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Induced pluripotent stem cell-based therapy for spinal regeneration

Objective

Low back pain (LBP) is a leading cause of disability and morbidity worldwide. It is widely accepted that a major contributor to LBP is intervertebral disc degeneration (IDD). IDD account for at least 40% (~280 million) of all LBP cases, leading to an EU-economic burden of ~€240 billion. These patients receive conservative treatment (e.g. pain relief medication and physiotherapy). When the latter is unsatisfactory, the only option left are invasive and costly surgical intervention. To date, no treatments halt or reverse IDD. Despite the profound socioeconomic burden and impact of IDD, decreasing the quality of life of millions of people, a game-changing treatment strategy for IDD-induced LBP is almost non-existent. The iPSpine consortium was formed to initiate a European-led research effort to identify a future advanced therapeutic strategy that results into a radical new treatment of IDD-induced LBP. With their multi-disciplinary expertise in the development of advanced therapies and their translation from bench to bedside, the aim of the iPSpine team is to investigate and develop a new advanced therapy medicinal product (ATMP) of the future, based on a novel developmental biology-based therapeutic strategy employing pluripotent stem cells (iPSC) and smart biomaterials. The iPSpine consortium will develop and demonstrate Proof-of-concept with the aid of novel and extended knowledge, tools and technology platforms. Hereby, iPSpine has the ambition to make a significant contribution by reducing translational bottlenecks through open innovation and take European leadership in the development of ATMPs. The iPSpine impact: iPSpine seeks to offer novel technologies and ATMPs for the advanced therapy research and development community. IDD will be the showcase, offering improved quality of life for millions of patients with IDD-induced LBP, through long-lasting reduction of LBP, reduced LBP-related premature retirement, and improved socio-economic contribution.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/clinical medicine/physiotherapy
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITEIT UTRECHT
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 303 164,75

Participants (20)

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 1 306 771,25
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE NANTES
France
EU contribution
€ 1 250 312,50
Address
Quai De Tourville 1
44035 Nantes Cedex 1
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 708 710
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 671 935
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 501 583,75
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET BERN
Switzerland
EU contribution
€ 419 000
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 826 617,50
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 867 156,25
Address
Markwiesenstrasse 55
72770 Reutlingen
Activity type
Research Organisations
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
EU contribution
€ 491 250
Address
Clavadelerstrasse 8
7270 Davos Platz
Activity type
Research Organisations
SHEFFIELD HALLAM UNIVERSITY
United Kingdom
EU contribution
€ 1 126 572,50
Address
Howard Street City Campus
S1 1WB Sheffield
Activity type
Higher or Secondary Education Establishments
UNIVERSITA CAMPUS BIO MEDICO DI ROMA
Italy
EU contribution
€ 557 975
Address
Via Alvaro Del Portillo 21
00128 Roma
Activity type
Higher or Secondary Education Establishments
NTRANS TECHNOLOGIES BV
Netherlands
EU contribution
€ 770 625
Address
Uppsalalaan 8
3584 CT Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE DE MONTPELLIER
France
EU contribution
€ 364 903,75
Address
163 Rue Auguste Broussonnet
34090 Montpellier
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF MIAMI
United States
EU contribution
€ 250 175
Address
1320 South Dixie Highway, Suite 1200
33146 Coral Gables Miami
Activity type
Higher or Secondary Education Establishments
SPINESERV GMBH & CO.KG
Germany
EU contribution
€ 321 250
Address
Soeflinger Strasse 100
89077 Ulm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY OF HONG KONG
Hong Kong
EU contribution
€ 0
Address
Pokfulam Road
Pokfulam
Activity type
Higher or Secondary Education Establishments
PHARMALEX GMBH
Germany
EU contribution
€ 676 381,25
Address
Bahnstrasse 42-46
61381 Friedrichsdorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Catalyze B.V.
Netherlands
EU contribution
€ 251 250
Address
Joop-geesinkweg 167
1114 AB Amsterdam-duivendrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING NATIONAAL REUMAFONDS
Netherlands
EU contribution
€ 75 000
Address
Dr J Van Breemenstraat 4
1056 AB Amsterdam
Activity type
Other
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 219 147,75
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments