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Soft Biocompatible Polymeric Nanostructures: A Toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Theoretical prediction of the relationships between topology and composition of multi-responsive nanogels and character of stimuli-induced volume transitions

A report describing the theoretical prediction of the relationships between polymer topology and composition of the multiresponsive nanogels and their stimuliinduced volume transitions will be prepared and submitted

Rheological properties of the self-assembled polymers as a function of the external stimuli

A report will be written by UREAD and other contributing partners on the rheological properties of the self-assembled polymers as a function of the external stimuli. This data will facilitate the in vitro and in vivo use of these systems.

Theoretical model predicting stimuli-induced drug uptake-release for nano/microgels and nanoparticles

A report will be prepared to describe the theoretical models used to study stimuli responsive nanoparticles and the drug uptake-release profiles of the nano/microgels and micellar carriers.

Intraocular nanoparticle diffusion in vitro

A report to describe the intraocular polymer nanoparticle diffusion, determined by the in vitro studies, will be prepared

Structure and dynamics of the self-assembled copolymers in solution and static/dynamic behavior of the drug loaded assemblies

A report will be prepared and submitted to be kept on file describing the structure and dynamics of the self-assembled copolymers in solution and the static/dynamic behavior of the drug loaded assemblies. This data will be kept on file and will be made available to the project partners.

In vitro toxicity/biocompatibility of the polymeric materials and their retention on ocular tissues in vitro

A report on the in vitro toxicity/biocompatibility results for the polymeric materials and their retention on ocular tissues as determined by the in vitro studies in the project will be prepared and submitted.

Project Website

The deliverable is related to the setup and update of the project website for the whole duration of the project.

Publications

Soft micron-sized polypeptide microgels: preparation, crosslink density, topography and nanomechanics in swollen state

Author(s): Oleksii Kotko, Petr Šálek, Jana Dvořáková, Miroslava Dušková Smrčková, Ján Šomvársky, Jean Jacques Bonvent, Sérgio Brochsztain, Miroslav Šlouf, Vladimír Proks
Published in: Materials Advances, Issue 5, 2024, Page(s) 5984-5997, ISSN 2633-5409
Publisher: ROYAL SOC CHEMISTRY
DOI: 10.1039/d4ma00356j

Non-linear elasticity effects and stratification in brushes of branched polyelectrolytes

Author(s): Lebedeva I.O.; Shavykin O.V.; Neelov I.M.; Zhulina E.B.; Leermakers F.A.M.; Borisov, O.V
Published in: Journal of Chemical Physics, 2019, Page(s) 2014902, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/1.5130580

Amphoteric nano‐ and microgels with acrylamide backbone for potential application in oil recovery

Author(s): Aigerim Ayazbayeva, Vikram Baddam, Alexey Shakhvorostov, Iskander Gussenov, Vladimir Aseyev, Mubarak Yermaganbetov, Sarkyt Kudaibergenov
Published in: Polymers for Advanced Technologies, Issue 34, 2023, Page(s) 3826-3837, ISSN 1042-7147
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pat.6182

Temperature and Salt Responsivity of Anionic, Cationic and Amphoteric Nanogels Based on N-Isopropylacrylamide, 2-Acrylamido-2-Methyl-1-Propanesulfonic Acid Sodium Salt and (3-Acrylamidopropyl) Trimethylammonium Chloride

Author(s): Aigerim Ye. Ayazbayeva, Alexey V. Shakhvorostov1, Sarkyt E. Kudaibergenov
Published in: Bulletin of the University of Karaganda Chemistry, Issue 108 (4), 2022, Page(s) 14-24, ISSN 2518-718X
Publisher: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2022ch4/4-22-15

Role of Membrane Features on the Permeability Behavior of Polymersomes and the Potential Impacts on Drug Encapsulation and Release

Author(s): Fernando A. de Oliveira, Carin Cristina da Silva Batista, Peter Černoch, Vladimir Sincari, Alessandro Jäger, Eliézer Jäger, Fernando C. Giacomelli
Published in: Biomacromolecules, Issue 24, 2023, Page(s) 2291-2300, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.3c00162

Fractionation and Characterization of Commercial Low Acyl Gellan Gum

Author(s): Gulnur S. Tatykhanova, Sami‐Pekka Hirvonen, Yuliia V. Bardadym, Nargiz N. Gizatullina, Moldir A. Saulimbay
Published in: Macromolecular Symposia, Issue 413, 2024, Page(s) 2400001, ISSN 1022-1360
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/masy.202400001

Anionic Polysaccharide – Gellan As Perspective Polymer for Potential Application in Medicine and Oil Recovery: A Mini-Review

Author(s): S.E. Kudaibergenov, Gulnur Tatykhanova, N.N. Gizatullina, R.N. Tuleyeva, D.B. Kaldybekov, I.Sh. Gussenov, R.Zh. Berzhanova, T.D. Mukasheva, Maria Vamvakaki, Vladimir Aseyev, Vitaliy V. Khutoryanskiy
Published in: Uzbekistan Journal of Polymers, Issue 2 (2), 2023, Page(s) 39-56, ISSN 2181-3256
Publisher: Institute of Chemistry and Physics of Polymers of the Academy of Sciences of the Republic of Uzbekistan

Tough Materials Through Ionic Interactions

Author(s): Linda Salminen, Erno Karjalainen, Vladimir Aseyev, Heikki Tenhu
Published in: Frontiers in Chemistry, Issue 9, 2021, Page(s) 721656, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2021.721656

Poly(2-ethyl-2-oxazoline) grafted gellan gum for potential application in transmucosal drug delivery

Author(s): Janni Lavikainen, Moldir Dauletbekova, Gaukhar Toleutay, Maria Kaliva, Maria Chatzinikolaidou, Sarkyt E. Kudaibergenov, Andrey Tenkovtsev, Vitaliy V. Khutoryanskiy, Maria Vamvakaki, Vladimir Aseyev
Published in: Polymers for Advanced Technologies, Issue 32 (7), 2021, Page(s) 2770-2780, ISSN 1042-7147
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pat.5298

Synthesis and characterization of novel thermo- and salt-sensitive amphoteric terpolymers based on acrylamide derivatives

Author(s): A.Ye. Ayazbayeva, A.V. Shakhvorostov, T.M. Seilkhanov, V.O. Aseyev, S.E. Kudaibergenov
Published in: Bulletin of the University of Karaganda Chemistry, Issue 104 (4), 2021, Page(s) 9-20, ISSN 2518-718X
Publisher: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2021ch4/9-20

Chitosan/Poly(2-ethyl-2-oxazoline) Films with Ciprofloxacin for Application in Vaginal Drug Delivery

Author(s): Guzel K. Abilova; Daulet B. Kaldybekov; G.S. Irmukhametova; Diara S. Kazybayeva; Zhanar A. Iskakbayeva; Sarkyt E. Kudaibergenov; Vitaliy V. Khutoryanskiy
Published in: Materials, 2020, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma13071709

Phase Separation of Aqueous Poly(diisopropylaminoethyl methacrylate) upon Heating.

Author(s): Linda Salminen; Erno Karjalainen; Vladimir Aseyev; Heikki Tenhu
Published in: Langmuir, Issue 5, 2022, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.1c02224

Mucoadhesive Properties of Gellan and Its Modified Derivatives

Author(s): Gul’nur Tatykhanova, Vladimir Aseyev, Sarkyt E. Kudaibergenov,
Published in: Reviews and Advances in Chemistry, Issue 10, 2020, Page(s) 140-157, ISSN 2634-8276
Publisher: Springer
DOI: 10.1134/s207997802003005x

Temperature and Salt Responsive Amphoteric Nanogels Based on N-Isopropylacrylamide, 2-Acrylamido-2-methyl-1-propanesulfonic Acid Sodium Salt and (3-Acrylamidopropyl) Trimethylammonium Chloride

Author(s): Aigerim Ye. Ayazbayeva, Alexey Shakhvorostov, Iskander Sh. Gussenov, Tulegen M. Seilkhanov, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Published in: Nanomaterials, Issue 12 (14), 2022, Page(s) 2343, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano12142343

Self-Organization in Dilute Aqueous Solutions of Thermoresponsive Star-Shaped Six-Arm Poly-2-Alkyl-2-Oxazines and Poly-2-Alkyl-2-Oxazolines

Author(s): Tatyana Kirila, Anna Smirnova, Vladimir Aseyev, Andrey Tenkovtsev, Heikki Tenhu, Alexander Filippov
Published in: Polymers, Issue 13 (9), 2021, Page(s) 1429, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym13091429

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Author(s): Onugwu, A. L., Nwagwu, C. S., Onugwu, O. S., Echezona, A. C., Agbo, C. P., Ihim, S. A., Emeh, P., Nnamani, P. O., Attama, A. A. and Khutoryanskiy, V. V.,
Published in: Journal of Controlled Release, 2023, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2023.01.018

Tuning the morphology of block copolymer-based pH-triggerednanoplatforms as driven by changes in molecular weight and protocol ofmanufacturing

Author(s): Fernando A. de Oliveira, Carin C. S. Batista, Lindomar J. C. Albuquerque, Peter Cernoch, Miloš Steinhart, Vladimir Sincari, Alessandro Jager, Eliezer Jager, Fernando C. Giacomelli
Published in: Journal of Colloid and Interface Science, 2023, ISSN 0021-9797
Publisher: Academic Press
DOI: 10.1016/j.jcis.2022.12.129

Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery

Author(s): Roman V. Moiseev; Daulet B. Kaldybekov; Sergey K. Filippov; Aurel Radulescu; Vitaliy V. Khutoryanskiy
Published in: Langmuir, 2022, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.2c02086

Protein coronas coating polymer-stabilized silver nanocolloids attenuate cytotoxicity with minor effects on antimicrobial performance

Author(s): Carin C. S. Batista, Jiří Trousil, Olga Janoušková, Carlos Eduardo de Castro, Petr Štěpánek Fernando C. Giacomelli
Published in: Colloids and Surfaces B: Biointerfaces, 2022, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2022.112778

Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: In vitro and in vivo studies.

Author(s): Laura E. Agibayeva; Daulet B. Kaldybekov; Natalia N. Porfiryeva; V. R. Garipova; R.A. Mangazbayeva; Rouslan I. Moustafine; I. I. Semina; Grigoriy A. Mun; Sarkyt E. Kudaibergenov; Vitaliy V. Khutoryanskiy; Vitaliy V. Khutoryanskiy
Published in: International Journal of Pharmaceutics, Issue 1, 2020, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2020.119093

Preparation and Characterization of Amphoteric Polysaccharides Derived From Chitosan and Gellan Gum

Author(s): Rysgul N. Tuleyeva, Gulnur S. Tatykhanova, Nargiz N. Gizatullina, Daulet B. Kaldybekov, Yuliia V. Bardadym, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Published in: Polymers for Advanced Technologies, Issue 35, 2024, Page(s) e70033, ISSN 1042-7147
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pat.70033

Comparative Study of Gellan Gum Derived from Domestic Raw Materials of Kazakhstan and Commercial Gellan

Author(s): Gulnur S. Tatykhanova, Nargiz N. Gizatullina, Gulnar M. Kudaibergenova, Ramza Zh. Berzhanova, Togzhan D. Mukasheva, Sarkyt E. Kudaibergenov
Published in: Macromolecular Symposia, Issue 413, 2024, Page(s) 2400004, ISSN 1022-1360
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/masy.202400004

Characterization of Biocompatible Gellan Gum Fractions for Prolonged Retention in Ocular Drug Delivery Systems

Author(s): Gulnur S. Tatykhanova, Rysgul N. Tuleyeva, Nargiz N. Gizatullina, Daulet B. Kaldybekov, Yuliia V. Bardadym, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Published in: Polymers for Advanced Technologies, Issue 35, 2024, Page(s) e6635, ISSN 1042-7147
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pat.6635

Electroresponsive polyelectrolyte brushes studied by self-consistent field theory

Author(s): Okrugin B.M.; Richter R.P.; Leermakers F.A.M.; Neelov I.M.; Zhulina E.B.; Borisov O.V.
Published in: Polymers, 2020, Page(s) 898, ISSN 2073-4360
Publisher: MDPI AG
DOI: 10.3390/polym12040898

Polymer‐Protected Gold Nanoparticles for Photothermal Treatment of Ehrlich Adenocarcinoma: In Vitro and In Vivo Studies

Author(s): Gulnur S. Tatykhanova, Rysgul N. Tuleyeva, Zhanara A. Nurakhmetova, Nargiz N. Gizatullina, Vladimir K. Krasnoshtanov, Daulet B. Kaldybekov, Vladimir O. Aseyev, Vitaliy V. Khutoryanskiy, Sarkyt E. Kudaibergenov
Published in: Macromolecular Chemistry and Physics, Issue 14 May 2024, 2024, Page(s) 2400128, ISSN 1022-1352
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/macp.202400128

Proteins and Polyampholytes Interacting with Polyelectrolyte Brushes and Microgels: the Charge Reversal Concept Revised

Author(s): Laktionov M.Y. Zhulina E.B.; Borisov O.V.
Published in: Langmuir, 2021, Page(s) 2865–2873, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.0c02837

Theory of polyelectrolyte dendrigrafts

Author(s): Borisov, O.V ; Shavykin O.V. ; Zhulina E.B.
Published in: Colloid and Polymer Science, 2020, Page(s) 951-959, ISSN 0303-402X
Publisher: Springer Verlag
DOI: 10.1007/s00396-019-04588-1

Synthesis of fluorescently-labelled poly(2-ethyl-2-oxazoline)-protected gold nanoparticles

Author(s): Elmira Nurgaziyeva, Sarkyt Kudaibergenov, Grigoriy Mun, Vitaliy Khutoryanskiy
Published in: Chemical Bulletin of Kazakh National University, Issue 100 (1), Published 2021-03-19, 2021, Page(s) 12-20, ISSN 2312-7554
Publisher: al-Farabi Kazakh National University
DOI: 10.15328/cb1185

Immobilization of Methyl Orange and Methylene Blue within the Matrix of Charge-Imbalanced Amphoteric Nanogels and Study of Dye Release Kinetics as a Function of Temperature and Ionic Strength

Author(s): A.Ye. Ayazbayeva, S.Z. Nauryzova, V.O. Aseyev, A.V. Shakhvorostov
Published in: Bulletin of the University of Karaganda Chemistry, Issue 107 (3), 2022, Page(s) 127-140, ISSN 2518-718X
Publisher: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2022ch3/3-22-4

Microfluidic-assisted synthesis of uniform polymer-stabilized silver colloids

Author(s): Carin C.S. Batista, Alessandro Jager, Brunno L. Albuquerque, Ewa Pavlova, Petr Stepanek, Fernando C. Giacomelli
Published in: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, ISSN 0927-7757
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfa.2021.126438

Probing protein adsorption onto polymer-stabilized silver nanocolloids towards a better understanding on the evolution and consequences of biomolecular coronas

Author(s): Carin C.S. Batista, Lindomar J.C. Albuquerque, Alessandro Jäger, Petr Stepánek, Fernando C. Giacomelli
Published in: Materials Science & Engineering C, 2020, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2020.110850

Ophthalmic drug delivery system based on the complex of gellan and ofloxacin

Author(s): Gulnur S. Tatykhanova, Vladimir O. Aseyev, Maria Vamvakaki, Vitaliy V. Khutoryanskiy, Sarkyt E. Kudaibergenov,
Published in: Chemical Bulletin of Kazakh National University, Issue 105 (2), 2022, Page(s) 4-12, ISSN 1563-0331
Publisher: Al-Farabi Kazakh National University
DOI: 10.15328/cb1239

Investigation of the Thermogelation of a Promising Biocompatible ABC Triblock Terpolymer and Its Comparison with Pluronic F127

Author(s): Anna P. Constantinou; Valeria Nele; James J. Doutch; Joana S. Correia; Roman V. Moiseev; Martina Cihova; David C. A. Gaboriau; Jonathan Krell; Vitaliy V. Khutoryanskiy; Molly M. Stevens; Theoni K. Georgiou
Published in: Macromolecules, 2022, ISSN 0024-9297
Publisher: American Chemical Society
DOI: 10.1021/acs.macromol.1c02123

Soft Biocompatible Polymeric Nanostructures: A toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

Author(s): Vladimir Aseyev
Published in: Kemiauutiset KemiNyheter ChemistryNews 2020, Issue annual, 2020, Page(s) 48, ISSN 2323-7775
Publisher: Helsingin yliopiston kemian laitos

Guest from Kazakhstan: Challenges and Impressions

Author(s): Moldir Dauletbekova
Published in: Kemiauutiset KemiNyheter ChemistryNews 2020, Issue annual, 2020, Page(s) 49, ISSN 2323-7767
Publisher: Helsingin yliopiston kemian laitos

Biomolecular Coronas Coating Silver Nanoparticles: Structural Analysis and Biological Consequences

Author(s): Carin Cristina da Silva Batista
Published in: PhD Thesis, 2022
Publisher: Federal University of ABC

Poly(2-ethyl-2-oxazoline) modified gellan gum

Author(s): Janni Lavikainen
Published in: Master thesis, 2020
Publisher: University of Helsinki

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