Repeat protein Function Refinement, Annotation and Classification of Topologies

Información del proyecto

REFRACT

Identificador del acuerdo de subvención: 823886

DOI

10.3030/823886

Proyecto cerrado

Fecha de la firma de la CE 26 Octubre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 2 392 000,00

Aportación de la UE

€ 2 226 400,00

Coordinado por

UNIVERSITA DEGLI STUDI DI PADOVA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (13)

Collection of TRP datasets.

Collection of TRP datasets

Report on the state-of-the-art of TRP-related HMMs and TRP covariance analysis.
Report on the function of new TRP families.

Report on the function of new TRP families

Report on examples of TRP evolution through internal duplication of coding sequence and repeat units recycled by evolution in globular structures.

Report on examples of TRP evolution through internal duplication of coding sequence and repeat units recycled by evolution in globular structures

Report on mapping and analysis of exon boundaries on TRPs, comparison with their modularity, and TRP amino acid vs DNA sequence variability.

Report on mapping and analysis of exon boundaries on TRPs comparison with their modularity and TRP amino acid vs DNA sequence variability

Symposia/Remote Symposia Period 2

Symposia Period 2. Europe: 2 x All-Hands Meeting, 1 x Dissemination Training School, 1 x Final Dissemination meeting. Latin America: 2 x Annual Latin America Visit.

TRP function, localization and organism distribution enrichment analysis.

TRP function localization and organism distribution enrichment analysis

Symposia/Remote Symposia Period 1

Symposia Period 1 Europe 2 x AllHands Meeting 1 x Dissemination Training School Latin America 2 x Annual Latin America Visit

Report about TRP roles in PPI networks and interaction with RNA/DNA molecules and role of TRPs in host interactions with viruses and pathogens.

Report about TRP roles in PPI networks and interaction with RNADNA molecules and role of TRPs in host interactions with viruses and pathogens

Report on TRP disorder, low-complexity, transmembrane domain overlap and examples of cooperative TRP folding.

Report on TRP disorder lowcomplexity transmembrane domain overlap and examples of cooperative TRP folding

Report on TRP sequence and structural classification as well as sequence and structural clustering of the TRP universe.
Cookbook for TRP annotation best-practices. Report about data format gold-standard, technical and implementation best-practices for TRP web resources.

Cookbook for TRP annotation bestpractices Report about data format goldstandard technical and implementation bestpractices for TRP web resources

Report on SLIMs in TRPs.

Report on SLIMs in TRPs

Demonstrators, pilots, prototypes (9)

Software for sequence- and structure-based pairwise TRP alignment

Software for sequence- and structure-based pairwise TRP alignment.

Cross-link of generated TRP data into core data resources (e.g. InterPro) and related resources.
Platform and metrics for TRP tools benchmarking, including consensus detection of sequence- and structure-based methods

Platform and metrics for TRP tools benchmarking, including consensus detection of sequence- and structure-based methods.

Deployment of TRP database APIs.
Software for automatic TRP region and unit annotation
Software for the identification of homologous TRPs from sequence databases.
Integration of novel classification in TRP databases.
Curation of Pfam TRP-related HMMs.
Software for modeling TRP regions by homology

Websites, patent fillings, videos etc. (1)

Online presence (website and social media)

Publicaciones

Peer reviewed articles (41)

The Feature-Viewer: a visualization tool for positional annotations on a sequence

Autores: Lisanna Paladin; Mathieu Schaeffer; Pascale Gaudet; Monique Zahn-Zabal; Pierre-André Michel; Damiano Piovesan; Silvio C. E. Tosatto; Amos Marc Bairoch
Publicado en: Bioinformatics, Edición 8, 2020, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btaa055

RING-PyMOL: residue interaction networks of structural ensembles and molecular dynamics

Autores: Del Conte A.; Monzon A. M.; Clementel D.; Camagni G. F.; Minervini G.; Tosatto S. C. E.; Piovesan D.
Publicado en: Bioinformatics, Edición 16, 2023, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btad260

Prokaryotic membrane coat - like proteins: An update

Autores: M. Leticia Ferrelli; Matías L. Pidre; Ruben García-Domínguez; Lucas N. Alberca; DMaría del Saz-Navarro; Carlos Santana-Molina; Damien P. Devos
Publicado en: Journal of Structural Biology, Edición 8, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.107987

ProSeqViewer: an interactive, responsive and efficient TypeScript library for visualization of sequences and alignments in web applications

Autores: Martina Bevilacqua, Lisanna Paladin, Silvio C E Tosatto, Damiano Piovesan
Publicado en: Bioinformatics, 2021, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btab764

A New Census of Protein Tandem Repeats and Their Relationship with Intrinsic Disorder

Autores: Matteo Delucchi, Elke Schaper, Oxana Sachenkova, Arne Elofsson and Maria Anisimova
Publicado en: Genes, 2020, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11040407

The sequence context in poly-alanine regions: structure, function and conservation

Autores: Pablo Mier, Carlos A Elena-Real, Juan Cortés, Pau Bernadó, Miguel A Andrade-Navarro
Publicado en: Bioinformatics, 2022, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btac610

The nucleotide landscape of polyXY regions

Autores: Pablo Mier, Miguel A. Andrade-Navarro
Publicado en: Computational and Structural Biotechnology Journal, Edición 21, 2024, Página(s) 5408-5412, ISSN 2001-0370
Editor: Elsevier
DOI: 10.1016/j.csbj.2023.10.054

"""Protein"" no longer means what it used to."

Autores: Gustavo Parisi; Nicolas Palopoli; Silvio C. E. Tosatto; María Silvina Fornasari; Peter Tompa
Publicado en: Current Research in Structural Biology, Edición 8, 2021, ISSN 2665-928X
Editor: Elsevier
DOI: 10.1016/j.crstbi.2021.06.002

WebSTR: A Population-wide Database of Short Tandem Repeat Variation in Humans

Autores: Lundström OS, Adriaan Verbiest M, Xia F, Jam HZ, Zlobec I, Anisimova M, Gymrek M
Publicado en: Journal of Molecular Biology, 2023, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2023.168260

DOME: recommendations for supervised machine learning validation in biology

Autores: Ian Walsh, Dmytro Fishman, Dario Garcia-Gasulla, Tiina Titma, Gianluca Pollastri, ELIXIR Machine Learning Focus Group, Jennifer Harrow, Fotis E. Psomopoulos & Silvio C. E. Tosatto
Publicado en: Nature Methods, 2021, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-021-01205-4

Experimentally determined long intrinsically disordered protein regions are now abundant in the Protein Data Bank

Autores: Alexander Miguel Monzon; Marco Necci; Federica Quaglia; Ian Walsh; Giuseppe Zanotti; Damiano Piovesan; Silvio C. E. Tosatto
Publicado en: International Journal of Molecular Sciences, Edición 8, 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.1101/2020.02.17.952028

Census of exposed aggregation-prone regions in proteomes

Autores: Théo Falgarone, Etienne Villain, Francois Richard, Zarifa Osmanli, Andrey V Kajava
Publicado en: Briefings in Bioinformatics, 2023, ISSN 1467-5463
Editor: Oxford University Press
DOI: 10.1093/bib/bbad183

The repetitive structure of DNA clamps: An overlooked protein tandem repeat

Autores: Arrías PN, Monzon AM, Clementel D, Mozaffari S, Piovesan D, Kajava AV, Tosatto SCE
Publicado en: Journal of Structural Biology, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.108001

RING 3.0: fast generation of probabilistic residue interaction networks from structural ensembles

Autores: Damiano Clementel, Alessio Del Conte, Alexander Miguel Monzon, Giorgia F Camagni, Giovanni Minervini, Damiano Piovesan, Silvio C E Tosatto
Publicado en: Nucleic Acids Research, 2022, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkac365

Daisy: An integrated repeat protein curation service

Autores: Manuel, Bezerra-Brandao; Ronaldo Romario, Tunque Cahui; Layla, Hirsh
Publicado en: Journal of Structural Biology, Edición 6, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.108033

Structured Tandem Repeats in Protein Interactions

Autores: Mac Donagh J, Marchesini A, Spiga A, Fallico MJ, Arrías PN, Monzon AM, Vagiona AC, Gonçalves-Kulik M, Mier P, Andrade-Navarro MA
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1661-6596
Editor: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/ijms25052994

CAFA-evaluator: A Python Tool for Benchmarking Ontological Classification Methods

Autores: Piovesan, Damiano; Zago, Davide; Joshi, Parnal; Kaluza, M. Clara De Paolis; Monzon, Alexander Miguel; Reade, Walter; Friedberg, Iddo; Radivojac, Predrag; Tosatto, Silvio C. E.
Publicado en: Bioinformatics Advances, Edición 16, 2024, ISSN 2635-0041
Editor: Oxford University Press
DOI: 10.1093/bioadv/vbae043

Structure-function relationships in protein homorepeats

Autores: Elena-Real CA, Mier P, Sibille N, Andrade-Navarro MA, Bernadó P.
Publicado en: Current Opinion in Structural Biology, 2023, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2023.102726

Protein repeats evolve and emerge in giant viruses

Autores: Erdozain Bagolin, Sofía Agostina; Barrionuevo, Emilia Mercedes; Ripoll, Lucas; Mier, Pablo; Andrade Navarro, Miguel A.
Publicado en: Journal of Structural Biology, Edición 11, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.107962

Tally-2.0: upgraded validator of tandem repeat detection in protein sequences.

Autores: Vladimir Perovic; Jeremy Y Leclercq; Neven Sumonja; Francois Richard; Francois Richard; Nevena Veljkovic; Andrey V. Kajava
Publicado en: Bioinformatics, Edición 8, 2020, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btaa121

Combining Protein Conformational Diversity and Phylogenetic Information Using CoDNaS and CoDNaS-Q

Autores: Escobedo N, Monzon AM, Fornasari MS, Palopoli N, Parisi G
Publicado en: Current Protocols, 2023, ISSN 2691-1299
Editor: John Wiley & Sons
DOI: 10.1002/cpz1.764

RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures.

Autores: Lisanna Paladin; Martina Bevilacqua; Sara Errigo; Damiano Piovesan; Ivan Mičetić; Marco Necci; Alexander Miguel Monzon; María Laura Fabre; José Luis López; Juliet F. Nilsson; Javier Rios; Pablo Lorenzano Menna; Maia Diana Eliana Cabrera; Martin Gonzalez Buitron; Mariane Gonçalves Kulik; Sebastian Fernandez-Alberti; María Silvina Fornasari; Gustavo Parisi; Antonio Lagares; Layla Hirsh; Migue
Publicado en: Nucleic Acids Research, Edición 4, 2021, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa1097

Why does the first protein repeat often become the only one?

Autores: Manasra S, Kajava AV
Publicado en: Journal of Structural Biology, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.108014

Critical assessment of protein intrinsic disorder prediction (<scp>CAID</scp>) ‐ Results of round 2

Autores: Del Conte A.; Mehdiabadi M.; Bouhraoua A.; Monzon A. M.; Tosatto S. C. E.; Piovesan D.
Publicado en: Proteins: Structure, Function and Bioinformatics, Edición 15, 2023, ISSN 0887-3585
Editor: Wiley-Liss Inc
DOI: 10.1002/prot.26582

Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families

Autores: Claudio Bassot, Arne Elofsson
Publicado en: PLOS Computational Biology, 2021, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1008798

Expanding the repertoire of human tandem repeat RNA-binding proteins

Autores: Agustín Ormazábal; Matías Sebastián Carletti; Tadeo Enrique Saldaño; Martín Gonzalez-Buitron; Julia Marchetti; Nicolas Palopoli; Alex Bateman
Publicado en: PLoS ONE, Edición 11, 2023, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0290890

A novel approach to investigate the evolution of structured tandem repeat protein families by exon duplication

Autores: Lisanna Paladin, Marco Necci, Damiano Piovesan, Pablo Mier, Miguel A.Andrade-Navarro, Silvio C.E.Tosatto
Publicado en: Journal of Structural Biology, 2022, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2020.107608

Short tandem repeat mutations regulate gene expression in colorectal cancer

Autores: Max A. Verbiest; Oxana Lundström; Feifei Xia; Michael Baudis; Tugce Bilgin Sonay; Maria Anisimova
Publicado en: Scientific Reports, Edición 18, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1101/2023.11.29.569189

Beyond Microsatellite Instability: Intrinsic Disorder as a Potential Link Between Protein Short Tandem Repeats and Cancer

Autores: Max A. Verbiest, Matteo Delucchi, Tugce Bilgin Sonay and Maria Anisimova
Publicado en: Frontiers in Bioinformatics, 2021, ISSN 2673-7647
Editor: Frontiers Media
DOI: 10.3389/fbinf.2021.685844

APICURON: a database to credit and acknowledge the work of biocurators

Autores: András Hatos, Federica Quaglia, Damiano Piovesan, Silvio C E Tosatto
Publicado en: Database, 2021, ISSN 1758-0463
Editor: Oxford University Press
DOI: 10.1093/database/baab019

CAID prediction portal: A comprehensive service for predicting intrinsic disorder and binding regions in proteins

Autores: Alessio Del Conte, Adel Bouhraoua, Mahta Mehdiabadi, Damiano Clementel, Alexander Miguel Monzon, CAID predictors , Silvio C E Tosatto, Damiano Piovesan
Publicado en: Nucleic Acids Research, 2023, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkad430

The features of polyglutamine regions depend on their evolutionary stability

Autores: Pablo Mier, Miguel A. Andrade-Navarro
Publicado en: BMC Ecology and Evolution, 2020, ISSN 2730-7182
Editor: Springer Nature
DOI: 10.1186/s12862-020-01626-3

The Difference in Structural States between Canonical Proteins and Their Isoforms Established by Proteome-Wide Bioinformatics Analysis

Autores: Osmanli, Z.; Falgarone, T.; Samadova, T.; Aldrian, G.; Leclercq, J.; Shahmuradov, I.; Kajava, A.V.
Publicado en: Biomolecules, 2022, ISSN 2218-273X
Editor: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/biom12111610

REP2: A Web Server to Detect Common Tandem Repeats in Protein Sequences

Autores: Mohamed Kamel, Kristina Kastano, Pablo Mier, Miguel A. Andrade
Publicado en: Journal of Molecular Biology, 2021, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2021.166895

PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins

Autores: Hamidreza Ghafouri; Tamas Lazar; Alessio Del Conte; Luiggi G Tenorio Ku; Maria C Aspromonte; Pau Bernadó; Belén Chaves-Arquero; Lucia Beatriz Chemes; Damiano Clementel; Tiago N Cordeiro; Carlos A Elena-Real; Michael Feig; Isabella C Felli; Carlo Ferrari; Julie D Forman-Kay; Tiago Gomes; Frank Gondelaud; Claudiu C Gradinaru; Tâp Ha-Duong; Teresa Head-Gordon; Pétur O Heidarsson; Giacomo Janson
Publicado en: Nucleic Acids Research, Edición 16, 2024, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkad947

TRAL 2.0 : tandem repeat detection with circular profile hidden Markov models and evolutionary aligner

Autores: Matteo Delucchi; Paulina Näf; Spencer Bliven; Maria Anisimova
Publicado en: Frontiers in Bioinformatics, Edición 5, 2021, ISSN 2673-7647
Editor: Frontiers Media
DOI: 10.21256/zhaw-22764

Pfam: The protein families database in 2021.

Autores: Jaina Mistry; Sara Chuguransky; Lowri Williams; Matloob Qureshi; Gustavo A. Salazar; Erik L. L. Sonnhammer; Silvio C. E. Tosatto; Lisanna Paladin; Shriya Raj; Lorna Richardson; Robert D. Finn; Alex Bateman
Publicado en: Nucleic Acids Research, Edición 5, 2020, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa913

A STRP-ed definition of Structured Tandem Repeats in Proteins

Autores: Monzon, Alexander Miguel; Arrías, Paula Nazarena; Elofsson, Arne; Mier, Pablo; Andrade-Navarro, Miguel A; Bevilacqua, Martina; Clementel, Damiano; Bateman, Alex; Hirsh, Layla; Fornasari, Maria Silvina; Parisi, Gustavo; Piovesan, Damiano; Kajava, Andrey V; Tosatto, Silvio C E
Publicado en: Journal of Structural Biology, Edición 5, 2023, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2023.108023

DisProt in 2024: improving function annotation of intrinsically disordered proteins

Autores: Maria Cristina Aspromonte; Maria Victoria Nugnes; Federica Quaglia; Adel Bouharoua; Vasileios Sagris; Vasilis J Promponas; Anastasia Chasapi; Erzsébet Fichó; Galo E Balatti; Gustavo Parisi; Martín González Buitrón; Gabor Erdos; Matyas Pajkos; Zsuzsanna Dosztányi; Laszlo Dobson; Alessio Del Conte; Damiano Clementel; Edoardo Salladini; Emanuela Leonardi; Fatemeh Kordevani; Hamidreza Ghafouri;
Publicado en: Nucleic Acids Research, Edición 18, 2024, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkad928

PlaToLoCo: the first web meta-server for visualization and annotation of low complexity regions in proteins.

Autores: Patryk Jarnot; Joanna Ziemska-Legiecka; László Dobson; Matthew Merski; Pablo Mier; Miguel A. Andrade-Navarro; John M. Hancock; Zsuzsanna Dosztányi; Lisanna Paladin; Marco Necci; Damiano Piovesan; Silvio C. E. Tosatto; Vasilis J. Promponas; Marcin Grynberg; Aleksandra Gruca
Publicado en: Nucleic Acids Research, Edición 7, 2020, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaa339

Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species

Autores: Max Verbiest; Mikhail Maksimov; Ye Jin; Maria Anisimova; Melissa Gymrek; Tugce Bilgin Sonay
Publicado en: Journal of Evolutionary Biology, Edición 18, 2023, ISSN 1010-061X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jeb.14106

Other (1)

14th Annual Biocuration Conference (virtual) - Abstracts from the invited speakers talks and poster session presentations

Autores: Federica Quaglia
Publicado en: Abstract booklet of the 14th Annual Biocuration Conference (virtual), including invited speakers talks and poster session presentations, 2021
Editor: Zenodo
DOI: 10.5281/zenodo.5570276

Non-peer reviewed articles (1)

CoDNaS-Q: a database of conformational diversity of the native state of proteins with quaternary structure

Autores: Nahuel Escobedo, Ronaldo Romario Tunque Cahui, Gastón Caruso, Emilio García Ríos, Layla Hirsh, Alexander Miguel Monzon, Gustavo Parisi, VNicolas Palopoli
Publicado en: bioRxiv, 2022, ISSN 2692-8205
Editor: bioRxiv
DOI: 10.1101/2022.02.15.480082

Conference proceedings (1)

Conference report: Biocuration 2021 Virtual Conference

Autores: Federica Quaglia, Rama Balakrishnan, Susan M Bello, Nicole Vasilevsky
Publicado en: Database, 2022, ISSN 1758-0463
Editor: Oxford University Press
DOI: 10.1093/database/baac027