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EBiSC2 – A sustainable European Bank for induced pluripotent Stem Cells


EBiSC2 regime for ethical and legal requirements

Guidelines describing all standard procedures set up to ensure compliance with ethical and legal requirements for the unlimited use and distribution of banked iPSC lines to promote best practice and international harmonisation

Integration concepts and banking workflows for iPSC lines from external consortia

Report describing the process enabling the integration of already existing and newly established iPSC assets into the EBiSC2 bank.

Data management handbook

Report (incl. SOPs) describing the concepts for data security, backup, protection and access regulations to provide safe, secure and up-to-date technical hardware structures.

Enhanced protocols for large-scale iPSC differentiation established

Set of refined large-scale iPSC differentiation protocols

QC criteria for progenitor cell types identified

QC panel identified and defined for progenitor cells. Panel identification transferred to WP3.

Automated data validation established

Automated IT workflow replaces the initial manual system while ensuring low maintenance, low risk and high automation

First induced differentiated GE line generated, characterised and banked for accelerated differentiation and maturation of CNS cell types

GE lines established, PoC models completed, data transferred to WP5 and EFPIA motivated cell line generation completed and transferred to WP3

Fully operable EBiSC2 bank established

All required operations have been performed to allow operations of the EBiSC2 bank after Month 3.

At least three EFPIA-driven cell line commissioning projects completed

Outcome of at least three EFPIA-driven cell line commissioning projects carried out.

Establishment of new branding and trademark registration

Presentation of the EBiSC2 branding and registration as trademark to ensure the legal framework

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The EBiSC iPSC bank for disease studies

Author(s): Rachel Steeg, Julia C. Neubauer, Sabine C. Müller, Andreas Ebneth, Heiko Zimmermann
Published in: Stem Cell Research, Issue 49, 2020, Page(s) 102034, ISSN 1873-5061
DOI: 10.1016/j.scr.2020.102034

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line

Author(s): Benjamin Schmid, Kennie R. Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Poulsen, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi Muddashetty, Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjørn Holst, Alfredo Cabrera-Socorro
Published in: Stem Cell Research, Issue 34, 2019, Page(s) 101349, ISSN 1873-5061
DOI: 10.1016/j.scr.2018.11.010

Development and implementation of large-scale quality control for the European bank for induced Pluripotent Stem Cells

Author(s): Orla O'Shea, Rachel Steeg, Charlotte Chapman, Peter Mackintosh, Glyn N Stacey
Published in: Stem Cell Research, Issue 45, 2020, Page(s) 101773, ISSN 1873-5061
DOI: 10.1016/j.scr.2020.101773

Access to stem cell data and registration of pluripotent cell lines: The Human Pluripotent Stem Cell Registry (hPSCreg)

Author(s): Nancy Mah, Stefanie Seltmann, Begoña Aran, Rachel Steeg, Johannes Dewender, Nils Bultjer, Anna Veiga, Glyn N. Stacey, Andreas Kurtz
Published in: Stem Cell Research, Issue 47, 2020, Page(s) 101887, ISSN 1873-5061
DOI: 10.1016/j.scr.2020.101887