PD-MitoQUANT – A quantitative approach towards the characterisation of mitochondrial dysfunction in Parkinson's disease

Informazioni relative al progetto

PD-MitoQUANT

ID dell’accordo di sovvenzione: 821522

DOI

10.3030/821522

Progetto chiuso

Data della firma CE 19 Febbraio 2019

Data di avvio 1 Febbraio 2019

Data di completamento 31 Luglio 2022

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 894 315,00

Contributo UE

€ 4 497 935,00

Coordinato da

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Final communication and dissemination status

Communication and dissemination status at the end of the project including legacy management of project data and impact on the broader community eg impact on standards in good research practice publications summarising the output of PD Mitoquant as a whole long term data repository etc

Update on communication and dissemination activities

Update on communication and dissemination activities for different stakeholders, including patients

Dissemination and Communication Plan

Dissemination and Communication Plan including timely open access publication of results green or gold OA and other dissemination activities including via project website

Open Research Data Pilot (3)

Data management & sharing plan (DMSP) - Final

Data management sharing plan DMSP Final version

Data management & sharing plan (DMSP) - Interim
Data management & sharing plan (DMSP) - Initial

Data management & sharing plan (DMSP) - Initial veresion

Pubblicazioni

Conference proceedings (1)

Phenomenological equations for electron transport chain-mediated reactive oxygen species metabolism

Autori: Prof. Jochen Prehn, Dr Niamh Connolly and Sandeep Chenna
Pubblicato in: 2021 IEEE International Conference on Bioinformatics and Biomedicine, Numero 2021, 2021, Pagina/e pp. 653-658
Editore: IEEE
DOI: 10.1109/bibm52615.2021.9669351

Peer reviewed articles (15)

Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation

Autori: Céline Galvagnion, Frederik Ravnkilde Marlet, Silvia Cerri, Anthony H V Schapira, Fabio Blandini, Donato A Di Monte
Pubblicato in: Brain Communications, 2022, ISSN 2632-1297
Editore: Oxford University Press
DOI: 10.1093/brain/awab371

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Autori: Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V. Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T. Heneka
Pubblicato in: Cell, Numero 184/20, 2021, Pagina/e 5089-5106.e21, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2021.09.007

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells

Autori: Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, DeboraGentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, KristianHändler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Pubblicato in: Molecular Metabolism, Numero 19 April 2022, 2022, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101503

CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants

Autori: Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gomez Martın, Fabio Bertan, Chester J J Wrobel, Frank C Schroeder, Dan Ehninger, Kristian H€andler, Joachim L Schultze, Lukas Schreiber, Gerhild van Echten-Deckert, Pierluigi Nicotera & Daniele Bano
Pubblicato in: EMBO Reports, Numero e52606, 2022, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.202152606

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Autori: Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Pubblicato in: Journal of Neurochemistry, Numero Volume150, Numero5 Special Numero: Synuclein Meeting 2019, 2019, Pagina/e 522-534, ISSN 0022-3042
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14808

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

Autori: M. Jacoupy, E. Hamon-Keromen, A. Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury la Cour, M. J. Millan, J. A. Boutin, J. W. Harper, A. Brice, D. Guedin, C. A. Gautier, O. Corti
Pubblicato in: Scientific Reports, Numero 9/1, 2019, Pagina/e 1-15, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-47352-9

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Autori: Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Pubblicato in: Acta Neuropathologica Communications, Numero 7/1, 2019, Pagina/e 1-18, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-019-0859-3

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Autori: Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Pubblicato in: Biophysical Journal, Numero 27 January 2020, 2020, ISSN 0006-3495
Editore: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Autori: Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-61757-x

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Autori: Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
Pubblicato in: Biochemical and Biophysical Research Communications, Numero 17 May 2020, 2020, ISSN 0006-291X
Editore: Academic Press
DOI: 10.1016/j.bbrc.2020.04.091

AMPK preferentially depresses retrograde transport of axonal mitochondria during localised nutrient deprivation

Autori: Orla Watters, Niamh M. C. Connolly, Hans-Georg König, Heiko Düssmann, Jochen H. M. Prehn
Pubblicato in: The Journal of Neuroscience, Numero 11 May 2020, 2020, Pagina/e JN-RM-2067-19, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.2067-19.2020

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress condition

Autori: Emilie Dinh, Thomas Rival, Alice Carrier, Noemi Asfogo, Olga Corti, Christophe Melon, Pascal Salin, Sylviane Lortet, Lydia Kerkerian-Le Goff
Pubblicato in: Cell Death & Disease, Numero 12/5, 2021, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-021-03742-4

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications

Autori: Angelo Iannielli et al.
Pubblicato in: Cell Death & Disease, 2022, Pagina/e 881, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-022-05330-6

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons

Autori: Aurore Tourville, David Akbar, Olga Corti, Jochen H. M. Prehn, Ronald Melki, Stéphane Hunot and Patrick P. Michel
Pubblicato in: Cells, Numero 2022, 11, 1640, 2022, ISSN 2073-4409
Editore: Molecular Diversity Preservation International
DOI: 10.3390/cells11101640

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Autori: Maud Landureau, Virginie Redeker, Tracy Bellande, Stéphanie Eyquem, Ronald Melki
Pubblicato in: Journal of Biological Chemistry, Numero 2021, 2021, Pagina/e 100737, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100737