Project description
Innovative membrane protein structural and biochemical analysis for drug discovery
Cellular proteins represent the majority of drug targets and are used as pharmaceuticals in biotechnology. Most commercial drugs are the results of conventional drug discovery. However, the information obtained from three-dimensional protein structures enables rational drug design with improved selectivity and pharmaceutical properties. Funded by the Marie Skłodowska-Curie Actions programme, the ProMeTeus consortium of international academia and industrial partners aims to develop a high-quality multidisciplinary training and research platform centering on proteins as molecular tools for drug discovery and delivery. The project will focus on membrane protein structural biology and biochemistry as well as state-of-the-art facilities to study high-throughput target selection and expression.
Objective
The aim of the ProMeTeus Consortium is to provide high-quality multidisciplinary knowledge through training and research on the development of protein studies as molecular tools for drug development and drug delivery. The focus of the action is the creation of a synergistic pipeline to yield target membrane protein structures and characterization and bioactive molecules design, harnessing the complementary skills from Academic and SME participants. We propose to join key expertise in protein structural biology and biochemistry with state-of-the art facilities for membrane protein high-throughput target selection and expression. A strategic contribution will be provided by SME in key technologies (virtual screening, detergent science, organic synthesis and biotech) and in exploitation, dissemination and resource acquisition skills. We will deliver crucial data for the development of new leads for health issues such as the design of new antibiotics or new strategies for theranostics and foster a synergistic approach to novel bioactive compounds development between academic and SME. The acquisition of new skill from staff will come from secondments aimed at training on research topics not available at the home institutions and attendance to courses, workshops, seminar and conferences. In an era where academic institutions are called to participate actively in technological and industrial development and SME provide services to and benefit of the wide breadth of academic research programs, we will foster a culture of synergistic exchange and cross-fertilization.
The consortium consists of 9 beneficiaries and 2 partners , of which 7 are academic and 4 are SME. During 4 years 16 ESRs, 6 ERs and 2 research managers will be seconded to 1 Institutions, where they will be supported by a team of leading scientists. The Network will promote the integration of academic and SME in combining excellent science with entrepreneurial approach and high-throughput methodologies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-RISE-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.