Rezultaty
Guidelines describing all standard procedures set up to ensure compliance with ethical and legal requirements for the unlimited use and distribution of banked iPSC lines to promote best practice and international harmonisation
Integration concepts and banking workflows for iPSC lines from external consortiaReport describing the process enabling the integration of already existing and newly established iPSC assets into the EBiSC2 bank.
Impact of biocompatible materials on iPSC-derived cardiac cell types functionality evaluatedReport evaluating the impact of biocompatible materials on iPSCderived cardiac cell types functionality
Hepatocyte modelling PoC completedPoC models completed and data transferred to WP5 gene editing tools established and EFPIA motivated cell line generation completed and transferred to WP3
Established workflows for certified re-banking of iPSC lines and derivative stocksPlan describing the generation of the initial stock and appropriate strategies and workflows for the rebanking of highindemand iPSC lines and iPSCderived cells as well as externally submitted assets
Protocols for cryopreservation of bulk quantities of iPSC and iPSC-derived cells establishedCryopreservation protocols for bulk quantities of iPSC and iPSCderived cells
Assessment of drug efficacy conductedReport on the assessment of drug efficacy and maturation
Data management handbookReport incl SOPs describing the concepts for data security backup protection and access regulations to provide safe secure and uptodate technical hardware structures
Protocol and workflow for optimized hepatocyte differentiation establishedPoC models completed and data transferred to WP5 gene editing tools established and EFPIA motivated cell line generation completed and transferred to WP3
Enhanced protocols for large-scale iPSC differentiation establishedSet of refined large-scale iPSC differentiation protocols
QC criteria for progenitor cell types identifiedQC panel identified and defined for progenitor cells. Panel identification transferred to WP3.
Definition of criteria for bulk QC testing of iPSC expansion and differentiation
Automated data validation establishedAutomated IT workflow replaces the initial manual system while ensuring low maintenance, low risk and high automation
Genetic/genome data access and searchabilityGenetic data integration and searchability established
LIMS integrationStrategy for the integration and enrichment of existing data established
Minimum three induced differentiation GE lines generated, characterized at least two aggregation modelling studies completedGE lines established, PoC models completed, data transferred to WP5 and EFPIA motivated cell line generation completed and transferred to WP3
Clinical data workflow pilot testedFirst induced differentiated GE line generated, characterised and banked for accelerated differentiation and maturation of CNS cell types
GE lines established, PoC models completed, data transferred to WP5 and EFPIA motivated cell line generation completed and transferred to WP3
Standard API established for data integrationDefinition and implementation of data standards and codification for automated data exchange and mapping
IT workflows for cell integration of pre-existing European iPSC projectsIT workflows for sample and data submission from pre-existing European iPSC projects established
Fully operable EBiSC2 bank establishedAll required operations have been performed to allow operations of the EBiSC2 bank after Month 3.
At least three EFPIA-driven cell line commissioning projects completedOutcome of at least three EFPIA-driven cell line commissioning projects carried out.
Presentation of the EBiSC2 branding and registration as trademark to ensure the legal framework
Portal and interface implementedPortal and website redesigned and launched
Publikacje
Autorzy:
Katrien Neyrinck, Johanna Van Den Daele, Tim Vervliet, Jonathan De Smedt, Keimpe Wierda, Melissa Nijs, Tom Vanbokhoven, Astrid D’hondt, Mélanie Planque, Sarah-Maria Fendt, Pei-Yu Shih, Frederik Seibt, Juan Pita Almenar, Mohamed Kreir, Devesh Kumar, Vania Broccoli, Geert Bultynck, Andreas Ebneth, Alfredo Cabrera-Socorro, Catherine Verfaillie
Opublikowane w:
Stem Cell Reviews and Reports, 2021, ISSN 2629-3269
Wydawca:
Springer
DOI:
10.1007/s12015-021-10179-x
Autorzy:
Rachel Steeg, Julia C. Neubauer, Sabine C. Müller, Andreas Ebneth, Heiko Zimmermann
Opublikowane w:
Stem Cell Research, Numer 49, 2020, Strona(/y) 102034, ISSN 1873-5061
Wydawca:
Elsevier
DOI:
10.1016/j.scr.2020.102034
Autorzy:
Rachel Steeg, Sabine C. Mueller, Nancy Mah, Bjørn Holst, Alfredo Cabrera-Socorro, Glyn N. Stacey, Paul A. De Sousa, Aidan Courtney, Heiko Zimmermann
Opublikowane w:
Stem Cell Reports, Numer 16/8, 2021, Strona(/y) 1853-1867, ISSN 2213-6711
Wydawca:
Cell Press
DOI:
10.1016/j.stemcr.2021.07.009
Autorzy:
Benjamin Schmid, Kennie R. Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Poulsen, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi Muddashetty, Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjørn Holst, Alfredo Cabrera-Socorro
Opublikowane w:
Stem Cell Research, Numer 48, 2020, Strona(/y) 102005, ISSN 1873-5061
Wydawca:
Elsevier
DOI:
10.1016/j.scr.2020.102005
Autorzy:
Benjamin Schmid, Kennie R. Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Poulsen, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi Muddashetty, Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjørn Holst, Alfredo Cabrera-Socorro
Opublikowane w:
Stem Cell Research, Numer 34, 2019, Strona(/y) 101349, ISSN 1873-5061
Wydawca:
Elsevier
DOI:
10.1016/j.scr.2018.11.010
Autorzy:
Saskia Altmaier, Ina Meiser, Emilie Lemesre, Benjamin Chanrion, Rachel Steeg, Lidia Elena Leonte, Bjørn Holst, Boye Schnack Nielsen, Christian Clausen, Katharina Schmidt, Anne Marie Vinggaard, Heiko Zimmermann, Julia Christiane Neubauer, Mikkel Aabech Rasmussen
Opublikowane w:
Reproductive Toxicology, Numer 111, 2022, Strona(/y) 68-80, ISSN 0890-6238
Wydawca:
Elsevier BV
DOI:
10.1016/j.reprotox.2022.05.005
Autorzy:
Orla O'Shea, Rachel Steeg, Charlotte Chapman, Peter Mackintosh, Glyn N Stacey
Opublikowane w:
Stem Cell Research, Numer 45, 2020, Strona(/y) 101773, ISSN 1873-5061
Wydawca:
Elsevier
DOI:
10.1016/j.scr.2020.101773
Autorzy:
Pei-Yu Shih, Mohamed Kreir, Devesh Kumar, Frederik Seibt, Francisco Pestana, Benjamin Schmid, Bjørn Holst, Christian Clausen, Rachel Steeg, Benjamin Fischer, Juan Pita-Almenar, Andreas Ebneth, Alfredo Cabrera-Socorro
Opublikowane w:
Stem Cell Research, Numer 54, 2021, Strona(/y) 102386, ISSN 1873-5061
Wydawca:
Elsevier
DOI:
10.1016/j.scr.2021.102386
Autorzy:
Chee Keong Kwok, Isabelle Sebastien, Krithika Hariharan, Ina Meiser, Jeanette Wihan,
Saskia Altmaier, Isabell Karnatz, Dominic Bauer, Benjamin Fischer, Alexander Feile,
Alfredo Cabrera-Socorro, Mikkel Rasmussen, Bjørn Holst, Julia C. Neubauer,
Christian Clausen, Catherine Verfaillie, Andreas Ebneth, Mattias Hansson, Rachel Steeg,
Heiko Zimmermann
Opublikowane w:
Reproductive Toxicology, Numer 112, 2022, Strona(/y) 23-35, ISSN 0890-6238
Wydawca:
Elsevier BV
DOI:
10.1016/j.reprotox.2022.05.007
Autorzy:
Nancy Mah, Stefanie Seltmann, Begoña Aran, Rachel Steeg, Johannes Dewender, Nils Bultjer, Anna Veiga, Glyn N. Stacey, Andreas Kurtz
Opublikowane w:
Stem Cell Research, Numer 47, 2020, Strona(/y) 101887, ISSN 1873-5061
Wydawca:
Elsevier
DOI:
10.1016/j.scr.2020.101887
Autorzy:
Jeanette Wihan
Opublikowane w:
Journal of Visualized Experiments, Numer 6, 2023, ISSN 1940-087X
Wydawca:
MYJoVE Corporation
DOI:
10.3791/65085
Autorzy:
Benjamin Schmid, Bjørn Holst, Ulla Poulsen, Ida Jørring, Christian Clausen, M. Rasmussen, Ulrike A. Mau-Holzmann, Rachel Steeg, Hugh Nuthall, A. Ebneth, A. Cabrera-Socorro
Opublikowane w:
Stem Cell Research, Numer 52, 2021, Strona(/y) 102240, ISSN 1873-5061
Wydawca:
Elsevier
DOI:
10.1016/j.scr.2021.102240
Prawa własności intelektualnej
Numer wniosku/publikacji:
EP A 06494/19
EP A 06494/19
Data:
2019-05-23
Numer wniosku/publikacji:
EP A 06494/19
EP A 06494/19
Data:
2019-05-23
Numer wniosku/publikacji:
30 2019 106 778.9
30 2019 106 778
Data:
2019-05-23
Numer wniosku/publikacji:
EP A 06494/19
EP A 06494/19
Data:
2019-05-23
Numer wniosku/publikacji:
30 2019 106 778.9
30 2019 106 778
Data:
2019-05-23
Numer wniosku/publikacji:
30 2019 106 778.9
30 2019 106 778
Data:
2019-05-23
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