Next generation precision antibody profiling - from science fiction to reality

Deliverables

Documents, reports (1)

Draft Exploitation plan and Business strategy document

Draft plan of Exploitation plan and Business strategy document delivered

Other (2)

Logo and Website launch and public accessibility

Project logo and website launch and public accessibility. Site will be constantly maintained and updated.

IP protection strategy finalized

Open Research Data Pilot (1)

Data management plan

Publications

Peer reviewed articles (9)

Exploring frontiers of orbitrap performance for long transients

Author(s): Eduard Denisov, Eugen Damoc, Alexander Makarov
Published in: International Journal of Mass Spectrometry, 466, 2021, Page(s) 116607, ISSN 1387-3806
Publisher: Elsevier BV
DOI: 10.1016/j.ijms.2021.116607

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

Author(s): Kristina Srzentić, Luca Fornelli, Yury O. Tsybin, Joseph A. Loo, Henrique Seckler, Jeffrey N. Agar, Lissa C. Anderson, Dina L. Bai, Alain Beck, Jennifer S. Brodbelt, Yuri E. M. van der Burgt, Julia Chamot-Rooke, Sneha Chatterjee, Yunqiu Chen, David J. Clarke, Paul O. Danis, Jolene K. Diedrich, Robert A. D’Ippolito, Mathieu Dupré, Natalia Gasilova, Ying Ge, Young Ah Goo, David R. Goodlett, Sylv
Published in: Journal of the American Society for Mass Spectrometry, 31/9, 2020, Page(s) 1783-1802, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.0c00036

Structural Analysis of Monoclonal Antibodies with Top-down and Middle-down Electron Transfer Dissociation Mass Spectrometry: The First Decade

Author(s): Fornelli, L., Ayoub, D., Srzentic, K. Nagornov, K. O. Kozhinov, A. N. Gasilova, N. Menin, L. Beck, A. Tsybin, Y. O.
Published in: Chimia, 2, 2022, Page(s) 114-126, ISSN 0009-4293
Publisher: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2022.114

Transient-Mediated Simulations of FTMS Isotopic Distributions and Mass Spectra to Guide Experiment Design and Data Analysis

Author(s): Konstantin O. Nagornov, Anton N. Kozhinov, Natalia Gasilova, Laure Menin, Yury O. Tsybin
Published in: Journal of the American Society for Mass Spectrometry, 31/9, 2020, Page(s) 1927-1942, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.0c00190

Drug-to-Antibody Ratio Estimation via Proteoform Peak Integration in the Analysis of Antibody-Oligonucleotide Conjugates with Orbitrap Fourier Transform Mass Spectrometry.

Author(s): Konstantin O. Nagornov; Natalia Gasilova; Anton N. Kozhinov; Pasi Virta; Patrik Holm; Laure Menin; Victor J Nesatyy; Yury O. Tsybin
Published in: Anal Chem, 14/9, 2021, Page(s) 12930–12937, ISSN 1520-6882
Publisher: ACS Publications
DOI: 10.1021/acs.analchem.1c02247

Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry

Author(s): Christoph Gstöttner, Dietmar Reusch, Markus Haberger, Irina Dragan, Peter Van Veelen, David P. A. Kilgour, Yury O. Tsybin, Yuri E. M. van der Burgt, Manfred Wuhrer, Simone Nicolardi
Published in: mAbs, 12/1, 2020, Page(s) 1682403, ISSN 1942-0870
Publisher: Landes Bioscience
DOI: 10.1080/19420862.2019.1682403

The Human Proteoform Project: Defining the human proteome

Author(s): Smith, L. M., Agar, J. N., Chamot-Rooke, J., Danis, P. O., Ge, Y., Loo, J. A., Pasa-Tolic, L., Tsybin, Y.O.. Kelleher, N. L. Consortium for Top-Down, Proteomics
Published in: Sci Adv, 12/11, 2021, Page(s) eabk0734, ISSN 2375-2548
Publisher: Sciense.org
DOI: 10.1126/sciadv.abk0734

The Omnitrap Platform: A Versatile Segmented Linear Ion Trap for Multidimensional Multiple-Stage Tandem Mass Spectrometry

Author(s): Dimitris Papanastasiou; Diamantis Kounadis; Alexandros Lekkas; Ioannis Orfanopoulos; Andreas Mpozatzidis; Athanasios Smyrnakis; Elias Panagiotopoulos; Mariangela Kosmopoulou; Maria Reinhardt-Szyba; Kyle Fort; Alexander Makarov; Roman A. Zubarev
Published in: J. Am. Soc. Mass Spectrom, 3, 2022, ISSN 1879-1123
Publisher: ACS Publications
DOI: 10.1021/jasms.2c00214

TDFragMapper: a visualization tool for evaluating experimental parameters in top-down proteomics

Author(s): Dhenin, J., Lima, D. B., Dupre, M., Chamot-Rooke, J.
Published in: Bioinformatics, 18/11, 2021, Page(s) 1136-8, ISSN 1367-4811
Publisher: Oxford Academic
DOI: 10.1093/bioinformatics/btab784

Other (3)

Adding colour to mass spectra: Charge Determination Analysis (CHARDA) assigns charge state to every ion peak

Author(s): Y. Lyutvinskiy, K.O. Nagornov, A.N. Kozhinov, N. Gasilova, L. Menin, Z. Meng, X. Zhang, A. Ata Saei, Y.O. Tsybin, A. Makarov, R.A. Zubarev
Published in: ChemRxiv, 17/9, 2021
Publisher: Cambridge University Press
DOI: 10.26434/chemrxiv-2021-f6n9j

Next-generation precision antibody profiling; from science fiction to reality

Author(s): Roman Zubarev, Dimitris Papanastasiou, Alexander Makarov, Yury Tsybin, Thorleif Lavold,David Kilgour, Julia Chamot-Rooke, Jan Commandeur
Published in: The Project Repository Journal, Volume 15, 2022, Page(s) 38-41
Publisher: EDMA
DOI: 10.54050/prj1519532

A Novel Family of Quadrupole-Orbitrap Mass Spectrometers for a Broad Range of Analytical Applications

Author(s): Hauschild J; Peterson Ac; Couzijn E; Eduard Denisov; Chernyshev D; Hock C; Hamish Stewart; Hartmer R; Dmitry Grinfeld; Thoeing C; Reitemeier B; Arne Kreutzmann; Lange O; Balschun W; Venckus A; Kanngiesser S; Kholomeev A; Quiring G; Czemper F; Wouters E; Belford M; Mueller M; Grote J; Arrey Tn; Kraegenbring J; Strupat K; Mohring S; Crone C; Harder A; Robitaille A; Gajadhar A; Motamed K; Liu Y; Lope
Published in: Preprints, 7, 2020
Publisher: Preprints.org
DOI: 10.20944/preprints202006.0111.v1