Light and Organic Nanotechnology for Cardiovascular Disease

Informazioni relative al progetto

LION-HEARTED

ID dell’accordo di sovvenzione: 828984

DOI 10.3030/828984

Progetto chiuso

Data della firma CE 16 Gennaio 2019

Data di avvio 1 Maggio 2019

Data di completamento 31 Ottobre 2023

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale € 2 904 413,75

Contributo UE € 2 904 413,75

Coordinato da

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

Risultati finali

Documents, reports (17)

kMC model to investigate organic/electrolyte interfaces

The deliverable will be represented by a kinetic Monte Carlo model for the simulation of the charge dynamics and optical processes at the macroscale in the range of hundreds of nm at the organicelectrolyte interface

In vivo delivery of polymer nanoparticles

Report on the effective vascular targeting of functionalized NPs and long term localization assessed by STED and IHC in pigs.

Validation of theoretical models prediction capability

Report on deviation between experimental results and theoretical prediction

Report on the website and logo

Communication of the URL, first contents and delivery of the logo. This will be a live document throughout the project. This initial version will evolve during the project according to the timely update of the website.

Effects of OS photoexcitation on stem and progenitor cells

Report on reactivation of the reparative potential of patientsderived cardiovascular stem and progenitor cells by organic semiconductors mediated photoexcitation

Technological solution for in vivo light excitation

Critical evaluation of commercially available light sources and of the need of implementing new ones to pursue LIONHEARTED goal

hiPSC-CMs production. Evaluation of differentiation/ maturation efficiency in dark/light conditions

Report on protocols for hiPSCCMs production in both dark and light conditions

Biocompatibility 1st generation materials with cell models

Viability tests to evaluate the effective biocompatibility of the 1st generation materials.

2nd generation materials biocompatibility

Evaluation of the biocompatibility of the 2nd generation materials and characterization of the internalization processes

Setup for photomodulation

Implementation of the setup that will be used for the optical stimulation of the cell models in incubating conditions.

Properties of activated CD31-aptamer-NPs

Report on the enhancement in the angiogenesis at the implant site after the insertion in the mouse ear of the CD31-aptamer-photoactivable material.

Effects of OS photoexcitation on iPSC-CM

Induction of cell maturation in iPSC-CM. Reactivation of CMs proliferation.

Dissemination and Exploitation plan

Summary of completed activities and plan for future dissemination. Organization of the international summer school and workshop. The Dissemination Plan will be a live document throughout the project. This initial version will evolve during the project according to the progress of project dissemination activities.

Acute and chronic inflammatory response after Polymer NPs delivery

Surgical protocols for implantation in pigs and evaluation of acute inflammatory response. Also chronic response will be assessed in a separate group of pigs 28 days after implant/NPs injection.

Report on LION-HEARTED tools efficacy in vitro

Critical comparison between LIONHEARTED modulation and existing pharmacological and electrical tools in vitro.

Report of the kick-off meeting

Report on the kick-off meeting including participants list, agenda, presentation slides and summary

Scanning Probe Microscopy at OS/liquid interface

Report on Scanning Probe Microscopy Techniques established to investigate light stimulated physico-chemical response at OS/liquid interface.

Open Research Data Pilot (1)

Data Management Plan

Report on how the research data collected and/or generated will be handled during and after the project. The Data Management Plan will be a live document throughout the project. This initial version will evolve during the project according to the progress of project activities.

Pubblicazioni

Peer reviewed articles (55)

Utilizing Data-Driven Optimization to Automate the Parametrization of Kinetic Monte Carlo Models

Autori: Ioannis Kouroudis, Manuel Gößwein, and Alessio Gagliardi
Pubblicato in: J. Phys. Chem. A, 2023, ISSN 1463-9084
Editore: American Chemical Society
DOI: 10.1021/acs.jpca.3c02482

The Emerging Role of N-Methyl-D-Aspartate (NMDA) Receptors in the Cardiovascular System: Physiological Implications, Pathological Consequences, and Therapeutic Perspectives

Autori: Teresa Soda; Valentina Brunetti; Roberto Berra-Romani; Francesco Moccia
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043914

Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range

Autori: Carlotta Ronchi, Camilla Galli, Gabriele Tullii, Camilla Marzuoli, Marta Mazzola, Marco Malferrari, Silvia Crasto, Stefania Rapino, Elisa Di Pasquale, Maria Rosa Antognazza
Pubblicato in: Advanced science, 2023, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202304303

Geneless optical control of cell redox balance in HL-1 cardiac muscle cells

Autori: Marco Malferrari , Gabriele Tullii, Carlotta Ronchi, Camilla Marzuoli, Ilaria Abdel Aziz, Maria Rosa Antognazza, Stefania Rapino
Pubblicato in: Electrochimica Acta, 2023, ISSN 0013-4686
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.electacta.2023.142429

Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development

Autori: Vincenzo Lionetti, Sveva Bollini, Raffaele Coppini, Andrea Gerbino, Alessandra Ghigo, Guido Iaccarino, Rosalinda Madonna, Fabio Mangiacapra, Michele Miragoli, Francesco Moccia, Luca Munaron, Pasquale Pagliaro, Astrid Parenti, Teresa Pasqua, Claudia Penna, Federico Quaini, Carmine Rocca, Michele Samaja, Laura Sartiani, Teresa Soda, Carlo Gabriele Tocchetti, Tommaso Angelone
Pubblicato in: Pharmacological Research, Numero 168, 2021, Pagina/e 105581, ISSN 1043-6618
Editore: Academic Press
DOI: 10.1016/j.phrs.2021.105581

The Molecular Heterogeneity of Store-Operated Ca2+ Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1/TRPC4 Channels in the Transition from Ca2+-Selective to Non-Selective Cation Currents

Autori: Francesco Moccia; Valentina Brunetti; Angelica Perna; Germano Guerra; Teresa Soda; Roberto Berra-Romani
Pubblicato in: Int J Mol Sci, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043259

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway

Autori: Floriana Maria Farina, Simone Serio, Ignacio Fernando Hall, Stefania Zani, Giada Andrea Cassanmagnago, Montserrat Climent, Efrem Civilini, Gianluigi Condorelli, Manuela Quintavalle, Leonardo Elia
Pubblicato in: European Heart Journal, 2022, ISSN 2752-4191
Editore: European Society of Cardiology
DOI: 10.1093/eurheartj/ehac097

High Aspect Ratio and Light-Sensitive Micropillars Based on a Semiconducting Polymer Optically Regulate Neuronal Growth

Autori: Frano Milos, Gabriele Tullii, Federico Gobbo, Francesco Lodola, Francesco Galeotti, Chiara Verpelli, Dirk Mayer, Vanessa Maybeck, Andreas Offenhäusser, Maria Rosa Antognazza
Pubblicato in: ACS Applied Materials & Interfaces, Numero 13/20, 2021, Pagina/e 23438-23451, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.1c03537

Semiconducting Polymer Nanoporous Thin Films as a Tool to Regulate Intracellular ROS Balance in Endothelial Cells

Autori: Miryam Criado-Gonzalez, Luca Bondi, Camilla Marzuoli, Edgar Gutierrez-Fernandez, Gabriele Tullii, Carlotta Ronchi, Elena Gabirondo, Haritz Sardon, Stefania Rapino, Marco Malferrari, Tobias Cramer, Maria Rosa Antognazza, and David Mecerreyes
Pubblicato in: ACS Appl. Mater. Interfaces, 2023, ISSN 1944-8252
Editore: American Chemical Society
DOI: 10.1021/acsami.3c06633

Modeling of Space-Charge Layers in Solid-State Electrolytes: A Kinetic Monte Carlo Approach and Its Validation

Autori: Leon Katzenmeier, Manuel Gößwein, Alessio Gagliardi*, and Aliaksandr S. Bandarenka
Pubblicato in: Journal of Physical Chemistry C, 2022, ISSN 1463-9084
Editore: ACS Publishing
DOI: 10.1021/acs.jpcc.2c02481

In Situ Nanomechanical Characterization Techniques forSoft Bioelectronic Interfaces and Their Building Blocks

Autori: Giorgio Cortelli, Tobias Cramer, Luca Patruno, Beatrice Fraboni, and Stefano de Miranda
Pubblicato in: Adv. Mat. Techn., 2023, ISSN 2365-709X
Editore: Wiley
DOI: 10.1002/admt.202300931

Mass transport and charge transfer through an electrified interface between metallic lithium and solid-state electrolytes

Autori: Leon Katzenmeier, Manuel Gößwein, Leif Carstensen, Johannes Sterzinger, Michael Ederer, Peter Müller-Buschbaum, Alessio Gagliardi & Aliaksandr S. Bandarenka
Pubblicato in: Communications Chemistry, 2023, ISSN 2399-3669
Editore: Nature Publishing Group (Nature Portfolio)
DOI: 10.1038/s42004-023-00923-4

Understanding Photocapacitive and Photofaradaic Processes in Organic Semiconductor Photoelectrodes for Optobioelectronics

Autori: Tommaso Paltrinieri, Luca Bondi, Vedran Đerek, Beatrice Fraboni, Eric Daniel Głowacki, Tobias Cramer
Pubblicato in: Advanced Functional Materials, Numero 31/16, 2021, Pagina/e 2010116, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202010116

Micro- and Nanopatterned Silk Substrates for Antifouling Applications

Autori: G. Tullii, S. Donini, C. Bossio, F. Lodola, M. Pasini, E. Parisini, F. Galeotti, M. R. Antognazza
Pubblicato in: ACS Applied Materials & Interfaces, Numero 12/5, 2020, Pagina/e 5437-5446, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.9b18187

Charge Carrier Mobility in Organic Mixed Ionic–Electronic Conductors by the Electrolyte‐Gated van der Pauw Method

Autori: Filippo Bonafè, Francesco Decataldo, Beatrice Fraboni, Tobias Cramer
Pubblicato in: Advanced Electronic Materials, Numero 7/10, 2021, Pagina/e 2100086, ISSN 2199-160X
Editore: London
DOI: 10.1002/aelm.202100086

Bimodal modulation of in vitro angiogenesis with photoactive polymer nanoparticles

Autori: Gabriele Tullii, Edgar Gutierrez-Fernandez, Carlotta Ronchi, Christian Bellacanzone, Luca Bondi, Miryam Criado-Gonzalez, Paola Lagonegro, Francesco Moccia, Tobias Cramer, David Mecerreyes, Jaime Martín and Maria Rosa Antognazza
Pubblicato in: Nanoscale, 2023, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/d3nr02743k

Y6 Organic Thin-Film Transistors with Electron Mobilities of 2.4 cm² V⁻¹ s⁻¹ via Microstructural Tuning

Autori: Gutiérrez Fernández, Edgar; Scaccabarozzi, Alberto D.; Basu, Aniruddha; Solano, Eduardo; Anthopoulos, Thomas D.; Martín, Jaime
Pubblicato in: Advanced Science, 2022, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202104977

Polymorphism in Non-Fullerene Acceptors Based on Indacenodithienothiophene

Autori: Sara Marina; Alberto D. Scaccabarozzi; Alberto D. Scaccabarozzi; Edgar Gutiérrez-Fernández; Eduardo Solano; Aditi Khirbat; Laura Ciammaruchi; Amaia Iturrospe; Alex H. Balzer; Liyang Yu; Elena Gabirondo; Xavier Monnier; Xavier Monnier; Haritz Sardon; Thomas D. Anthopoulos; Mario Caironi; Mariano Campoy-Quiles; Christian Müller; Daniele Cangialosi; Natalie Stingelin; Natalie Stingelin; Jaime Mart
Pubblicato in: Advanced Functional Materials, Numero 12, 2021, ISSN 1616-3028
Editore: John Wiley & Sons, Inc.
DOI: 10.1002/adfm.202103784

P-type Semiconducting Polymers as Photocathodes: A Comparative Study for Optobioelectronics

Autori: Luca Bondi, Camilla Marzuoli, Edgar Gutiérrez-Fernández, Gabriele Tullii, Jaime Martín, Beatrice Fraboni, David Mecerreyes, Maria Rosa Antognazza, Tobias Cramer
Pubblicato in: Advanced Electronic Materials, 2023, ISSN 2199-160X
Editore: Wiley-VCH Verlag
DOI: 10.1002/aelm.202300146

Nicotinic acid adenine dinucleotide phosphate activates two‐pore channel TPC1 to mediate lysosomal Ca 2+ release in endothelial colony‐forming cells

Autori: Francesco Moccia, Estella Zuccolo, Francesca Di Nezza, Giorgia Pellavio, Pawan S. Faris, Sharon Negri, Antonio De Luca, Umberto Laforenza, Luigi Ambrosone, Vittorio Rosti, Germano Guerra
Pubblicato in: Journal of Cellular Physiology, Numero 236/1, 2021, Pagina/e 688-705, ISSN 0021-9541
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jcp.29896

In Situ Force Microscopy to Investigate Fracture in Stretchable Electronics: Insights on Local Surface Mechanics and Conductivity

Autori: Giorgio Cortelli; Luca Patruno; Tobias Cramer; Beatrice Fraboni; Stefano de Miranda
Pubblicato in: ACS Applied Electronic Materials, 2022, ISSN 2637-6113
Editore: ACS Publications
DOI: 10.1021/acsaelm.2c00328

Additive Manufacturing of Conducting Polymers: Recent Advances, Challenges, and Opportunities

Autori: Miryam Criado-Gonzalez, Antonio Dominguez-Alfaro, Naroa Lopez-Larrea, Nuria Alegret, David Mecerreyes
Pubblicato in: ACS Applied Polymer Materials, Numero 3/6, 2021, Pagina/e 2865-2883, ISSN 2637-6105
Editore: ACS publications
DOI: 10.1021/acsapm.1c00252

Wireless nanotechnologies light up the next frontier in cell Calcium signalling

Autori: Ilaria Abdel Aziz, Maria Rosa Antognazza
Pubblicato in: MRS Advances, Numero 5/64, 2020, Pagina/e 3473-3489, ISSN 2059-8521
Editore: Springer
DOI: 10.1557/adv.2020.348

Water Soluble Cationic Poly(3,4‐Ethylenedioxythiophene) PEDOT‐N as a Versatile Conducting Polymer for Bioelectronics

Autori: Daniela Minudri, Daniele Mantione, Antonio Dominguez‐Alfaro, Sergio Moya, Eliana Maza, Christian Bellacanzone, Maria Rosa Antognazza, David Mecerreyes
Pubblicato in: Advanced Electronic Materials, Numero 6/10, 2020, Pagina/e 2000510, ISSN 2199-160X
Editore: Wiley-VCH GmbH
DOI: 10.1002/aelm.202000510

Atomic Force Microscopy Nanomechanics of Hard Nanometer-Thick Films on Soft Substrates: Insights into Stretchable Conductors

Autori: Giorgio Cortelli, Luca Patruno, Tobias Cramer, Mauro Murgia, Beatrice Fraboni, Stefano de Miranda
Pubblicato in: ACS Applied Nano Materials, Numero 4/8, 2021, Pagina/e 8376-8382, ISSN 2574-0970
Editore: ACS publications
DOI: 10.1021/acsanm.1c01590

Real-Time Monitoring of Cellular Cultures with Electrolyte-Gated Carbon Nanotube Transistors

Autori: Francesca Scuratti, Giorgio E. Bonacchini, Caterina Bossio, Jorge M. Salazar-Rios, Wytse Talsma, Maria A. Loi, Maria Rosa Antognazza, Mario Caironi
Pubblicato in: ACS Applied Materials & Interfaces, Numero 11/41, 2019, Pagina/e 37966-37972, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.9b11383

Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: just What It Takes to Make a Blood Vessel

Autori: Moccia, Negri, Shekha, Faris, Guerra
Pubblicato in: International Journal of Molecular Sciences, Numero 20/16, 2019, Pagina/e 3962, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20163962

Conjugated polymers optically regulate the fate of endothelial colony-forming cells

Autori: F. Lodola, V. Rosti, G. Tullii, A. Desii, L. Tapella, P. Catarsi, D. Lim, F. Moccia, M. R. Antognazza
Pubblicato in: Science Advances, Numero 5/9, 2019, Pagina/e eaav4620, ISSN 2375-2548
Editore: xx
DOI: 10.1126/sciadv.aav4620

Calcium as a Key Player in Arrhythmogenic Cardiomyopathy: Adhesion Disorder or Intracellular Alteration?

Autori: Francesco Moccia, Francesco Lodola, Ilaria Stadiotti, Chiara Assunta Pilato, Milena Bellin, Stefano Carugo, Giulio Pompilio, Elena Sommariva, Angela Serena Maione
Pubblicato in: International Journal of Molecular Sciences, Numero 20/16, 2019, Pagina/e 3986, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20163986

Light-Triggered Electron Transfer between a Conjugated Polymer and Cytochrome C for Optical Modulation of Redox Signaling

Autori: Ilaria Abdel Aziz, Marco Malferrari, Francesco Roggiani, Gabriele Tullii, Stefania Rapino, Maria Rosa Antognazza
Pubblicato in: iScience, Numero 23/5, 2020, Pagina/e 101091, ISSN 2589-0042
Editore: xxx
DOI: 10.1016/j.isci.2020.101091

High-Aspect-Ratio Semiconducting Polymer Pillars for 3D Cell Cultures

Autori: Gabriele Tullii, Federica Giona, Francesco Lodola, Silvio Bonfadini, Caterina Bossio, Simone Varo, Andrea Desii, Luigino Criante, Carlo Sala, Mariacecilia Pasini, Chiara Verpelli, Francesco Galeotti, Maria Rosa Antognazza
Pubblicato in: ACS Applied Materials & Interfaces, Numero 11/31, 2019, Pagina/e 28125-28137, ISSN 1944-8244
Editore: American Chemical Society
DOI: 10.1021/acsami.9b08822

Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies

Autori: Marta Mazzola, Elisa Di Pasquale
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: XX
DOI: 10.3389/fbioe.2020.00455

Endothelial TRPV1 as an Emerging Molecular Target to Promote Therapeutic Angiogenesis

Autori: Sharon Negri, Pawan Faris, Vittorio Rosti, Maria Rosa Antognazza, Francesco Lodola, Francesco Moccia
Pubblicato in: Cells, Numero 9/6, 2020, Pagina/e 1341, ISSN 2073-4409
Editore: XX
DOI: 10.3390/cells9061341

COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches

Autori: Moccia, Francesco
Pubblicato in: GeroScience, Numero 2, 2020, ISSN 2509-2723
Editore: Springer
DOI: 10.5281/zenodo.3978136

Acceleration scheme for particle transport in kinetic Monte Carlo methods

Autori: Waldemar Kaiser, Manuel Gößwein, Alessio Gagliardi
Pubblicato in: The Journal of Chemical Physics, Numero 152/17, 2020, Pagina/e 174106, ISSN 0021-9606
Editore: American Institute of Physics
DOI: 10.1063/5.0002289

Machine-Learned Charge Transfer Integrals for Multiscale Simulations in Organic Thin Films

Autori: Michael Rinderle, Waldemar Kaiser, Alessandro Mattoni, Alessio Gagliardi
Pubblicato in: The Journal of Physical Chemistry C, 2020, ISSN 1932-7447
Editore: American Chemical Society
DOI: 10.1021/acs.jpcc.0c04355

Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019

Autori: Francesco Moccia, Sharon Negri, Pawan Faris, Angelica Perna, Antonio De Luca, Teresa Soda, Roberto Berra-Romani, Germano Guerra
Pubblicato in: Frontiers in Physiology, Numero 12, 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.629119

Cracking the Endothelial Calcium (Ca2+) Code: A Matter of Timing and Spacing

Autori: Francesco Moccia, Valentina Brunetti, Teresa Soda, Roberto Berra-Romani, Giorgia Scarpellino
Pubblicato in: Int J Mol Sci, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316765

Systemic lupus erythematosus, endothelial progenitor cells and intracellular Ca2+ signaling: A novel approach for an old disease

Autori: Klara Komici, Pawan Faris, Sharon Negri, Vittorio Rosti, Mario García-Carrasco, Claudia Mendoza-Pinto, Roberto Berra-Romani, Ricard Cervera, Germano Guerra, Francesco Moccia
Pubblicato in: Journal of Autoimmunity, Numero 112, 2020, Pagina/e 102486, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2020.102486

Therapeutic Potential of Endothelial Colony Forming Cells in Ischemic Disease: Strategies to Improve Their Regenerative Efficacy

Autori: Pawan Faris; Sharon Negri; Angelica Perna; Vittorio Rosti; Germano Guerra; Francesco Moccia
Pubblicato in: International Journal of Molecular Sciences, Numero 2, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/preprints202009.0547.v1

The “TIDE”-Algorithm for the Weaning of Patients With Cardiogenic Shock and Temporarily Mechanical Left Ventricular Support With Impella Devices. A Cardiovascular Physiology-Based Approach

Autori: Tschöpe C, Spillmann F, Potapov E, Faragli A, Rapis K, Nelki V, Post H, Schmidt G, Alogna A.
Pubblicato in: Frontiers in cardiovascular medicine, 2021, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2021.563484

Towards Novel Geneless Approaches for Therapeutic Angiogenesis

Autori: Francesco Moccia, Maria Rosa Antognazza, Francesco Lodola
Pubblicato in: Frontiers in Physiology, Numero 11, 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.616189

Local Temporal Acceleration Scheme to Couple Transport and Reaction Dynamics in Kinetic Monte Carlo Models of Electrochemical Systems

Autori: Manuel Gößwein, Waldemar Kaiser, and Alessio Gagliardi
Pubblicato in: Journal of Chemical Theory and Computation, 2022, ISSN 1549-9618
Editore: American Chemical Society
DOI: 10.1021/acs.jctc.1c01010

Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs

Autori: Faragli A, Alogna A, Lee CB, Zhu M, Ghorbani N, Lo Muzio FP, Schnackenburg B, Stehning C, Kuehne T, Post H, Goubergrits L, Nagel E, Pieske B, Kelle S, Kelm M.
Pubblicato in: Frontiers in Cardiovascular Medicine, 2021, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2021.689255

rs41291957 controls miR‐143 and miR‐145 expression and impacts coronary artery disease risk

Autori: Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E Kleber, Winfried März, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Pubblicato in: EMBO Molecular Medicine, Numero 13/10, 2021, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202114060

Thioether-based ROS responsive polymers for biomedical applications

Autori: David Mecerreyes; Miryam Criado-Gonzalez
Pubblicato in: Journal of Materials Chemistry B, Numero 6, 2022, ISSN 2050-750X
Editore: Royal Society of Chemistry
DOI: 10.1039/d2tb00615d

Stable and Solution‐Processable Cumulenic sp‐Carbon Wires: A New Paradigm for Organic Electronics

Autori: Stefano Pecorario; Alberto D. Scaccabarozzi; Daniele Fazzi; Edgar Gutiérrez‐Fernández; Vito Vurro; Lorenzo Maserati; Mengting Jiang; Tommaso Losi; Bozheng Sun; Rik R. Tykwinski; Carlo S. Casari; Mario Caironi
Pubblicato in: Advanced Materials, 2022, ISSN 1521-4095
Editore: Wiley-Blackwell
DOI: 10.1002/adma.202110468

Vascular malformation rupture in a patient affected by Costello syndrome

Autori: Francesca Barbieri, Ignacio Fernando Hall, Leonardo Elia, Efrem Civilini
Pubblicato in: BMJ Case Rep, 2023, ISSN 1757-790X
Editore: BMJ Publishing Group
DOI: 10.1136/bcr-2022-250948

Deep Learning Total Energies and Orbital Energies of Large Organic Molecules Using Hybridization of Molecular Fingerprints

Autori: Obaidur Rahaman, Alessio Gagliardi
Pubblicato in: Journal of Chemical Information and Modeling, Numero 60/12, 2020, Pagina/e 5971-5983, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.0c00687

The Importance of Quantifying the Composition of the Amorphous Intermixed Phase in Organic Solar Cells

Autori: Sara Marina; Noëmi Petrina Kaufmann; Akchheta Karki; Elizabeth Gutiérrez-Meza; Edgar Gutiérrez-Fernández; Joachim Vollbrecht; Eduardo Solano; Barnaby E. Walker; James H. Bannock; John C. de Mello; Carlos Silva; Thuc-Quyen Nguyen; Daniele Cangialosi; Daniele Cangialosi; Natalie Stingelin; Jaime Martín; Jaime Martín
Pubblicato in: Advanced Science, 2020, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/adma.202005241

Defect formation and healing at grain boundaries in lead-halide perovskites

Autori: Waldemar Kaiser; Kashif Hussain; Ajay Singh; Asma A. Alothman; Daniele Meggiolaro; Alessio Gagliardi; Edoardo Mosconi; Filippo De Angelis
Pubblicato in: J. Mater. Chem. A, 2022, ISSN 2050-7488
Editore: Royal Society of Chemistry
DOI: 10.1039/d2ta06336k

Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloid 1 (TRPV1)

Autori: Sharon Negri, Pawan Faris, Gabriele Tullii, Mauro Vismara, Alessandro F. Pellegata, Francesco Lodola, Gianni Guidetti, Vittorio Rosti, Maria Rosa Antognazza, Francesco Moccia
Pubblicato in: Cell Calcium, 2021, Pagina/e 102502, ISSN 0143-4160
Editore: Churchill Livingstone
DOI: 10.1016/j.ceca.2021.102502

Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?

Autori: Sharon Negri, Pawan Faris, Francesco Moccia
Pubblicato in: International Journal of Molecular Sciences, Numero 22/18, 2021, Pagina/e 9821, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22189821

Therapeutic Potential of Endothelial Colony-Forming Cells in Ischemic Disease: Strategies to Improve their Regenerative Efficacy

Autori: Pawan Faris, Sharon Negri, Angelica Perna, Vittorio Rosti, Germano Guerra, Francesco Moccia
Pubblicato in: International Journal of Molecular Sciences, Numero 21/19, 2020, Pagina/e 7406, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197406

GABAA and GABAB Receptors Mediate GABA-Induced Intracellular Ca2+ Signals in Human Brain Microvascular Endothelial Cells

Autori: Sharon Negri; Francesca Scolari; Mauro Vismara; Valentina Brunetti; Pawan Faris; Giulia Terribile; Giulio Sancini; Roberto Berra-Romani; Francesco Moccia
Pubblicato in: Cells, Numero 1, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11233860