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CORDIS - Forschungsergebnisse der EU
CORDIS

EBiSC2 – A sustainable European Bank for induced pluripotent Stem Cells

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

EBiSC2 regime for ethical and legal requirements (öffnet in neuem Fenster)

Guidelines describing all standard procedures set up to ensure compliance with ethical and legal requirements for the unlimited use and distribution of banked iPSC lines to promote best practice and international harmonisation

Integration concepts and banking workflows for iPSC lines from external consortia (öffnet in neuem Fenster)

Report describing the process enabling the integration of already existing and newly established iPSC assets into the EBiSC2 bank.

Impact of biocompatible materials on iPSC-derived cardiac cell types functionality evaluated (öffnet in neuem Fenster)

Report evaluating the impact of biocompatible materials on iPSCderived cardiac cell types functionality

Hepatocyte modelling PoC completed (öffnet in neuem Fenster)

PoC models completed and data transferred to WP5 gene editing tools established and EFPIA motivated cell line generation completed and transferred to WP3

Established workflows for certified re-banking of iPSC lines and derivative stocks (öffnet in neuem Fenster)

Plan describing the generation of the initial stock and appropriate strategies and workflows for the rebanking of highindemand iPSC lines and iPSCderived cells as well as externally submitted assets

Protocols for cryopreservation of bulk quantities of iPSC and iPSC-derived cells established (öffnet in neuem Fenster)

Cryopreservation protocols for bulk quantities of iPSC and iPSCderived cells

Assessment of drug efficacy conducted (öffnet in neuem Fenster)

Report on the assessment of drug efficacy and maturation

Data management handbook (öffnet in neuem Fenster)

Report incl SOPs describing the concepts for data security backup protection and access regulations to provide safe secure and uptodate technical hardware structures

Protocol and workflow for optimized hepatocyte differentiation established (öffnet in neuem Fenster)

PoC models completed and data transferred to WP5 gene editing tools established and EFPIA motivated cell line generation completed and transferred to WP3

Enhanced protocols for large-scale iPSC differentiation established (öffnet in neuem Fenster)

Set of refined large-scale iPSC differentiation protocols

QC criteria for progenitor cell types identified (öffnet in neuem Fenster)

QC panel identified and defined for progenitor cells. Panel identification transferred to WP3.

QC regime according to EBiSC guidelines to support high-quality of iPSCs and iPSC-derived cell lines (öffnet in neuem Fenster)

Definition of criteria for bulk QC testing of iPSC expansion and differentiation

Automated data validation established (öffnet in neuem Fenster)

Automated IT workflow replaces the initial manual system while ensuring low maintenance, low risk and high automation

Genetic/genome data access and searchability (öffnet in neuem Fenster)

Genetic data integration and searchability established

LIMS integration (öffnet in neuem Fenster)

Strategy for the integration and enrichment of existing data established

Minimum three induced differentiation GE lines generated, characterized at least two aggregation modelling studies completed (öffnet in neuem Fenster)

GE lines established, PoC models completed, data transferred to WP5 and EFPIA motivated cell line generation completed and transferred to WP3

Clinical data workflow pilot tested (öffnet in neuem Fenster)
First induced differentiated GE line generated, characterised and banked for accelerated differentiation and maturation of CNS cell types (öffnet in neuem Fenster)

GE lines established, PoC models completed, data transferred to WP5 and EFPIA motivated cell line generation completed and transferred to WP3

Standard API established for data integration (öffnet in neuem Fenster)

Definition and implementation of data standards and codification for automated data exchange and mapping

IT workflows for cell integration of pre-existing European iPSC projects (öffnet in neuem Fenster)

IT workflows for sample and data submission from pre-existing European iPSC projects established

Fully operable EBiSC2 bank established (öffnet in neuem Fenster)

All required operations have been performed to allow operations of the EBiSC2 bank after Month 3.

At least three EFPIA-driven cell line commissioning projects completed (öffnet in neuem Fenster)

Outcome of at least three EFPIA-driven cell line commissioning projects carried out.

Establishment of new branding and trademark registration (öffnet in neuem Fenster)

Presentation of the EBiSC2 branding and registration as trademark to ensure the legal framework

Portal and interface implemented (öffnet in neuem Fenster)

Portal and website redesigned and launched

Veröffentlichungen

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System (öffnet in neuem Fenster)

Autoren: Katrien Neyrinck, Johanna Van Den Daele, Tim Vervliet, Jonathan De Smedt, Keimpe Wierda, Melissa Nijs, Tom Vanbokhoven, Astrid D’hondt, Mélanie Planque, Sarah-Maria Fendt, Pei-Yu Shih, Frederik Seibt, Juan Pita Almenar, Mohamed Kreir, Devesh Kumar, Vania Broccoli, Geert Bultynck, Andreas Ebneth, Alfredo Cabrera-Socorro, Catherine Verfaillie
Veröffentlicht in: Stem Cell Reviews and Reports, 2021, ISSN 2629-3269
Herausgeber: Springer
DOI: 10.1007/s12015-021-10179-x

The EBiSC iPSC bank for disease studies (öffnet in neuem Fenster)

Autoren: Rachel Steeg, Julia C. Neubauer, Sabine C. Müller, Andreas Ebneth, Heiko Zimmermann
Veröffentlicht in: Stem Cell Research, Ausgabe 49, 2020, Seite(n) 102034, ISSN 1873-5061
Herausgeber: Elsevier
DOI: 10.1016/j.scr.2020.102034

EBiSC best practice: How to ensure optimal generation, qualification, and distribution of iPSC lines (öffnet in neuem Fenster)

Autoren: Rachel Steeg, Sabine C. Mueller, Nancy Mah, Bjørn Holst, Alfredo Cabrera-Socorro, Glyn N. Stacey, Paul A. De Sousa, Aidan Courtney, Heiko Zimmermann
Veröffentlicht in: Stem Cell Reports, Ausgabe 16/8, 2021, Seite(n) 1853-1867, ISSN 2213-6711
Herausgeber: Cell Press
DOI: 10.1016/j.stemcr.2021.07.009

Corrigendum to “Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line” [Stem Cell Res. 34/1873–5061 (2019) 101349–55] (öffnet in neuem Fenster)

Autoren: Benjamin Schmid, Kennie R. Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Poulsen, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi Muddashetty, Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjørn Holst, Alfredo Cabrera-Socorro
Veröffentlicht in: Stem Cell Research, Ausgabe 48, 2020, Seite(n) 102005, ISSN 1873-5061
Herausgeber: Elsevier
DOI: 10.1016/j.scr.2020.102005

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line (öffnet in neuem Fenster)

Autoren: Benjamin Schmid, Kennie R. Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Poulsen, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi Muddashetty, Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjørn Holst, Alfredo Cabrera-Socorro
Veröffentlicht in: Stem Cell Research, Ausgabe 34, 2019, Seite(n) 101349, ISSN 1873-5061
Herausgeber: Elsevier
DOI: 10.1016/j.scr.2018.11.010

Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies (öffnet in neuem Fenster)

Autoren: Saskia Altmaier, Ina Meiser, Emilie Lemesre, Benjamin Chanrion, Rachel Steeg, Lidia Elena Leonte, Bjørn Holst, Boye Schnack Nielsen, Christian Clausen, Katharina Schmidt, Anne Marie Vinggaard, Heiko Zimmermann, Julia Christiane Neubauer, Mikkel Aabech Rasmussen
Veröffentlicht in: Reproductive Toxicology, Ausgabe 111, 2022, Seite(n) 68-80, ISSN 0890-6238
Herausgeber: Elsevier BV
DOI: 10.1016/j.reprotox.2022.05.005

Development and implementation of large-scale quality control for the European bank for induced Pluripotent Stem Cells (öffnet in neuem Fenster)

Autoren: Orla O'Shea, Rachel Steeg, Charlotte Chapman, Peter Mackintosh, Glyn N Stacey
Veröffentlicht in: Stem Cell Research, Ausgabe 45, 2020, Seite(n) 101773, ISSN 1873-5061
Herausgeber: Elsevier
DOI: 10.1016/j.scr.2020.101773

Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies (öffnet in neuem Fenster)

Autoren: Pei-Yu Shih, Mohamed Kreir, Devesh Kumar, Frederik Seibt, Francisco Pestana, Benjamin Schmid, Bjørn Holst, Christian Clausen, Rachel Steeg, Benjamin Fischer, Juan Pita-Almenar, Andreas Ebneth, Alfredo Cabrera-Socorro
Veröffentlicht in: Stem Cell Research, Ausgabe 54, 2021, Seite(n) 102386, ISSN 1873-5061
Herausgeber: Elsevier
DOI: 10.1016/j.scr.2021.102386

Scalable expansion of iPSC and their derivatives across multiple lineages (öffnet in neuem Fenster)

Autoren: Chee Keong Kwok, Isabelle Sebastien, Krithika Hariharan, Ina Meiser, Jeanette Wihan, Saskia Altmaier, Isabell Karnatz, Dominic Bauer, Benjamin Fischer, Alexander Feile, Alfredo Cabrera-Socorro, Mikkel Rasmussen, Bjørn Holst, Julia C. Neubauer, Christian Clausen, Catherine Verfaillie, Andreas Ebneth, Mattias Hansson, Rachel Steeg, Heiko Zimmermann
Veröffentlicht in: Reproductive Toxicology, Ausgabe 112, 2022, Seite(n) 23-35, ISSN 0890-6238
Herausgeber: Elsevier BV
DOI: 10.1016/j.reprotox.2022.05.007

Access to stem cell data and registration of pluripotent cell lines: The Human Pluripotent Stem Cell Registry (hPSCreg) (öffnet in neuem Fenster)

Autoren: Nancy Mah, Stefanie Seltmann, Begoña Aran, Rachel Steeg, Johannes Dewender, Nils Bultjer, Anna Veiga, Glyn N. Stacey, Andreas Kurtz
Veröffentlicht in: Stem Cell Research, Ausgabe 47, 2020, Seite(n) 101887, ISSN 1873-5061
Herausgeber: Elsevier
DOI: 10.1016/j.scr.2020.101887

Production of Human Neurogenin 2-Inducible Neurons in a Three-Dimensional Suspension Bioreactor (öffnet in neuem Fenster)

Autoren: Jeanette Wihan
Veröffentlicht in: Journal of Visualized Experiments, Ausgabe 6, 2023, ISSN 1940-087X
Herausgeber: MYJoVE Corporation
DOI: 10.3791/65085

Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus (öffnet in neuem Fenster)

Autoren: Benjamin Schmid, Bjørn Holst, Ulla Poulsen, Ida Jørring, Christian Clausen, M. Rasmussen, Ulrike A. Mau-Holzmann, Rachel Steeg, Hugh Nuthall, A. Ebneth, A. Cabrera-Socorro
Veröffentlicht in: Stem Cell Research, Ausgabe 52, 2021, Seite(n) 102240, ISSN 1873-5061
Herausgeber: Elsevier
DOI: 10.1016/j.scr.2021.102240

Rechte des geistigen Eigentums

EBiSC

Antrags-/Publikationsnummer: EP A 06494/19 EP A 06494/19
Datum: 2019-05-23
Antragsteller: FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV

EBiSC

Antrags-/Publikationsnummer: 30 2019 106 778.9 30 2019 106 778
Datum: 2019-05-23
Antragsteller: FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV

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