Descripción del proyecto
Ensayos con vertebrados inferiores para probar el efecto de sustancias químicas sobre la salud humana
Muchos de los productos químicos que utilizamos hoy en día pueden tener un impacto negativo sobre el medio ambiente y la salud humana, y posiblemente interrumpir nuestro sistema endocrino. Para mejorar la identificación y caracterización de los alteradores endocrinos, es necesario desarrollar herramientas de cribaje innovadoras. Los científicos del proyecto ERGO, financiado con fondos europeos, proponen aplicar un enfoque integrado destinado a extrapolar los efectos de los alteradores endocrinos a diferentes clases de vertebrados. Esto significa que, si una sustancia química tiene efectos adversos para los peces, puede ser también peligrosa para los humanos. El enfoque de ERGO prevé procedimientos más rápidos, seguros y sencillos para evaluar los peligros y riesgos.
Objetivo
ERGO presents a new approach that will support a paradigm shift in the regulatory use of standardized test guidelines (TGs) by breaking the existing wall between mammalian and non-mammalian vertebrate testing and assessment of endocrine disrupting chemicals (EDCs). The highly conserved thyroid system will be used as the “proof of concept”, but also other conserved endocrine axes/systems such as the Retinoid X Receptor (RXR) and the Hypothalamus Pituitary Gonadal (HPG) axis can be adapted to the cross-vertebrate class approach. ERGO will investigate a battery of draft in vitro assays and evaluate thyroid-responsive biomarkers and endpoints (B/E) suitable for extrapolation of effects from fish and amphibian tests to humans and other mammals (and vice versa) and finally validate successful B/E for inclusion in existing in vivo or new in vitro OECD TGs. A cross-class adverse outcome pathway (AOP) network will provide the scientifically plausible and evidence-based foundation for the selection of B/E in lower vertebrate assays predictive of human health outcomes. In silico modeling and biotransformation data will support cross-vertebrate class effect extrapolation. Major outcomes of ERGO will be: 1) New thyroid-related B/E for inclusion in OECD TGs for improved identification of TDC. 2) An Integrated Approach to Testing and Assessment (IATA) of chemicals for TD based on a multi-class vertebrate AOP network connecting endocrine mechanisms in one vertebrate class to adverse outcomes in another class for safer regulation of EDCs. 3) A tool for TG end users, such as regulators and industry, to extrapolate thyroid effects between vertebrate classes. Implementation of the ERGO IATA strategy in regulations of EDC will make hazard and risk assessment faster, cheaper, simpler and safer and support industry in the development of EDC-free products beneficial for environmental and human safety.
Ámbito científico
Palabras clave
Programa(s)
Tema(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SC1-2018-Single-Stage-RTD
Régimen de financiación
RIA - Research and Innovation actionCoordinador
5230 Odense M
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