Project description
Predictive systems medicine resource for the management of atopic dermatitis and psoriasis
The goal of the EU-funded BIOMAP project is to provide a predictive systems medicine model of atopic dermatitis and psoriasis based on clinical and molecular profiling. The consortium will identify clinical determinants of relevant outcomes, elucidate disease mechanisms and deliver biomarkers for the prediction of disease trajectories and treatment response for use in drug development and clinical practice. BIOMAP will create a biospecimen and data resource of unprecedented scale and depth, accessible via a central data and analysis portal. The resource will support analyses in epidemiology, molecular profiling, skin biology and mathematical modelling to define disease and drug endotypes as well as critical lifestyle and environmental factors.
Objective
Our objective is to provide a taxonomic and predictive systems medicine model of Atopic Dermatitis and Psoriasis based on clinical and molecular profiling to (i) identify determinants of clinically relevant outcomes (disease manifestation, progression, comorbidity development and treatment response) (ii) improve understanding on shared and distinct disease mechanism(s) and associated signatures, and their relative importance in patient subpopulations and (iii) deliver biomarkers that identify disease trajectories and treatment response for use in drug development and clinical practice. BIOMAP will create a biospecimen and data resource of unprecedented scale and depth, accessible via a central data and analysis portal, harmonizing diverse, high quality, multi-dimensional datasets on skin and blood (whole and single cell), large scale population-based and trial data; parallel clinical research infrastructure will deliver supplementary material flexible to the needs of the consortium. This resource will be systematically analyzed using state-of-the-art methodologies in epidemiology, molecular profiling, skin biology and mathematical modelling to define disease and drug endotypes and how these interact with lifestyle and environmental factors. Selected, highly discriminatory, associated biomarkers will pass through a diagnostics pipeline (novel in-silico trial methods and assay development), ready for immediate translation. BIOMAP is expected to drive drug discovery to target causal mechanisms, shorten drug development pathways, and fundamentally change the diagnosis and management paradigm, from re-active to pro-active strategies that encompass disease biology and life-time trajectory, matching the intervention (prevention, modification of risk factors, therapeutics) with endotypes. Clinically annotated endotypes and associated biomarkers will identify when, in whom and how to intervene to minimize disease impact and improve outcomes.
Fields of science
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Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
24118 Kiel
Germany
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Participants (35)
WC2R 2LS London
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17177 Stockholm
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2333 ZA Leiden
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4365 ESCH-SUR-ALZETTE
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33100 Tampere
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81675 Muenchen
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1210 Wien
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20251 Hamburg
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BS8 1QU Bristol
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Participation ended
DD1 4HN Dundee
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1165 Kobenhavn
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2820 Gentofte
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Participation ended
6525 XZ Nijmegen
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51005 Tartu
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1011 Lausanne
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70211 KUOPIO
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40225 Dusseldorf
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D02 CX56 DUBLIN 2
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1081 HV Amsterdam
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4354 ESCH SUR ALZETTE
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
78052 Villingen Schwenning
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WC1E 7HT London
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66386 St Ingbert
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1010 Wien
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65929 Frankfurt Am Main
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2750 Ballerup
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55218 Ingelheim
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CT13 9NJ Sandwich
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1070 Bruxelles / Brussel
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80333 Muenchen
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4056 Basel
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08022 Barcelona
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EH8 9YL Edinburgh
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6525 GA Nijmegen
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79106 Freiburg
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