CardioReGenix: Development of Next-Generation Gene Therapies for Cardiovascular Disease

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Publications

Antagonism of miRNA in heart failure: first evidence in human

Auteurs: Andrew H. Baker and Mauro Giacca
Publié dans: European Heart Journal, 2021, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehaa967

AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes

Auteurs: Laura Rode; Christian Bär; Sonja Groß; Axel Rossi; Nadja Meumann; Janika Viereck; Naisam Abbas; Ke Xiao; Isabelle Riedel; Anika Gietz; Karina Zimmer; Margarete Odenthal; Hildegard Büning; Thomas Thum
Publié dans: Crossref, Numéro 4, 2023, ISSN 1525-0016
Éditeur: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.07.003

RNA interference therapeutics for cardiac regeneration

Auteurs: Josef Huntington, Manendra Pachauri, Hashim Ali and Mauro Giacca
Publié dans: Current Opinion in Genetics & Development, 2021, ISSN 1523-3782
Éditeur: Current Science Inc.
DOI: 10.1016/j.gde.2021.05.007

Reciprocal organ interactions during heart failure: a position paper from the ESCWorking Group on Myocardial Function

Auteurs: Michele Ciccarelli, Dana Dawson, Ines Falcao-Pires, Mauro Giacca, Nazha Hamdani, Stephane Heymans, Astrid Hooghiemstra, Annebet Leeuwis, Dorien Hermkens, Carlo Gabriele Tocchetti, Jolanda van der Velden, Serena Zacchigna, and Thomas Thum
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvab009

Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library

Auteurs: Giulia Ruozi, Francesca Bortolotti, Antonio Mura, Mateusz Tomczyk, Antonella Falcione, Valentina Martinelli, Simone Vodret, Luca Braga, Matteo Dal Ferro, Antonio Cannatà, Lorena Zentilin, Gianfranco Sinagra, Serena Zacchigna, Mauro Giacca
Publié dans: Science Translational Medicine, 2022, ISSN 1946-6234
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abo0699

Gene Therapy for the Heart

Auteurs: Antonio Cannatà, Hashim Ali, Gianfranco Sinagra, Mauro Giacca
Publié dans: Circulation Research, 2020, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.315855

Cardiac Regeneration After Myocardial Infarction: an Approachable Goal

Auteurs: Mauro Giacca
Publié dans: Current Cardiology Reports, 2020, ISSN 1523-3782
Éditeur: Current Science Inc.
DOI: 10.1007/s11886-020-01361-7

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective

Auteurs: Laura Santer, Christian Bär, Thomas Thum
Publié dans: Molecular Therapy, Numéro 27/8, 2019, Page(s) 1350-1363, ISSN 1525-0016
Éditeur: Nature Publishing Group
DOI: 10.1016/j.ymthe.2019.07.001

Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue

Auteurs: Anca Remes; Dima Ibrahim Basha; Thomas Puehler; Christopher Borowski; Susanne Hille; Laura Kummer; Andreas H. Wagner; Markus Hecker; Jasmin Soethoff; Georg Lutter; Derk Frank; Rawa Arif; Norbert Frey; Marcin Zaradzki; Oliver J. Müller
Publié dans: Molecular Therapy. Methods & Clinical Development, Numéro 1, 2021, ISSN 1525-0016
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtm.2021.02.017

The LINC00961 transcript and its encoded micropeptide, small regulatory polypeptide of amino acid response, regulate endothelial cell function

Auteurs: Helen L Spencer, Rachel Sanders, Mounia Boulberdaa, Marco Meloni, Amy Cochrane, Ana-Mishel Spiroski, Joanne Mountford, Costanza Emanueli, Andrea Caporali, Mairi Brittan, Julie Rodor, Andrew H Baker
Publié dans: Cardiovascular Research, 2020, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvaa008

Small non-coding RNA therapeutics for cardiovascular disease

Auteurs: Ajay M. Shah and Mauro Giacca
Publié dans: European Heart Journal, 2022, ISSN 0195-668X
Éditeur: Oxford University Press
DOI: 10.1093/eurheartj/ehac463

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

Auteurs: Dongchao Lu, Thomas Thum
Publié dans: Nature Reviews Cardiology, 2019, ISSN 1759-5002
Éditeur: Nature Publishing Group
DOI: 10.1038/s41569-019-0218-x

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

Auteurs: D. Julia Trembinski, Diewertje I. Bink, Kosta Theodorou, Janina Sommer, Ariane Fischer, Anke van Bergen, Chao-Chung Kuo, Ivan G. Costa, Christoph Schürmann, Matthias S. Leisegang, Ralf P. Brandes, Tijna Alekseeva, Boris Brill, Astrid Wietelmann, Christopher N. Johnson, Alexander Spring-Connell, Manuel Kaulich, Stanislas Werfel, Stefan Engelhardt, Marc N. Hirt, Kaja Yorgan, Thomas Eschenhagen, Lui
Publié dans: Nature Communications, Numéro 11/1, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-15995-2

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

Auteurs: Laura Stanicek, Noelia Lozano-Vidal, Diewertje Ilse Bink, Aukie Hooglugt, Wenjie Yao, Ilka Wittig, Jos van Rijssel, Jaap Diederik van Buul, Anke van Bergen, Alina Klems, Anne Sophie Ramms, Ferdinand Le Noble, Patrick Hofmann, Robert Szulcek, ShengPeng Wang, Stefan Offermanns, Meryem Seda Ercanoglu, Hyouk-Bum Kwon, Didier Stainier, Stephan Huveneers, Leo Kurian, Stefanie Dimmeler, Reinier Abraham B
Publié dans: Communications Biology, Numéro 3/1, 2020, Page(s) 265, ISSN 2399-3642
Éditeur: Europe PMC
DOI: 10.1038/s42003-020-0987-0

Cardiac regeneration and remodelling of the cardiomyocyte cytoarchitecture

Auteurs: Hashim Ali, Luca Braga and Mauro Giacca
Publié dans: The FEBS Journal, 2020, ISSN 1742-464X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/febs.15146

Non-coding RNA therapeutics for cardiac regeneration

Auteurs: Luca Braga, Hashim Ali, Ilaria Secco, and Mauro Giacca
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvaa071

RNA- based diagnostic and therapeutic strategies for cardiovascular disease

Auteurs: Dongchao Lu and Thomas Thum
Publié dans: Nature Reviews Cardiology, 2019, ISSN 1759-5002
Éditeur: Nature Publishing Group
DOI: 10.1038/s41569-019-0218-x

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

Auteurs: Kesidou D, da Costa Martins PA, de Windt LJ, Brittan M, Beqqali A, Baker AH
Publié dans: Frontiers in Physiology, 2020, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579892

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

Auteurs: Henna Korpela, Jaakko Lampela, Jonna Airaksinen, Niko Järveläinen, Satu Siimes, Kaisa Valli, Tiina Nieminen, Minttu Turunen, Maria Grönman, Antti Saraste, Juhani Knuuti, Mikko Hakulinen, Pekka Poutiainen, Vesa Kärjä, Jussi Nurro and Seppo Ylä-Herttuala
Publié dans: Gene Therapy, 2022, ISSN 0969-7128
Éditeur: Nature Publishing Group
DOI: 10.1038/s41434-022-00322-9

Human AdV-20-42-42, a Promising Novel Adenoviral Vector for Gene Therapy and Vaccine Product Development

Auteurs: Mónika Z Ballmann 1 , Svjetlana Raus 2 , Ruben Engelhart 1 2 , Győző L Kaján 3 , Abdelaziz Beqqali 2 , Patrick W F Hadoke 2 , Chantal van der Zalm 1 , Tibor Papp 4 , Lijo John 3 , Selina Khan 4 , Satish Boedhoe 4 , Katarina Danskog 3 , Lars Frängsmyr 3 , Jerome Custers 4 , Wilfried A M Bakker 1 , Hilde M van der Schaar 1 , Niklas Arnberg 3 , Angelique A C Lemckert 1 , Menz
Publié dans: Journal of Virology, Numéro Oct 27;95(22):e0038721, 2021, ISSN 0022-538X
Éditeur: American Society for Microbiology
DOI: 10.1128/jvi.00387-21

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease.

Auteurs: Cheng-Kai Huang; Sabine Kafert-Kasting; Thomas Thum
Publié dans: Circulation Research, Numéro 2, 2020, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315856

The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction

Auteurs: Spiroski AM, Sanders R, Meloni M, McCracken IR, Thomson A, Brittan M, Gray GA, Baker AH
Publié dans: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020969

Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Auteurs: 12) Serena Zacchigna, Alessia Paldino, Ines Falcao-Pires, Evangelos P. Daskalopoulos,Matteo Dal Ferro, Simone Vodret, Pierluigi Lesizza, Antonio Cannata, Daniela Miranda-Silva, Andre P. Lourenc, Bruno Pinamonti, Gianfranco Sinagra, FlorianWeinberger, Thomas Eschenhagen, Lucie Carrier, Izhak Kehat, Carlo G. Tocchetti, Michele Russo, Alessandra Ghigo, James Cimino, Emilio Hirsch, Dana Dawson, Michel
Publié dans: Cardiovascular Research, 2021, ISSN 0008-6363
Éditeur: Elsevier BV
DOI: 10.1093/cvr/cvaa110

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