Repeat protein Function Refinement, Annotation and Classification of Topologies

Risultati finali

Collection of TRP datasets

Report on the state-of-the-art of TRP-related HMMs and TRP covariance analysis.
Report on the function of new TRP families.

Report on the function of new TRP families

Report on examples of TRP evolution through internal duplication of coding sequence and repeat units recycled by evolution in globular structures.

Report on examples of TRP evolution through internal duplication of coding sequence and repeat units recycled by evolution in globular structures

Report on mapping and analysis of exon boundaries on TRPs, comparison with their modularity, and TRP amino acid vs DNA sequence variability.

Report on mapping and analysis of exon boundaries on TRPs comparison with their modularity and TRP amino acid vs DNA sequence variability

Symposia/Remote Symposia Period 2

Symposia Period 2. Europe: 2 x All-Hands Meeting, 1 x Dissemination Training School, 1 x Final Dissemination meeting. Latin America: 2 x Annual Latin America Visit.

TRP function, localization and organism distribution enrichment analysis.

TRP function localization and organism distribution enrichment analysis

Symposia/Remote Symposia Period 1

Symposia Period 1 Europe 2 x AllHands Meeting 1 x Dissemination Training School Latin America 2 x Annual Latin America Visit

Report about TRP roles in PPI networks and interaction with RNA/DNA molecules and role of TRPs in host interactions with viruses and pathogens.

Report about TRP roles in PPI networks and interaction with RNADNA molecules and role of TRPs in host interactions with viruses and pathogens

Report on TRP disorder, low-complexity, transmembrane domain overlap and examples of cooperative TRP folding.

Report on TRP disorder lowcomplexity transmembrane domain overlap and examples of cooperative TRP folding

Report on TRP sequence and structural classification as well as sequence and structural clustering of the TRP universe.
Cookbook for TRP annotation best-practices. Report about data format gold-standard, technical and implementation best-practices for TRP web resources.

Cookbook for TRP annotation bestpractices Report about data format goldstandard technical and implementation bestpractices for TRP web resources

Report on SLIMs in TRPs.

Report on SLIMs in TRPs

Software for sequence- and structure-based pairwise TRP alignment

Software for sequence- and structure-based pairwise TRP alignment.

Cross-link of generated TRP data into core data resources (e.g. InterPro) and related resources.
Platform and metrics for TRP tools benchmarking, including consensus detection of sequence- and structure-based methods

Platform and metrics for TRP tools benchmarking, including consensus detection of sequence- and structure-based methods.

Deployment of TRP database APIs.
Software for automatic TRP region and unit annotation
Software for the identification of homologous TRPs from sequence databases.
Integration of novel classification in TRP databases.
Curation of Pfam TRP-related HMMs.
Software for modeling TRP regions by homology

Online presence (website and social media)

Pubblicazioni

The Feature-Viewer: a visualization tool for positional annotations on a sequence

Autori: Lisanna Paladin; Mathieu Schaeffer; Pascale Gaudet; Monique Zahn-Zabal; Pierre-André Michel; Damiano Piovesan; Silvio C. E. Tosatto; Amos Marc Bairoch
Pubblicato in: Bioinformatics, Numero 8, 2020, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btaa055

RING-PyMOL: residue interaction networks of structural ensembles and molecular dynamics

Autori: Del Conte A.; Monzon A. M.; Clementel D.; Camagni G. F.; Minervini G.; Tosatto S. C. E.; Piovesan D.
Pubblicato in: Bioinformatics, Numero 16, 2023, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btad260

Prokaryotic membrane coat - like proteins: An update

Autori: M. Leticia Ferrelli; Matías L. Pidre; Ruben García-Domínguez; Lucas N. Alberca; DMaría del Saz-Navarro; Carlos Santana-Molina; Damien P. Devos
Pubblicato in: Journal of Structural Biology, Numero 8, 2023, ISSN 1047-8477
Editore: Academic Press
DOI: 10.1016/j.jsb.2023.107987

ProSeqViewer: an interactive, responsive and efficient TypeScript library for visualization of sequences and alignments in web applications

Autori: Martina Bevilacqua, Lisanna Paladin, Silvio C E Tosatto, Damiano Piovesan
Pubblicato in: Bioinformatics, 2021, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btab764

A New Census of Protein Tandem Repeats and Their Relationship with Intrinsic Disorder

Autori: Matteo Delucchi, Elke Schaper, Oxana Sachenkova, Arne Elofsson and Maria Anisimova
Pubblicato in: Genes, 2020, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11040407

"""Protein"" no longer means what it used to."

Autori: Gustavo Parisi; Nicolas Palopoli; Silvio C. E. Tosatto; María Silvina Fornasari; Peter Tompa
Pubblicato in: Current Research in Structural Biology, Numero 8, 2021, ISSN 2665-928X
Editore: Elsevier
DOI: 10.1016/j.crstbi.2021.06.002

DOME: recommendations for supervised machine learning validation in biology

Autori: Ian Walsh, Dmytro Fishman, Dario Garcia-Gasulla, Tiina Titma, Gianluca Pollastri, ELIXIR Machine Learning Focus Group, Jennifer Harrow, Fotis E. Psomopoulos & Silvio C. E. Tosatto
Pubblicato in: Nature Methods, 2021, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-021-01205-4

Experimentally determined long intrinsically disordered protein regions are now abundant in the Protein Data Bank

Autori: Alexander Miguel Monzon; Marco Necci; Federica Quaglia; Ian Walsh; Giuseppe Zanotti; Damiano Piovesan; Silvio C. E. Tosatto
Pubblicato in: International Journal of Molecular Sciences, Numero 8, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1101/2020.02.17.952028

RING 3.0: fast generation of probabilistic residue interaction networks from structural ensembles

Autori: Damiano Clementel, Alessio Del Conte, Alexander Miguel Monzon, Giorgia F Camagni, Giovanni Minervini, Damiano Piovesan, Silvio C E Tosatto
Pubblicato in: Nucleic Acids Research, 2022, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkac365

Daisy: An integrated repeat protein curation service

Autori: Manuel, Bezerra-Brandao; Ronaldo Romario, Tunque Cahui; Layla, Hirsh
Pubblicato in: Journal of Structural Biology, Numero 6, 2023, ISSN 1047-8477
Editore: Academic Press
DOI: 10.1016/j.jsb.2023.108033

CAFA-evaluator: A Python Tool for Benchmarking Ontological Classification Methods

Autori: Piovesan, Damiano; Zago, Davide; Joshi, Parnal; Kaluza, M. Clara De Paolis; Monzon, Alexander Miguel; Reade, Walter; Friedberg, Iddo; Radivojac, Predrag; Tosatto, Silvio C. E.
Pubblicato in: Bioinformatics Advances, Numero 16, 2024, ISSN 2635-0041
Editore: Oxford University Press
DOI: 10.1093/bioadv/vbae043

Protein repeats evolve and emerge in giant viruses

Autori: Erdozain Bagolin, Sofía Agostina; Barrionuevo, Emilia Mercedes; Ripoll, Lucas; Mier, Pablo; Andrade Navarro, Miguel A.
Pubblicato in: Journal of Structural Biology, Numero 11, 2023, ISSN 1047-8477
Editore: Academic Press
DOI: 10.1016/j.jsb.2023.107962

Tally-2.0: upgraded validator of tandem repeat detection in protein sequences.

Autori: Vladimir Perovic; Jeremy Y Leclercq; Neven Sumonja; Francois Richard; Francois Richard; Nevena Veljkovic; Andrey V. Kajava
Pubblicato in: Bioinformatics, Numero 8, 2020, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btaa121

RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures.

Autori: Lisanna Paladin; Martina Bevilacqua; Sara Errigo; Damiano Piovesan; Ivan Mičetić; Marco Necci; Alexander Miguel Monzon; María Laura Fabre; José Luis López; Juliet F. Nilsson; Javier Rios; Pablo Lorenzano Menna; Maia Diana Eliana Cabrera; Martin Gonzalez Buitron; Mariane Gonçalves Kulik; Sebastian Fernandez-Alberti; María Silvina Fornasari; Gustavo Parisi; Antonio Lagares; Layla Hirsh; Migue
Pubblicato in: Nucleic Acids Research, Numero 4, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa1097

Critical assessment of protein intrinsic disorder prediction (<scp>CAID</scp>) ‐ Results of round 2

Autori: Del Conte A.; Mehdiabadi M.; Bouhraoua A.; Monzon A. M.; Tosatto S. C. E.; Piovesan D.
Pubblicato in: Proteins: Structure, Function and Bioinformatics, Numero 15, 2023, ISSN 0887-3585
Editore: Wiley-Liss Inc
DOI: 10.1002/prot.26582

Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families

Autori: Claudio Bassot, Arne Elofsson
Pubblicato in: PLOS Computational Biology, 2021, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1371/journal.pcbi.1008798

Expanding the repertoire of human tandem repeat RNA-binding proteins

Autori: Agustín Ormazábal; Matías Sebastián Carletti; Tadeo Enrique Saldaño; Martín Gonzalez-Buitron; Julia Marchetti; Nicolas Palopoli; Alex Bateman
Pubblicato in: PLoS ONE, Numero 11, 2023, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0290890

A novel approach to investigate the evolution of structured tandem repeat protein families by exon duplication

Autori: Lisanna Paladin, Marco Necci, Damiano Piovesan, Pablo Mier, Miguel A.Andrade-Navarro, Silvio C.E.Tosatto
Pubblicato in: Journal of Structural Biology, 2022, ISSN 1047-8477
Editore: Academic Press
DOI: 10.1016/j.jsb.2020.107608

Short tandem repeat mutations regulate gene expression in colorectal cancer

Autori: Max A. Verbiest; Oxana Lundström; Feifei Xia; Michael Baudis; Tugce Bilgin Sonay; Maria Anisimova
Pubblicato in: Scientific Reports, Numero 18, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1101/2023.11.29.569189

Beyond Microsatellite Instability: Intrinsic Disorder as a Potential Link Between Protein Short Tandem Repeats and Cancer

Autori: Max A. Verbiest, Matteo Delucchi, Tugce Bilgin Sonay and Maria Anisimova
Pubblicato in: Frontiers in Bioinformatics, 2021, ISSN 2673-7647
Editore: Frontiers Media
DOI: 10.3389/fbinf.2021.685844

APICURON: a database to credit and acknowledge the work of biocurators

Autori: András Hatos, Federica Quaglia, Damiano Piovesan, Silvio C E Tosatto
Pubblicato in: Database, 2021, ISSN 1758-0463
Editore: Oxford University Press
DOI: 10.1093/database/baab019

The features of polyglutamine regions depend on their evolutionary stability

Autori: Pablo Mier, Miguel A. Andrade-Navarro
Pubblicato in: BMC Ecology and Evolution, 2020, ISSN 2730-7182
Editore: Springer Nature
DOI: 10.1186/s12862-020-01626-3

REP2: A Web Server to Detect Common Tandem Repeats in Protein Sequences

Autori: Mohamed Kamel, Kristina Kastano, Pablo Mier, Miguel A. Andrade
Pubblicato in: Journal of Molecular Biology, 2021, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2021.166895

PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins

Autori: Hamidreza Ghafouri; Tamas Lazar; Alessio Del Conte; Luiggi G Tenorio Ku; Maria C Aspromonte; Pau Bernadó; Belén Chaves-Arquero; Lucia Beatriz Chemes; Damiano Clementel; Tiago N Cordeiro; Carlos A Elena-Real; Michael Feig; Isabella C Felli; Carlo Ferrari; Julie D Forman-Kay; Tiago Gomes; Frank Gondelaud; Claudiu C Gradinaru; Tâp Ha-Duong; Teresa Head-Gordon; Pétur O Heidarsson; Giacomo Janson
Pubblicato in: Nucleic Acids Research, Numero 16, 2024, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkad947

TRAL 2.0 : tandem repeat detection with circular profile hidden Markov models and evolutionary aligner

Autori: Matteo Delucchi; Paulina Näf; Spencer Bliven; Maria Anisimova
Pubblicato in: Frontiers in Bioinformatics, Numero 5, 2021, ISSN 2673-7647
Editore: Frontiers Media
DOI: 10.21256/zhaw-22764

Pfam: The protein families database in 2021.

Autori: Jaina Mistry; Sara Chuguransky; Lowri Williams; Matloob Qureshi; Gustavo A. Salazar; Erik L. L. Sonnhammer; Silvio C. E. Tosatto; Lisanna Paladin; Shriya Raj; Lorna Richardson; Robert D. Finn; Alex Bateman
Pubblicato in: Nucleic Acids Research, Numero 5, 2020, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa913

A STRP-ed definition of Structured Tandem Repeats in Proteins

Autori: Monzon, Alexander Miguel; Arrías, Paula Nazarena; Elofsson, Arne; Mier, Pablo; Andrade-Navarro, Miguel A; Bevilacqua, Martina; Clementel, Damiano; Bateman, Alex; Hirsh, Layla; Fornasari, Maria Silvina; Parisi, Gustavo; Piovesan, Damiano; Kajava, Andrey V; Tosatto, Silvio C E
Pubblicato in: Journal of Structural Biology, Numero 5, 2023, ISSN 1047-8477
Editore: Academic Press
DOI: 10.1016/j.jsb.2023.108023

Conference report: Biocuration 2021 Virtual Conference

Autori: Federica Quaglia, Rama Balakrishnan, Susan M Bello, Nicole Vasilevsky
Pubblicato in: Database, 2022, ISSN 1758-0463
Editore: Oxford University Press
DOI: 10.1093/database/baac027

DisProt in 2024: improving function annotation of intrinsically disordered proteins

Autori: Maria Cristina Aspromonte; Maria Victoria Nugnes; Federica Quaglia; Adel Bouharoua; Vasileios Sagris; Vasilis J Promponas; Anastasia Chasapi; Erzsébet Fichó; Galo E Balatti; Gustavo Parisi; Martín González Buitrón; Gabor Erdos; Matyas Pajkos; Zsuzsanna Dosztányi; Laszlo Dobson; Alessio Del Conte; Damiano Clementel; Edoardo Salladini; Emanuela Leonardi; Fatemeh Kordevani; Hamidreza Ghafouri;
Pubblicato in: Nucleic Acids Research, Numero 18, 2024, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkad928

PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins.

Autori: Patryk Jarnot; Joanna Ziemska-Legiecka; László Dobson; Matthew Merski; Pablo Mier; Miguel A. Andrade-Navarro; John M. Hancock; Zsuzsanna Dosztányi; Lisanna Paladin; Marco Necci; Damiano Piovesan; Silvio C. E. Tosatto; Vasilis J. Promponas; Marcin Grynberg; Aleksandra Gruca
Pubblicato in: Nucleic Acids Research, Numero 7, 2020, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkaa339

Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species

Autori: Max Verbiest; Mikhail Maksimov; Ye Jin; Maria Anisimova; Melissa Gymrek; Tugce Bilgin Sonay
Pubblicato in: Journal of Evolutionary Biology, Numero 18, 2023, ISSN 1010-061X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jeb.14106

14th Annual Biocuration Conference (virtual) - Abstracts from the invited speakers talks and poster session presentations

Autori: Federica Quaglia
Pubblicato in: Abstract booklet of the 14th Annual Biocuration Conference (virtual), including invited speakers talks and poster session presentations, 2021
Editore: Zenodo
DOI: 10.5281/zenodo.5570276

CoDNaS-Q: a database of conformational diversity of the native state of proteins with quaternary structure

Autori: Nahuel Escobedo, Ronaldo Romario Tunque Cahui, Gastón Caruso, Emilio García Ríos, Layla Hirsh, Alexander Miguel Monzon, Gustavo Parisi, VNicolas Palopoli
Pubblicato in: bioRxiv, 2022, ISSN 2692-8205
Editore: bioRxiv
DOI: 10.1101/2022.02.15.480082

Risultati finali

Pubblicazioni

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