PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

Informacje na temat projektu

PD-MitoQUANT

Identyfikator umowy o grant: 821522

DOI

10.3030/821522

Projekt został zamknięty

Data podpisania przez KE 19 Lutego 2019

Data rozpoczęcia 1 Lutego 2019

Data zakończenia 31 Lipca 2022

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 894 315,00

Wkład UE

€ 4 497 935,00

Koordynowany przez

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (3)

Final communication and dissemination status

Communication and dissemination status at the end of the project including legacy management of project data and impact on the broader community eg impact on standards in good research practice publications summarising the output of PD Mitoquant as a whole long term data repository etc

Update on communication and dissemination activities

Update on communication and dissemination activities for different stakeholders, including patients

Dissemination and Communication Plan

Dissemination and Communication Plan including timely open access publication of results green or gold OA and other dissemination activities including via project website

Open Research Data Pilot (3)

Data management & sharing plan (DMSP) - Final

Data management sharing plan DMSP Final version

Data management & sharing plan (DMSP) - Interim
Data management & sharing plan (DMSP) - Initial

Data management & sharing plan (DMSP) - Initial veresion

Publikacje

Conference proceedings (1)

Phenomenological equations for electron transport chain-mediated reactive oxygen species metabolism

Autorzy: Prof. Jochen Prehn, Dr Niamh Connolly and Sandeep Chenna
Opublikowane w: 2021 IEEE International Conference on Bioinformatics and Biomedicine, Numer 2021, 2021, Strona(/y) pp. 653-658
Wydawca: IEEE
DOI: 10.1109/bibm52615.2021.9669351

Peer reviewed articles (15)

Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation

Autorzy: Céline Galvagnion, Frederik Ravnkilde Marlet, Silvia Cerri, Anthony H V Schapira, Fabio Blandini, Donato A Di Monte
Opublikowane w: Brain Communications, 2022, ISSN 2632-1297
Wydawca: Oxford University Press
DOI: 10.1093/brain/awab371

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Autorzy: Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V. Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T. Heneka
Opublikowane w: Cell, Numer 184/20, 2021, Strona(/y) 5089-5106.e21, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2021.09.007

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Autorzy: Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, DeboraGentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, KristianHändler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Opublikowane w: Molecular Metabolism, Numer 19 April 2022, 2022, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101503

CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants

Autorzy: Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gomez Martın, Fabio Bertan, Chester J J Wrobel, Frank C Schroeder, Dan Ehninger, Kristian H€andler, Joachim L Schultze, Lukas Schreiber, Gerhild van Echten-Deckert, Pierluigi Nicotera & Daniele Bano
Opublikowane w: EMBO Reports, Numer e52606, 2022, ISSN 1469-221X
Wydawca: Nature Publishing Group
DOI: 10.15252/embr.202152606

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Autorzy: Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Opublikowane w: Journal of Neurochemistry, Numer Volume150, Numer5 Special Numer: Synuclein Meeting 2019, 2019, Strona(/y) 522-534, ISSN 0022-3042
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14808

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

Autorzy: M. Jacoupy, E. Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury la Cour, M. J. Millan, J. A. Boutin, J. W. Harper, A. Brice, D. Guedin, C. A. Gautier, O. Corti
Opublikowane w: Scientific Reports, Numer 9/1, 2019, Strona(/y) 1-15, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-47352-9

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Autorzy: Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Opublikowane w: Acta Neuropathologica Communications, Numer 7/1, 2019, Strona(/y) 1-18, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-019-0859-3

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Autorzy: Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Opublikowane w: Biophysical Journal, Numer 27 January 2020, 2020, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Autorzy: Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-61757-x

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Autorzy: Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
Opublikowane w: Biochemical and Biophysical Research Communications, Numer 17 May 2020, 2020, ISSN 0006-291X
Wydawca: Academic Press
DOI: 10.1016/j.bbrc.2020.04.091

AMPK preferentially depresses retrograde transport of axonal mitochondria during localised nutrient deprivation

Autorzy: Orla Watters, Niamh M. C. Connolly, Hans-Georg König, Heiko Düssmann, Jochen H. M. Prehn
Opublikowane w: The Journal of Neuroscience, Numer 11 May 2020, 2020, Strona(/y) JN-RM-2067-19, ISSN 0270-6474
Wydawca: Society for Neuroscience
DOI: 10.1523/jneurosci.2067-19.2020

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition

Autorzy: Emilie Dinh, Thomas Rival, Alice Carrier, Noemi Asfogo, Olga Corti, Christophe Melon, Pascal Salin, Sylviane Lortet, Lydia Kerkerian-Le Goff
Opublikowane w: Cell Death & Disease, Numer 12/5, 2021, ISSN 2041-4889
Wydawca: Nature Publishing Group
DOI: 10.1038/s41419-021-03742-4

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications

Autorzy: Angelo Iannielli et al.
Opublikowane w: Cell Death & Disease, 2022, Strona(/y) 881, ISSN 2041-4889
Wydawca: Nature Publishing Group
DOI: 10.1038/s41419-022-05330-6

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons

Autorzy: Aurore Tourville, David Akbar, Olga Corti, Jochen H. M. Prehn, Ronald Melki, Stéphane Hunot and Patrick P. Michel
Opublikowane w: Cells, Numer 2022, 11, 1640, 2022, ISSN 2073-4409
Wydawca: Molecular Diversity Preservation International
DOI: 10.3390/cells11101640

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Autorzy: Maud Landureau, Virginie Redeker, Tracy Bellande, Stéphanie Eyquem, Ronald Melki
Opublikowane w: Journal of Biological Chemistry, Numer 2021, 2021, Strona(/y) 100737, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100737