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EBiSC2 – A sustainable European Bank for induced pluripotent Stem Cells

Deliverables

EBiSC2 regime for ethical and legal requirements

Guidelines describing all standard procedures set up to ensure compliance with ethical and legal requirements for the unlimited use and distribution of banked iPSC lines to promote best practice and international harmonisation

Integration concepts and banking workflows for iPSC lines from external consortia

Report describing the process enabling the integration of already existing and newly established iPSC assets into the EBiSC2 bank.

Data management handbook

Report (incl. SOPs) describing the concepts for data security, backup, protection and access regulations to provide safe, secure and up-to-date technical hardware structures.

Enhanced protocols for large-scale iPSC differentiation established

Set of refined large-scale iPSC differentiation protocols

QC criteria for progenitor cell types identified

QC panel identified and defined for progenitor cells. Panel identification transferred to WP3.

Automated data validation established

Automated IT workflow replaces the initial manual system while ensuring low maintenance, low risk and high automation

First induced differentiated GE line generated, characterised and banked for accelerated differentiation and maturation of CNS cell types

GE lines established, PoC models completed, data transferred to WP5 and EFPIA motivated cell line generation completed and transferred to WP3

Fully operable EBiSC2 bank established

All required operations have been performed to allow operations of the EBiSC2 bank after Month 3.

At least three EFPIA-driven cell line commissioning projects completed

Outcome of at least three EFPIA-driven cell line commissioning projects carried out.

Establishment of new branding and trademark registration

Presentation of the EBiSC2 branding and registration as trademark to ensure the legal framework

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