Neurotoxicity De-Risking in Preclinical Drug Discovery

Project description

A platform for predicting neurotoxicity of drug candidates

Many drug candidates can introduce toxicity in the central nervous system, which can be poorly predicted during the research and development process. To address this problem, the EU-funded NeuroDeRisk project will study the mechanisms of neurotoxicity, specifically manifested as seizures, psychiatric changes and peripheral neuropathies. Researchers will develop a platform that integrates biological models, artificial intelligence, biomarkers, omics data and compound design tools to improve risk-assessment during the drug development pipeline. This platform will support decision-making in the pharmaceutical industry, offering better protection of human volunteers and patients.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• natural sciences › computer and information sciences › artificial intelligence
• natural sciences › biological sciences › neurobiology

Programme(s)

• H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme
• H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2)

Topic(s)

• IMI2-2017-13-10 - Improving the preclinical prediction of adverse effects of pharmaceuticals on the nervous system

Call for proposal

H2020-JTI-IMI2-2017-13-two-stage

See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

UNIVERSITAT WIEN

Net EU contribution

€ 594 450,00

Address

Universitatsring 1
1010 Wien
Austria

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 7 425,00

Region

Wien › Wien

Participants (17)

MEDIZINISCHE UNIVERSITAET WIEN

Austria

Net EU contribution

€ 372 200,00

Address

Spitalgasse 23
1090 Wien

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 5 300,00

Region

Wien › Wien

FARMACEUTSKI FAKULTET UNIVERZITETAU BEOGRADU

Serbia

Net EU contribution

€ 696 150,00

Address

Vojvode Stepe 450
52600 Belgrade

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 9 850,00

 

 

INTE:LIGAND SOFTWARE-ENTWICKLUNGS-UND CONSULTING GMBH

Austria

Net EU contribution

€ 341 400,00

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes

Address

Clemens Maria Hofbauer Gasse 6
2344 Maria Enzersdorf

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 4 850,00

Region

Niederösterreich › Wiener Umland/Südteil

ITA-SUOMEN YLIOPISTO

Finland

Net EU contribution

€ 804 900,00

Address

Yliopistonranta 1 E
70211 Kuopio

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 11 412,50

Region

Manner-Suomi › Pohjois- ja Itä-Suomi › Pohjois-Savo

UNIVERSITA DEGLI STUDI DI FIRENZE

Italy

Net EU contribution

€ 391 500,00

Address

Piazza San Marco 4
50121 Florence

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 5 562,50

Region

Centro (IT) › Toscana › Firenze

ICETA INSTITUTO DE CIENCIAS, TECNOLOGIAS E AGROAMBIENTE DA UNIVERSIDADE DO PORTO

Portugal

Net EU contribution

€ 403 500,00

Address

Rua D Manuel Ii Apartado 55142
4051 401 Porto

Activity type

Research Organisations

Non-EU contribution

€ 5 687,50

Region

Continente › Norte › Área Metropolitana do Porto

 

UPPSALA UNIVERSITET

Sweden

Net EU contribution

€ 307 400,00

Address

Von Kraemers Alle 4
751 05 Uppsala

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 4 350,00

Region

Östra Sverige › Östra Mellansverige › Uppsala län

ALCEDIAG

France

Net EU contribution

€ 583 300,00

Address

Route Des Michels La Corneirelle
13790 Peynier

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 8 262,50

 

 

UNIVERSITE CLERMONT AUVERGNE

France

Net EU contribution

€ 429 400,00

Address

49 Bd Francois Mitterrand
63000 Clermont Ferrand

Activity type

Higher or Secondary Education Establishments

Non-EU contribution

€ 6 100,00

Region

Auvergne-Rhône-Alpes › Auvergne › Puy-de-Dôme

 

A. PERSIDIS & SIA OE

Greece

Net EU contribution

€ 406 800,00

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes

Address

Rodopoleos Street 34
167 77 Athina

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 5 762,50

Region

Νότιος Τομέας Αθηνών › Aττική › Αττική

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT

France

Net EU contribution

€ 0,00

Address

Pierre Brossolette 1
91380 Chilly Mazarin

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 1 613 000,00

Region

Ile-de-France › Ile-de-France › Essonne

ASTRAZENECA AB

Sweden

Net EU contribution

€ 0,00

Address

Vastra Maelarhamnen
151 85 Sodertaelje

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 185 000,00

Region

Östra Sverige › Stockholm › Stockholms län

FUJIFILM CELLULAR DYNAMICS INC

United States

Net EU contribution

€ 0,00

Address

Science Drive 525 Suite 200
53711 Madison Wi

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 600 000,00

 

 

MERCK SHARP & DOHME CORP

United States

Net EU contribution

€ 0,00

Address

One Merck Drive
08889 Whitehouse Station Nj

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 638 500,00

 

NOVARTIS PHARMA AG

Switzerland

Net EU contribution

€ 0,00

Address

Lichtstrasse 35
4056 Basel

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 1 100 000,00

Region

Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt

PFIZER LIMITED

United Kingdom

Net EU contribution

€ 0,00

Address

Ramsgate Road
CT13 9NJ Sandwich

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 75 000,00

Region

South East (England) › Kent › East Kent

UCB BIOPHARMA

Belgium

Net EU contribution

€ 0,00

Address

Allee De La Recherche 60
1070 Bruxelles

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Non-EU contribution

€ 135 000,00

Region

Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest