''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals

Información del proyecto

NOVIRUSES2BRAIN

Identificador del acuerdo de subvención: 828774

DOI

10.3030/828774

Proyecto cerrado

Fecha de la firma de la CE 17 Diciembre 2018

Fecha de inicio 1 Septiembre 2019

Fecha de finalización 31 Agosto 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 3 933 965,63

Aportación de la UE

€ 3 933 965,63

Coordinado por

FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

"A Data Management Plan (DMP) will be elaborated including what data the project will generate, whether and how it will be made accessible for verification and re-use, and how it will be curated and preserved. Through this DMP the Consortium can define certain datasets to remain closed according to the principle ""as open as possible, as closed as necessary""."

Documents, reports (3)

Communication and dissemination outputs

1. Outreach: >60 visitors, >5 journalists, and >2 decision–empowered politicians in outreaching activities; >5 international press releases on achievements2. Dissemination: >2 patents, >6 papers in Q1 journals, >3 seminars, >8 communications.

First technical/scientific review meeting report

The Report will include the draft agenda and the presentations to be delivered during the review meeting with the REAEC

Second technical/scientific review meeting report

The Report will include the draft agenda and the presentations to be delivered during the review meeting with the REAEC

Websites, patent fillings, videos etc. (1)

Website and project logo

Dedicated website will be launched and a project logo, as the first communication package of the project.

Publicaciones

Peer reviewed articles (7)

A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms

Autores: Dias, Susana Pinto, Sandra Silva-Herdade, Ana S. Cheneval, Olivier Craik, David J Coutinho, Ana Castanho, Miguel A. R. B. Henriques, Sónia T. Veiga, Ana Salomé
Publicado en: J Antimicrob Chemother., 2022, ISSN 0305-7453
Editor: Oxford University Press
DOI: 10.1093/jac/dkac309

Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity.

Autores: Mendonça, Diogo A. Bakker, Mariët Cruz-Oliveira, Christine Neves, Vera Angeles Jiménez, Maria Defaus, Sira Cavaco, Marco Veiga, Ana Salomé Cadima Couto, Carla Iris Castanho, Miguel A. R. B. Andreu, David Todorovski, Toni
Publicado en: Bioconjugate Chem., 2021, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00123

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates

Autores: Toni Todorovski ,Diogo A. Mendonça ,Lorena O. Fernandes-Siqueira, Christine Cruz-Oliveira ,Giuseppina Guida 1,Javier Valle 1,Marco Cavaco 2ORCID,Fernanda I. V. Limas 3,Vera Neves 2ORCID,Íris Cadima-Couto 2,Sira Defaus 1,Ana Salomé Veiga 2,Andrea T. Da Poian 3,Miguel A. R. B. Castanho 2 and David Andreu
Publicado en: Pharmaceutics, 2022, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14040738

Design of Natterins-based peptides improves antimicrobial and antiviral activities

Autores: Gabrielle L. de Cena, Dayane B. Tada, Danilo B.M. Lucchi, Tiago A.A. Santos, Montserrat Heras, Maria Juliano, Carla Torres Braconi, Miguel A.R.B. Castanho, Mônica Lopes-Ferreira, Katia Conceição
Publicado en: Biotechnology Reports, Edición 45, 2025, Página(s) e00867, ISSN 2215-017X
Editor: Elsevier BV
DOI: 10.1016/j.btre.2024.e00867

Antiviral Peptide-Based Conjugates: State of the Art and Future Perspectives

Autores: David Andreu; Daniela Kalafatovic; Toni Todorovski
Publicado en: Pharmaceutics, 2023, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020357

Unravelling the role of key amino acid residues of the parainfluenza fusion peptide in membrane fusion

Autores: Mariana Valério, Carolina C. Buga, Diogo A. Mendonça, Miguel A. R. B. Castanho, Manuel N. Melo, Cláudio M. Soares, Diana Lousa, Ana Salomé Veiga
Publicado en: RSC Chemical Biology, Edición 6, 2025, Página(s) 1100-1114, ISSN 2633-0679
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5cb00058k

Repurposing anti-cancer porphyrin derivative drugs to target SARS-CoV-2 envelope

Autores: Diogo A. Mendonça, Iris Cadima-Couto, Carolina C. Buga, Zoe A. Arnaut, Fabio A. Schaberle, Luis G. Arnaut, Miguel A.R.B. Castanho, Christine Cruz-Oliveira
Publicado en: Biomedicine & Pharmacotherapy, Edición 176, 2024, Página(s) 116768, ISSN 0753-3322
Editor: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116768