Induced pluripotent stem cell-based therapy for spinal regeneration

Spheroid-Like Cultures for Expanding Angiopoietin Receptor-1 (aka. Tie2) Positive Cells from the Human Intervertebral Disc

Author(s): Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Published in: International Journal of Molecular Sciences, Issue 21/24, 2020, Page(s) 9423, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21249423

Roles and responsibilities in stem cell research: a focus group study with stem cell researchers and patients

Author(s): Lars S Assen, Karin R Jongsma, Rosario Isasi, Marianna A Tryfonidou & Annelien L Bredenoord
Published in: Regenerative Medicine, 2022, ISSN 2613-5914
Publisher: Future Medicine
DOI: 10.2217/rme-2022-0019

Harmonization and standardization of nucleus pulposus cell extraction and culture methods

Author(s): Shaghayegh Basatvat, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Jennifer Gansau, Benjamin Gantenbein, Rahul Gawri, Juliane D. Glaeser, Sibylle Grad, Julien Guerrero, Lisbet Haglund, Paula A. Hernandez, Judith A. Hoyland, Charles Huang, James C. Iatridis, Sve
Published in: JOR Spine, 2023, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1238

Detergent-Free Decellularization of Notochordal Cell-Derived Matrix Yields a Regenerative, Injectable, and Swellable Biomaterial

Author(s): Tara C. Schmitz; Marina van Doeselaar; Marianna A. Tryfonidou; Keita Ito
Published in: Tissue Engineering and Regenerative Medicine, Issue 10, 2022, ISSN 1932-7005
Publisher: ACS Publications
DOI: 10.1021/acsbiomaterials.2c00790

Cell sources proposed for nucleus pulposus regeneration

Author(s): Williams, Rebecca J.; Tryfonidou, Marianna A.; Snuggs, Joseph William; Le Maitre, Christine Lyn
Published in: JOR Spine, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1175

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration

Author(s): Frances C Bach 1, Deepani W Poramba-Liyanage 1, Frank M Riemers 1, Jerome Guicheux 2 3 4, Anne Camus 2, James C Iatridis 5, Danny Chan 6, Keita Ito 7 8, Christine L Le Maitre 9, Marianna A Tryfonidou 1
Published in: Front Cell Dev Biol, 2021, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2021.780749

The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?

Author(s): Guerrero, J.; Häckel, S.; Croft, A.S.; Hoppe, S.; Albers, C.E.; Gantenbein, B.
Published in: eCM (Eur Cell Mater / e Cells & Materials), Issue 41, 2021, Page(s) 707-738, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v041a46

EX VIVO INTERVERTEBRAL DISC CULTURES:DEGENERATION-INDUCTION METHODS AND THEIRIMPLICATIONS FOR CLINICAL TRANSLATION

Author(s): E Salzer1 , T.C. Schmitz1 , V.H.M. Mouser1 , A. Vernengo2 , B. Gantenbein3,4, J.U. Jansen5 , C. Neidlinger-Wilke5 , H-J. Wilke5 , S. Grad2 , C.L. Le Maitre6 , M.A. Tryfonidou7 and K. Ito1 *
Published in: European Cells and Materials, 2023, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v045a07

One-pot precipitation polymerisation strategy for tuneable injectable Laponite®-pNIPAM hydrogels: Polymerisation, processability and beyond

Author(s): Victoria L.Boyes, RonakJanani, SimonPartridge, Lee A.Fielding, Christopher Breen, Jonathan Foulkes, Christine L.Le Maitre, Chris Sammon
Published in: Polymer, Issue 233, 2021, ISSN 0032-3861
Publisher: Elsevier BV
DOI: 10.1016/j.polymer.2021.124201

An insight on the N-glycome of notochordal cell-rich porcine nucleus pulposus during maturation

Author(s): Büşra Günay, Elizabeth Matthews, Jack Morgan, Marianna A. Tryfonidou, Radka Saldova, Abhay Pandit
Published in: FASEB BioAdvances, 2023, ISSN 2573-9832
Publisher: FASEB
DOI: 10.1096/fba.2023-00011

Non-viral Gene Delivery Methods for Bone and Joints

Author(s): Gantenbein, Benjamin; Tang, Shirley; Guerrero, Julien; Higuita-Castro, Natalia; Salazar-Puerta, Ana I.; Croft, Andreas S.; Gazdhar, Amiq; Purmessur, Devina
Published in: Frontiers in Bioengineering and Biotechnology, Issue 1, 2020, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.598466

Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes

Author(s): Martijn Beukers, Guy C. M. Grinwis, Johannes C. M. Vernooij, Lisanne van der Hoek, Anna R. Tellegen, Björn P. Meij, Stefanie Veraa, Dino Samartzis, Marianna A. Tryfonidou, Frances C. Bach
Published in: JOR Spine, 2023, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1273

The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency

Author(s): Guerrero, Julien; Häckel, Sonja; Croft, Andreas S.; Albers, Christoph E.; Gantenbein, Benjamin
Published in: JOR Spine, Issue 1, 2020, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1131

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Author(s): Kieran Joyce, Georgina Targa Fabra, Yagmur Bozkurt & Abhay Pandit
Published in: Signal Transduction and Targeted Therapy, Issue 6, 2021, ISSN 2059-3635
Publisher: Springer Nature
DOI: 10.1038/s41392-021-00512-8

A comprehensive tool box for large animal studies of intervertebral disc degeneration

Author(s): Lee, Naomi N.; Salzer, Elias; Bach, Frances C.; Bonilla, Andres F.; Cook, James L.; Gazit, Zulma; Grad, Sybille; Ito, Keita; Smith, Lachlan J.; Vernengo, Andrea; Wilke, Hans-Joachim; Engiles, Julie B.; Tryfonidou, Marianna A.
Published in: JOR Spine, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1162

Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration

Author(s): Tilotta, Veronica; Vadala, Gianluca; Ambrosio, Luca; Russo, Fabrizio; Cicione, Claudia; Di Giacomo, Giuseppina; Papalia, Rocco; Denaro, Vincenzo
Published in: Applied Sciences, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app112311222

New Frontiers towards Regeneration of the Intervertebral Disc: On Progenitor Cells, Growth Factors and Biomaterials

Author(s): Benjamin Gantenbein
Published in: Applied Sciences, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app112411913

Effect of different cryopreservation media on human nucleus pulposus cells' viability and trilineage potential

Author(s): Andreas S. Croft, Julien Guerrero, Katharina A. C. Oswald, Sonja Häckel, Christoph E. Albers, Benjamin Gantenbein
Published in: JOR SPINE, 2021, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1140

A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series

Author(s): Chitra Lekha Dahia; Chitra Lekha Dahia; Julie B. Engiles; Sarah E. Gullbrand; Sarah E. Gullbrand; James C. Iatridis; Alon Lai; Christine L. Le Maitre; Jeffrey C. Lotz; Koichi Masuda; Cheryle A. Séguin; Marianna A. Tryfonidou
Published in: JOR Spine, Issue 1, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1165

Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization

Author(s): Rebecca J. Williams, Lisanne T. Laagland, Frances C. Bach, Lizzy Ward, Wilson Chan, Vivian Tam, Adel Medzikovic, Shaghayegh Basatvat, Lily Paillat, Nicolas Vedrenne, Joseph W. Snuggs, Deepani W. Poramba-Liyanage, Judith A. Hoyland, Danny Chan, Anne Camus, Stephen M. Richardson, Marianna A. Tryfonidou, Christine L. Le Maitre
Published in: JOR Spine, 2023, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1272

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

Author(s): Laagland, Lisanne T; Bach, Frances C; Creemers, Laura B; Le Maitre, Christine L; Poramba-Liyanage, Deepani W; Tryfonidou, Marianna A; Chirurgie; CS_Locomotion
Published in: JOR Spine, Issue 10, 2022, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1219

Issues with Tissues: Trends in Tissue-Engineered Products in Clinical Trials in the European Union

Author(s): Kieran Joyce, Zaklina Buljovcic, Goran Rosic, Marietta Kaszkin-Bettag, and Abhay Pandit
Published in: Tissue Engineering Part B, 2023, ISSN 2152-4955
Publisher: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.teb.2022.0094

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

Author(s): Vivian Tam Peikai Chen Danny Chan
Published in: eLife, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.64940

Using responsibility as a strategy

Author(s): Assen, LS; Jongsma, KR; Isasi, R; Utomo, L; Tryfonidou, MA; Bredenoord, AL; Chirurgie; CS_Locomotion
Published in: Regenerative Medicine, 18(3). Future Medicine Ltd., Issue 7, 2023, ISSN 2613-5914
Publisher: Future Medicine
DOI: 10.2217/rme-2022-0187

Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods

Author(s): Daniela A. Frauchiger, Adel Tekari, Rahel D. May, Emina Džafo, Samantha C.W. Chan, Jivko Stoyanov, Alessandro Bertolo, Xingshuo Zhang, Julien Guerrero, Daisuke Sakai, Jordy Schol, Sibylle Grad, Marianna Tryfonidou, Lorin M. Benneker, Benjamin Gantenbein
Published in: Tissue Engineering Part C: Methods, Issue 25/10, 2019, Page(s) 571-580, ISSN 1937-3384
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2018.0375

Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification

Author(s): Frances C. Bach, Kim M. Rooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. Jong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou
Published in: JOR SPINE, Issue 2/4, 2019, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1071

Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues

Author(s): Abbie Binch, Joseph Snuggs, Christine L. Le Maitre
Published in: JOR SPINE, 2020, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1098

NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate

Author(s): Pauline Colombier, Boris Halgand, Claire Chédeville, Caroline Chariau, Valentin François-Campion, Stéphanie Kilens, Nicolas Vedrenne, Johann Clouet, Laurent David, Jérôme Guicheux, Anne Camus
Published in: Cells, Issue 9/2, 2020, Page(s) 509, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9020509

Moral imagination as an instrument for ethics education for biomedical researchers

Author(s): Elianne M. Gerrits, Lars S. Assen, Liesbeth Noordegraaf-Eelens, Annelien L. Bredenoord & Marc H. W. van Mil
Published in: International Journal of Ethics Education, 2023, ISSN 2364-0006
Publisher: Springer
DOI: 10.1007/s40889-023-00171-z

A Combined Western and Bead-Based Multiplex Platform to Characterize Extracellular Vesicles

Author(s): Josette C. van Maanen, Frances C. Bach, Theresa S. Braun, Alberta Giovanazzi, Bas W.M. van Balkom, Markus Templin, Marca H.M. Wauben, and Marianna A. Tryfonidou
Published in: Tissue Engineer Part C, 2023, ISSN 2152-4955
Publisher: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.tec.2023.0056

A bovine nucleus pulposus explant culture model

Author(s): Salzer, Elias; Mouser, Vivian H.M.; Tryfonidou, Marianna A.; Ito, Keita
Published in: Journal of Orthopaedic Research, 2021, ISSN 1554-527X
Publisher: Wiley-Blackwell
DOI: 10.1002/jor.25226

Context-aware modeling for knowledge-intensive medicinal product development processes

Author(s): Zeynep Ozturk Yurt, Rik Eshuis, Anna Wilbik & Irene Vanderfeesten
Published in: Software and Systems Modeling, 2023, ISSN 1619-1374
Publisher: Springer Link
DOI: 10.1007/s10270-022-01070-5

Simple, fast and efficient iTOP-mediated delivery of CRISPR/Cas9 RNP in difficult-to-transduce human cells including primary T cells

Author(s): Waleed M Kholosy, Marieke Visscher, Kim Ogink, Helen Buttstedt, Kelli Griffin, Axel Beier, Jan Patrick Gerlach, Jan J Molenaar, Niels Geijsen, Marco de Boer, Anna Chatsisvili
Published in: Journal of Biotechnology, Issue 338, 2021, Page(s) 71-80, ISSN 0168-1656
Publisher: Elsevier BV
DOI: 10.1016/j.jbiotec.2021.07.006

Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs

Author(s): Tara C. Schmitz, Elias Salzer, João F. Crispim, Georgina Targa Fabra, Catherine LeVisage, Abhay Pandit, Marianna Tryfonidou, Christine Le Maitre, Keita Ito
Published in: Acta Biomaterialia, Issue 114, 2020, Page(s) 1-15, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2020.08.001

Influence of Angiopoietin Treatment with Hypoxia and Normoxia on Human Intervertebral Disc Progenitor Cell's Proliferation, Metabolic Activity, and Phenotype

Author(s): Bischof, Muriel C.; Häckel, Sonja; Oberli, Andrea; Croft, Andreas S.; Oswald, Katharina A.C.; Albers, Christoph E.; Gantenbein, Benjamin; Guerrero, Julien
Published in: Applied Sciences, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11157144

Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative

Author(s): Le Maitre, Christine C.; Dahia, Chitra L.; Giers, Morgan; Illien-Junger, Svenja; Cicione, Claudia; Samartzis, Dino; Vadala, Gianluca; Fields, Aaron; Lotz, Jeffrey
Published in: JOR Spine, 2021, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1167

Recognizing the ethical implications of stem cell research: A call for broadening the scope

Author(s): Assen, L.S.; Jongsma, K.R.; Isasi, R.; Tryfonidou, M.A.; Bredenoord, A.L.
Published in: Stem Cell Reports, Issue 16, 2021, Page(s) 1656-1661, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2021.05.021

Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue

Author(s): Elias Salzer; Vivian H. M. Mouser; Jurgen A. Bulsink; Marianna A. Tryfonidou; Keita Ito
Published in: JOR Spine, Issue 5, 2023, ISSN 2572-1143
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1002/jsp2.1240

Towards Tissue-Specific Stem Cell Therapy for the Intervertebral Disc: PPARδ Agonist Increases the Yield of Human Nucleus Pulposus Progenitor Cells in Expansion

Author(s): Xingshuo Zhang, Julien Guerrero, Andreas S. Croft, Katharina A.C. Oswald, Christoph E. Albers, Sonja Häckel, Benjamin Gantenbein
Published in: Surgeries, Issue 2/1, 2021, Page(s) 92-104, ISSN 2673-4095
Publisher: MDPI
DOI: 10.3390/surgeries2010008

Intervertebral Disc Regeneration II

Author(s): Benjamin Gantenbein
Published in: 2023
Publisher: MDPI
DOI: 10.3390/books978-3-0365-8199-6

Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects

Author(s): Bram Zoetebier; Tara C Schmitz; Keita Ito; Marcel Karperien; Marianna A Tryfonidou; Julieta Paez
Published in: Tissue Engineering, Issue 16, 2022, ISSN 2152-4955
Publisher: Mary Ann Liebert Incorporated Publishers
DOI: 10.1089/ten.tea.2021.0226

BPM Support for Regulatory Compliance in ATMP Development Processes

Author(s): Ozturk Yurt, Zeynep
Published in: CEUR Workshop Proceedings, Issue 2973, 2021
Publisher: CEUR-WS

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