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Personalized Recommendations for Neurodegenerative Disease

Objective

The annual worldwide cost of Alzheimer’s dementia was 777.81 billion Euro in 2015. This number will rise to 7.41 trillion Euro in 2050. Early diagnosis would save up to $7.9 trillion in medical and care costs by 2050 in the US alone. However, the emergent pathology is highly variable across people, necehighly variable across people, necessitating individualized diagnostics and interventions. The VirtualBrainCloud addresses this by bridging the gap between computational neuroscience and subcellular systems biology, integrating both research streams into a unifying computational model that supports personalized diagnostics and treatments in NDD. TheVirtualBrainCloud not only integrates existing software tools, it also merges the efforts of two big EU initiatives, namely The Virtual Brain large scale simulation platform of the EU Flagship Human Brain Project and IMI-EPAD initiative (European prevention of Alzheimer’s dementia consortium). VirtualBrainCloud will develop and validate a decision support system that provides access to high quality multi-disciplinary data for clinical practice. The result will be a cloud-based brain simulation platform to support personalized diagnostics and treatments in NDD. The EU PRACE (Partnership for Advanced Computing in Europe) initiative, will provide the required computing infrastructure. The VirtualBrainCloud will develop robust solutions for legal and ethical matters by interacting with EU projects such as European Open Science Cloud (EOSC), ‘cloud4health’, Alzheimer’s Europe patient organizations and ELIXIR, an organization that manages and safeguards EU research data. Our software developers have already produced highly successful brain simulation and clinical decision support tools. The resulting software will be a cloud based computational modeling system that is tailored to the individual, and bridges multiple scales to identify key mechanisms that predict NDD progression and serves as Precision Decision Support System.

Call for proposal

H2020-SC1-DTH-2018-1
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Address
Chariteplatz 1
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 985 750

Participants (16)

UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 1 107 093,10
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 1 868 750
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 462 430
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
FORSCHUNGSZENTRUM JULICH GMBH
Germany
EU contribution
€ 3 736 728,74
Address
Wilhelm Johnen Strasse
52428 Julich
Activity type
Research Organisations
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
EU contribution
€ 1 188 750
Address
Boulevard De L'hopital 47
75013 Paris
Activity type
Research Organisations
INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE
France
EU contribution
€ 324 435
Address
Domaine De Voluceau Rocquencourt
78153 Le Chesnay Cedex
Activity type
Research Organisations
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain
EU contribution
€ 686 937,50
Address
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Activity type
Research Organisations
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 840 280
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
EU contribution
€ 425 091,25
Address
Via Balbi 5
16126 Genova
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 396 250
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
CODEBOX GMBH
Germany
EU contribution
€ 217 750
Address
Hugo Eckener Strasse 7
70184 Stuttgart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CODEMART SRL
Romania
EU contribution
€ 353 750
Address
Str Petofi Sandor 13 Ap 4
400610 Cluj-napoca
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EODYNE SYSTEMS SL
Spain
EU contribution
€ 407 500
Address
Cl Venezuela 35 First Floor
08019 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAT WIEN
Austria
EU contribution
€ 462 097,50
Address
Universitatsring 1
1010 Wien
Activity type
Higher or Secondary Education Establishments
TP21 GMBH
Germany
EU contribution
€ 376 250
Address
Luisenstrasse 14
10117 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALZHEIMER EUROPE
Luxembourg
EU contribution
€ 176 500
Address
Rue Dicks 14
1417 Luxembourg
Activity type
Other