CardioReGenix: Development of Next-Generation Gene Therapies for Cardiovascular Disease

Informacje na temat projektu

CardioReGenix

Identyfikator umowy o grant: 825670

DOI

10.3030/825670

Projekt został zamknięty

Data podpisania przez KE 21 Listopada 2018

Data rozpoczęcia 1 Stycznia 2019

Data zakończenia 30 Czerwca 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 14 839 773,50

Wkład UE

€ 14 839 773,50

Koordynowany przez

VRIJE UNIVERSITEIT BRUSSEL
Belgium

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (2)

Project Website

Project website live

Multimedia presentation available

Multimedia presentation about the project for social media release

Publikacje

Peer reviewed articles (50)

Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis

Autorzy: Isidore Mushimiyimana, Henri Niskanen, Mustafa Beter, Johanna P Laakkonen, Minna U Kaikkonen, Seppo Ylä-Herttuala, Nihay Laham-Karam
Opublikowane w: Nucleic Acids Research, Numer 49, 2021, Strona(/y) 8078-8096, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkab633

Antagonism of miRNA in heart failure: first evidence in human

Autorzy: Andrew H. Baker and Mauro Giacca
Opublikowane w: European Heart Journal, 2021, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehaa967

AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes

Autorzy: Laura Rode; Christian Bär; Sonja Groß; Axel Rossi; Nadja Meumann; Janika Viereck; Naisam Abbas; Ke Xiao; Isabelle Riedel; Anika Gietz; Karina Zimmer; Margarete Odenthal; Hildegard Büning; Thomas Thum
Opublikowane w: Crossref, Numer 4, 2023, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2022.07.003

Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular Endothelial Growth Factor Receptor 1 and Is Required for Endothelial Function

Autorzy: Veerle Kremer, Jetta J. Oppelaar, Theresa Gimbel, Susanne Koziarek, Wessel Ganzevoort, Mariëlle G. van Pampus, Bert-Jan van den Born, Liffert Vogt, Christianne de Groot, Reinier A. Boon
Opublikowane w: Reproductive Sciences, Numer 30, 2023, Strona(/y) 678-689, ISSN 1933-7191
Wydawca: SAGE Publications
DOI: 10.1007/s43032-022-01044-4

MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease

Autorzy: João P. Monteiro, Julie Rodor, Axelle Caudrillier, Jessica P. Scanlon, Ana-Mishel Spiroski, Tatiana Dudnakova, Beatrice Pflüger-Müller, Alena Shmakova, Alex von Kriegsheim, Lin Deng, Richard S. Taylor, John R. Wilson-Kanamori, Shiau-Haln Chen, Kevin Stewart, Adrian Thomson, Tijana Mitić, John D. McClure, Jean Iynikkel, Patrick W.F. Hadoke, Laura Denby, Angela C. Bradshaw, Paola Caruso, Nichola
Opublikowane w: Circulation Research, Numer 128, 2024, Strona(/y) 1173-1190, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.318124

Gene editing for cardiomyopathy takes a step forward

Autorzy: Mauro Giacca
Opublikowane w: Cardiovascular Research, Numer 118, 2023, Strona(/y) 3011-3012, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvac164

Fulfilling the Promise of RNA Therapies for Cardiac Repair and Regeneration

Autorzy: Mauro Giacca
Opublikowane w: Stem Cells Translational Medicine, Numer 12, 2023, Strona(/y) 527-535, ISSN 2157-6564
Wydawca: AlphaMed Press
DOI: 10.1093/stcltm/szad038

<i>CARMN</i> Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice

Autorzy: Francesca Vacante, Julie Rodor, Mukesh K. Lalwani, Amira D. Mahmoud, Matthew Bennett, Azzurra L. De Pace, Eileen Miller, Kim Van Kuijk, Jenny de Bruijn, Marion Gijbels, Thomas C. Williams, Michael B. Clark, Jessica P. Scanlon, Amanda C. Doran, Rusty Montgomery, David E. Newby, Mauro Giacca, Dónal O’Carroll, Patrick W.F. Hadoke, Laura Denby, Judith C. Sluimer, Andrew H. Baker
Opublikowane w: Circulation Research, Numer 128, 2024, Strona(/y) 1258-1275, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.318688

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing

Autorzy: Veerle Kremer, Laura Stanicek, Eva van Ingen, Diewertje I. Bink, Sarah Hilderink, Anke J. Tijsen, Ilka Wittig, Lars Mägdefessel, Anne Yaël Nossent, Reinier A. Boon
Opublikowane w: Journal of Cell Science, Numer 135, 2022, ISSN 0021-9533
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/jcs.259671

Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129

Autorzy: Lina Badimon, Emma L Robinson, Amela Jusic, Irina Carpusca, Leon J deWindt, Costanza Emanueli, Péter Ferdinandy, Wei Gu, Mariann Gyöngyösi, Matthias Hackl, Kanita Karaduzovic-Hadziabdic, Mitja Lustrek, Fabio Martelli, Eric Nham, Ines Potočnjak, Venkata Satagopam, Reinhard Schneider, Thomas Thum, Yvan Devaux
Opublikowane w: Cardiovascular Research, Numer 117, 2023, Strona(/y) 1823-1840, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvab094

Persistent <scp>SARS‐CoV</scp>‐2 infection in patients seemingly recovered from <scp>COVID</scp>‐19

Autorzy: Rossana Bussani, Lorena Zentilin, Ricardo Correa, Andrea Colliva, Furio Silvestri, Serena Zacchigna, Chiara Collesi, Mauro Giacca
Opublikowane w: The Journal of Pathology, Numer 259, 2023, Strona(/y) 254-263, ISSN 0022-3417
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/path.6035

RNA interference therapeutics for cardiac regeneration

Autorzy: Josef Huntington, Manendra Pachauri, Hashim Ali and Mauro Giacca
Opublikowane w: Current Opinion in Genetics & Development, 2021, ISSN 1523-3782
Wydawca: Current Science Inc.
DOI: 10.1016/j.gde.2021.05.007

Development and characterization of anti-fibrotic natural compound similars with improved effectivity

Autorzy: Fabian Philipp Kreutzer, Anna Meinecke, Saskia Mitzka, Hannah Jill Hunkler, Lisa Hobuß, Naisam Abbas, Robert Geffers, Jan Weusthoff, Ke Xiao, Danny David Jonigk, Jan Fiedler, Thomas Thum
Opublikowane w: Basic Research in Cardiology, Numer 117, 2023, ISSN 0300-8428
Wydawca: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00395-022-00919-6

Reciprocal organ interactions during heart failure: a position paper from the ESCWorking Group on Myocardial Function

Autorzy: Michele Ciccarelli, Dana Dawson, Ines Falcao-Pires, Mauro Giacca, Nazha Hamdani, Stephane Heymans, Astrid Hooghiemstra, Annebet Leeuwis, Dorien Hermkens, Carlo Gabriele Tocchetti, Jolanda van der Velden, Serena Zacchigna, and Thomas Thum
Opublikowane w: Cardiovascular Research, 2021, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvab009

COVID19 Impairs Cardiac Function via Endothelial H19 and IL6 Signaling

Autorzy: Rio P. Juni, Philippa G. Phelp, Diewertje I. Bink, Veerle Kremer, Anke S. van Bergen, Pedro Espinosa Gonzalez, Karlijn B. Rombouts, Karl J. Harber, Daan A.F. Heister, Kak K. Yeung, Jan Van den Bossche, Diederik W.D. Kuster, null null, Paul A.J. Krijnen, Hans W.M. Niessen, Reinier A. Boon
Opublikowane w: Circulation Research, Numer 132, 2024, Strona(/y) 648-651, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.322166

Gene Therapeutic Strategies for Peripheral Artery Disease and New Opportunities Provided by Adeno-Associated Virus Vectors

Autorzy: Levon M. Khachigian, Ramon L. Varcoe, Tuisku Suoranta, Nihay Laham-Karam, Seppo Ylä-Herttuala
Opublikowane w: Arteriosclerosis, Thrombosis, and Vascular Biology, Numer 43, 2024, Strona(/y) 836-851, ISSN 1079-5642
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.122.318902

Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems

Autorzy: Gaia Spinetti, Martina Mutoli, Simona Greco, Federica Riccio, Soumaya Ben-Aicha, Franziska Kenneweg, Amela Jusic, David de Gonzalo-Calvo, Anne Yaël Nossent, Susana Novella, Georgios Kararigas, Thomas Thum, Costanza Emanueli, Yvan Devaux, Fabio Martelli
Opublikowane w: Cardiovascular Diabetology, Numer 22, 2023, ISSN 1475-2840
Wydawca: BioMed Central
DOI: 10.1186/s12933-023-01842-3

Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library

Autorzy: Giulia Ruozi, Francesca Bortolotti, Antonio Mura, Mateusz Tomczyk, Antonella Falcione, Valentina Martinelli, Simone Vodret, Luca Braga, Matteo Dal Ferro, Antonio Cannatà, Lorena Zentilin, Gianfranco Sinagra, Serena Zacchigna, Mauro Giacca
Opublikowane w: Science Translational Medicine, 2022, ISSN 1946-6234
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abo0699

Gene Therapy for the Heart

Autorzy: Antonio Cannatà, Hashim Ali, Gianfranco Sinagra, Mauro Giacca
Opublikowane w: Circulation Research, 2020, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.315855

The pathological maelstrom of COVID-19 and cardiovascular disease

Autorzy: Mauro Giacca, Ajay M. Shah
Opublikowane w: Nature Cardiovascular Research, Numer 1, 2022, Strona(/y) 200-210, ISSN 2731-0590
Wydawca: Nature
DOI: 10.1038/s44161-022-00029-5

Cardiac Regeneration After Myocardial Infarction: an Approachable Goal

Autorzy: Mauro Giacca
Opublikowane w: Current Cardiology Reports, 2020, ISSN 1523-3782
Wydawca: Current Science Inc.
DOI: 10.1007/s11886-020-01361-7

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective

Autorzy: Laura Santer, Christian Bär, Thomas Thum
Opublikowane w: Molecular Therapy, Numer 27/8, 2019, Strona(/y) 1350-1363, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.ymthe.2019.07.001

Gene transfer to the vascular system: Novel translational perspectives for vascular diseases

Autorzy: A. Remes, D.I. Basha, N. Frey, A.H. Wagner, O.J. Müller
Opublikowane w: Biochemical Pharmacology, Numer 182, 2021, Strona(/y) 114265, ISSN 0006-2952
Wydawca: Elsevier BV
DOI: 10.1016/j.bcp.2020.114265

Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue

Autorzy: Anca Remes; Dima Ibrahim Basha; Thomas Puehler; Christopher Borowski; Susanne Hille; Laura Kummer; Andreas H. Wagner; Markus Hecker; Jasmin Soethoff; Georg Lutter; Derk Frank; Rawa Arif; Norbert Frey; Marcin Zaradzki; Oliver J. Müller
Opublikowane w: Molecular Therapy. Methods & Clinical Development, Numer 1, 2021, ISSN 1525-0016
Wydawca: Nature Publishing Group
DOI: 10.1016/j.omtm.2021.02.017

Omics phenotyping in heart failure: the next frontier

Autorzy: Antoni Bayes-Genis, Peter P Liu, David E Lanfear, Rudolf A de Boer, Arantxa González, Thomas Thum, Michele Emdin, James L Januzzi
Opublikowane w: European Heart Journal, Numer 41, 2022, Strona(/y) 3477-3484, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehaa270

Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function

Autorzy: Tan Phát Pham, Diewertje I. Bink, Laura Stanicek, Anke van Bergen, Esmee van Leeuwen, Yvonne Tran, Ljubica Matic, Ulf Hedin, Ilka Wittig, Stefanie Dimmeler, Reinier A. Boon
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 8, 2022, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/fcell.2020.619079

The LINC00961 transcript and its encoded micropeptide, small regulatory polypeptide of amino acid response, regulate endothelial cell function

Autorzy: Helen L Spencer, Rachel Sanders, Mounia Boulberdaa, Marco Meloni, Amy Cochrane, Ana-Mishel Spiroski, Joanne Mountford, Costanza Emanueli, Andrea Caporali, Mairi Brittan, Julie Rodor, Andrew H Baker
Opublikowane w: Cardiovascular Research, 2020, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvaa008

Small non-coding RNA therapeutics for cardiovascular disease

Autorzy: Ajay M. Shah and Mauro Giacca
Opublikowane w: European Heart Journal, 2022, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehac463

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

Autorzy: Dongchao Lu, Thomas Thum
Opublikowane w: Nature Reviews Cardiology, 2019, ISSN 1759-5002
Wydawca: Nature Publishing Group
DOI: 10.1038/s41569-019-0218-x

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

Autorzy: D. Julia Trembinski, Diewertje I. Bink, Kosta Theodorou, Janina Sommer, Ariane Fischer, Anke van Bergen, Chao-Chung Kuo, Ivan G. Costa, Christoph Schürmann, Matthias S. Leisegang, Ralf P. Brandes, Tijna Alekseeva, Boris Brill, Astrid Wietelmann, Christopher N. Johnson, Alexander Spring-Connell, Manuel Kaulich, Stanislas Werfel, Stefan Engelhardt, Marc N. Hirt, Kaja Yorgan, Thomas Eschenhagen, Lui
Opublikowane w: Nature Communications, Numer 11/1, 2020, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-020-15995-2

Regnase-1 overexpression as a therapeutic approach of Marfan syndrome

Autorzy: Marie Noormalal, Nesrin Schmiedel, Tarik Bozoglu, Andrea Matzen, Susanne Hille, Dima Ibrahim Basha, Prithviraj Manohar Vijaya Shetty, Anja Wolf, Marcin Zaradzki, Rawa Arif, Thomas Pühler, Georg Lutter, Andreas H. Wagner, Christian Kupatt, Derk Frank, Norbert Frey, Anca Remes, Oliver J. Müller
Opublikowane w: Molecular Therapy - Methods &amp; Clinical Development, Numer 32, 2024, Strona(/y) 101163, ISSN 2329-0501
Wydawca: Molecular Therapy
DOI: 10.1016/j.omtm.2023.101163

Regulation of endogenous cardiomyocyte proliferation: The known unknowns

Autorzy: Ilaria Secco, Mauro Giacca
Opublikowane w: Journal of Molecular and Cellular Cardiology, Numer 179, 2023, Strona(/y) 80-89, ISSN 0022-2828
Wydawca: Academic Press
DOI: 10.1016/j.yjmcc.2023.04.001

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

Autorzy: Laura Stanicek, Noelia Lozano-Vidal, Diewertje Ilse Bink, Aukie Hooglugt, Wenjie Yao, Ilka Wittig, Jos van Rijssel, Jaap Diederik van Buul, Anke van Bergen, Alina Klems, Anne Sophie Ramms, Ferdinand Le Noble, Patrick Hofmann, Robert Szulcek, ShengPeng Wang, Stefan Offermanns, Meryem Seda Ercanoglu, Hyouk-Bum Kwon, Didier Stainier, Stephan Huveneers, Leo Kurian, Stefanie Dimmeler, Reinier Abraham B
Opublikowane w: Communications Biology, Numer 3/1, 2020, Strona(/y) 265, ISSN 2399-3642
Wydawca: Europe PMC
DOI: 10.1038/s42003-020-0987-0

Cardiac regeneration and remodelling of the cardiomyocyte cytoarchitecture

Autorzy: Hashim Ali, Luca Braga and Mauro Giacca
Opublikowane w: The FEBS Journal, 2020, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.15146

Alternative strategies in cardiac preclinical research and new clinical trial formats

Autorzy: Fabian Philipp Kreutzer, Anna Meinecke, Kevin Schmidt, Jan Fiedler, Thomas Thum
Opublikowane w: Cardiovascular Research, Numer 118, 2022, Strona(/y) 746-762, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvab075

Non-coding RNA therapeutics for cardiac regeneration

Autorzy: Luca Braga, Hashim Ali, Ilaria Secco, and Mauro Giacca
Opublikowane w: Cardiovascular Research, 2021, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvaa071

RNA- based diagnostic and therapeutic strategies for cardiovascular disease

Autorzy: Dongchao Lu and Thomas Thum
Opublikowane w: Nature Reviews Cardiology, 2019, ISSN 1759-5002
Wydawca: Nature Publishing Group
DOI: 10.1038/s41569-019-0218-x

Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation

Autorzy: Kesidou D, da Costa Martins PA, de Windt LJ, Brittan M, Beqqali A, Baker AH
Opublikowane w: Frontiers in Physiology, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.579892

LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition

Autorzy: Tan Phát Pham, Anke S. van Bergen, Veerle Kremer, Simone F. Glaser, Stefanie Dimmeler, Reinier A. Boon
Opublikowane w: International Journal of Molecular Sciences, Numer 22, 2024, Strona(/y) 8088, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22158088

Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)

Autorzy: Rudolf A. de Boer, Stephane Heymans, Johannes Backs, Lucie Carrier, Andrew J.S. Coats, Stefanie Dimmeler, Thomas Eschenhagen, Gerasimos Filippatos, Lior Gepstein, Jean‐Sebastien Hulot, Ralph Knöll, Christian Kupatt, Wolfgang A. Linke, Christine E. Seidman, C. Gabriele Tocchetti, Jolanda van der Velden, Roddy Walsh, Petar M. Seferovic, Thomas Thum
Opublikowane w: European Journal of Heart Failure, Numer 24, 2023, Strona(/y) 406-420, ISSN 1388-9842
Wydawca: Elsevier BV
DOI: 10.1002/ejhf.2414

Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression

Autorzy: Noelia Lozano-Vidal, Laura Stanicek, Diewertje I. Bink, Rio P. Juni, Aukie Hooglugt, Veerle Kremer, Philippa Phelp, Anke van Bergen, Alyson W. MacInnes, Stefanie Dimmeler, Reinier A. Boon
Opublikowane w: Communications Biology, Numer 7, 2024, ISSN 2399-3642
Wydawca: Communications Biology
DOI: 10.1038/s42003-024-06230-5

AAV2-VEGF-B gene therapy failed to induce angiogenesis in ischemic porcine myocardium due to inflammatory responses

Autorzy: Henna Korpela, Jaakko Lampela, Jonna Airaksinen, Niko Järveläinen, Satu Siimes, Kaisa Valli, Tiina Nieminen, Minttu Turunen, Maria Grönman, Antti Saraste, Juhani Knuuti, Mikko Hakulinen, Pekka Poutiainen, Vesa Kärjä, Jussi Nurro and Seppo Ylä-Herttuala
Opublikowane w: Gene Therapy, 2022, ISSN 0969-7128
Wydawca: Nature Publishing Group
DOI: 10.1038/s41434-022-00322-9

Human AdV-20-42-42, a Promising Novel Adenoviral Vector for Gene Therapy and Vaccine Product Development

Autorzy: Mónika Z Ballmann 1 , Svjetlana Raus 2 , Ruben Engelhart 1 2 , Győző L Kaján 3 , Abdelaziz Beqqali 2 , Patrick W F Hadoke 2 , Chantal van der Zalm 1 , Tibor Papp 4 , Lijo John 3 , Selina Khan 4 , Satish Boedhoe 4 , Katarina Danskog 3 , Lars Frängsmyr 3 , Jerome Custers 4 , Wilfried A M Bakker 1 , Hilde M van der Schaar 1 , Niklas Arnberg 3 , Angelique A C Lemckert 1 , Menz
Opublikowane w: Journal of Virology, Numer Oct 27;95(22):e0038721, 2021, ISSN 0022-538X
Wydawca: American Society for Microbiology
DOI: 10.1128/jvi.00387-21

Cell-Specific Targeting of the Endothelium in the CardioRenal Syndrome

Autorzy: Nihay Laham-Karam, Johanna P. Laakkonen, Seppo Yla-Herttuala, Annayya Aroor, Guanghong Jia, Adam Whaley-Connell
Opublikowane w: Cardiorenal Medicine, 2024, ISSN 1664-3828
Wydawca: S. Karger AG
DOI: 10.1159/000537764

MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium

Autorzy: Veerle Kremer, Diewertje I. Bink, Laura Stanicek, Eva van Ingen, Theresa Gimbel, Sarah Hilderink, Stefan Günther, Anne Yaël Nossent, Reinier A. Boon
Opublikowane w: Scientific Reports, Numer 12, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-04812-z

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease.

Autorzy: Cheng-Kai Huang; Sabine Kafert-Kasting; Thomas Thum
Opublikowane w: Circulation Research, Numer 2, 2020, ISSN 0009-7330
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315856

The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction

Autorzy: Spiroski AM, Sanders R, Meloni M, McCracken IR, Thomson A, Brittan M, Gray GA, Baker AH
Opublikowane w: International Journal of Molecular Sciences, 2021, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020969

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells

Autorzy: Rahul Mallick, Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen, Seppo Ylä-Herttuala
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 10, 2022, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.907538

Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Autorzy: 12) Serena Zacchigna, Alessia Paldino, Ines Falcao-Pires, Evangelos P. Daskalopoulos,Matteo Dal Ferro, Simone Vodret, Pierluigi Lesizza, Antonio Cannata, Daniela Miranda-Silva, Andre P. Lourenc, Bruno Pinamonti, Gianfranco Sinagra, FlorianWeinberger, Thomas Eschenhagen, Lucie Carrier, Izhak Kehat, Carlo G. Tocchetti, Michele Russo, Alessandra Ghigo, James Cimino, Emilio Hirsch, Dana Dawson, Michel
Opublikowane w: Cardiovascular Research, 2021, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvaa110

Targeting muscle-enriched long non-coding RNA <i>H19</i> reverses pathological cardiac hypertrophy

Autorzy: Janika Viereck, Anne Bührke, Ariana Foinquinos, Shambhabi Chatterjee, Jan A Kleeberger, Ke Xiao, Heike Janssen-Peters, Sandor Batkai, Deepak Ramanujam, Theresia Kraft, Serghei Cebotari, Faikah Gueler, Andreas M Beyer, Jessica Schmitz, Jan H Bräsen, Jan D Schmitto, Mariann Gyöngyösi, Alexandra Löser, Marc N Hirt, Thomas Eschenhagen, Stefan Engelhardt, Christian Bär, Thomas Thum
Opublikowane w: European Heart Journal, Numer 41, 2022, Strona(/y) 3462-3474, ISSN 0195-668X
Wydawca: Oxford University Press
DOI: 10.1093/eurheartj/ehaa519

Prawa własności intelektualnej

Patent (2)

TREATMENT

Numer wniosku/publikacji: 20 23052170
Data: 2023-08-18
Wnioskodawca/wnioskodawcy: THE UNIVERSITY OF EDINBURGH

ADENOVIRUS VECTORS AND USES THEREOF

Numer wniosku/publikacji: 20 786618
Data: 2020-10-02
Wnioskodawca/wnioskodawcy: BATAVIA BIOSCIENCES BV