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Soft Biocompatible Polymeric Nanostructures: A Toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

Objective

We propose a research and innovation project that aims to develop a rational, knowledge-based toolbox for the fabrication of (1) biodegradable and biocompatible associating (gel-forming) polymers, (2) nanogels and (3) nanoparticles tailored as multifunctional therapeutic agents in ophthalmological applications. We seek for novel methods to replace currently used approaches with biocompatible and biodegradable synthetic/natural polymers. Macromolecules of increasingly complex architectures including block, graft and star-like polymers will be explored with respect to their ability to build up transient networks or nanoparticles with well-controlled rheological and structural properties and targeted performance. Profound understanding of the relation between architectural complexity and properties of the macromolecules is crucial for the fabrication of functional polymer-based materials for biomedicine and will greatly enhance the competitiveness of Europe in the field. Such conceptual understanding can only be achieved based on a rational interdisciplinary approach, in which theory and simulations guide experiments. Our work plan includes the design, synthesis and characterization of novel macromolecular architectures dictated by theoretical and simulation outcomes on the properties of the materials, followed by toxicity and in vitro/in vivo testing of the materials/structures and industrial feasibility studies. The macromolecular assemblies will be investigated as complex carriers enabling (1) prolonged retention in the eye and (2) controlled ocular drug release under external stimuli (i.e. temperature, light, pH). The synergy resulting from the cooperation between world-leading in their respective fields academic groups and companies though the effective secondments plan will provide a unique interdisciplinary research and training environment that will allow to address unmet challenges in the area and will ensure European leadership in cutting-edge technologies.

Field of science

  • /natural sciences/chemical sciences/polymer science
  • /medical and health sciences/clinical medicine/ophthalmology

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

PANEPISTIMIO KRITIS
Address
University Campus Gallos
74100 Rethimno
Greece
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 156 400

Participants (6)

HELSINGIN YLIOPISTO
Finland
EU contribution
€ 147 200
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF READING
United Kingdom
EU contribution
€ 78 200
Address
Whiteknights Campus Whiteknights House
RG6 6AH Reading
Activity type
Higher or Secondary Education Establishments
USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI
Czechia
EU contribution
€ 69 000
Address
Heyrovsky Sq 2
162 06 Praha 6
Activity type
Research Organisations
BIONAVIS OY
Finland
EU contribution
€ 32 200
Address
Hermiankatu 6-8H
33720 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 124 200
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
NANOMATERIALES Y POLIMEROS SL
Spain
EU contribution
€ 78 200
Address
Avenida De La Innovacion 1, Edificio Bic
18100 Armilla Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

INSTITUTION OF RUSSIAN ACADEMY OF SCIENCES INSTITUTE OF MACROMOLECULAR COMPOUNDS RAS
Russia
Address
Bolshoy Prospekt 31
199004 St Petersburg
Activity type
Research Organisations
INSTITUTE OF POLYMER MATERIALS ANDTECHNOLOGY
Kazakhstan
Address
Satpayev Str.22
050013 Almaty
Activity type
Other
FUNDACAO UNIVERSIDADE FEDERAL DO ABC
Brazil
Address
Rua Santa Adelia 166
09 210 170 Santo Andre
Activity type
Higher or Secondary Education Establishments
DELSI OOO
Russia
Address
Ul Marshala Govorova 29 Bld. O
198097 Saint Petersburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)