Soft Biocompatible Polymeric Nanostructures: A Toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

Rezultaty

Theoretical prediction of the relationships between topology and composition of multi-responsive nanogels and character of stimuli-induced volume transitions

A report describing the theoretical prediction of the relationships between polymer topology and composition of the multiresponsive nanogels and their stimuliinduced volume transitions will be prepared and submitted

Rheological properties of the self-assembled polymers as a function of the external stimuli

A report will be written by UREAD and other contributing partners on the rheological properties of the self-assembled polymers as a function of the external stimuli. This data will facilitate the in vitro and in vivo use of these systems.

Development of synthetic protocols for lysozyme responsive nanoparticles based on complexes of gelatin with chitosan as eye drug delivery systems

A report will be prepared to describe the development of gelatin-chitosan nanoparticles which will be responsive to lysozyme for ocular drug delivery

Theoretical model predicting stimuli-induced drug uptake-release for nano/microgels and nanoparticles

A report will be prepared to describe the theoretical models used to study stimuli responsive nanoparticles and the drug uptake-release profiles of the nano/microgels and micellar carriers.

Intraocular nanoparticle diffusion in vitro

A report to describe the intraocular polymer nanoparticle diffusion, determined by the in vitro studies, will be prepared

In vivo acceptability/toxicity of the polymeric carriers and drug bioavailability in ophthalmic fluids

A report describing the acceptability/toxicity of the polymeric carriers and the drug bioavailability in the ophthalmic fluids as determined by the project partners in animal models (in vivo studies) will be prepared.

Structure and dynamics of the self-assembled copolymers in solution and static/dynamic behavior of the drug loaded assemblies

A report will be prepared and submitted to be kept on file describing the structure and dynamics of the self-assembled copolymers in solution and the static/dynamic behavior of the drug loaded assemblies. This data will be kept on file and will be made available to the project partners.

In vitro toxicity/biocompatibility of the polymeric materials and their retention on ocular tissues in vitro

A report on the in vitro toxicity/biocompatibility results for the polymeric materials and their retention on ocular tissues as determined by the in vitro studies in the project will be prepared and submitted.

In vivo drug efficacy upon topical or intraocular administration

A report describing the drug efficacy upon topical or intraocular administration of the polymeric nanocarriers in vivo will be prepared and submitted.

Phase diagram of DNA-copolymer biohybrid/protein mixtures

A report to describe the phase diagram of the DNA-copolymer biohybrid/protein mixtures will be prepared by CNRS and will be kept on file

Proceedings of industrial workshops, summer schools and international conference

The deliverable will include the proceedings of the industrial workshops, summer schools and international conference organized by the consortium during the project. Relevant websites and photos, videos from these events will be also included in the deliverable.

Project Website

The deliverable is related to the setup and update of the project website for the whole duration of the project.

Publikacje

Soft micron-sized polypeptide microgels: preparation, crosslink density, topography and nanomechanics in swollen state

Autorzy: Oleksii Kotko, Petr Šálek, Jana Dvořáková, Miroslava Dušková Smrčková, Ján Šomvársky, Jean Jacques Bonvent, Sérgio Brochsztain, Miroslav Šlouf, Vladimír Proks
Opublikowane w: Materials Advances, Numer 5, 2024, Strona(/y) 5984-5997, ISSN 2633-5409
Wydawca: ROYAL SOC CHEMISTRY
DOI: 10.1039/d4ma00356j

Non-linear elasticity effects and stratification in brushes of branched polyelectrolytes

Autorzy: Lebedeva I.O.; Shavykin O.V.; Neelov I.M.; Zhulina E.B.; Leermakers F.A.M.; Borisov, O.V
Opublikowane w: Journal of Chemical Physics, 2019, Strona(/y) 2014902, ISSN 0021-9606
Wydawca: American Institute of Physics
DOI: 10.1063/1.5130580

Amphoteric nano‐ and microgels with acrylamide backbone for potential application in oil recovery

Autorzy: Aigerim Ayazbayeva, Vikram Baddam, Alexey Shakhvorostov, Iskander Gussenov, Vladimir Aseyev, Mubarak Yermaganbetov, Sarkyt Kudaibergenov
Opublikowane w: Polymers for Advanced Technologies, Numer 34, 2023, Strona(/y) 3826-3837, ISSN 1042-7147
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/pat.6182

Temperature and Salt Responsivity of Anionic, Cationic and Amphoteric Nanogels Based on N-Isopropylacrylamide, 2-Acrylamido-2-Methyl-1-Propanesulfonic Acid Sodium Salt and (3-Acrylamidopropyl) Trimethylammonium Chloride

Autorzy: Aigerim Ye. Ayazbayeva, Alexey V. Shakhvorostov1, Sarkyt E. Kudaibergenov
Opublikowane w: Bulletin of the University of Karaganda Chemistry, Numer 108 (4), 2022, Strona(/y) 14-24, ISSN 2518-718X
Wydawca: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2022ch4/4-22-15

Role of Membrane Features on the Permeability Behavior of Polymersomes and the Potential Impacts on Drug Encapsulation and Release

Autorzy: Fernando A. de Oliveira, Carin Cristina da Silva Batista, Peter Černoch, Vladimir Sincari, Alessandro Jäger, Eliézer Jäger, Fernando C. Giacomelli
Opublikowane w: Biomacromolecules, Numer 24, 2023, Strona(/y) 2291-2300, ISSN 1525-7797
Wydawca: American Chemical Society
DOI: 10.1021/acs.biomac.3c00162

Fractionation and Characterization of Commercial Low Acyl Gellan Gum

Autorzy: Gulnur S. Tatykhanova, Sami‐Pekka Hirvonen, Yuliia V. Bardadym, Nargiz N. Gizatullina, Moldir A. Saulimbay
Opublikowane w: Macromolecular Symposia, Numer 413, 2024, Strona(/y) 2400001, ISSN 1022-1360
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/masy.202400001

Anionic Polysaccharide – Gellan As Perspective Polymer for Potential Application in Medicine and Oil Recovery: A Mini-Review

Autorzy: S.E. Kudaibergenov, Gulnur Tatykhanova, N.N. Gizatullina, R.N. Tuleyeva, D.B. Kaldybekov, I.Sh. Gussenov, R.Zh. Berzhanova, T.D. Mukasheva, Maria Vamvakaki, Vladimir Aseyev, Vitaliy V. Khutoryanskiy
Opublikowane w: Uzbekistan Journal of Polymers, Numer 2 (2), 2023, Strona(/y) 39-56, ISSN 2181-3256
Wydawca: Institute of Chemistry and Physics of Polymers of the Academy of Sciences of the Republic of Uzbekistan

Tough Materials Through Ionic Interactions

Autorzy: Linda Salminen, Erno Karjalainen, Vladimir Aseyev, Heikki Tenhu
Opublikowane w: Frontiers in Chemistry, Numer 9, 2021, Strona(/y) 721656, ISSN 2296-2646
Wydawca: Frontiers
DOI: 10.3389/fchem.2021.721656

Poly(2-ethyl-2-oxazoline) grafted gellan gum for potential application in transmucosal drug delivery

Autorzy: Janni Lavikainen, Moldir Dauletbekova, Gaukhar Toleutay, Maria Kaliva, Maria Chatzinikolaidou, Sarkyt E. Kudaibergenov, Andrey Tenkovtsev, Vitaliy V. Khutoryanskiy, Maria Vamvakaki, Vladimir Aseyev
Opublikowane w: Polymers for Advanced Technologies, Numer 32 (7), 2021, Strona(/y) 2770-2780, ISSN 1042-7147
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/pat.5298

Synthesis and characterization of novel thermo- and salt-sensitive amphoteric terpolymers based on acrylamide derivatives

Autorzy: A.Ye. Ayazbayeva, A.V. Shakhvorostov, T.M. Seilkhanov, V.O. Aseyev, S.E. Kudaibergenov
Opublikowane w: Bulletin of the University of Karaganda Chemistry, Numer 104 (4), 2021, Strona(/y) 9-20, ISSN 2518-718X
Wydawca: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2021ch4/9-20

Chitosan/Poly(2-ethyl-2-oxazoline) Films with Ciprofloxacin for Application in Vaginal Drug Delivery

Autorzy: Guzel K. Abilova; Daulet B. Kaldybekov; G.S. Irmukhametova; Diara S. Kazybayeva; Zhanar A. Iskakbayeva; Sarkyt E. Kudaibergenov; Vitaliy V. Khutoryanskiy
Opublikowane w: Materials, 2020, ISSN 1996-1944
Wydawca: MDPI Open Access Publishing
DOI: 10.3390/ma13071709

Phase Separation of Aqueous Poly(diisopropylaminoethyl methacrylate) upon Heating.

Autorzy: Linda Salminen; Erno Karjalainen; Vladimir Aseyev; Heikki Tenhu
Opublikowane w: Langmuir, Numer 5, 2022, ISSN 0743-7463
Wydawca: American Chemical Society
DOI: 10.1021/acs.langmuir.1c02224

Mucoadhesive Properties of Gellan and Its Modified Derivatives

Autorzy: Gul’nur Tatykhanova, Vladimir Aseyev, Sarkyt E. Kudaibergenov,
Opublikowane w: Reviews and Advances in Chemistry, Numer 10, 2020, Strona(/y) 140-157, ISSN 2634-8276
Wydawca: Springer
DOI: 10.1134/s207997802003005x

Temperature and Salt Responsive Amphoteric Nanogels Based on N-Isopropylacrylamide, 2-Acrylamido-2-methyl-1-propanesulfonic Acid Sodium Salt and (3-Acrylamidopropyl) Trimethylammonium Chloride

Autorzy: Aigerim Ye. Ayazbayeva, Alexey Shakhvorostov, Iskander Sh. Gussenov, Tulegen M. Seilkhanov, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Opublikowane w: Nanomaterials, Numer 12 (14), 2022, Strona(/y) 2343, ISSN 2079-4991
Wydawca: MDPI
DOI: 10.3390/nano12142343

Self-Organization in Dilute Aqueous Solutions of Thermoresponsive Star-Shaped Six-Arm Poly-2-Alkyl-2-Oxazines and Poly-2-Alkyl-2-Oxazolines

Autorzy: Tatyana Kirila, Anna Smirnova, Vladimir Aseyev, Andrey Tenkovtsev, Heikki Tenhu, Alexander Filippov
Opublikowane w: Polymers, Numer 13 (9), 2021, Strona(/y) 1429, ISSN 2073-4360
Wydawca: MDPI
DOI: 10.3390/polym13091429

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Autorzy: Onugwu, A. L., Nwagwu, C. S., Onugwu, O. S., Echezona, A. C., Agbo, C. P., Ihim, S. A., Emeh, P., Nnamani, P. O., Attama, A. A. and Khutoryanskiy, V. V.,
Opublikowane w: Journal of Controlled Release, 2023, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2023.01.018

Tuning the morphology of block copolymer-based pH-triggerednanoplatforms as driven by changes in molecular weight and protocol ofmanufacturing

Autorzy: Fernando A. de Oliveira, Carin C. S. Batista, Lindomar J. C. Albuquerque, Peter Cernoch, Miloš Steinhart, Vladimir Sincari, Alessandro Jager, Eliezer Jager, Fernando C. Giacomelli
Opublikowane w: Journal of Colloid and Interface Science, 2023, ISSN 0021-9797
Wydawca: Academic Press
DOI: 10.1016/j.jcis.2022.12.129

Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery

Autorzy: Roman V. Moiseev; Daulet B. Kaldybekov; Sergey K. Filippov; Aurel Radulescu; Vitaliy V. Khutoryanskiy
Opublikowane w: Langmuir, 2022, ISSN 0743-7463
Wydawca: American Chemical Society
DOI: 10.1021/acs.langmuir.2c02086

Protein coronas coating polymer-stabilized silver nanocolloids attenuate cytotoxicity with minor effects on antimicrobial performance

Autorzy: Carin C. S. Batista, Jiří Trousil, Olga Janoušková, Carlos Eduardo de Castro, Petr Štěpánek Fernando C. Giacomelli
Opublikowane w: Colloids and Surfaces B: Biointerfaces, 2022, ISSN 0927-7765
Wydawca: Elsevier BV
DOI: 10.1016/j.colsurfb.2022.112778

Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: In vitro and in vivo studies.

Autorzy: Laura E. Agibayeva; Daulet B. Kaldybekov; Natalia N. Porfiryeva; V. R. Garipova; R.A. Mangazbayeva; Rouslan I. Moustafine; I. I. Semina; Grigoriy A. Mun; Sarkyt E. Kudaibergenov; Vitaliy V. Khutoryanskiy; Vitaliy V. Khutoryanskiy
Opublikowane w: International Journal of Pharmaceutics, Numer 1, 2020, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2020.119093

Preparation and Characterization of Amphoteric Polysaccharides Derived From Chitosan and Gellan Gum

Autorzy: Rysgul N. Tuleyeva, Gulnur S. Tatykhanova, Nargiz N. Gizatullina, Daulet B. Kaldybekov, Yuliia V. Bardadym, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Opublikowane w: Polymers for Advanced Technologies, Numer 35, 2024, Strona(/y) e70033, ISSN 1042-7147
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/pat.70033

Comparative Study of Gellan Gum Derived from Domestic Raw Materials of Kazakhstan and Commercial Gellan

Autorzy: Gulnur S. Tatykhanova, Nargiz N. Gizatullina, Gulnar M. Kudaibergenova, Ramza Zh. Berzhanova, Togzhan D. Mukasheva, Sarkyt E. Kudaibergenov
Opublikowane w: Macromolecular Symposia, Numer 413, 2024, Strona(/y) 2400004, ISSN 1022-1360
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/masy.202400004

Characterization of Biocompatible Gellan Gum Fractions for Prolonged Retention in Ocular Drug Delivery Systems

Autorzy: Gulnur S. Tatykhanova, Rysgul N. Tuleyeva, Nargiz N. Gizatullina, Daulet B. Kaldybekov, Yuliia V. Bardadym, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Opublikowane w: Polymers for Advanced Technologies, Numer 35, 2024, Strona(/y) e6635, ISSN 1042-7147
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/pat.6635

Electroresponsive polyelectrolyte brushes studied by self-consistent field theory

Autorzy: Okrugin B.M.; Richter R.P.; Leermakers F.A.M.; Neelov I.M.; Zhulina E.B.; Borisov O.V.
Opublikowane w: Polymers, 2020, Strona(/y) 898, ISSN 2073-4360
Wydawca: MDPI AG
DOI: 10.3390/polym12040898

Polymer‐Protected Gold Nanoparticles for Photothermal Treatment of Ehrlich Adenocarcinoma: In Vitro and In Vivo Studies

Autorzy: Gulnur S. Tatykhanova, Rysgul N. Tuleyeva, Zhanara A. Nurakhmetova, Nargiz N. Gizatullina, Vladimir K. Krasnoshtanov, Daulet B. Kaldybekov, Vladimir O. Aseyev, Vitaliy V. Khutoryanskiy, Sarkyt E. Kudaibergenov
Opublikowane w: Macromolecular Chemistry and Physics, Numer 14 May 2024, 2024, Strona(/y) 2400128, ISSN 1022-1352
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/macp.202400128

Proteins and Polyampholytes Interacting with Polyelectrolyte Brushes and Microgels: the Charge Reversal Concept Revised

Autorzy: Laktionov M.Y. Zhulina E.B.; Borisov O.V.
Opublikowane w: Langmuir, 2021, Strona(/y) 2865–2873, ISSN 0743-7463
Wydawca: American Chemical Society
DOI: 10.1021/acs.langmuir.0c02837

Theory of polyelectrolyte dendrigrafts

Autorzy: Borisov, O.V ; Shavykin O.V. ; Zhulina E.B.
Opublikowane w: Colloid and Polymer Science, 2020, Strona(/y) 951-959, ISSN 0303-402X
Wydawca: Springer Verlag
DOI: 10.1007/s00396-019-04588-1

Synthesis of fluorescently-labelled poly(2-ethyl-2-oxazoline)-protected gold nanoparticles

Autorzy: Elmira Nurgaziyeva, Sarkyt Kudaibergenov, Grigoriy Mun, Vitaliy Khutoryanskiy
Opublikowane w: Chemical Bulletin of Kazakh National University, Numer 100 (1), Published 2021-03-19, 2021, Strona(/y) 12-20, ISSN 2312-7554
Wydawca: al-Farabi Kazakh National University
DOI: 10.15328/cb1185

Immobilization of Methyl Orange and Methylene Blue within the Matrix of Charge-Imbalanced Amphoteric Nanogels and Study of Dye Release Kinetics as a Function of Temperature and Ionic Strength

Autorzy: A.Ye. Ayazbayeva, S.Z. Nauryzova, V.O. Aseyev, A.V. Shakhvorostov
Opublikowane w: Bulletin of the University of Karaganda Chemistry, Numer 107 (3), 2022, Strona(/y) 127-140, ISSN 2518-718X
Wydawca: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2022ch3/3-22-4

Microfluidic-assisted synthesis of uniform polymer-stabilized silver colloids

Autorzy: Carin C.S. Batista, Alessandro Jager, Brunno L. Albuquerque, Ewa Pavlova, Petr Stepanek, Fernando C. Giacomelli
Opublikowane w: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, ISSN 0927-7757
Wydawca: Elsevier BV
DOI: 10.1016/j.colsurfa.2021.126438

Probing protein adsorption onto polymer-stabilized silver nanocolloids towards a better understanding on the evolution and consequences of biomolecular coronas

Autorzy: Carin C.S. Batista, Lindomar J.C. Albuquerque, Alessandro Jäger, Petr Stepánek, Fernando C. Giacomelli
Opublikowane w: Materials Science & Engineering C, 2020, ISSN 0928-4931
Wydawca: Elsevier BV
DOI: 10.1016/j.msec.2020.110850

Ophthalmic drug delivery system based on the complex of gellan and ofloxacin

Autorzy: Gulnur S. Tatykhanova, Vladimir O. Aseyev, Maria Vamvakaki, Vitaliy V. Khutoryanskiy, Sarkyt E. Kudaibergenov,
Opublikowane w: Chemical Bulletin of Kazakh National University, Numer 105 (2), 2022, Strona(/y) 4-12, ISSN 1563-0331
Wydawca: Al-Farabi Kazakh National University
DOI: 10.15328/cb1239

Investigation of the Thermogelation of a Promising Biocompatible ABC Triblock Terpolymer and Its Comparison with Pluronic F127

Autorzy: Anna P. Constantinou; Valeria Nele; James J. Doutch; Joana S. Correia; Roman V. Moiseev; Martina Cihova; David C. A. Gaboriau; Jonathan Krell; Vitaliy V. Khutoryanskiy; Molly M. Stevens; Theoni K. Georgiou
Opublikowane w: Macromolecules, 2022, ISSN 0024-9297
Wydawca: American Chemical Society
DOI: 10.1021/acs.macromol.1c02123

Soft Biocompatible Polymeric Nanostructures: A toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

Autorzy: Vladimir Aseyev
Opublikowane w: Kemiauutiset KemiNyheter ChemistryNews 2020, Numer annual, 2020, Strona(/y) 48, ISSN 2323-7775
Wydawca: Helsingin yliopiston kemian laitos

Guest from Kazakhstan: Challenges and Impressions

Autorzy: Moldir Dauletbekova
Opublikowane w: Kemiauutiset KemiNyheter ChemistryNews 2020, Numer annual, 2020, Strona(/y) 49, ISSN 2323-7767
Wydawca: Helsingin yliopiston kemian laitos

Biomolecular Coronas Coating Silver Nanoparticles: Structural Analysis and Biological Consequences

Autorzy: Carin Cristina da Silva Batista
Opublikowane w: PhD Thesis, 2022
Wydawca: Federal University of ABC

Poly(2-ethyl-2-oxazoline) modified gellan gum

Autorzy: Janni Lavikainen
Opublikowane w: Master thesis, 2020
Wydawca: University of Helsinki

Rezultaty

Publikacje

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