Risultati finali Documents, reports (14) Communication plan and website Immunoscore on most of ONCOBIOME cohorts Immunoscore on most of ONCOBIOME cohorts using a standardized methodology Completion of running the metagenomics protocols Completion of running the metagenomics protocols on all the samples included in the project Epidemiological analysis Epidemiological analysis of main flaws in data interpretation Discovery of commensal-specific regulatory properties Discovery of commensalspecific regulatory properties on immune cell migration Banking, sequencing and functional description of new commensals Banking sequencing and functional description of new commensals Metabolomics on plasma Metabolomics on plasma in dedicated cohorts Preliminary dietary data Preliminary dietary data from existing cohorts where available Standardization of shotgun microbiome analysis A detailed technical description of standardization of shotgun microbiome analysis on the unified database Tumor mutational burden Tumor mutational burden and PDL1 for dedicated cohorts Discovery of commensal-specific metabolites Discovery of commensal one or severalspecific metabolites Freeze of the database of the profiles Freeze of the database of the profiles from all the metagenomes of the project obtained with the tools of D22 Culturomics of E. hirae Culturomics of E hirae for most cohorts amenable to ICBs Completion of the curatedCancerMetagenomicData resource Websites, patent fillings, videos etc. (1) ONCOBIOME logo and graphic chart Pubblicazioni Peer reviewed articles (51) Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients. Autori: Picard M, Yonekura S, Slowicka K, Petta I, Rauber C, Routy B, Richard C, Iebba V, Tidjani Alou M, Becharef S, Ly P, Pizzato E, Lehmann CHK, Amon L, Klein C, Opolon P, Gomperts Boneca I, Scoazec JY, Hollebecque A, Malka D, Ghiringhelli F, Dudziak D, Berx G, Vereecke L, van Loo G, Kroemer G, Zitvogel L, Roberti MP. Pubblicato in: Cell Death Differ., 2021, ISSN 1350-9047 Editore: Nature Publishing Group DOI: 10.1038/s41418-020-00684-w Gut microbiota composition in colorectal cancer patients is genetically regulated Autori: Francesca Colombo, Oscar Illescas, Sara Noci, Francesca Minnai, Giulia Pintarelli, Angela Pettinicchio, Alberto Vannelli, Luca Sorrentino, Luigi Battaglia, Maurizio Cosimelli, Tommaso A. Dragani & Manuela Gariboldi Pubblicato in: Scientific Reports, Issue 12, 2022, Page(s) 11424, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/s41598-022-15230-6 Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases Autori: Gianluca Ianiro, Michal Punčochář, Nicolai Karcher, Serena Porcari, Federica Armanini, Francesco Asnicar, Francesco Beghini, Aitor Blanco-Míguez, Fabio Cumbo, Paolo Manghi, Federica Pinto, Luca Masucci, Gianluca Quaranta, Silvia De Giorgi, Giusi Desirè Sciumè, Stefano Bibbò, Federica Del Chierico, Lorenza Putignani, Maurizio Sanguinetti, Antonio Gasbarrini, Mireia Valles-Colomer, Giovanni C Pubblicato in: Nature Medicine, 2022, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-022-01964-3 Using empirical biological knowledge to infer regulatory networks from multi-omics data Autori: Pačínková A., Popovici V. Pubblicato in: BMC Bioinformatics, Issue 23, 2022, Page(s) 351, ISSN 1471-2105 Editore: BioMed Central DOI: 10.1186/s12859-022-04891-9 Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in advanced non-small cell lung cancer patients Autori: Lisa Derosa, Bertrand Routy, Andrew Maltez Thomas, Valerio Iebba, Gerard Zalcman, Sylvie Friard, Julien Mazieres, Clarisse Audigier-Valette, Denis Moro-Sibilot, François Goldwasser, Carolina Alves Costa Silva, Safae Terrisse, Melodie Bonvalet, Arnaud Scherpereel, Hervé Pegliasco, Corentin Richard, François Ghiringhelli, Arielle Elkrief, Antoine Desilets, Felix Blanc-Durand, Fabio Cumbo, Aitor B Pubblicato in: Nature Medicine, Issue 28, 2022, Page(s) 315-324, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-021-01655-5 Blue poo: impact of gut transit time on the gut microbiome using a novel marker. Autori: Francesco Asnicar; Emily R Leeming; Eirini Dimidi; Mohsen Mazidi; Paul W. Franks; Haya Al Khatib; Ana M. Valdes; Richard Davies; Elco Bakker; Lucy Francis; Andrew T. Chan; Rachel J. Gibson; George Hadjigeorgiou; Jonathan Wolf; Tim D. Spector; Nicola Segata; Sarah Berry Pubblicato in: Gut, Issue 7, 2021, ISSN 0017-5749 Editore: BMJ Publishing Group DOI: 10.1136/gutjnl-2020-323877 Luxibacter massiliensis gen. nov., sp. nov., a new bacterium isolated from the human gut microbiota. Autori: Naud S, Bellali S, Anani H, Lo CI, Yacouba A, Tidjani Alou M, Armstrong N, Bonvalet M, Zitvogel L, Raoult D, Lagier JC. Pubblicato in: New microbes and new infections., 2021, ISSN 2052-2975 Editore: John Wiley & Sons Inc. DOI: 10.1016/j.nmni.2021.100850 A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency. Autori: Le Naour J, Liu P, Zhao L, Adjemian S, Sztupinszki Z, Taieb J, Mulot C, Silvin A, Dutertre CA, Ginhoux F, Sauvat A, Cerrato G, Castoldi F, Martins I, Stoll G, Paillet J, Mangane K, Richter C, Kepp O, Maiuri MC, Pietrocola F, Vandenabeele P, André F, Delaloge S, Szallasi Z, Laurent-Puig P, Zucman-Rossi J, Zitvogel L, Pol JG, Vacchelli E, Kroemer G. Pubblicato in: Cancer Discov, 2021, ISSN 2159-8274 Editore: American Association for Cancer Research Inc. DOI: 10.1158/2159-8290.cd-20-0465 Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade. Autori: Ferrere G, Tidjani Alou M, Liu P, Goubet AG, Fidelle M, Kepp O, Durand S, Iebba V, Fluckiger A, Daillère R, Thelemaque C, Grajeda-Iglesias C, Alves Costa Silva C, Aprahamian F, Lefevre D, Zhao L, Ryffel B, Colomba E, Arnedos M, Drubay D, Rauber C, Raoult D, Asnicar F, Spector T, Segata N, Derosa L, Kroemer G, Zitvogel L. Pubblicato in: JCI Insight, 2021, ISSN 0021-9738 Editore: American Society for Clinical Investigation DOI: 10.1172/jci.insight.145207 Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients. Autori: Bourgin M, Derosa L, Silva CAC, Goubet AG, Dubuisson A, Danlos FX, Grajeda-Iglesias C, Cerbone L, Geraud A, Laparra A, Aprahamian F, Nirmalathasan N, Madeo F, Zitvogel L, Kroemer G, Durand S. Pubblicato in: Aging (Albany NY), 2021, ISSN 1945-4589 Editore: Impact Journals DOI: 10.18632/aging.203525 Multifaceted modes of action of the anticancer probiotic Enterococcus hirae Autori: Goubet, Anne-Gaëlle; Wheeler, Richard; Fluckiger, Aurélie; Qu, Bo; Lemaître, Fabien; Iribarren, Kristina; Mondragón, Laura; Tidjani Alou, Maryam; Pizzato, Eugénie; Durand, Sylvère; Derosa, Lisa; Aprahamian, Fanny; Bossut, Noélie; Moya-Nilges, Maryse; Derrien, Diane; Chen, Guo; Leduc, Marion; Joseph, Adrien; Pons, Nicolas; Le Chatelier, Emmanuelle; Segata, Nicola; Yonekura, Satoru; Iebba, Va Pubblicato in: "Cell Death and Differentiation, Nature Publishing Group, 2021, 28 (7), pp.2276-2295. ⟨10.1038/s41418-021-00753-8⟩", Issue 4, 2021, ISSN 1350-9047 Editore: Nature Publishing Group DOI: 10.1038/s41418-021-00753-8 Intake of Natural Compounds and Circulating microRNA Expression Levels: Their Relationship Investigated in Healthy Subjects With Different Dietary Habits. Autori: Ferrero G, Carpi S, Polini B, Pardini B, Nieri P, Impeduglia A, Grioni S, Tarallo S, Naccarati A. Pubblicato in: Frontiers in pharmacology., 2021, ISSN 1663-9812 Editore: Frontiers Media S.A. DOI: 10.3389/fphar.2020.619200 Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with biobakery 3 Autori: Francesco Beghini; Lauren J. McIver; Aitor Blanco-Míguez; Leonard Dubois; Francesco Asnicar; Sagun Maharjan; Sagun Maharjan; Ana Mailyan; Ana Mailyan; Paolo Manghi; Matthias Scholz; Andrew Maltez Thomas; Mireia Valles-Colomer; George Weingart; George Weingart; Yancong Zhang; Yancong Zhang; Moreno Zolfo; Curtis Huttenhower; Curtis Huttenhower; Eric A. Franzosa; Eric A. Franzosa; Nicola Segata; Nic Pubblicato in: eLife, Issue 2, 2021, ISSN 2050-084X Editore: eLife Sciences Publications DOI: 10.7554/elife.65088 Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Autori: Francesco Asnicar, Sarah E. Berry, Ana M. Valdes, Long H. Nguyen, Gianmarco Piccinno, David A. Drew, Emily Leeming, Rachel Gibson, Caroline Le Roy, Haya Al Khatib, Lucy Francis, Mohsen Mazidi, Olatz Mompeo, Mireia Valles-Colomer, Adrian Tett, Francesco Beghini, Léonard Dubois, Davide Bazzani, Andrew Maltez Thomas, Chloe Mirzayi, Asya Khleborodova, Sehyun Oh, Rachel Hine, Christopher Bonnett, Joan Pubblicato in: Nature Medicine, 2021, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-020-01183-8 The 8q24 region hosts miRNAs altered in biospecimens of colorectal and bladder cancer patients Autori: Amedeo Gagliardi, Giulia Francescato, Giulio Ferrero, Giovanni Birolo, Sonia Tarallo, Antonio Francavilla, Giulia Piaggeschi, Carla Di Battista, Gaetano Gallo, Alberto Realis Luc, Carlotta Sacerdote, Giuseppe Matullo, Paolo Vineis, Alessio Naccarati, Barbara Pardini Pubblicato in: Cancer Medicine, Issue 00, 2022, Page(s) 1-15, ISSN 2045-7634 Editore: John Wiley & Sons Ltd DOI: 10.1002/cam4.5375 Faecal miRNA profiles associated with age, sex, BMI, and lifestyle habits in healthy individuals. Autori: Antonio Francavilla; Amedeo Gagliardi; Giulia Piaggeschi; Sonia Tarallo; Francesca Cordero; Ruggero G. Pensa; Alessia Impeduglia; Gian Paolo Caviglia; Davide Giuseppe Ribaldone; Gaetano Gallo; Sara Grioni; Giulio Ferrero; Barbara Pardini; Alessio Naccarati Pubblicato in: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021), Issue 2, 2021, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/s41598-021-00014-1 Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer Autori: Safae Terrisse; Anne-Gaelle Goubet; Kousuke Ueda; Andrew Maltez Thomas; Valentin Quiniou; Cassandra Thelemaque; Garett Dunsmore; Emmanuel Clave; Melissa Gamat-Huber; Satoru Yonekura; Gladys Ferrere; Conrad Rauber; Hang Phuong Pham; Jean-Eudes Fahrner; Eugenie Pizzato; Pierre Ly; Marine Fidelle; Marine Mazzenga; Carolina Alves Costa Silva; Federica Armanini; Federica Pinto; Francesco Asnicar; Romai Pubblicato in: Journal for ImmunoTherapy of Cancer, Issue 10, 2022, ISSN 2051-1426 Editore: BMJ Publishing Group Ltd & Society for Immunotherapy of Cancer DOI: 10.1136/jitc-2021-004191 Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites Autori: Grajeda-Iglesias C, Durand S, Daillère R, Iribarren K, Lemaitre F, Derosa L, Aprahamian F, Bossut N, Nirmalathasan N, Madeo F, Zitvogel L, Kroemer G. Pubblicato in: Aging (Albany NY)., 2021, ISSN 1945-4589 Editore: Impact Journals DOI: 10.18632/aging.202739 Analysis of 1321 Eubacterium rectale genomes from metagenomes uncovers complex phylogeographic population structure and subspecies functional adaptations Autori: Karcher, N.; Pasolli, E.; Asnicar, F.; Huang, K. D.; Huang, K. D.; Tett, A.; Manara, S.; Armanini, F.; Bain, D.; Duncan, S. H.; Louis, P.; Zolfo, M.; Manghi, P.; Valles-Colomer, M.; Raffaeta, R.; Rota-Stabelli, O.; Collado, M. C.; Zeller, G.; Falush, D.; Maixner, F.; Walker, A. W.; Huttenhower, C.; Huttenhower, C.; Segata, N. Pubblicato in: Genome Biology, Issue 9, 2020, ISSN 1474-7596 Editore: BioMed Central DOI: 10.1186/s13059-020-02042-y Stool microRNA profiles reflect different dietary and gut microbiome patterns in healthy individuals. Autori: Sonia Tarallo; Giulio Ferrero; Francesca De Filippis; Antonio Francavilla; Edoardo Pasolli; Valentina Panero; Francesca Cordero; Nicola Segata; Sara Grioni; Ruggero G. Pensa; Barbara Pardini; Danilo Ercolini; Alessio Naccarati Pubblicato in: Gut, Issue 1, 2021, ISSN 1468-3288 Editore: BMJ DOI: 10.1136/gutjnl-2021-325168 A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti-PD-1 Resistance through Effects on the Gut Microbiota Autori: Meriem Messaoudene, Reilly Pidgeon, Corentin Richard, Mayra Ponce, Khoudia Diop, Myriam Benlaifaoui, Alexis Nolin-Lapalme, Florent Cauchois, Julie Malo, Wiam Belkaid, Stephane Isnard, Yves Fradet, Lharbi Dridi, Dominique Velin, Paul Oster, Didier Raoult, François Ghiringhelli, Romain Boidot, Sandy Chevrier, David T. Kysela, Yves V. Brun, Emilia Liana Falcone, Geneviève Pilon, Florian Plaza Oñat Pubblicato in: Cancer Discovery, Issue 12, 2022, Page(s) 1070-1087, ISSN 2159-8274 Editore: American Association for Cancer Research Inc. DOI: 10.1158/2159-8290.cd-21-0808 At the forefront of the sequencing revolution—notes from the RNGS19 conference Autori: Sander Wuyts, Nicola Segata Pubblicato in: Genome Biology, Issue 20/1, 2019, ISSN 1474-760X Editore: Springer Nature DOI: 10.1186/s13059-019-1714-3 The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations Autori: Adrian Tett, Kun D. Huang, Francesco Asnicar, Hannah Fehlner-Peach, Edoardo Pasolli, Nicolai Karcher, Federica Armanini, Paolo Manghi, Kevin Bonham, Moreno Zolfo, Francesca De Filippis, Cara Magnabosco, Richard Bonneau, John Lusingu, John Amuasi, Karl Reinhard, Thomas Rattei, Fredrik Boulund, Lars Engstrand, Albert Zink, Maria Carmen Collado, Dan R. Littman, Daniel Eibach, Danilo Ercolini, Omar Ro Pubblicato in: Cell Host & Microbe, Issue 26/5, 2019, Page(s) 666-679.e7, ISSN 1931-3128 Editore: Cell Press DOI: 10.1016/j.chom.2019.08.018 Multiple levels of the unknown in microbiome research Autori: Andrew Maltez Thomas, Nicola Segata Pubblicato in: BMC Biology, Issue 17/1, 2019, ISSN 1741-7007 Editore: BioMed Central DOI: 10.1186/s12915-019-0667-z Altered Fecal Small RNA Profiles in Colorectal Cancer Reflect Gut Microbiome Composition in Stool Samples Autori: Sonia Tarallo, Giulio Ferrero, Gaetano Gallo, Antonio Francavilla, Giuseppe Clerico, Alberto Realis Luc, Paolo Manghi, Andrew Maltez Thomas, Paolo Vineis, Nicola Segata, Barbara Pardini, Alessio Naccarati, Francesca Cordero Pubblicato in: mSystems, Issue 4/5, 2019, ISSN 2379-5077 Editore: American Society for Microbiology Journals DOI: 10.1128/mSystems.00289-19 Detecting contamination in viromes using ViromeQC Autori: Moreno Zolfo, Federica Pinto, Francesco Asnicar, Paolo Manghi, Adrian Tett, Frederic D. Bushman, Nicola Segata Pubblicato in: Nature Biotechnology, Issue 37/12, 2019, Page(s) 1408-1412, ISSN 1087-0156 Editore: Nature Publishing Group DOI: 10.1038/s41587-019-0334-5 Precise phylogenetic analysis of microbial isolates and genomes from metagenomes using PhyloPhlAn 3.0 Autori: Francesco Asnicar, Andrew Maltez Thomas, Francesco Beghini, Claudia Mengoni, Serena Manara, Paolo Manghi, Qiyun Zhu, Mattia Bolzan, Fabio Cumbo, Uyen May, Jon G. Sanders, Moreno Zolfo, Evguenia Kopylova, Edoardo Pasolli, Rob Knight, Siavash Mirarab, Curtis Huttenhower, Nicola Segata Pubblicato in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Editore: Nature Publishing Group DOI: 10.1038/s41467-020-16366-7 Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients Autori: Lisa Derosa, Bertrand Routy, Marine Fidelle, Valerio Iebba, Laurie Alla, Edoardo Pasolli, Nicola Segata, Aude Desnoyer, Filippo Pietrantonio, Gladys Ferrere, Jean-Eudes Fahrner, Emmanuelle Le Chatellier, Nicolas Pons, Nathalie Galleron, Hugo Roume, Connie P.M. Duong, Laura Mondragón, Kristina Iribarren, Mélodie Bonvalet, Safae Terrisse, Conrad Rauber, Anne-Gaëlle Goubet, Romain Daillère, Fabie Pubblicato in: European Urology, Issue 78/2, 2020, Page(s) 195-206, ISSN 0302-2838 Editore: Elsevier BV DOI: 10.1016/j.eururo.2020.04.044 A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies Autori: Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ģirts Šķenders, Marcis Leja, Lars Engstrand Pubblicato in: Gut, Issue 68/9, 2019, Page(s) 1723-1725, ISSN 0017-5749 Editore: BMJ Publishing Group DOI: 10.1136/gutjnl-2018-316225 A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results Autori: Patrizia Pasanisi, Manuela Gariboldi, Paolo Verderio, Stefano Signoroni, Andrea Mancini, Licia Rivoltini, Massimo Milione, Enzo Masci, Chiara Maura Ciniselli, Eleonora Bruno, Alessandra Macciotta, Antonino Belfiore, Maria Teresa Ricci, Giuliana Gargano, Daniele Morelli, Giovanni Apolone, Marco Vitellaro Pubblicato in: Integrative Cancer Therapies, Issue 18, 2019, Page(s) 153473541984640, ISSN 1534-7354 Editore: Sage Science Press DOI: 10.1177/1534735419846400 Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer Autori: Maria Paula Roberti, Satoru Yonekura, Connie P. M. Duong, Marion Picard, Gladys Ferrere, Maryam Tidjani Alou, Conrad Rauber, Valerio Iebba, Christian H. K. Lehmann, Lukas Amon, Diana Dudziak, Lisa Derosa, Bertrand Routy, Caroline Flament, Corentin Richard, Romain Daillère, Aurélie Fluckiger, Isabelle Van Seuningen, Mathias Chamaillard, Audrey Vincent, Stephanie Kourula, Paule Opolon, Pierre Ly, Pubblicato in: Nature Medicine, Issue 26/6, 2020, Page(s) 919-931, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-020-0882-8 Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy Autori: Romain Daillère, Lisa Derosa, Mélodie Bonvalet, Nicola Segata, Bertrand Routy, Manuela Gariboldi, Eva Budinská, I. Jolanda M. De Vries, Alessio Gordon Naccarati, Valérie Zitvogel, Carlos Caldas, Lars Engstrand, Sibylle Loilbl, Jacques Fieschi, Lucie Heinzerling, Guido Kroemer, Laurence Zitvogel Pubblicato in: OncoImmunology, Issue 9/1, 2020, Page(s) 1774298, ISSN 2162-402X Editore: Taylor & Francis Group, LLC DOI: 10.1080/2162402x.2020.1774298 Can we harness the microbiota to enhance the efficacy of cancer immunotherapy? Autori: B. Brett Finlay, Romina Goldszmid, Kenya Honda, Giorgio Trinchieri, Jennifer Wargo, Laurence Zitvogel Pubblicato in: Nature Reviews Immunology, 2020, ISSN 1474-1733 Editore: Nature Publishing Group DOI: 10.1038/s41577-020-0374-6 Immunostimulatory gut bacteria Autori: Laurence Zitvogel, Guido Kroemer Pubblicato in: Science, Issue 366/6469, 2019, Page(s) 1077-1078, ISSN 0036-8075 Editore: American Association for the Advancement of Science DOI: 10.1126/science.aaz7595 Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology? Autori: Lisa Derosa, Bertrand Routy, Antoine Desilets, Romain Daillère, Safae Terrisse, Guido Kroemer and Laurence Zitvogel Pubblicato in: Cancer discovery, 2021, ISSN 2159-8274 Editore: American Association for Cancer Research Inc. DOI: 10.1158/2159-8290.cd-21-0236 Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly Autori: Nicolai Karcher; Eleonora Nigro; Michal Punčochář; Aitor Blanco-Míguez; Matteo Ciciani; Paolo Manghi; Moreno Zolfo; Fabio Cumbo; Serena Manara; Davide Golzato; Anna Cereseto; Manimozhiyan Arumugam; Thi Phuong Nam Bui; Hanne L. P. Tytgat; Hanne L. P. Tytgat; Mireia Valles-Colomer; Willem M. de Vos; Willem M. de Vos; Nicola Segata; Nicola Segata Pubblicato in: Genome Biology, Issue 4, 2021, ISSN 1474-7596 Editore: BioMed Central DOI: 10.1186/s13059-021-02427-7 Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment. Autori: Terrisse S, Derosa L, Iebba V, Ghiringhelli F, Vaz-Luis I, Kroemer G, Fidelle M, Christodoulidis S, Segata N, Thomas AM, Martin AL, Sirven A, Everhard S, Aprahamian F, Nirmalathasan N, Aarnoutse R, Smidt M, Ziemons J, Caldas C, Loibl S, Denkert C, Durand S, Iglesias C, Pietrantonio F, Routy B, André F, Pasolli E, Delaloge S, Zitvogel L. Pubblicato in: Cell Death Differ., 2021, ISSN 1350-9047 Editore: Nature Publishing Group DOI: 10.1038/s41418-021-00784-1 Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade. Autori: Andrews MC, Duong CPM, Gopalakrishnan V, Iebba V, Chen WS, Derosa L, Khan MAW, Cogdill AP, White MG, Wong MC, Ferrere G, Fluckiger A, Roberti MP, Opolon P, Alou MT, Yonekura S, Roh W, Spencer CN, Curbelo IF, Vence L, Reuben A, Johnson S, Arora R, Morad G, Lastrapes M, Baruch EN, Little L, Gumbs C, Cooper ZA, Prieto PA, Wani K, Lazar AJ, Tetzlaff MT, Hudgens CW, Callahan MK, Adamow M, Postow MA, Ar Pubblicato in: Nature Medicine, 2021, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-021-01406-6 Extending and improving metagenomic taxonomic profiling with uncharacterized species with MetaPhlAn 4 Autori: Aitor Blanco-Miguez, Francesco Beghini, Fabio Cumbo, Lauren J. McIver, Kelsey N. Thompson, Moreno Zolfo, Paolo Manghi, Leonard Dubois, Kun D. Huang, Andrew Maltez Thomas, Gianmarco Piccinno, Elisa Piperni, Michal Punčochář, Mireia Valles-Colomer, Adrian Tett, Francesca Giordano, Richard Davies, Jonathan Wolf, Sarah E. Berry, Tim D. Spector, Eric A. Franzosa, Edoardo Pasolli, F Pubblicato in: Nature Biotechnology, 2023, ISSN 1087-0156 Editore: Nature Publishing Group DOI: 10.1038/s41587-023-01688-w Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma Autori: Karla A. Lee, Andrew Maltez Thomas, Laura A. Bolte, Johannes R. Björk, Laura Kist de Ruijter, Federica Armanini, Francesco Asnicar, Aitor Blanco-Miguez, Ruth Board, Neus Calbet-Llopart, Lisa Derosa, Nathalie Dhomen, Kelly Brooks, Mark Harland, Mark Harries, Emily R. Leeming, Paul Lorigan, Paolo Manghi, Richard Marais, Julia Newton-Bishop, Luigi Nezi, Federica Pinto, Miriam Potrony, Susana Puig, P Pubblicato in: Nature Medicine, Issue 28, 2022, Page(s) 535-544, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-022-01695-5 Prevotella diversity, niches and interactions with the human host Autori: Adrian Tett, Edoardo Pasolli, Giulia Masetti, Danilo Ercolini, Nicola Segata Pubblicato in: Nature reviews. Microbiology, 2021, ISSN 1740-1526 Editore: Nature Publishing Group DOI: 10.1038/s41579-021-00559-y Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers. Autori: Danlos FX, Grajeda-Iglesias C, Durand S, Sauvat A, Roumier M, Cantin D, Colomba E, Rohmer J, Pommeret F, Baciarello G, Willekens C, Vasse M, Griscelli F, Fahrner JE, Goubet AG, Dubuisson A, Derosa L, Nirmalathasan N, Bredel D, Mouraud S, Pradon C, Stoclin A, Rozenberg F, Duchemin J, Jourdi G, Ellouze S, Levavasseur F, Albigès L, Soria JC, Barlesi F, Solary E, André F, Pène F, Ackerman F, Moutho Pubblicato in: Cell Death Dis., 2021, ISSN 2041-4889 Editore: Nature Publishing Group DOI: 10.1038/s41419-021-03540-y Human postprandial responses to food and potential for precision nutrition Autori: Sarah E. Berry, Ana M. Valdes, David A. Drew, Francesco Asnicar, Mohsen Mazidi, Jonathan Wolf, Joan Capdevila, George Hadjigeorgiou, Richard Davies, Haya Al Khatib, Christopher Bonnett, Sajaysurya Ganesh, Elco Bakker, Deborah Hart, Massimo Mangino, Jordi Merino, Inba Linenberg, Patrick Wyatt, Jose M. Ordovas, Christopher D. Gardner, Linda M. Delahanty, Andrew T. Chan, Nicola Segata, Paul W. Franks Pubblicato in: Nature Medicine, 2020, ISSN 1078-8956 Editore: Nature Publishing Group DOI: 10.1038/s41591-020-0934-0 Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis. Autori: Goubet AG, Dubuisson A, Geraud A, Danlos FX, Terrisse S, Silva CAC, Drubay D, Touri L, Picard M, Mazzenga M, Silvin A, Dunsmore G, Haddad Y, Pizzato E, Ly P, Flament C, Melenotte C, Solary E, Fontenay M, Garcia G, Balleyguier C, Lassau N, Maeurer M, Grajeda-Iglesias C, Nirmalathasan N, Aprahamian F, Durand S, Kepp O, Ferrere G, Thelemaque C, Lahmar I, Fahrner JE, Meziani L, Ahmed-Belkacem A, Saïd Pubblicato in: Cell Death Differ, 2021, ISSN 1350-9047 Editore: Nature Publishing Group DOI: 10.1038/s41418-021-00817-9 Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors Autori: Daillère R, Routy B, Goubet AG, Cogdill A, Ferrere G, Alves-Costa Silva C, Fluckiger A, Ly P, Haddad Y, Pizzato E, Thelemaque C, Fidelle M, Mazzenga M, Roberti MP, Melenotte C, Liu P, Terrisse S, Kepp O, Kroemer G, Zitvogel L, Derosa L. Pubblicato in: Oncoimmunology, 2020, ISSN 2162-4011 Editore: Landes Bioscience DOI: 10.1080/2162402x.2020.1794423 Mediterranean Diet to Prevent the Development of Colon Diseases: A Meta-Analysis of Gut Microbiota Studies Autori: Illescas O, Rodríguez-Sosa M, Gariboldi M. Pubblicato in: Nutrients, 2021, ISSN 2072-6643 Editore: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/nu13072234 Genes Encoding Microbial Acyl Coenzyme A Binding Protein/Diazepam-Binding Inhibitor Orthologs Are Rare in the Human Gut Microbiome and Show No Links to Obesity. Autori: Thomas AM, Asnicar F, Kroemer G, Segata N. Pubblicato in: Appl Environ Microbiol., 2021, ISSN 0099-2240 Editore: American Society for Microbiology DOI: 10.1128/aem.00471-21 A TLR3 ligand reestablishes chemotherapeutic responses in the context of FPR1 deficiency Autori: Julie Le Naour; Peng Liu; Liwei Zhao; Sandy Adjemian; Zsofia Sztupinszki; Julien Taieb; Claire Mulot; Aymeric Silvin; Charles-Antoine Dutertre; Florent Ginhoux; Allan Sauvat; Giulia Cerrato; Francesca Castoldi; Isabelle Martins; Gautier Stoll; Juliette Paillet; Khady Mangane; Cornelia Richter; Oliver Kepp; Maria Chiara Maiuri; Federico Pietrocola; Peter Vandenabeele; Fabrice Andre; Suzette Delalog Pubblicato in: Cancer Discovery, Issue 13, 2021, ISSN 2159-8274 Editore: American Association for Cancer Research Inc. DOI: 10.1158/2159-8290.cd-20-0465 Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury. Autori: Wrzosek L, Ciocan D, Hugot C, Spatz M, Dupeux M, Houron C, Lievin-Le Moal V, Puchois V, Ferrere G, Trainel N, Mercier-Nomé F, Durand S, Kroemer G, Voican CS, Emond P, Straube M, Sokol H, Perlemuter G, Cassard AM. Pubblicato in: Gut, 2021, ISSN 0017-5749 Editore: BMJ Publishing Group DOI: 10.1136/gutjnl-2020-321565 Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis Autori: Yonekura S, Terrisse S, Alves Costa Silva C, Lafarge A, Iebba V, Ferrere G, Goubet AG, Fahrner JE, Lahmar I, Ueda K, Mansouri G, Pizzato E, Ly P, Mazzenga M, Thelemaque C, Fidelle M, Jaulin F, Cartry J, Deloger M, Aglave M, Droin N, Opolon P, Puget A, Mann F, Neunlist M, Bessard A, Aymeric L, Matysiak-Budnik T, Bosq J, Hofman P, Duong CPM, Ugolini S, Quiniou V, Berrard S, Ryffel B, Kepp O, Kroemer Pubblicato in: Cancer Discovery, Issue 12, 2022, Page(s) 1128-1151, ISSN 2159-8274 Editore: American Association for Cancer Research Inc. DOI: 10.1158/2159-8290.cd-21-0999 Colorectal Tumour Mucosa Microbiome Is Enriched in Oral Pathogens and Defines Three Subtypes That Correlate with Markers of Tumour Progression. Autori: Barbora Zwinsová; Vyacheslav A. Petrov; Martina Hrivňáková; Stanislav Smatana; Stanislav Smatana; Lenka Micenková; Natálie Kazdová; Vlad Popovici; Roman Hrstka; Roman Šefr; Beatrix Bencsiková; Lenka Zdražilová-Dubská; Veronika Brychtová; Rudolf Nenutil; Petra Vídeňská; Eva Budinská Pubblicato in: Volume 13, Issue 1, 2021, ISSN 2072-6694 Editore: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13194799 È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
