PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease | PD-MitoQUANT | Project | Results | H2020 | CORDIS

Livrables

Final communication and dissemination status

Communication and dissemination status at the end of the project including legacy management of project data and impact on the broader community eg impact on standards in good research practice publications summarising the output of PD Mitoquant as a whole long term data repository etc

Update on communication and dissemination activities

Update on communication and dissemination activities for different stakeholders, including patients

Dissemination and Communication Plan

Dissemination and Communication Plan including timely open access publication of results green or gold OA and other dissemination activities including via project website

Data management & sharing plan (DMSP) - Final

Data management sharing plan DMSP Final version

Data management & sharing plan (DMSP) - Interim
Data management & sharing plan (DMSP) - Initial

Data management & sharing plan (DMSP) - Initial veresion

Publications

Phenomenological equations for electron transport chain-mediated reactive oxygen species metabolism

Auteurs: Prof. Jochen Prehn, Dr Niamh Connolly and Sandeep Chenna
Publié dans: 2021 IEEE International Conference on Bioinformatics and Biomedicine, Numéro 2021, 2021, Page(s) pp. 653-658
Éditeur: IEEE
DOI: 10.1109/bibm52615.2021.9669351

Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation

Auteurs: Céline Galvagnion, Frederik Ravnkilde Marlet, Silvia Cerri, Anthony H V Schapira, Fabio Blandini, Donato A Di Monte
Publié dans: Brain Communications, 2022, ISSN 2632-1297
Éditeur: Oxford University Press
DOI: 10.1093/brain/awab371

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Auteurs: Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V. Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T. Heneka
Publié dans: Cell, Numéro 184/20, 2021, Page(s) 5089-5106.e21, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2021.09.007

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Auteurs: Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, DeboraGentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, KristianHändler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Publié dans: Molecular Metabolism, Numéro 19 April 2022, 2022, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101503

CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants

Auteurs: Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gomez Martın, Fabio Bertan, Chester J J Wrobel, Frank C Schroeder, Dan Ehninger, Kristian H€andler, Joachim L Schultze, Lukas Schreiber, Gerhild van Echten-Deckert, Pierluigi Nicotera & Daniele Bano
Publié dans: EMBO Reports, Numéro e52606, 2022, ISSN 1469-221X
Éditeur: Nature Publishing Group
DOI: 10.15252/embr.202152606

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Auteurs: Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Publié dans: Journal of Neurochemistry, Numéro Volume150, Numéro5 Special Numéro: Synuclein Meeting 2019, 2019, Page(s) 522-534, ISSN 0022-3042
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14808

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

Auteurs: M. Jacoupy, E. Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury la Cour, M. J. Millan, J. A. Boutin, J. W. Harper, A. Brice, D. Guedin, C. A. Gautier, O. Corti
Publié dans: Scientific Reports, Numéro 9/1, 2019, Page(s) 1-15, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-47352-9

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Auteurs: Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Publié dans: Acta Neuropathologica Communications, Numéro 7/1, 2019, Page(s) 1-18, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-019-0859-3

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Auteurs: Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Publié dans: Biophysical Journal, Numéro 27 January 2020, 2020, ISSN 0006-3495
Éditeur: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Auteurs: Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-61757-x

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Auteurs: Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
Publié dans: Biochemical and Biophysical Research Communications, Numéro 17 May 2020, 2020, ISSN 0006-291X
Éditeur: Academic Press
DOI: 10.1016/j.bbrc.2020.04.091

AMPK preferentially depresses retrograde transport of axonal mitochondria during localised nutrient deprivation

Auteurs: Orla Watters, Niamh M. C. Connolly, Hans-Georg König, Heiko Düssmann, Jochen H. M. Prehn
Publié dans: The Journal of Neuroscience, Numéro 11 May 2020, 2020, Page(s) JN-RM-2067-19, ISSN 0270-6474
Éditeur: Society for Neuroscience
DOI: 10.1523/jneurosci.2067-19.2020

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition

Auteurs: Emilie Dinh, Thomas Rival, Alice Carrier, Noemi Asfogo, Olga Corti, Christophe Melon, Pascal Salin, Sylviane Lortet, Lydia Kerkerian-Le Goff
Publié dans: Cell Death & Disease, Numéro 12/5, 2021, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-021-03742-4

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications

Auteurs: Angelo Iannielli et al.
Publié dans: Cell Death & Disease, 2022, Page(s) 881, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-022-05330-6

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons

Auteurs: Aurore Tourville, David Akbar, Olga Corti, Jochen H. M. Prehn, Ronald Melki, Stéphane Hunot and Patrick P. Michel
Publié dans: Cells, Numéro 2022, 11, 1640, 2022, ISSN 2073-4409
Éditeur: Molecular Diversity Preservation International
DOI: 10.3390/cells11101640

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Auteurs: Maud Landureau, Virginie Redeker, Tracy Bellande, Stéphanie Eyquem, Ronald Melki
Publié dans: Journal of Biological Chemistry, Numéro 2021, 2021, Page(s) 100737, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100737

PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

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