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European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development

Deliverables

Dissemination and exploitation plan

Dissemination and exploitation plan

Standard operating procedures in English and Spanish

Standard operating procedures in English and Spanish

A Quality Assurance Plan

A Quality Assurance Plan

Midterm recruitment report of GBC patients

Midterm recruitment report of GBC patients

First dissemination report

First dissemination report

Report of the kick-off meeting

Report of the kick-off meeting

Completion of trainings at all sites

Completion of trainings at all sites

Searching for OpenAIRE data...

Publications

Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia

Author(s): Lorena Rosa, Lorena Lobos‐González, Natalia Muñoz‐Durango, Patricia García, Carolina Bizama, Natalia Gómez, Ximena González, Ignacio A. Wichmann, Nicolás Saavedra, Francisca Guevara, Jaime Villegas, Marco Arrese, Catterina Ferreccio, Alexis M. Kalergis, Juan Francisco Miquel, Jaime A. Espinoza, Juan C. Roa
Published in: Molecular Oncology, 2020, ISSN 1574-7891
DOI: 10.1002/1878-0261.12766

Liver metastases of intrahepatic cholangiocarcinoma: implications for a potential new staging system.

Author(s): Angela Lamarca, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle
Published in: Hepatology, 2020, ISSN 0270-9139
DOI: 10.1002/hep.31598

Current and novel therapeutic opportunities for systemic therapy in biliary cancer

Author(s): José J. G. Marin, Maria Giuseppina Prete, Angela Lamarca, Simona Tavolari, Ana Landa-Magdalena, Giovanni Brandi, Oreste Segatto, Arndt Vogel, Rocío I. R. Macias, Pedro M. Rodrigues, Adelaida La Casta, Joachim Mertens, Cecilia M. P. Rodrigues, Maite G. Fernandez-Barrena, Ana Da Silva Ruivo, Marco Marzioni, Giulia Mentrasti, Pilar Acedo, Patricia Munoz-Garrido, Vincenzo Cardinale, Jesus M. Banales
Published in: British Journal of Cancer, Issue 123/7, 2020, Page(s) 1047-1059, ISSN 0007-0920
DOI: 10.1038/s41416-020-0987-3

Hepatitis B core‐related antigen levels predict recurrence‐free survival in patients with HBV‐associated early‐stage hepatocellular carcinoma: results from a Dutch long‐term follow‐up study

Author(s): Boris J. B. Beudeker, Zwier M. A. Groothuismink, Robert A. Man, Caroline D. M. Witjes, Annemiek A. Eijk, Andre Boonstra, Milan J. Sonneveld
Published in: Journal of Viral Hepatitis, Issue 28/1, 2021, Page(s) 205-208, ISSN 1352-0504
DOI: 10.1111/jvh.13394

HPB cancers in older patients | inclusion of older/senior patients in clinical trials

Author(s): Alison Backen, Angela Lamarca, Richard A. Hubner, Mairéad G. McNamara, Juan W. Valle
Published in: European Journal of Surgical Oncology, Issue 47/3, 2021, Page(s) 597-602, ISSN 0748-7983
DOI: 10.1016/j.ejso.2020.11.002

A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

Author(s): Rocio I. R. Macias, Luis Muñoz-Bellvís, Anabel Sánchez-Martín, Enara Arretxe, Ibon Martínez-Arranz, Ainhoa Lapitz, M. Laura Gutiérrez, Adelaida La La Casta, Cristina Alonso, Luis M. González, Matias A. Avila, Maria L. Martinez-Chantar, Rui E. Castro, Luis Bujanda, Jesus M. Banales, Jose J. G. Marin
Published in: Cancers, Issue 12/6, 2020, Page(s) 1433, ISSN 2072-6694
DOI: 10.3390/cancers12061433

Current and New Biomarkers for Early Detection, Prognostic Stratification, and Management of Gallbladder Cancer Patients

Author(s): Patricia García, Angela Lamarca, Javier Díaz, Enrique Carrera, Juan Roa
Published in: Cancers, Issue 12/12, 2020, Page(s) 3670, ISSN 2072-6694
DOI: 10.3390/cancers12123670

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Author(s): Jesus M. Banales, Jose J. G. Marin, Angela Lamarca, Pedro M. Rodrigues, Shahid A. Khan, Lewis R. Roberts, Vincenzo Cardinale, Guido Carpino, Jesper B. Andersen, Chiara Braconi, Diego F. Calvisi, Maria J. Perugorria, Luca Fabris, Luke Boulter, Rocio I. R. Macias, Eugenio Gaudio, Domenico Alvaro, Sergio A. Gradilone, Mario Strazzabosco, Marco Marzioni, Cédric Coulouarn, Laura Fouassier, Chiara Ragg
Published in: Nature Reviews Gastroenterology & Hepatology, Issue 17/9, 2020, Page(s) 557-588, ISSN 1759-5045
DOI: 10.1038/s41575-020-0310-z

Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology

Author(s): Chimaobi M. Anugwom, Manon Allaire, Sheikh Mohammad Fazle Akbar, Amir Sultan, Steven Bollipo, Angelo Z. Mattos, Jose D. Debes
Published in: Hepatoma Research, 2021, ISSN 2454-2520
DOI: 10.20517/2394-5079.2021.06

Ivosidenib: an investigational drug for the treatment of biliary tract cancers

Author(s): Angelos Angelakas, Angela Lamarca, Richard a Hubner, Mairéad G McNamara, Juan W. Valle
Published in: Expert Opinion on Investigational Drugs, Issue 30/4, 2021, Page(s) 301-307, ISSN 1354-3784
DOI: 10.1080/13543784.2021.1900115

Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation

Author(s): Sabine K. Urban, Hanna Sänger, Marcin Krawczyk, Henrike Julich‐Haertel, Arnulf Willms, Joanna Ligocka, Mikel Azkargorta, Tudor Mocan, Christoph Kahlert, Beata Kruk, Krzysztof Jankowski, Waldemar Patkowski, Marek Krawczyk, Krzysztof Zieniewicz, Wacław Hołówko, Łukasz Krupa, Mateusz Rzucidło, Krzysztof Gutkowski, Wojciech Wystrychowski, Robert Król, Joanna Raszeja‐Wyszomirska, Artur Słom
Published in: Liver International, Issue 40/12, 2020, Page(s) 3103-3116, ISSN 1478-3223
DOI: 10.1111/liv.14585

Advances in systemic therapy for the first-line treatment of unresectable HCC

Author(s): Arndt Vogel, Melanie Bathon, Anna Saborowski
Published in: Expert Review of Anticancer Therapy, 2021, ISSN 1473-7140
DOI: 10.1080/14737140.2021.1882855

Implicit bias in region-dependent publication potential can partly be counteracted by Academic collaboration

Author(s): Maikel P. Peppelenbosch, Carmen V. Ferreira
Published in: Clinical Gastroenterology and Hepatology, 2021, ISSN 1542-3565
DOI: 10.1016/j.cgh.2021.04.001

Reply to “Does multiple intrahepatic cholangiocarcinoma worsen prognosis as “M1” stage?”; multiple primaries vs liver metastases

Author(s): Angela Lamarca, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle
Published in: Hepatology, 2021, ISSN 0270-9139
DOI: 10.1002/hep.31740

Hepatobiliary cancers in South America: disparity strikes

Author(s): Jose D Debes, Andre Boonstra, Domingo Balderramo, Angelo Z Mattos, Marco Arrese, Juan C. Roa, Juan W. Valle, Jesus M. Banales, Enrique Carrera, Pablo A. Romagnoli, Jhon E. Prieto, Bettina E. Hansen, Arndt Vogel, Angela Lamarca
Published in: The Lancet Gastroenterology & Hepatology, Issue 4/8, 2019, Page(s) 581, ISSN 2468-1253
DOI: 10.1016/s2468-1253(19)30188-8

Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Author(s): Jesus M. Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntané, Luis Muñoz-Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez-Arranz, Ainhoa Lapitz, Alvaro Santos-Laso, Matias A. Avila, Maria L. Martínez-Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias
Published in: Hepatology, Issue 70/2, 2019, Page(s) 547-562, ISSN 0270-9139
DOI: 10.1002/hep.30319

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor

Author(s): Patricia García, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sánchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Dávila-López, Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato, Pamela Leal, Marcela Lagos, Juan Carlos Roa
Published in: Biological Research, Issue 53/1, 2020, ISSN 0717-6287
DOI: 10.1186/s40659-020-00282-7

Hepatocellular Carcinoma: Unraveling the Role of Occult Hepatitis B Virus Infection

Author(s): Ângelo Z. Mattos, Angelo A. Mattos, Jose D. Debes
Published in: Clinical Gastroenterology and Hepatology, 2020, ISSN 1542-3565
DOI: 10.1016/j.cgh.2020.03.028

Diagnostic and prognostic biomarkers in cholangiocarcinoma

Author(s): Rocio I. R. Macias, Miroslaw Kornek, Pedro M. Rodrigues, Nuno A. Paiva, Rui E. Castro, Sabine Urban, Stephen P. Pereira, Massimiliano Cadamuro, Christian Rupp, Sven H. Loosen, Tom Luedde, Jesus M. Banales
Published in: Liver International, Issue 39/S1, 2019, Page(s) 108-122, ISSN 1478-3223
DOI: 10.1111/liv.14090

Hepatocellular carcinoma, a unique tumor with a lack of biomarkers

Author(s): Jose D. Debes, Enrique Carrera, Angelo Z. Mattos, Jhon E. Prieto, Andre Boonstra
Published in: Annals of Hepatology, Issue 18/6, 2019, Page(s) 786-787, ISSN 1665-2681
DOI: 10.1016/j.aohep.2019.07.009

Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer

Author(s): Patricia García, Lorena Rosa, Sergio Vargas, Helga Weber, Jaime A. Espinoza, Felipe Suárez, Isabel Romero-Calvo, Nicole Elgueta, Vanessa Rivera, Bruno Nervi, Javiera Obreque, Pamela Leal, Eduardo Viñuela, Gloria Aguayo, Sabrina Muñiz, Alfredo Sagredo, Juan C. Roa, Carolina Bizama
Published in: Cancers, Issue 12/4, 2020, Page(s) 778, ISSN 2072-6694
DOI: 10.3390/cancers12040778

NAFLD‐Related Hepatocellular Carcinoma and the Four Horsemen of the Apocalypse

Author(s): Jose D. Debes, Andre Boonstra, Robert J. Knegt
Published in: Hepatology, Issue 71/3, 2020, Page(s) 774-776, ISSN 0270-9139
DOI: 10.1002/hep.31170

Circulating biomarkers for early detection of hepatocellular carcinoma

Author(s): Boris J. B. Beudeker, Andre Boonstra
Published in: Therapeutic Advances in Gastroenterology, Issue 13, 2020, Page(s) 175628482093173, ISSN 1756-2848
DOI: 10.1177/1756284820931734

Current and Future Systemic Therapies in Biliary Tract Cancer

Author(s): Arndt Vogel, Anna Saborowski
Published in: Visceral Medicine, Issue 37/1, 2021, Page(s) 32-38, ISSN 2297-4725
DOI: 10.1159/000513969

Immunotherapies in clinical development for biliary tract cancer

Author(s): Arndt Vogel, Melanie Bathon, Anna Saborowski
Published in: Expert Opinion on Investigational Drugs, Issue 30/4, 2021, Page(s) 351-363, ISSN 1354-3784
DOI: 10.1080/13543784.2021.1868437

Pathogenesis of Cholangiocarcinoma

Author(s): Pedro M. Rodrigues, Paula Olaizola, Nuno A. Paiva, Irene Olaizola, Alona Agirre-Lizaso, Ana Landa, Luis Bujanda, Maria J. Perugorria, Jesus M. Banales
Published in: Annual Review of Pathology: Mechanisms of Disease, Issue 16/1, 2021, Page(s) 433-463, ISSN 1553-4006
DOI: 10.1146/annurev-pathol-030220-020455

Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic

Author(s): Massimiliano Cadamuro, Alberto Lasagni, Angela Lamarca, Laura Fouassier, Maria Guido, Samantha Sarcognato, Enrico Gringeri, Umberto Cillo, Mario Strazzabosco, Jose JG Marin, Jesus M Banales, Luca Fabris
Published in: Expert Opinion on Investigational Drugs, Issue 30/4, 2021, Page(s) 377-388, ISSN 1354-3784
DOI: 10.1080/13543784.2021.1880564

Serum Biomarkers for the Prediction of Hepatocellular Carcinoma

Author(s): José Debes, Pablo Romagnoli, Jhon Prieto, Marco Arrese, Angelo Mattos, André Boonstra
Published in: Cancers, Issue 13/7, 2021, Page(s) 1681, ISSN 2072-6694
DOI: 10.3390/cancers13071681

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

Author(s): Ainhoa Lapitz, Ander Arbelaiz, Colm J. O’Rourke, Jose L. Lavin, Adelaida La Casta, Cesar Ibarra, Juan P. Jimeno, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Marcin Krawczyk, Maria J. Perugorria, Raul Jimenez-Aguero, Alberto Sanchez-Campos, Ioana Riaño, Esperanza Gónzalez, Frank Lammert, Marco Marzioni, Rocio I.R. Macias, Jose J. G. Marin, Tom H. Karlsen, Luis Bujanda, Juan M. Falcón-Pérez,
Published in: Cells, Issue 9/3, 2020, Page(s) 721, ISSN 2073-4409
DOI: 10.3390/cells9030721

Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management

Author(s): Amedeo Lonardo, Juan Pablo Arab, Marco Arrese
Published in: Advances in Therapy, 2021, ISSN 0741-238X
DOI: 10.1007/s12325-021-01690-1

Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach

Author(s): Jesús M. Urman, José M. Herranz, Iker Uriarte, María Rullán, Daniel Oyón, Belén González, Ignacio Fernandez-Urién, Juan Carrascosa, Federico Bolado, Lucía Zabalza, María Arechederra, Gloria Alvarez-Sola, Leticia Colyn, María U. Latasa, Leonor Puchades-Carrasco, Antonio Pineda-Lucena, María J. Iraburu, Marta Iruarrizaga-Lejarreta, Cristina Alonso, Bruno Sangro, Ana Purroy, Isabel Gil, L
Published in: Cancers, Issue 12/6, 2020, Page(s) 1644, ISSN 2072-6694
DOI: 10.3390/cancers12061644