European-Latin American network for the assessment of biomarkers to predict and diagnose hepatobiliary malignancies and characterization of risk factors for cancer development

Risultati finali

Report on distinctive protein signatures to identify intrahepatic CCA versus HCC
Report on the content of the first Latin-American database of CCA
Report on serum protein levels in GBC patients of Amerindian and non Amerindian ancestry
Dissemination and exploitation plan
Standard operating procedures in English and Spanish
Report on serum biomarkers to predict HCC in individuals at risk.
Report on HBV-related risk factors leading to early HCC in Latin America.
Report on the proteomic signature to diagnose CCA in individuals at risk
Policy briefs for prevention and screening of HCC, CCA and GBC
Report on risk factors related to HCC development in NAFLD patients.
Midterm report on the evaluation of risk factors related to HBV-induced HCC.

Midterm report on the evaluation of risk factors related to HBVinduced HCC

A Quality Assurance Plan
Report on validation of the protein signature described in deliverable D2.1 to diagnose CCA in individuals at risk
Midterm recruitment report of GBC patients
Third dissemination report
Report of immune-phenotypic and functional markers in GBC patients of Amerindian and non Amerindian ancestry
Midterm recruitment report of HCC patients and patients at risk of developing HCC
First dissemination report
Report on clinical and genetic parameters as risk factors for HCC
Exploitation report
Report of the kick-off meeting
Midterm recruitment report of CCA patients and patients predisposed to develop CCA
Report on risk factors in individuals with predisposing factors for CCA
Report on the use of exoDNA as a biomarker for GBC
Final dissemination report
Second dissemination report

A Data Management Plan with ORDP

Public website and social media profiles
Newsletters every 6 months (8 in total) with project news and findings

Completion of trainings at all sites

Pubblicazioni

Circulating cytokines reflect the etiology-specific immune environment in cirrhosis and HCC

Autori: Beudeker BJB, Groothuismink ZMA, van der Eijk AA, Debes JD, Boonstra A.
Pubblicato in: Cancers (Basel), 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194900

Assessment of TLL1 variant and risk of hepatocellular carcinoma in Latin Americans and Europeans.

Autori: """Fu S, Karim D, Prieto J, Balderramo D, Ferrer JD, Mattos AZ, Arrese M, Carrera E, Oliveira J, Debes JD, Boonstra A"""
Pubblicato in: Ann Hepatol, 2023, ISSN 1665-2681
Editore: Ediciones Medicina y Cultura
DOI: 10.1016/j.aohep.2023.101181

Medical therapy of HCC

Autori: Vogel A, Saborowski A.
Pubblicato in: Journal of Hepatology, 2021, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.05.017

Next-Generation Biomarkers for Cholangiocarcinoma

Autori: Pedro Miguel Rodrigues, Arndt Vogel, Marco Arrese, Domingo C. Balderramo, Juan W. Valle, Jesus Maria Banales
Pubblicato in: Cancers, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13133222

Potential utility of liquid biopsies in the management of patients with biliary tract cancers: A review.

Autori: Rohan Shotton, Angela Lamarca, Juan Valle, Mairéad G McNamara.
Pubblicato in: World Journal of Gastrointestinal Oncology., 2021, ISSN 1948-5204
Editore: Baishideng Publishing Group
DOI: 10.4251/wjgo.v13.i9.1073

Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma.

Autori: Lewinska M, Zhuravleva E, Satriano L, Martinez MB, Bhatt DK, Oliveira DVNP, Antoku Y, Keggenhoff FL, Castven D, Marquardt JU, Matter MS, Erler JT, Oliveira RC, Aldana BI, Al-Abdulla R, Perugorria MJ, Calvisi DF, Perez LA, Rodrigues PM, Labiano I, Banales JM, Andersen JB.
Pubblicato in: Gastroenterology, 2023, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2023.11.302.

Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia

Autori: Lorena Rosa, Lorena Lobos‐González, Natalia Muñoz‐Durango, Patricia García, Carolina Bizama, Natalia Gómez, Ximena González, Ignacio A. Wichmann, Nicolás Saavedra, Francisca Guevara, Jaime Villegas, Marco Arrese, Catterina Ferreccio, Alexis M. Kalergis, Juan Francisco Miquel, Jaime A. Espinoza, Juan C. Roa
Pubblicato in: Molecular Oncology, 2020, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.12766

Exploring the Promise of Second-Line Chemotherapy in Biliary Tract Tumours: A Glimpse into Novel Treatment Approaches.

Autori: Villalba Cuesta P, Avedillo Ruidiaz M, Ruiz Hispán E, Fuentes Mateos R, Lamarca A.
Pubblicato in: Cancers (Basel), 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15235543

Molecular profiling and precision medicine in rare gastrointestinal cancers within EURACAN in the SPECTA Arcagen study (EORTC-1843): too few patients treated in Europe.

Autori: Angela Lamarca, Marie Morfouace, Sabine Tejpar, Julio Oliveira, Andreia Capela, Nicolas Penel, Christine Gennigens, Birute Brasiuniene, Julien Peron, Aleksandra Stevovic, Jean-Yves Blay, Heinz-Josef Klümpen.
Pubblicato in: Annals of Oncology, 2022, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1016/j.annonc.2022.07.006

Intrahepatic cholangiocarcinoma hidden within cancer of unknown primary

Autori: Alicia-Marie Conway, Georgina C. Morris, Sarah Smith, Monique Vekeria, Prakash Manoharan, Claire Mitchell, Alison Backen, Pedro Oliveira, Richard A. Hubner, Angela Lamarca, Mairéad G. McNamara, Juan W. Valle and Natalie Cook
Pubblicato in: British Journal of Cancer, 2022, ISSN 1532-1827
Editore: Nature
DOI: 10.1038/s41416-022-01824-4

Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic

Autori: Cadamuro M, Lasagni A, Lamarca A, Fouassier L, Guido M, Sarcognato S, Gringeri E, Cillo U, Strazzabosco M, Marin JJ, Banales JM, Fabris L.
Pubblicato in: Expert Opin Investig Drugs., 2021, ISSN 1354-3784
Editore: Ashley Publications Ltd.
DOI: 10.1080/13543784.2021.1880564

Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy

Autori: Roseanna C Wheatley, Elaine Kilgour, Timothy Jacobs, Angela Lamarca, Richard A Hubner , Juan W Valle, Mairéad G McNamara
Pubblicato in: British Journal of Cancer, 2022, ISSN 1532-1827
Editore: Nature
DOI: 10.1038/s41416-021-01583-8

Liver metastases of intrahepatic cholangiocarcinoma: implications for a potential new staging system.

Autori: Angela Lamarca, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle
Pubblicato in: Hepatology, 2020, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.31598

The Emerging Role of PIWI-Interacting RNAs (piRNAs) in Gastrointestinal Cancers: An Updated Perspective

Autori: Riquelme I, Pérez-Moreno P, Letelier P, Brebi P, Roa JC
Pubblicato in: Cancers, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010202

Current and novel therapeutic opportunities for systemic therapy in biliary cancer

Autori: José J. G. Marin, Maria Giuseppina Prete, Angela Lamarca, Simona Tavolari, Ana Landa-Magdalena, Giovanni Brandi, Oreste Segatto, Arndt Vogel, Rocío I. R. Macias, Pedro M. Rodrigues, Adelaida La Casta, Joachim Mertens, Cecilia M. P. Rodrigues, Maite G. Fernandez-Barrena, Ana Da Silva Ruivo, Marco Marzioni, Giulia Mentrasti, Pilar Acedo, Patricia Munoz-Garrido, Vincenzo Cardinale, Jesus M. Banales
Pubblicato in: British Journal of Cancer, Numero 123/7, 2020, Pagina/e 1047-1059, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-020-0987-3

Acute and chronic HBV infection in central Argentina: High frequency of sub-genotype F1b, low detection of clinically relevant mutations and first evidence of HDV

Autori: Castro GM, Sosa MJ, Sicilia PE, Riberi MI, Moreno C, Cattaneo R, Debes JD, Barbás MG, Cudolá AE, Pisano MB, Ré VE
Pubblicato in: Front Med (Lausanne), 2023, ISSN 2296-858X
Editore: Lausanne: Frontiers Media S.A
DOI: 10.3389/fmed.2022.1057194

A look back at cholangiocarcinoma in Finland

Autori: Izquierdo-Sanchez L, Banales JM, Rodrigues PM.
Pubblicato in: United European Gastroenterol J, 2021, ISSN 2050-6414
Editore: SAGE Publications Inc.
DOI: 10.1002/ueg2.12157

Hepatocellular carcinoma in nonalcoholic fatty liver disease: A growing challenge

Autori: Mattos ÂZ, Debes JD, Dhanasekaran R, Benhammou JN, Arrese M, Patrício ALV, Zilio AC, Mattos AA.
Pubblicato in: World Journal of Hepatology, 2021, ISSN 1948-5182
Editore: Baishideng Publishing Group
DOI: 10.4254/wjh.v13.i9.1107

Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis.

Autori: Tovo CV, de Mattos AZ, Coral GP, Sartori GDP, Nogueira LV, Both GT, Villela-Nogueira CA, de Mattos AA.
Pubblicato in: World J Gastroenterol, 2023, ISSN 1007-9327
Editore: W J G Press
DOI: 10.3748/wjg.v29.i2.343

Combination therapies for targeting FGFR2 fusions in cholangiocarcinoma.

Autori: Saborowski A, Vogel A, Segatto O.
Pubblicato in: Trends Cancer., 2021, ISSN 2405-8033
Editore: Cell Press
DOI: 10.1016/j.trecan.2021.11.001

Hepatitis B core‐related antigen levels predict recurrence‐free survival in patients with HBV‐associated early‐stage hepatocellular carcinoma: results from a Dutch long‐term follow‐up study

Autori: Boris J. B. Beudeker, Zwier M. A. Groothuismink, Robert A. Man, Caroline D. M. Witjes, Annemiek A. Eijk, Andre Boonstra, Milan J. Sonneveld
Pubblicato in: Journal of Viral Hepatitis, Numero 28/1, 2021, Pagina/e 205-208, ISSN 1352-0504
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jvh.13394

Use of the Rockwood Clinical Frailty Scale in patients with advanced hepatopancreaticobiliary malignancies

Autori: Dinakshi Shah, Zainul Abedin Kapacee, Angela Lamarca, Richard A Hubner, Juan W Valle & Mairéad G McNamara
Pubblicato in: Expert Review of Anticancer Therapy, 2022, ISSN 1744-8328
Editore: Taylor & Francis
DOI: 10.1080/14737140.2022.2096594

Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions

Autori: Macias RIR, Cardinale V, Kendall TJ, Avila MA, Guido M, Coulouarn C, Braconi C, Frampton AE, Bridgewater J, Overi D, Pereira SP, Rengo M, Kather JN, Lamarca A, Pedica F, Forner A, Valle JW, Gaudio E, Alvaro D, Banales JM, Carpino G.
Pubblicato in: Gut, 2022, ISSN 1468-3288
Editore: BMJ
DOI: 10.1136/gutjnl-2022-327099

HPB cancers in older patients | inclusion of older/senior patients in clinical trials

Autori: Alison Backen, Angela Lamarca, Richard A. Hubner, Mairéad G. McNamara, Juan W. Valle
Pubblicato in: European Journal of Surgical Oncology, Numero 47/3, 2021, Pagina/e 597-602, ISSN 0748-7983
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejso.2020.11.002

Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance

Autori: Qian Wan, Chimaobi Anugwom, Hailemichael Desalegn , Jose D Debes
Pubblicato in: Hepatoma research, 2022, ISSN 2454-2520
Editore: OAE Publishing Inc.
DOI: 10.20517/2394-5079.2022.32

Work-up and outcome of hepatic resection for peri-hilar cholangiocarcinoma (PH-CCA) without staging laparoscopy

Autori: Santhalingam Jegatheeswaran, Panagiotis Stathakis, Harry V M Spiers, Fawwaz Mohammed, Panagiotis Petras, Thomas Satyadas, Michael Parker, Angela Lamarca, Saurabh Jamdar, Aali J Sheen, Ajith Kumar Siriwardena
Pubblicato in: Cancers (Basel), 2022, Pagina/e 1841, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14071841

A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma

Autori: Rocio I. R. Macias, Luis Muñoz-Bellvís, Anabel Sánchez-Martín, Enara Arretxe, Ibon Martínez-Arranz, Ainhoa Lapitz, M. Laura Gutiérrez, Adelaida La La Casta, Cristina Alonso, Luis M. González, Matias A. Avila, Maria L. Martinez-Chantar, Rui E. Castro, Luis Bujanda, Jesus M. Banales, Jose J. G. Marin
Pubblicato in: Cancers, Numero 12/6, 2020, Pagina/e 1433, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061433

Current and New Biomarkers for Early Detection, Prognostic Stratification, and Management of Gallbladder Cancer Patients

Autori: Patricia García, Angela Lamarca, Javier Díaz, Enrique Carrera, Juan Roa
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3670, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123670

Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer

Autori: Pérez-Moreno P, Riquelme I, García P, Brebi P, Roa JC.
Pubblicato in: Journal of Personalized Medicine, 2022, ISSN 2075-4426
Editore: MDPI
DOI: 10.3390/jpm12020234

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Autori: Jesus M. Banales, Jose J. G. Marin, Angela Lamarca, Pedro M. Rodrigues, Shahid A. Khan, Lewis R. Roberts, Vincenzo Cardinale, Guido Carpino, Jesper B. Andersen, Chiara Braconi, Diego F. Calvisi, Maria J. Perugorria, Luca Fabris, Luke Boulter, Rocio I. R. Macias, Eugenio Gaudio, Domenico Alvaro, Sergio A. Gradilone, Mario Strazzabosco, Marco Marzioni, Cédric Coulouarn, Laura Fouassier, Chiara Ragg
Pubblicato in: Nature Reviews Gastroenterology & Hepatology, Numero 17/9, 2020, Pagina/e 557-588, ISSN 1759-5045
Editore: Nature Publishing Group
DOI: 10.1038/s41575-020-0310-z

Autori: Chimaobi M. Anugwom, Manon Allaire, Sheikh Mohammad Fazle Akbar, Amir Sultan, Steven Bollipo, Angelo Z. Mattos, Jose D. Debes
Pubblicato in: Hepatoma Research, 2021, ISSN 2454-2520
Editore: OAE publishing
DOI: 10.20517/2394-5079.2021.06

DNA methylation markers in the detection of hepatocellular carcinoma

Autori: Fu S, Debes JD, Boonstra A.
Pubblicato in: Eur J Cancer, 2023, ISSN 0959-8049
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2023.112960

Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis and prognostication of cholangiocarcinoma.

Autori: Lapitz A, Azkargorta M, Milkiewicz P, Olaizola P, Zhuravleva E, Grimsrud MM, Schramm C, Arbelaiz A, O'Rourke CJ, La Casta A, Milkiewicz M, Pastor T, Vesterhus M, Jimenez-Agüero R, Dill MT, Lamarca A, Valle JW, Macias RIR, Izquierdo-Sanchez L, Castaño YP, Caballero-Camino FJ, Riaño I, Krawczyk M, Ibarra C, Bustamante J, Nova-Camacho LM, Falcon-Perez JM, Elortza F, Perugorria MJ, Andersen JB, Buj
Pubblicato in: J Hepatol, 2023, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2023.02.027

Role of lncRNAs in the development of an aggressive phenotype in gallbladder cancer

Autori: Pablo Pérez-Moreno, Ismael Riquelme, Priscilla Brebi, Juan Carlos Roa
Pubblicato in: Journal of Clinical Medicine, 2021, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10184206

What is the gender representation in authorship in later phase systemic clinical trials in biliary tract cancer (BTC)? - a retrospective review of the published literature - PubMed (nih.gov)

Autori: Mairéad G McNamara, John Bridgewater, Lipika Goyal, Timothy Jacobs, Anna D Wagner, David Goldstein, Rachna Shroff, Markus Moehler, Maeve Lowery, Tanios Bekaii-Saab, Robin K Kelley, Junji Furuse, Lorenza Rimassa, Chigusa Morizane, Angela Lamarca, Richard Hubner, Jennifer Knox, Juan Valle
Pubblicato in: BMJ Open, 2023, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2022-064954

"""MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort"""

Autori: Goble S, Akambase J, Prieto J, Balderramo D, Ferrer JD, Mattos AZ, Arrese M, Carrera E, Groothuismink ZMA, Oliveira J, Boonstra A, Debes JD
Pubblicato in: Dig Dis Sci, 2023, ISSN 0163-2116
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10620-023-08104-y

Ivosidenib: an investigational drug for the treatment of biliary tract cancers

Autori: Angelos Angelakas, Angela Lamarca, Richard a Hubner, Mairéad G McNamara, Juan W. Valle
Pubblicato in: Expert Opinion on Investigational Drugs, Numero 30/4, 2021, Pagina/e 301-307, ISSN 1354-3784
Editore: Ashley Publications Ltd.
DOI: 10.1080/13543784.2021.1900115

Druggable molecular alterations in bile duct cancer: potential and current therapeutic applications in clinical trials.

Autori: Héloïse Bourien, Angela Lamarca, Mairéad G McNamara, Richard A Hubner, Juan W Valle, Julien Edeline
Pubblicato in: Expert Opinion on Investigational Drugs, 2021, ISSN 1354-3784
Editore: Ashley Publications Ltd.
DOI: 10.1080/13543784.2021.1964470

A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multi-organ activity and shows translational relevance to humans.

Autori: Caballero-Camino FJ, Rodrigues PM, Wångsell F, Agirre-Lizaso A, Olaizola P, Izquierdo-Sanchez L, Perugorria MJ, Bujanda L, Angelin B, Straniero S, Wallebäck A, Starke I, Gillberg PG, Strängberg E, Bonn B, Mattsson JP, Madsen MR, Hansen HH, Lindström E, Åkerblad P, Banales JM.
Pubblicato in: Hepatology, 2023, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000376

Cryptogenic non‑cirrhotic HCC: Clinical, prognostic and immunologic aspects of an emerging HCC etiology.

Autori: Boris J. B. Beudeker, Rael Guha, Kalina Stoyanova, Jan N. M. IJzermans, Robert A. de Man, Dave Sprengers & Andre Boonstra.
Pubblicato in: Scientific Reports, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-52884-w.

Lacking Immunotherapy Biomarkers for Biliary Tract Cancer: A Comprehensive Systematic Literature Review and Meta-Analysis.

Autori: Frega G, Cossio FP, Banales JM, Cardinale V, Macias RIR, Braconi C, Lamarca A.
Pubblicato in: Cells, 2023, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12162098

Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation

Autori: Sabine K. Urban, Hanna Sänger, Marcin Krawczyk, Henrike Julich‐Haertel, Arnulf Willms, Joanna Ligocka, Mikel Azkargorta, Tudor Mocan, Christoph Kahlert, Beata Kruk, Krzysztof Jankowski, Waldemar Patkowski, Marek Krawczyk, Krzysztof Zieniewicz, Wacław Hołówko, Łukasz Krupa, Mateusz Rzucidło, Krzysztof Gutkowski, Wojciech Wystrychowski, Robert Król, Joanna Raszeja‐Wyszomirska, Artur Słom
Pubblicato in: Liver International, Numero 40/12, 2020, Pagina/e 3103-3116, ISSN 1478-3223
Editore: Blackwell Publishing Inc.
DOI: 10.1111/liv.14585

Locoregional therapies in patients with intrahepatic cholangiocarcinoma: a systematic review and pooled analysis.

Autori: Julien Edeline, Angela Lamarca, Mairéad G McNamara, Timothy Jacobs, Richard A Hubner, Dan Palmer, Bas Groot Koerkamp, Philip Johnson, Boris Guiu and Juan W Valle.
Pubblicato in: Cancer Treatment reviews, 2021, ISSN 0305-7372
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ctrv.2021.102258

Dysplasia and carcinoma of the gallbladder: pathological evaluation, sampling, differential diagnosis and clinical implications

Autori: Juan C Roa, Olca Basturk, Volkan Adsay
Pubblicato in: Histopathology, 2022, ISSN 1365-2559
Editore: Wiley
DOI: 10.1111/his.14360

"""Hepatitis C and hepatocellularcarcinoma in Latin America: Elimination as a path to cancer prevention."""

Autori: Goble S, Mattos AZ, Mendizabal M, Debes JD
Pubblicato in: Ann Hepatol, 2023, ISSN 1665-2681
Editore: Ediciones Medicina y Cultura
DOI: 10.1016/j.aohep.2023.101149

Advances in systemic therapy for the first-line treatment of unresectable HCC

Autori: Arndt Vogel, Melanie Bathon, Anna Saborowski
Pubblicato in: Expert Review of Anticancer Therapy, 2021, ISSN 1473-7140
Editore: Future Drugs Ltd.
DOI: 10.1080/14737140.2021.1882855

Non-alcoholic fatty liver disease-related hepatocellular carcinoma: Is there a role for immunotherapy?

Autori: Ângelo Z Mattos, Jose D Debes, Arndt Vogel, Marco Arrese, Xavier Revelo, Tales Henrique S Pase, Muriel Manica, Angelo A Mattos
Pubblicato in: World Journal of Gastroenterology, 2022, ISSN 2219-2840
Editore: Baishideng Publishing Group
DOI: 10.3748/wjg.v28.i28.3595

Hypermethylation of DNA methylation markers in non-cirrhotic hepatocellular carcinoma

Autori: Fu S, Deger T, Boers RG, Boers JB, Doukas M, Gribnau J, Wilting SM, Debes JD, Boonstra A
Pubblicato in: Cancers (Basel), 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15194784

Epidemiology and risk factors for histopathologic characteristics of non-alcoholic fatty liver disease in South America

Autori: Akambase JA, Prieto JE, Mattos AZ, Mattos AA, Carrera E, Díaz-Ferrer J, Gallardo P, Curia A, Ballerga EG, Tovo CV, Balderramo D, Debes JD.
Pubblicato in: Aliment Pharmacol Ther, 2023, ISSN 0269-2813
Editore: Blackwell Publishing Inc.
DOI: 10.1111/apt.17615

Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America

Autori: Balderramo D, Mattos AZ, Mulqui V, Chiesa T, Plácido-Damián Z, Abarca J, Bolomo A, Carlino Y, Bombassaro IZ, Wiltgen D, Castillo LT, Díaz K, Acuña J, Manero E, Prieto J, Carrera E, Díaz-Ferrer J, Debes JD
Pubblicato in: Can J Gastroenterol Hepatol, 2021, ISSN 2291-2789
Editore: Pulsus Group Inc.
DOI: 10.1155/2021/1622533

Hepatocellular carcinoma

Autori: Arndt Vogel, Tim Meyer, Gonzalo Sapisochin, Riad Salem, Anna Saborowski
Pubblicato in: The lancet, 2022, ISSN 0140-6736
Editore: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(22)01200-4

Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry.

Autori: Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborow
Pubblicato in: J Hepatol., 2022, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2021.12.010

Brightline-2: a phase IIa/IIb trial of brigimadlin (BI 907828) in advanced biliary tract cancer, pancreatic ductal adenocarcinoma or other solid tumors

Autori: Yoo C, Lamarca A, Choi HJ, Vogel A, Pishvaian MJ, Goyal L, Ueno M, Märten A, Teufel M, Geng L, Morizane C.
Pubblicato in: Future Oncol, 2024, ISSN 1744-8301
Editore: Future Medicine
DOI: 10.2217/fon-2023-0963

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells.

Autori: Duwe L, Munoz-Garrido P, Lewinska M, Lafuente-Barquero J, Satriano L, Høgdall D, Taranta A, Nielsen BS, Ghazal A, Matter MS, Banales JM, Aldana BI, Gao YT, Marquardt JU, Roberts LR, Oliveira RC, Koshiol J, O'Rourke CJ, Andersen JB.
Pubblicato in: Duwe L, Munoz-Garrido P, Lewinska M, Lafuente-Barquero J, Satriano L, Høgdall D, Taranta A, Nielsen BS, Ghazal A, Matter MS, Banales JM, Aldana BI, Gao YT, Marquardt JU, Roberts LR, Oliveira RC, Koshiol J, O'Rourke CJ, Andersen JB., 2023, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2022.10.012

PIGR-enriched circulating vesicles contributes to hepatocellular carcinoma aggressiveness

Autori: Zingoni A, Banales JM.
Pubblicato in: J Hepatol., 2022, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2022.02.001

Insights into NAFLD heterogeneity

Autori: Marco Arrese, MD, Juan Pablo Arab, MD, Francisco Barrera, MD, Ben Kaufmann, MD, Luca Valenti; MD, PhD, Ariel E. Feldstein, MD
Pubblicato in: Seminars in Liver Disease, 2021, ISSN 1098-8971
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Implicit bias in region-dependent publication potential can partly be counteracted by Academic collaboration

Autori: Maikel P. Peppelenbosch, Carmen V. Ferreira
Pubblicato in: Clinical Gastroenterology and Hepatology, 2021, ISSN 1542-3565
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Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Autori: Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M
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Validation and optimization of AFP-based biomarker panels for early HCC detection in Latin America and Europe

Autori: Beudeker BJB, Fu S, Balderramo D, Mattos AZ, Carrera E, Diaz J, Prieto J, Banales J, Vogel A, Arrese M, Oliveira J, Groothuismink ZMA, van Oord G, Hansen BE, de Man RA, Debes JD, Boonstra A
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Current impact of viral hepatitis on liver cancer development: The challenge remains

Autori: """Ângelo Zambam de Mattos, Jose D Debes, Andre Boonstra, Ju-Dong Yang, Domingo C Balderramo, Giovana D P Sartori, Angelo Alves de Mattos"""
Pubblicato in: World J Gastroenterol, 2021, ISSN 1007-9327
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Reply to “Does multiple intrahepatic cholangiocarcinoma worsen prognosis as “M1” stage?”; multiple primaries vs liver metastases

Autori: Angela Lamarca, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle
Pubblicato in: Hepatology, 2021, ISSN 0270-9139
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Assessment of STAT4 variant and risk of Hepatocellular carcinoma in Latin Americans and Europeans

Autori: Ayoub A, Anugwom CM, Prieto J, Balderramo D, Ferrer JD, Mattos AZ, Arrese M, Carrera E, Groothuismink ZMA, Oliveira J, Boonstra A, Debes JD
Pubblicato in: Cancers (Basel), 2023, ISSN 2072-6694
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Cholangiocarcinoma – novel biological insights and therapeutic strategies

Autori: Gregory Gores, Sumera I. Ilyas, Silvia Affo, Lipika Goyal, Angela Lamarca, Gonzalo Sapisochin, and Ju Dong Ya
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Understanding immune perspectives and options for the use of checkpoint immunotherapy in HCC post liver transplant

Autori: Chimaobi M Anugwom, Thomas M Leventhal, Jose D Debes
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Hepatobiliary cancers in South America: disparity strikes

Autori: Jose D Debes, Andre Boonstra, Domingo Balderramo, Angelo Z Mattos, Marco Arrese, Juan C. Roa, Juan W. Valle, Jesus M. Banales, Enrique Carrera, Pablo A. Romagnoli, Jhon E. Prieto, Bettina E. Hansen, Arndt Vogel, Angela Lamarca
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Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Autori: Jesus M. Banales, Mercedes Iñarrairaegui, Ander Arbelaiz, Piotr Milkiewicz, Jordi Muntané, Luis Muñoz-Bellvis, Adelaida La Casta, Luis M. Gonzalez, Enara Arretxe, Cristina Alonso, Ibon Martínez-Arranz, Ainhoa Lapitz, Alvaro Santos-Laso, Matias A. Avila, Maria L. Martínez-Chantar, Luis Bujanda, Jose J.G. Marin, Bruno Sangro, Rocio I.R. Macias
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Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor

Autori: Patricia García, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sánchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Dávila-López, Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato, Pamela Leal, Marcela Lagos, Juan Carlos Roa
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Hepatocellular Carcinoma: Unraveling the Role of Occult Hepatitis B Virus Infection

Autori: Ângelo Z. Mattos, Angelo A. Mattos, Jose D. Debes
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Diagnostic and prognostic biomarkers in cholangiocarcinoma

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Hepatocellular carcinoma, a unique tumor with a lack of biomarkers

Autori: Jose D. Debes, Enrique Carrera, Angelo Z. Mattos, Jhon E. Prieto, Andre Boonstra
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Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer

Autori: Patricia García, Lorena Rosa, Sergio Vargas, Helga Weber, Jaime A. Espinoza, Felipe Suárez, Isabel Romero-Calvo, Nicole Elgueta, Vanessa Rivera, Bruno Nervi, Javiera Obreque, Pamela Leal, Eduardo Viñuela, Gloria Aguayo, Sabrina Muñiz, Alfredo Sagredo, Juan C. Roa, Carolina Bizama
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Autori: Jose D. Debes, Andre Boonstra, Robert J. Knegt
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Circulating biomarkers for early detection of hepatocellular carcinoma

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The promise of precision medicine: how biomarkers are shaping the future of cholangiocarcinoma treatment

Autori: Rocio I.R. Macias, Lorenza Rimassa, Angela Lamarca
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Molecular diagnostics and therapies for gastrointestinal tumors: a real-world experience.

Autori: Welland S, deCastro T, Bathon M, Wirth TC, Reineke-Plaaß T, Saborowski M, Lehmann U, Saborowski A, Vogel A.
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Targeted therapies for Perihilar Cholangiocarcinoma

Autori: Simon Gray, Angela Lamarca, Julien Edeline, Heinz-Josef Klümpen, Richard A. Hubner, Mairéad G. McNamara, Juan W. Valle
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Immune aspects of hepatocellular carcinoma: From immune markers for early detection to immunotherapy

Autori: Mattos ÂZ, Debes JD, Boonstra A, Vogel A, Mattos AA
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Prevalence of hepatitis delta virus among chronic hepatitis B carriers in a large tertiary center in the Netherlands.

Autori: Beudeker BJB, Voermans JJC, Geurtsvankessel CH, de Knegt RJ, Kuhlemann T, Boonstra A, van der Eijk AA
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Chemotherapy with or without Selective Internal Radiation Therapy for intrahepatic cholangiocarcinoma: data from clinical trials

Autori: Julien Edeline, John Bridgewater, Boris Campillo-Gimenez, Estelle Neveu, Jean-Marc Pheli4, Cindy Neuzillet, Karim Boudjema, Yan Rolland, Juan W Valle, Etienne Garin, David Malka and Angela Lamarca
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Setup of multidisciplinary team discussions for patients with cholangiocarcinoma: current practice and recommendations from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).

Autori: Casadio M, Cardinale V, Klümpen HJ, Morement H, Lacasta A, Koerkamp BG, Banales J, Alvaro D, Valle JW, Lamarca A.
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Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Autori: Calvisi DF, Boulter L, Vaquero J, Saborowski A, Fabris L, Rodrigues PM, Coulouarn C, Castro RE, Segatto O, Raggi C, van der Laan LJW, Carpino G, Goeppert B, Roessler S, Kendall TJ, Evert M, Gonzalez-Sanchez E, Valle JW, Vogel A, Bridgewater J, Borad MJ, Gores GJ, Roberts LR, Marin JJG, Andersen JB, Alvaro D, Forner A, Banales JM, Cardinale V, Macias RIR, Vicent S, Chen X, Braconi C, Verstegen MMA,
Pubblicato in: Nat Rev Gastroenterol Hepatol, 2023, ISSN 1759-5045
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Surgery for advanced intrahepatic cholangiocarcinoma warrants further investigation

Autori: Angela Lamarca, Alvaro Santos-Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle
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Gallbladder cancer

Autori: Juan C. Roa, Patricia García, Vinay K. Kapoor, Shishir K. Maithel, Milind Javle & Jill Koshiol
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Current and Future Systemic Therapies in Biliary Tract Cancer

Autori: Arndt Vogel, Anna Saborowski
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The Role of PIVKA-II as a Predictor of Early Hepatocellular Carcinoma Recurrence-Free Survival after Liver Transplantation in a Low Alpha-Fetoprotein Population.

Autori: Devillers MJC, Pluimers JKF, van Hooff MC, Doukas M, Polak WG, de Man RA, Sonneveld MJ, Boonstra A, den Hoed CM.
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Immunotherapies in clinical development for biliary tract cancer

Autori: Arndt Vogel, Melanie Bathon, Anna Saborowski
Pubblicato in: Expert Opinion on Investigational Drugs, Numero 30/4, 2021, Pagina/e 351-363, ISSN 1354-3784
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Changing epidemiology of hepatocellular carcinoma in South America: a report from the South American Liver Research Network

Autori: Marina Faraha, Chimaobi Anugwomb, Javier Diaz Ferrerc, Estefania Liza Bacac, Angelo Z. Mattosd, João Pedro P. Possebond, Marco Arresee, Jhon Prietof, Domingo Balderramog, Enrique Carrerah, Jose D. Debes
Pubblicato in: Annals of Hepatology, 2022, ISSN 1665-2681
Editore: Ediciones Medicina y Cultura
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The Role of Cytokines in the Different Stages of Hepatocellular Carcinoma

Autori: Noe Rico Montanari, Chimaobi M. Anugwom, Andre Boonstra and Jose D. Debes
Pubblicato in: Cancers, 2021, ISSN 2072-6694
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Hepatitis E virus infection in the United States: Seroprevalence, risk factors and the influence of immunological assays

Autori: Pisano MB, Campbell C, Anugwom C, Ré VE, Debes JD
Pubblicato in: Plos One, 2023, ISSN 1932-6203
Editore: Public Library of Science
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Advances in the management of hepatobiliary and pancreatic malignancies: highlights from the ESMO Annual Meeting 2023 by the EORTC GI Tract Cancer Group

Autori: Claudia Fulgenzi, Ingrid Garajová, Markus Moehler, Manfred P Lutz, Elisabeth Smyth, Lorenza Rimassa, Cindy Neuzillet, Angela Lamarca
Pubblicato in: ESMO Gastrointestinal Oncology, 2024, ISSN 2949-8198
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Pathogenesis of Cholangiocarcinoma

Autori: Pedro M. Rodrigues, Paula Olaizola, Nuno A. Paiva, Irene Olaizola, Alona Agirre-Lizaso, Ana Landa, Luis Bujanda, Maria J. Perugorria, Jesus M. Banales
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Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic

Autori: Massimiliano Cadamuro, Alberto Lasagni, Angela Lamarca, Laura Fouassier, Maria Guido, Samantha Sarcognato, Enrico Gringeri, Umberto Cillo, Mario Strazzabosco, Jose JG Marin, Jesus M Banales, Luca Fabris
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PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation.

Autori: Olaizola P, Banales JM.
Pubblicato in: Cell Mol Gastroenterol Hepatol, 2023, ISSN 2352-345X
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Serum Biomarkers for the Prediction of Hepatocellular Carcinoma

Autori: José Debes, Pablo Romagnoli, Jhon Prieto, Marco Arrese, Angelo Mattos, André Boonstra
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New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Autori: Colyn L, Alvarez-Sola G, Latasa MU, Uriarte I, Herranz JM, Arechederra M, Vlachogiannis G, Rae C, Pineda-Lucena A, Casadei-Gardini A, Pedica F, Aldrighetti L, López-López A, López-Gonzálvez A, Barbas C, Ciordia S, Van Liempd SM, Falcón-Pérez JM, Urman J, Sangro B, Vicent S, Iraburu MJ, Prosper F, Nelson LJ, Banales JM, Martinez-Chantar ML, Marin JJG, Braconi C, Trautwein C, Corrales FJ, Cub
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Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry

Autori: Nooijen LE, Banales JM, de Boer MT, Braconi C, Folseraas T, Forner A, Holowko W, Hoogwater FJH, Klümpen HJ, Groot Koerkamp B, Lamarca A, La Casta A, López-López F, Izquierdo-Sánchez L, Scheiter A, Utpatel K, Swijnenburg RJ, Kazemier G, Erdmann JI; ENSCCA Group.
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Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

Autori: Ainhoa Lapitz, Ander Arbelaiz, Colm J. O’Rourke, Jose L. Lavin, Adelaida La Casta, Cesar Ibarra, Juan P. Jimeno, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Marcin Krawczyk, Maria J. Perugorria, Raul Jimenez-Aguero, Alberto Sanchez-Campos, Ioana Riaño, Esperanza Gónzalez, Frank Lammert, Marco Marzioni, Rocio I.R. Macias, Jose J. G. Marin, Tom H. Karlsen, Luis Bujanda, Juan M. Falcón-Pérez,
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Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives

Autori: Haaft BHT, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
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Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management

Autori: Amedeo Lonardo, Juan Pablo Arab, Marco Arrese
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Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach

Autori: Jesús M. Urman, José M. Herranz, Iker Uriarte, María Rullán, Daniel Oyón, Belén González, Ignacio Fernandez-Urién, Juan Carrascosa, Federico Bolado, Lucía Zabalza, María Arechederra, Gloria Alvarez-Sola, Leticia Colyn, María U. Latasa, Leonor Puchades-Carrasco, Antonio Pineda-Lucena, María J. Iraburu, Marta Iruarrizaga-Lejarreta, Cristina Alonso, Bruno Sangro, Ana Purroy, Isabel Gil, L
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Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

Autori: Laura Izquierdo-Sanchez, Angela Lamarca, Adelaida La Casta, Stefan Buettner, Kirsten Utpatel, Heinz-Josef Klümpen, Jorge Adeva, Arndt Vogel, Ana Lleo, Luca Fabris, Mariano Ponz-Sarvise, Raffaele Brustia, Vincenzo Cardinale, Chiara Braconi, Gianpaolo Vidili, Nigel B Jamieson, Rocio Ir Macias, Jan Philipp Jonas, Marco Marzioni, Wacław Hołówko, Trine Folseraas, Juozas Kupčinskas, Zeno Sparchez,
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