''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals

Informacje na temat projektu

NOVIRUSES2BRAIN

Identyfikator umowy o grant: 828774

DOI

10.3030/828774

Projekt został zamknięty

Data podpisania przez KE 17 Grudnia 2018

Data rozpoczęcia 1 Września 2019

Data zakończenia 31 Sierpnia 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity

€ 3 933 965,63

Wkład UE

€ 3 933 965,63

Koordynowany przez

FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Open Research Data Pilot (1)

Data Management Plan

"A Data Management Plan (DMP) will be elaborated including what data the project will generate, whether and how it will be made accessible for verification and re-use, and how it will be curated and preserved. Through this DMP the Consortium can define certain datasets to remain closed according to the principle ""as open as possible, as closed as necessary""."

Documents, reports (3)

Communication and dissemination outputs

1. Outreach: >60 visitors, >5 journalists, and >2 decision–empowered politicians in outreaching activities; >5 international press releases on achievements2. Dissemination: >2 patents, >6 papers in Q1 journals, >3 seminars, >8 communications.

First technical/scientific review meeting report

The Report will include the draft agenda and the presentations to be delivered during the review meeting with the REAEC

Second technical/scientific review meeting report

The Report will include the draft agenda and the presentations to be delivered during the review meeting with the REAEC

Websites, patent fillings, videos etc. (1)

Website and project logo

Dedicated website will be launched and a project logo, as the first communication package of the project.

Publikacje

Peer reviewed articles (7)

A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms

Autorzy: Dias, Susana Pinto, Sandra Silva-Herdade, Ana S. Cheneval, Olivier Craik, David J Coutinho, Ana Castanho, Miguel A. R. B. Henriques, Sónia T. Veiga, Ana Salomé
Opublikowane w: J Antimicrob Chemother., 2022, ISSN 0305-7453
Wydawca: Oxford University Press
DOI: 10.1093/jac/dkac309

Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity.

Autorzy: Mendonça, Diogo A. Bakker, Mariët Cruz-Oliveira, Christine Neves, Vera Angeles Jiménez, Maria Defaus, Sira Cavaco, Marco Veiga, Ana Salomé Cadima Couto, Carla Iris Castanho, Miguel A. R. B. Andreu, David Todorovski, Toni
Opublikowane w: Bioconjugate Chem., 2021, ISSN 1043-1802
Wydawca: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00123

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates

Autorzy: Toni Todorovski ,Diogo A. Mendonça ,Lorena O. Fernandes-Siqueira, Christine Cruz-Oliveira ,Giuseppina Guida 1,Javier Valle 1,Marco Cavaco 2ORCID,Fernanda I. V. Limas 3,Vera Neves 2ORCID,Íris Cadima-Couto 2,Sira Defaus 1,Ana Salomé Veiga 2,Andrea T. Da Poian 3,Miguel A. R. B. Castanho 2 and David Andreu
Opublikowane w: Pharmaceutics, 2022, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14040738

Design of Natterins-based peptides improves antimicrobial and antiviral activities

Autorzy: Gabrielle L. de Cena, Dayane B. Tada, Danilo B.M. Lucchi, Tiago A.A. Santos, Montserrat Heras, Maria Juliano, Carla Torres Braconi, Miguel A.R.B. Castanho, Mônica Lopes-Ferreira, Katia Conceição
Opublikowane w: Biotechnology Reports, Numer 45, 2025, Strona(/y) e00867, ISSN 2215-017X
Wydawca: Elsevier BV
DOI: 10.1016/j.btre.2024.e00867

Antiviral Peptide-Based Conjugates: State of the Art and Future Perspectives

Autorzy: David Andreu; Daniela Kalafatovic; Toni Todorovski
Opublikowane w: Pharmaceutics, 2023, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15020357

Unravelling the role of key amino acid residues of the parainfluenza fusion peptide in membrane fusion

Autorzy: Mariana Valério, Carolina C. Buga, Diogo A. Mendonça, Miguel A. R. B. Castanho, Manuel N. Melo, Cláudio M. Soares, Diana Lousa, Ana Salomé Veiga
Opublikowane w: RSC Chemical Biology, Numer 6, 2025, Strona(/y) 1100-1114, ISSN 2633-0679
Wydawca: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5cb00058k

Repurposing anti-cancer porphyrin derivative drugs to target SARS-CoV-2 envelope

Autorzy: Diogo A. Mendonça, Iris Cadima-Couto, Carolina C. Buga, Zoe A. Arnaut, Fabio A. Schaberle, Luis G. Arnaut, Miguel A.R.B. Castanho, Christine Cruz-Oliveira
Opublikowane w: Biomedicine & Pharmacotherapy, Numer 176, 2024, Strona(/y) 116768, ISSN 0753-3322
Wydawca: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116768