The Mobilise-D project will develop digital technology, including body-worn sensors, to monitor mobility. They aim to deliver a solution for real-world digital mobility assessment and validate digital mobility outcomes to predict clinical endpoints in multiple sclerosis, hip fracture recovery, chronic obstructive pulmonary disease, and Parkinson’s disease. The results will facilitate drug development and establish a roadmap for the clinical implementation of new digital tools to identify, stratify, and monitor disability. Show the project objective Hide the project objective Objective Optimal treatment of the impaired mobility resulting from ageing and chronic disease is one of the 21st century's greatest challenges facing patients, society, governments, healthcare services, and science. New interventions are a key focus. However, to accelerate their development, we need better ways to detect and measure mobility loss. Digital technology, including body worn sensors, has the potential to revolutionise mobility assessment. The overarching objectives of MOBILISE-D are threefold: to deliver a valid solution (consisting of sensor, algorithms, data analytics, outcomes) for real-world digital mobility assessment; to validate digital outcomes in predicting clinical outcome in chronic obstructive pulmonary disease, Parkinson’s disease, multiple sclerosis, proximal femoral fracture recovery and congestive heart failure; and, to obtain key regulatory and health stakeholder approval for digital mobility assessment. The objectives address the call directly by linking digital assessment of mobility to clinical endpoints to support regulatory acceptance and clinical practice. MOBILISE-D consists of 35 partners from 13 countries with long, successful collaboration, combining the requisite expertise to address the technical and clinical challenges. To achieve the objectives, partners will jointly develop and implement a digital mobility assessment solution to demonstrate that real-world digital mobility outcomes can successfully predict relevant clinical outcomes and provide a better, safer and quicker way to arrive at the development of innovative medicines. MOBILISE-D's results will directly facilitate drug development, and establish the roadmap for clinical implementation of new, complementary tools to identify, stratify and monitor disability, so enabling widespread, cost-effective access to optimal clinical mobility management through personalised healthcare. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicineneurologymultiple sclerosisengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health scienceshealth scienceshealth care servicesmedical and health sciencesclinical medicinecardiology Keywords Digital mobility assessment ageing digital outcomes COPD PD MS hip fracture recovery clinical cohorts Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2) Topic(s) IMI2-2017-13-07 - Linking digital assessment of mobility to clinical endpoints to support regulatory acceptance and clinical practice Call for proposal H2020-JTI-IMI2-2017-13-two-stage See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITY OF NEWCASTLE UPON TYNE Net EU contribution € 3 590 382,85 Address KINGS GATE NE1 7RU Newcastle Upon Tyne United Kingdom See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 4 297 692,00 Participants (37) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. THE NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST United Kingdom Net EU contribution € 226 059,00 Address FREEMAN HOSPITAL, HIGH HEATON NE7 7DN Newcastle-Upon-Tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 226 059,00 THE UNIVERSITY OF SHEFFIELD United Kingdom Net EU contribution € 1 643 146,61 Address FIRTH COURT WESTERN BANK S10 2TN Sheffield See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 207 966,25 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST United Kingdom Net EU contribution € 449 819,64 Address BEECH HILL ROAD 8 S10 2SB Sheffield See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 449 819,64 THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV Israel Net EU contribution € 1 117 625,00 Address WEIZMANN STREET 6 64239 Tel Aviv See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 117 625,00 CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Germany Net EU contribution € 1 072 068,75 Address OLSHAUSENSTRASSE 40 24118 Kiel See on map Region Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 072 068,75 ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Italy Net EU contribution € 855 665,00 Address VIA ZAMBONI 33 40126 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 855 665,00 KATHOLIEKE UNIVERSITEIT LEUVEN Belgium Net EU contribution € 831 661,25 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 831 661,25 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland Net EU contribution € 993 625,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 993 625,00 FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG Germany Net EU contribution € 897 863,75 Address SCHLOSSPLATZ 4 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 897 863,75 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland Net EU contribution € 1 551 550,00 Address BELFIELD 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 551 550,00 NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Norway Net EU contribution € 2 261 648,75 Address HOGSKOLERINGEN 1 7491 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 261 648,75 ROBERT BOSCH GESELLSCHAFT FUR MEDIZINISCHE FORSCHUNG MBH Germany Net EU contribution € 2 432 796,40 Address AUERBACHSTRASSE 112 70376 Stuttgart See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 432 796,40 UNIVERSITA DEGLI STUDI DI SASSARI Italy Net EU contribution € 428 750,00 Address PIAZZA UNIVERSITA 21 07100 Sassari See on map Region Isole Sardegna Sassari Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 428 750,00 FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA Spain Net EU contribution € 1 614 656,25 Address C ROSSELLO 132 PLANTA 05 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 819 656,25 UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE United Kingdom Net EU contribution € 432 260,75 Address SUTHERLAND BUILDING COLLEGE STREET NE1 8ST Newcastle Upon Tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 432 260,75 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom Net EU contribution € 390 540,00 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 390 540,00 UNIVERSITA VITA-SALUTE SAN RAFFAELE Italy Net EU contribution € 704 105,00 Address VIA OLGETTINA 58 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 704 105,00 UNIVERSITAT ZURICH Switzerland Net EU contribution € 532 500,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 532 500,00 IXSCIENT LIMITED United Kingdom Net EU contribution € 464 000,00 Address POPES GROVE 76 TW1 4JX Twickenham Middlesex See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 504 000,00 MCROBERTS BV Netherlands Net EU contribution € 519 020,50 Address RAAMWEG 43 2596HN 's-Gravenhage (Den Haag) See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 519 020,50 UNIVERSITATSKLINIKUM ERLANGEN Germany Net EU contribution € 1 125 055,00 Address MAXIMILIANSPLATZ 2 91054 Erlangen See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 125 055,00 VELOCITY CLINICAL RESEARCH GROSSHANSDORF GMBH Germany Net EU contribution € 796 412,50 Address WOHRENDAMM 80 22927 Grosshansdorf See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schleswig-Holstein Schleswig-Holstein Stormarn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 796 412,50 CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER France Net EU contribution € 464 685,00 Address AVENUE DU DOYEN GASTON GIRAUD 191 34000 Montpellier See on map Region Occitanie Languedoc-Roussillon Hérault Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 464 685,00 AMGEN LIMITED Participation ended United Kingdom Net EU contribution € 0,00 Address Cambridge Science Park - Milton Road 240 CB4 0WD Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 20 212,54 ASTRAZENECA AB Sweden Net EU contribution € 0,00 Address Vastra Maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700 000,00 BAYER AKTIENGESELLSCHAFT Germany Net EU contribution € 0,00 Address KAISER-WILHELM-ALLEE 1 51373 Leverkusen See on map Region Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 3 050 000,00 ERESEARCH TECHNOLOGY INC United States Net EU contribution € 0,00 Address 1818 MARKET STREET SUITE 1000 19103 Philadelphia See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 100 000,00 GRUNENTHAL GMBH Germany Net EU contribution € 0,00 Address ZIEGLERSTRASSE 6 52078 Aachen See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 85 000,00 ICON CLINICAL RESEARCH LIMITED Ireland Net EU contribution € 0,00 Address SOUTH COUNTY BUSINESS PARK LEOPARDSTOWN 18 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 000 000,00 MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN Germany Net EU contribution € 0,00 Address FRANKFURTER STRASSE 250 64293 Darmstadt See on map Region Hessen Darmstadt Darmstadt, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 500 000,00 NOVARTIS PHARMA AG Switzerland Net EU contribution € 0,00 Address LICHTSTRASSE 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 14 296 667,00 PFIZER LIMITED United Kingdom Net EU contribution € 0,00 Address RAMSGATE ROAD CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 333 333,00 SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France Net EU contribution € 0,00 Address 82 AVENUE RASPAIL 94250 GENTILLY See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 375 000,00 TAKEDA DEVELOPMENT CENTRE EUROPE LTD Participation ended United Kingdom Net EU contribution € 0,00 Address ALDWYCH 61 WC2B 4AE London See on map Region London Inner London — West Westminster Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 58 165,47 TEVA PHARMACEUTICAL INDUSTRIES LIMITED Israel Net EU contribution € 0,00 Address 5 BASEL ST 49131 Petach Tivka See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 500 000,00 TAKEDA PHARMACEUTICALS INTERNATIONAL AG Switzerland Net EU contribution € 0,00 Address THURGAUERSTRASSE 130 8152 Glattpark See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 141 834,53 AMGEN Belgium Net EU contribution € 0,00 Address TELECOMLAAN 5-7 1831 Diegem See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Halle-Vilvoorde Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 514 204,46