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Soft Biocompatible Polymeric Nanostructures: A Toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

Objective

We propose a research and innovation project that aims to develop a rational, knowledge-based toolbox for the fabrication of (1) biodegradable and biocompatible associating (gel-forming) polymers, (2) nanogels and (3) nanoparticles tailored as multifunctional therapeutic agents in ophthalmological applications. We seek for novel methods to replace currently used approaches with biocompatible and biodegradable synthetic/natural polymers. Macromolecules of increasingly complex architectures including block, graft and star-like polymers will be explored with respect to their ability to build up transient networks or nanoparticles with well-controlled rheological and structural properties and targeted performance. Profound understanding of the relation between architectural complexity and properties of the macromolecules is crucial for the fabrication of functional polymer-based materials for biomedicine and will greatly enhance the competitiveness of Europe in the field. Such conceptual understanding can only be achieved based on a rational interdisciplinary approach, in which theory and simulations guide experiments. Our work plan includes the design, synthesis and characterization of novel macromolecular architectures dictated by theoretical and simulation outcomes on the properties of the materials, followed by toxicity and in vitro/in vivo testing of the materials/structures and industrial feasibility studies. The macromolecular assemblies will be investigated as complex carriers enabling (1) prolonged retention in the eye and (2) controlled ocular drug release under external stimuli (i.e. temperature, light, pH). The synergy resulting from the cooperation between world-leading in their respective fields academic groups and companies though the effective secondments plan will provide a unique interdisciplinary research and training environment that will allow to address unmet challenges in the area and will ensure European leadership in cutting-edge technologies.

Coordinator

PANEPISTIMIO KRITIS
Net EU contribution
€ 234 600,00
Address
University Campus Gallos
74100 Rethimno
Greece

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Region
Ρέθυμνο Κρήτη Νησιά Αιγαίου
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 18 400,00

Participants (6)

HELSINGIN YLIOPISTO
Finland
Net EU contribution
€ 147 200,00
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 23 000,00
THE UNIVERSITY OF READING
United Kingdom
Net EU contribution
€ 78 200,00
Address
Whiteknights Campus Whiteknights House
RG6 6AH Reading

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 23 000,00
USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI
Czechia
Net EU contribution
€ 69 000,00
Address
Heyrovsky Sq 2
162 06 Praha 6

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Region
Praha Hlavní město Praha
Activity type
Research Organisations
Non-EU contribution
€ 32 200,00
BIONAVIS OY
Finland
Net EU contribution
€ 32 200,00
Address
Hermiankatu 6-8H
33720 Tampere

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 124 200,00
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 13 800,00
NANOMATERIALES Y POLIMEROS SL

Participation ended

Spain
Net EU contribution
€ 0,00
Address
Avenida De La Innovacion 1, Edificio Bic
18100 Armilla Granada

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Andalucía Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Partners (4)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

INSTITUTION OF RUSSIAN ACADEMY OF SCIENCES INSTITUTE OF MACROMOLECULAR COMPOUNDS RAS

Participation ended

Russia
Net EU contribution
€ 0,00
Address
Bolshoy Prospekt 31
199004 St Petersburg

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Activity type
Research Organisations
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

INSTITUTE OF POLYMER MATERIALS ANDTECHNOLOGY
Kazakhstan
Net EU contribution
€ 0,00
Non-EU contribution
€ 105 800,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FUNDACAO UNIVERSIDADE FEDERAL DO ABC
Brazil
Net EU contribution
€ 0,00
Address
Rua Santa Adelia 166
09 210 170 Santo Andre

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 110 400,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

DELSI OOO

Participation ended

Russia
Net EU contribution
€ 0,00
Address
Ul Marshala Govorova 29 Bld. O
198097 Saint Petersburg

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00