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Soft Biocompatible Polymeric Nanostructures: A Toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Theoretical prediction of the relationships between topology and composition of multi-responsive nanogels and character of stimuli-induced volume transitions

A report describing the theoretical prediction of the relationships between polymer topology and composition of the multiresponsive nanogels and their stimuliinduced volume transitions will be prepared and submitted

Rheological properties of the self-assembled polymers as a function of the external stimuli

A report will be written by UREAD and other contributing partners on the rheological properties of the self-assembled polymers as a function of the external stimuli. This data will facilitate the in vitro and in vivo use of these systems.

Theoretical model predicting stimuli-induced drug uptake-release for nano/microgels and nanoparticles

A report will be prepared to describe the theoretical models used to study stimuli responsive nanoparticles and the drug uptake-release profiles of the nano/microgels and micellar carriers.

Intraocular nanoparticle diffusion in vitro

A report to describe the intraocular polymer nanoparticle diffusion, determined by the in vitro studies, will be prepared

In vitro toxicity/biocompatibility of the polymeric materials and their retention on ocular tissues in vitro

A report on the in vitro toxicity/biocompatibility results for the polymeric materials and their retention on ocular tissues as determined by the in vitro studies in the project will be prepared and submitted.

Project Website

The deliverable is related to the setup and update of the project website for the whole duration of the project.

Publicaciones

Soft micron-sized polypeptide microgels: preparation, crosslink density, topography and nanomechanics in swollen state

Autores: Oleksii Kotko, Petr Šálek, Jana Dvořáková, Miroslava Dušková Smrčková, Ján Šomvársky, Jean Jacques Bonvent, Sérgio Brochsztain, Miroslav Šlouf, Vladimír Proks
Publicado en: Materials Advances, Edición 5, 2024, Página(s) 5984-5997, ISSN 2633-5409
Editor: ROYAL SOC CHEMISTRY
DOI: 10.1039/d4ma00356j

Non-linear elasticity effects and stratification in brushes of branched polyelectrolytes

Autores: Lebedeva I.O.; Shavykin O.V.; Neelov I.M.; Zhulina E.B.; Leermakers F.A.M.; Borisov, O.V
Publicado en: Journal of Chemical Physics, 2019, Página(s) 2014902, ISSN 0021-9606
Editor: American Institute of Physics
DOI: 10.1063/1.5130580

Amphoteric nano‐ and microgels with acrylamide backbone for potential application in oil recovery

Autores: Aigerim Ayazbayeva, Vikram Baddam, Alexey Shakhvorostov, Iskander Gussenov, Vladimir Aseyev, Mubarak Yermaganbetov, Sarkyt Kudaibergenov
Publicado en: Polymers for Advanced Technologies, Edición 34, 2023, Página(s) 3826-3837, ISSN 1042-7147
Editor: John Wiley & Sons Inc.
DOI: 10.1002/pat.6182

Temperature and Salt Responsivity of Anionic, Cationic and Amphoteric Nanogels Based on N-Isopropylacrylamide, 2-Acrylamido-2-Methyl-1-Propanesulfonic Acid Sodium Salt and (3-Acrylamidopropyl) Trimethylammonium Chloride

Autores: Aigerim Ye. Ayazbayeva, Alexey V. Shakhvorostov1, Sarkyt E. Kudaibergenov
Publicado en: Bulletin of the University of Karaganda Chemistry, Edición 108 (4), 2022, Página(s) 14-24, ISSN 2518-718X
Editor: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2022ch4/4-22-15

Role of Membrane Features on the Permeability Behavior of Polymersomes and the Potential Impacts on Drug Encapsulation and Release

Autores: Fernando A. de Oliveira, Carin Cristina da Silva Batista, Peter Černoch, Vladimir Sincari, Alessandro Jäger, Eliézer Jäger, Fernando C. Giacomelli
Publicado en: Biomacromolecules, Edición 24, 2023, Página(s) 2291-2300, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.3c00162

Fractionation and Characterization of Commercial Low Acyl Gellan Gum

Autores: Gulnur S. Tatykhanova, Sami‐Pekka Hirvonen, Yuliia V. Bardadym, Nargiz N. Gizatullina, Moldir A. Saulimbay
Publicado en: Macromolecular Symposia, Edición 413, 2024, Página(s) 2400001, ISSN 1022-1360
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/masy.202400001

Anionic Polysaccharide – Gellan As Perspective Polymer for Potential Application in Medicine and Oil Recovery: A Mini-Review

Autores: S.E. Kudaibergenov, Gulnur Tatykhanova, N.N. Gizatullina, R.N. Tuleyeva, D.B. Kaldybekov, I.Sh. Gussenov, R.Zh. Berzhanova, T.D. Mukasheva, Maria Vamvakaki, Vladimir Aseyev, Vitaliy V. Khutoryanskiy
Publicado en: Uzbekistan Journal of Polymers, Edición 2 (2), 2023, Página(s) 39-56, ISSN 2181-3256
Editor: Institute of Chemistry and Physics of Polymers of the Academy of Sciences of the Republic of Uzbekistan

Tough Materials Through Ionic Interactions

Autores: Linda Salminen, Erno Karjalainen, Vladimir Aseyev, Heikki Tenhu
Publicado en: Frontiers in Chemistry, Edición 9, 2021, Página(s) 721656, ISSN 2296-2646
Editor: Frontiers
DOI: 10.3389/fchem.2021.721656

Poly(2-ethyl-2-oxazoline) grafted gellan gum for potential application in transmucosal drug delivery

Autores: Janni Lavikainen, Moldir Dauletbekova, Gaukhar Toleutay, Maria Kaliva, Maria Chatzinikolaidou, Sarkyt E. Kudaibergenov, Andrey Tenkovtsev, Vitaliy V. Khutoryanskiy, Maria Vamvakaki, Vladimir Aseyev
Publicado en: Polymers for Advanced Technologies, Edición 32 (7), 2021, Página(s) 2770-2780, ISSN 1042-7147
Editor: John Wiley & Sons Inc.
DOI: 10.1002/pat.5298

Synthesis and characterization of novel thermo- and salt-sensitive amphoteric terpolymers based on acrylamide derivatives

Autores: A.Ye. Ayazbayeva, A.V. Shakhvorostov, T.M. Seilkhanov, V.O. Aseyev, S.E. Kudaibergenov
Publicado en: Bulletin of the University of Karaganda Chemistry, Edición 104 (4), 2021, Página(s) 9-20, ISSN 2518-718X
Editor: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2021ch4/9-20

Chitosan/Poly(2-ethyl-2-oxazoline) Films with Ciprofloxacin for Application in Vaginal Drug Delivery

Autores: Guzel K. Abilova; Daulet B. Kaldybekov; G.S. Irmukhametova; Diara S. Kazybayeva; Zhanar A. Iskakbayeva; Sarkyt E. Kudaibergenov; Vitaliy V. Khutoryanskiy
Publicado en: Materials, 2020, ISSN 1996-1944
Editor: MDPI Open Access Publishing
DOI: 10.3390/ma13071709

Phase Separation of Aqueous Poly(diisopropylaminoethyl methacrylate) upon Heating.

Autores: Linda Salminen; Erno Karjalainen; Vladimir Aseyev; Heikki Tenhu
Publicado en: Langmuir, Edición 5, 2022, ISSN 0743-7463
Editor: American Chemical Society
DOI: 10.1021/acs.langmuir.1c02224

Mucoadhesive Properties of Gellan and Its Modified Derivatives

Autores: Gul’nur Tatykhanova, Vladimir Aseyev, Sarkyt E. Kudaibergenov,
Publicado en: Reviews and Advances in Chemistry, Edición 10, 2020, Página(s) 140-157, ISSN 2634-8276
Editor: Springer
DOI: 10.1134/s207997802003005x

Temperature and Salt Responsive Amphoteric Nanogels Based on N-Isopropylacrylamide, 2-Acrylamido-2-methyl-1-propanesulfonic Acid Sodium Salt and (3-Acrylamidopropyl) Trimethylammonium Chloride

Autores: Aigerim Ye. Ayazbayeva, Alexey Shakhvorostov, Iskander Sh. Gussenov, Tulegen M. Seilkhanov, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Publicado en: Nanomaterials, Edición 12 (14), 2022, Página(s) 2343, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano12142343

Self-Organization in Dilute Aqueous Solutions of Thermoresponsive Star-Shaped Six-Arm Poly-2-Alkyl-2-Oxazines and Poly-2-Alkyl-2-Oxazolines

Autores: Tatyana Kirila, Anna Smirnova, Vladimir Aseyev, Andrey Tenkovtsev, Heikki Tenhu, Alexander Filippov
Publicado en: Polymers, Edición 13 (9), 2021, Página(s) 1429, ISSN 2073-4360
Editor: MDPI
DOI: 10.3390/polym13091429

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Autores: Onugwu, A. L., Nwagwu, C. S., Onugwu, O. S., Echezona, A. C., Agbo, C. P., Ihim, S. A., Emeh, P., Nnamani, P. O., Attama, A. A. and Khutoryanskiy, V. V.,
Publicado en: Journal of Controlled Release, 2023, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2023.01.018

Tuning the morphology of block copolymer-based pH-triggerednanoplatforms as driven by changes in molecular weight and protocol ofmanufacturing

Autores: Fernando A. de Oliveira, Carin C. S. Batista, Lindomar J. C. Albuquerque, Peter Cernoch, Miloš Steinhart, Vladimir Sincari, Alessandro Jager, Eliezer Jager, Fernando C. Giacomelli
Publicado en: Journal of Colloid and Interface Science, 2023, ISSN 0021-9797
Editor: Academic Press
DOI: 10.1016/j.jcis.2022.12.129

Maleimide-Decorated PEGylated Mucoadhesive Liposomes for Ocular Drug Delivery

Autores: Roman V. Moiseev; Daulet B. Kaldybekov; Sergey K. Filippov; Aurel Radulescu; Vitaliy V. Khutoryanskiy
Publicado en: Langmuir, 2022, ISSN 0743-7463
Editor: American Chemical Society
DOI: 10.1021/acs.langmuir.2c02086

Protein coronas coating polymer-stabilized silver nanocolloids attenuate cytotoxicity with minor effects on antimicrobial performance

Autores: Carin C. S. Batista, Jiří Trousil, Olga Janoušková, Carlos Eduardo de Castro, Petr Štěpánek Fernando C. Giacomelli
Publicado en: Colloids and Surfaces B: Biointerfaces, 2022, ISSN 0927-7765
Editor: Elsevier BV
DOI: 10.1016/j.colsurfb.2022.112778

Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: In vitro and in vivo studies.

Autores: Laura E. Agibayeva; Daulet B. Kaldybekov; Natalia N. Porfiryeva; V. R. Garipova; R.A. Mangazbayeva; Rouslan I. Moustafine; I. I. Semina; Grigoriy A. Mun; Sarkyt E. Kudaibergenov; Vitaliy V. Khutoryanskiy; Vitaliy V. Khutoryanskiy
Publicado en: International Journal of Pharmaceutics, Edición 1, 2020, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2020.119093

Preparation and Characterization of Amphoteric Polysaccharides Derived From Chitosan and Gellan Gum

Autores: Rysgul N. Tuleyeva, Gulnur S. Tatykhanova, Nargiz N. Gizatullina, Daulet B. Kaldybekov, Yuliia V. Bardadym, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Publicado en: Polymers for Advanced Technologies, Edición 35, 2024, Página(s) e70033, ISSN 1042-7147
Editor: John Wiley & Sons Inc.
DOI: 10.1002/pat.70033

Comparative Study of Gellan Gum Derived from Domestic Raw Materials of Kazakhstan and Commercial Gellan

Autores: Gulnur S. Tatykhanova, Nargiz N. Gizatullina, Gulnar M. Kudaibergenova, Ramza Zh. Berzhanova, Togzhan D. Mukasheva, Sarkyt E. Kudaibergenov
Publicado en: Macromolecular Symposia, Edición 413, 2024, Página(s) 2400004, ISSN 1022-1360
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/masy.202400004

Characterization of Biocompatible Gellan Gum Fractions for Prolonged Retention in Ocular Drug Delivery Systems

Autores: Gulnur S. Tatykhanova, Rysgul N. Tuleyeva, Nargiz N. Gizatullina, Daulet B. Kaldybekov, Yuliia V. Bardadym, Vladimir O. Aseyev, Sarkyt E. Kudaibergenov
Publicado en: Polymers for Advanced Technologies, Edición 35, 2024, Página(s) e6635, ISSN 1042-7147
Editor: John Wiley & Sons Inc.
DOI: 10.1002/pat.6635

Electroresponsive polyelectrolyte brushes studied by self-consistent field theory

Autores: Okrugin B.M.; Richter R.P.; Leermakers F.A.M.; Neelov I.M.; Zhulina E.B.; Borisov O.V.
Publicado en: Polymers, 2020, Página(s) 898, ISSN 2073-4360
Editor: MDPI AG
DOI: 10.3390/polym12040898

Polymer‐Protected Gold Nanoparticles for Photothermal Treatment of Ehrlich Adenocarcinoma: In Vitro and In Vivo Studies

Autores: Gulnur S. Tatykhanova, Rysgul N. Tuleyeva, Zhanara A. Nurakhmetova, Nargiz N. Gizatullina, Vladimir K. Krasnoshtanov, Daulet B. Kaldybekov, Vladimir O. Aseyev, Vitaliy V. Khutoryanskiy, Sarkyt E. Kudaibergenov
Publicado en: Macromolecular Chemistry and Physics, Edición 14 May 2024, 2024, Página(s) 2400128, ISSN 1022-1352
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/macp.202400128

Proteins and Polyampholytes Interacting with Polyelectrolyte Brushes and Microgels: the Charge Reversal Concept Revised

Autores: Laktionov M.Y. Zhulina E.B.; Borisov O.V.
Publicado en: Langmuir, 2021, Página(s) 2865–2873, ISSN 0743-7463
Editor: American Chemical Society
DOI: 10.1021/acs.langmuir.0c02837

Theory of polyelectrolyte dendrigrafts

Autores: Borisov, O.V ; Shavykin O.V. ; Zhulina E.B.
Publicado en: Colloid and Polymer Science, 2020, Página(s) 951-959, ISSN 0303-402X
Editor: Springer Verlag
DOI: 10.1007/s00396-019-04588-1

Synthesis of fluorescently-labelled poly(2-ethyl-2-oxazoline)-protected gold nanoparticles

Autores: Elmira Nurgaziyeva, Sarkyt Kudaibergenov, Grigoriy Mun, Vitaliy Khutoryanskiy
Publicado en: Chemical Bulletin of Kazakh National University, Edición 100 (1), Published 2021-03-19, 2021, Página(s) 12-20, ISSN 2312-7554
Editor: al-Farabi Kazakh National University
DOI: 10.15328/cb1185

Immobilization of Methyl Orange and Methylene Blue within the Matrix of Charge-Imbalanced Amphoteric Nanogels and Study of Dye Release Kinetics as a Function of Temperature and Ionic Strength

Autores: A.Ye. Ayazbayeva, S.Z. Nauryzova, V.O. Aseyev, A.V. Shakhvorostov
Publicado en: Bulletin of the University of Karaganda Chemistry, Edición 107 (3), 2022, Página(s) 127-140, ISSN 2518-718X
Editor: Academician Ye.A. Buketov Karaganda University
DOI: 10.31489/2022ch3/3-22-4

Microfluidic-assisted synthesis of uniform polymer-stabilized silver colloids

Autores: Carin C.S. Batista, Alessandro Jager, Brunno L. Albuquerque, Ewa Pavlova, Petr Stepanek, Fernando C. Giacomelli
Publicado en: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, ISSN 0927-7757
Editor: Elsevier BV
DOI: 10.1016/j.colsurfa.2021.126438

Probing protein adsorption onto polymer-stabilized silver nanocolloids towards a better understanding on the evolution and consequences of biomolecular coronas

Autores: Carin C.S. Batista, Lindomar J.C. Albuquerque, Alessandro Jäger, Petr Stepánek, Fernando C. Giacomelli
Publicado en: Materials Science & Engineering C, 2020, ISSN 0928-4931
Editor: Elsevier BV
DOI: 10.1016/j.msec.2020.110850

Ophthalmic drug delivery system based on the complex of gellan and ofloxacin

Autores: Gulnur S. Tatykhanova, Vladimir O. Aseyev, Maria Vamvakaki, Vitaliy V. Khutoryanskiy, Sarkyt E. Kudaibergenov,
Publicado en: Chemical Bulletin of Kazakh National University, Edición 105 (2), 2022, Página(s) 4-12, ISSN 1563-0331
Editor: Al-Farabi Kazakh National University
DOI: 10.15328/cb1239

Investigation of the Thermogelation of a Promising Biocompatible ABC Triblock Terpolymer and Its Comparison with Pluronic F127

Autores: Anna P. Constantinou; Valeria Nele; James J. Doutch; Joana S. Correia; Roman V. Moiseev; Martina Cihova; David C. A. Gaboriau; Jonathan Krell; Vitaliy V. Khutoryanskiy; Molly M. Stevens; Theoni K. Georgiou
Publicado en: Macromolecules, 2022, ISSN 0024-9297
Editor: American Chemical Society
DOI: 10.1021/acs.macromol.1c02123

Soft Biocompatible Polymeric Nanostructures: A toolbox for Novel Generation of Nano Pharmaceuticals in Ophthalmology

Autores: Vladimir Aseyev
Publicado en: Kemiauutiset KemiNyheter ChemistryNews 2020, Edición annual, 2020, Página(s) 48, ISSN 2323-7775
Editor: Helsingin yliopiston kemian laitos

Guest from Kazakhstan: Challenges and Impressions

Autores: Moldir Dauletbekova
Publicado en: Kemiauutiset KemiNyheter ChemistryNews 2020, Edición annual, 2020, Página(s) 49, ISSN 2323-7767
Editor: Helsingin yliopiston kemian laitos

Biomolecular Coronas Coating Silver Nanoparticles: Structural Analysis and Biological Consequences

Autores: Carin Cristina da Silva Batista
Publicado en: PhD Thesis, 2022
Editor: Federal University of ABC

Poly(2-ethyl-2-oxazoline) modified gellan gum

Autores: Janni Lavikainen
Publicado en: Master thesis, 2020
Editor: University of Helsinki

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