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Induced pluripotent stem cell-based therapy for spinal regeneration

Deliverables

Set up of Patient Advisory Board

Set up of Patient Advisory Board

Guidelines and requirements for pre-in vivo evaluation of IVD advanced therapeutics

Guidelines and requirements for prein vivo evaluation of IVD advanced therapeutics

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Publications

Spheroid-Like Cultures for Expanding Angiopoietin Receptor-1 (aka. Tie2) Positive Cells from the Human Intervertebral Disc

Author(s): Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Published in: International Journal of Molecular Sciences, 21/24, 2020, Page(s) 9423, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249423

A perspective on the ORS Spine Section initiative to develop a multi-species JOR Spine histopathology series

Author(s): Dahia, Chitra L.; Engiles, Julie B.; Gullbrand, Sarah E.; Iatridis, James C.; Lai, Alon; Le Maitre, Christine L.; Lotz, Jeffrey C.; Masuda, Koichi; Séguin, Cheryle A.; Tryfonidou, Marianna A.
Published in: JOR Spine, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1165

Cell sources proposed for nucleus pulposus regeneration

Author(s): Williams, Rebecca J.; Tryfonidou, Marianna A.; Snuggs, Joseph William; Le Maitre, Christine Lyn
Published in: JOR Spine, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1175

The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?

Author(s): Guerrero, J.; Häckel, S.; Croft, A.S.; Hoppe, S.; Albers, C.E.; Gantenbein, B.
Published in: eCM (Eur Cell Mater / e Cells & Materials), 41, 2021, Page(s) 707-738, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v041a46

PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modelling

Author(s): Kudelko, Mateusz; Chen, Peikai; Tam, Vivian; Zhang, Ying; Kong, Oi-Yin; Sharma, Rakesh; Au, Tiffany Y.K.; To, Michael Kai-Tsun; Cheah, Kathryn S.E.; Chan, Wilson C.W.; Chan, Danny
Published in: Matrix Biology Plus, 2021, ISSN 2590-0285
Publisher: Elsevier
DOI: 10.1016/j.mbplus.2021.100082

One-pot precipitation polymerisation strategy for tuneable injectable Laponite®-pNIPAM hydrogels: Polymerisation, processability and beyond

Author(s): Victoria L.Boyes, RonakJanani, SimonPartridge, Lee A.Fielding, Christopher Breen, Jonathan Foulkes, Christine L.Le Maitre, Chris Sammon
Published in: Polymer, 233, 2021, ISSN 0032-3861
Publisher: Elsevier BV
DOI: 10.1016/j.polymer.2021.124201

Non-viral Gene Delivery Methods for Bone and Joints

Author(s): Gantenbein, Benjamin; Tang, Shirley; Guerrero, Julien; Higuita-Castro, Natalia; Salazar-Puerta, Ana I.; Croft, Andreas S.; Gazdhar, Amiq; Purmessur, Devina
Published in: Frontiers in Bioengineering and Biotechnology, 1, 2020, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.598466

The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency

Author(s): Guerrero, Julien; Häckel, Sonja; Croft, Andreas S.; Albers, Christoph E.; Gantenbein, Benjamin
Published in: JOR Spine, 1, 2020, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1131

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Author(s): Kieran Joyce, Georgina Targa Fabra, Yagmur Bozkurt & Abhay Pandit
Published in: Signal Transduction and Targeted Therapy, 6, 2021, ISSN 2059-3635
Publisher: Springer Nature
DOI: 10.1038/s41392-021-00512-8

A comprehensive tool box for large animal studies of intervertebral disc degeneration

Author(s): Lee, Naomi N.; Salzer, Elias; Bach, Frances C.; Bonilla, Andres F.; Cook, James L.; Gazit, Zulma; Grad, Sybille; Ito, Keita; Smith, Lachlan J.; Vernengo, Andrea; Wilke, Hans-Joachim; Engiles, Julie B.; Tryfonidou, Marianna A.
Published in: JOR Spine, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1162

Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration

Author(s): Tilotta, Veronica; Vadala, Gianluca; Ambrosio, Luca; Russo, Fabrizio; Cicione, Claudia; Di Giacomo, Giuseppina; Papalia, Rocco; Denaro, Vincenzo
Published in: Applied Sciences, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app112311222

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

Author(s): Benjamin Gantenbein
Published in: Applied Sciences, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app112411913

Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential

Author(s): Andreas S. Croft, Julien Guerrero, Katharina A. C. Oswald, Sonja Häckel, Christoph E. Albers, Benjamin Gantenbein
Published in: JOR SPINE, 2021, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1140

Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods

Author(s): Daniela A. Frauchiger, Adel Tekari, Rahel D. May, Emina Džafo, Samantha C.W. Chan, Jivko Stoyanov, Alessandro Bertolo, Xingshuo Zhang, Julien Guerrero, Daisuke Sakai, Jordy Schol, Sibylle Grad, Marianna Tryfonidou, Lorin M. Benneker, Benjamin Gantenbein
Published in: Tissue Engineering Part C: Methods, 25/10, 2019, Page(s) 571-580, ISSN 1937-3384
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0375

Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification

Author(s): Frances C. Bach, Kim M. Rooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. Jong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou
Published in: JOR SPINE, 2/4, 2019, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1071

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues

Author(s): Abbie Binch, Joseph Snuggs, Christine L. Le Maitre
Published in: JOR SPINE, 2020, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1098

NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate

Author(s): Pauline Colombier, Boris Halgand, Claire Chédeville, Caroline Chariau, Valentin François-Campion, Stéphanie Kilens, Nicolas Vedrenne, Johann Clouet, Laurent David, Jérôme Guicheux, Anne Camus
Published in: Cells, 9/2, 2020, Page(s) 509, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9020509

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

Author(s): Tam, Vivian; Chen, Peikai; Yee, Anita; Solis, Nestor; Klein, Theo; Kudelko, Mateusz; Sharma, Rakesh; Chan, Wilson CW; Overall, Christopher M; Haglund, Lisbet; Sham, Pak C; Cheah, Kathryn Song Eng; Chan, Danny
Published in: eLife, 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.64940

A bovine nucleus pulposus explant culture model

Author(s): Salzer, Elias; Mouser, Vivian H.M.; Tryfonidou, Marianna A.; Ito, Keita
Published in: Journal of Orthopaedic Research, 2021, ISSN 1554-527X
Publisher: Wiley-Blackwell
DOI: 10.1002/jor.25226

Simple, fast and efficient iTOP-mediated delivery of CRISPR/Cas9 RNP in difficult-to-transduce human cells including primary T cells

Author(s): Waleed M Kholosy, Marieke Visscher, Kim Ogink, Helen Buttstedt, Kelli Griffin, Axel Beier, Jan Patrick Gerlach, Jan J Molenaar, Niels Geijsen, Marco de Boer, Anna Chatsisvili
Published in: Journal of Biotechnology, 338, 2021, Page(s) 71-80, ISSN 0168-1656
Publisher: Elsevier BV
DOI: 10.1016/j.jbiotec.2021.07.006

Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs

Author(s): Tara C. Schmitz, Elias Salzer, João F. Crispim, Georgina Targa Fabra, Catherine LeVisage, Abhay Pandit, Marianna Tryfonidou, Christine Le Maitre, Keita Ito
Published in: Acta Biomaterialia, 114, 2020, Page(s) 1-15, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.08.001

Influence of Angiopoietin Treatment with Hypoxia and Normoxia on Human Intervertebral Disc Progenitor Cell's Proliferation, Metabolic Activity, and Phenotype

Author(s): Bischof, Muriel C.; Häckel, Sonja; Oberli, Andrea; Croft, Andreas S.; Oswald, Katharina A.C.; Albers, Christoph E.; Gantenbein, Benjamin; Guerrero, Julien
Published in: Applied Sciences, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11157144

Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative

Author(s): Le Maitre, Christine C.; Dahia, Chitra L.; Giers, Morgan; Illien-Junger, Svenja; Cicione, Claudia; Samartzis, Dino; Vadala, Gianluca; Fields, Aaron; Lotz, Jeffrey
Published in: JOR Spine, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1167

Recognizing the ethical implications of stem cell research: A call for broadening the scope

Author(s): Assen, L.S.; Jongsma, K.R.; Isasi, R.; Tryfonidou, M.A.; Bredenoord, A.L.
Published in: Stem Cell Reports, 16, 2021, Page(s) 1656-1661, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2021.05.021

Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion

Author(s): Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Katharina A.C. Oswald, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Published in: Surgeries, 2/1, 2021, Page(s) 92-104, ISSN 2673-4095
Publisher: MDPI
DOI: 10.3390/surgeries2010008

BPM Support for Regulatory Compliance in ATMP Development Processes

Author(s): Ozturk Yurt, Zeynep
Published in: CEUR Workshop Proceedings, 2973, 2021
Publisher: CEUR-WS

Context-Aware Process Modelling for Medicinal Product Development

Author(s): Zeynep Ozturk Yurt, Rik Eshuis, Anna Wilbik, Irene Vanderfeesten
Published in: PoEM 2021: The Practice of Enterprise Modeling, 2021, Page(s) 168-183
Publisher: Springer