Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies

Project Information

Immune-Image

Grant agreement ID: 831514

DOI

10.3030/831514

EC signature date 26 September 2019

Start date 1 October 2019

End date 31 March 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 27 154 551,37

EU contribution

€ 15 000 000,00

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (13)

Midterm recruitment report for task 6.4

For further details see WP6Task 64

Midterm recruitment report for task 6.3

For further details see WP6Task 63

Draft Data Management Plan for Immune-Imaging data storage and analysis infrastructure using FAIR as guiding principles

For further details see WP2Task 21

SOP to transfer new tracers to WP6

For further details see WP5/Task 5.1

68Ga-MMR liquid formulation

For further details see WP6Task 61

First study subject approvals package for task 6.3

For further details see WP6Task 63

First study subject approvals package for task 6.1

For further details see WP6Task 61

SOP/CoA to transfer new tracers to WP4

For further details see WP3/Task 3.1,3.2,3.3,3.4,3.6

SOP for data collection and storage

For further details see WP2/Task 2.3

Report on the feasibility of harmonising preclinical systems and prototype harmonising system performance standards with WP3,4,5

For further details see WP2Task 27

First study subject approvals package for task 6.4

For further details see WP6Task 64

Completed clinical imaging protocols and setup/design of imaging system accreditation programme for clinical studies in WP6

For further details see WP2Task 2227

First study subject approvals package for task 6.6

For further details see WP6Task 66

Websites, patent fillings, videos etc. (1)

Public web site in place

For further details see WP1/Task 1.6

Other (1)

Immune-Image biosample meta-data catalogue available online and loaded with first sample data

For further details see WP2/Task 2.4

Publications

Peer reviewed articles (24)

Imaging temozolomide-induced changes in the myeloid glioma microenvironment

Author(s): Claudia Foray, Silvia Valtorta, Cristina Barca, Alexandra Winkeler, Wolfgang Roll, Michael Müther, Stefan Wagner, Miranda L. Gardner, Sven Hermann, Michael Schäfers, Oliver Martin Grauer, Rosa Maria Moresco, Bastian Zinnhardt, Andreas H. Jacobs
Published in: Theranostics, Issue 11/5, 2021, Page(s) 2020-2033, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.47269

Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI

Author(s): Foray, Claudia; Barca, Cristina; Winkeler, Alexandra; Wagner, Stefan; Hermann, Sven; Schäfers, Michael; Grauer, Oliver Martin; Zinnhardt, Bastian; Jacobs, Andreas H.
Published in: Journal of Nuclear Medicine, Issue 2159662X, 2022, Page(s) 1386-1393, ISSN 2159-662X
Publisher: Society of Nuclear Medicine and Molecular Imaging
DOI: 10.2967/jnumed.121.263318

Characterization of the inflammatory post-ischemic tissue by full volumetric analysis of a multimodal imaging dataset

Author(s): Cristina Barca, Claudia Foray, Sven Hermann, Christian Döring, Michael Schäfers, Andreas H. Jacobs, Bastian Zinnhardt
Published in: NeuroImage, Issue 222, 2020, Page(s) 117217, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.117217

Concerning the photophysics of fluorophores towards tailoredbioimaging compounds: a case study involving S100A9 inflammationmarkers

Author(s): Simon T. Steiner,Iván Maisuls, Anna Junker, Günter Fritz, Andreas Faust, Cristian A. Strassert
Published in: Photochemical & Photobiological Sciences, 2023, ISSN 1474-905X
Publisher: Royal Society of Chemistry
DOI: 10.1007/s43630-023-00432-2

Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors

Author(s): Macarena Román Alonso, Ariadna Grinyó-Escuer, Santiago Duro-Sánchez, Irene Rius-Ruiz, Marta Bort-Brusca, Marta Escorihuela, Susana Maqueda-Marcos, Sandra Pérez-Ramos, Judit Gago, Vanesa Nogales, Martín Espinosa-Bravo, Vicente Peg, Santiago Escrivá-de-Romaní, Laia Foradada, Laura Soucek, Irene Braña, Vladimir Galvao, Silvia Martín-Lluesma, Ekkehard Moessner, Christian Klein, Elena Garralda
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-53265-7

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes

Author(s): Cristina Barca, Maximilian Wiesmann, Jesús Calahorra, Lydia Wachsmuth, Christian Döring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Ángeles Peinado, Eva Siles, Cornelius Faber, Michael Schäfers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Zinnhardt
Published in: Theranostics, Issue 11/9, 2021, Page(s) 4030-4049, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.48110

Radiomic Signatures Associated with CD8+ Tumour-Infiltrating Lymphocytes: A Systematic Review and Quality Assessment Study 

Author(s): Syafiq Ramlee, David Hulse, Kinga Bernatowicz, Raquel Pérez-López, Evis Sala, Luigi Aloj 
Published in: Cancers, Issue 20726694, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153656

Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study

Author(s): Wijngaarden, Jessica E.; Huisman, Marc C.; Pouw, Johanna E. E.; Menke-van der Houven van Oordt, C. Willemien; Jauw, Yvonne W. S.; Boelaard, Ronald
Published in: EJNMMI Research, Issue 2191219X, 2022, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-022-00927-6

Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β

Author(s): Timo W.M. De Groof, Yoline Lauwers, Tessa De Pauw, Mohit Saxena, Cécile Vincke, Jolien Van Craenenbroeck, Catherine Chapon, Roger Le Grand, Geert Raes, Thibaut Naninck, Jo A. Van Ginderachter, Nick Devoogdt
Published in: European Journal of Nuclear Medicine and Molecular Imaging, 2024, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-024-06896-3

Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Author(s): Gondry, Odrade; Xavier, Catarina; Raes, Laurens; Heemskerk, Johannes; Devoogdt, Nick; Everaert, Hendrik; Breckpot, Karine; Lecocq, Quentin; Decoster, Lore; Fontaine, Christel; Schallier, Denis; Aspeslagh, Sandrine; Vaneycken, Ilse; Raes, Geert; Van Ginderachter, Jo A.; Lahoutte, Tony; Cavaliers, Vicky; Keyaerts, Marleen
Published in: Journal of Nuclear Medicine, Issue 5, 2023, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.122.264853

How to obtain the image‑derived blood concentration from 89Zr‑immuno‑PET scans

Author(s): Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke‑van der Houven van Oordt, Marc C. Huisman
Published in: EJNMMI Physics, 2024, ISSN 1619-7089
Publisher: Springer Science+Business Media
DOI: 10.1186/s40658-024-00621-7

Navigating the landscape of PD-1/PD-L1 imaging tracers: from challenges to opportunities

Author(s): Melinda Badenhorst, Albert D. Windhorst, Wissam Beaino
Published in: Frontiers in Medicine, 2024, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2024.1401515

A novel 18 F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo

Author(s): Dominic Alexej Depke, Christian Paul Konken, Lukas Rösner, Sven Hermann, Michael Schäfers, Andrea Rentmeister
Published in: Chemical Communications, Issue 57/77, 2021, Page(s) 9850-9853, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc03871k

Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake

Author(s): Wiijngaarden, Jessica E; Huisman, Marc C; Jauw, Yvonne W S; van Dongen, Guus A M S; Greuter, Henri N J M; Schuit, Robert C; Cleceland, Matthew; Gootjes, Elske C; Vugts, Danielle J; Menke-van der Houven van Oordt, C Willemien; Boellaard, Ronald
Published in: European Journal of Nuclear Medicine and Molecular Imaging, Issue 1, 2023, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-023-06151-1

Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica

Author(s): van der Geest, Kornelis S.M.; Sandovici, Maria; Nienhues, Peter H.; Slart, Riemer H.J.A.; Heeringa, Peter; Brouwer, Elisabeth; Jiemy, William
Published in: Frontiers in Medicine, Issue 2, 2022, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2022.902155

89Zr-Immuno-PET with Immune Checkpoint Inhibitors: Measuring Target Engagement in Healthy Organs

Author(s): Iris H. C. Miedema, Jessica E. Wijngaarden, Johanna E. E. Pouw, Gerben J. C. Zwezerijnen, Hylke J. Sebus, Egbert Smit, Adrianus J. de Langen, Idris Bahce, Andrea Thiele, Daniëlle J. Vugts, Ronald Boellaard, Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt
Published in: Cancers, Issue 6, 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15235546

Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

Author(s): Arnouk, Sana; De Groof, Timo; Van Ginderachter, Jo
Published in: Advanced Drug Delivery Review, Issue 184, 2022, Page(s) 114239, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114239

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD81 T cells in giant cell arteritis

Author(s): Reitsema, Rosanne D.; van der Geest, Kornelis S. M.; Sandovici, Maria; Jiemy, William F.; Graver, Jacoba C.; Abdulahad, Wayel H.; Boots, Annemieke M.H.; Herringa, Peter; Brouwer, Elisabeth
Published in: The Journal of Rheuatology, Issue 6, 2022, ISSN 0315-162X
Publisher: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.1093/rheumatology/keac250

TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma

Author(s): Bastian Zinnhardt, Michael Müther, Wolfgang Roll, Philipp Backhaus, Astrid Jeibmann, Claudia Foray, Cristina Barca, Christian Döring, Bertrand Tavitian, Frédéric Dollé, Matthias Weckesser, Alexandra Winkeler, Sven Hermann, Stefan Wagner, Heinz Wiendl, Walter Stummer, Andreas H Jacobs, Michael Schäfers, Oliver M Grauer
Published in: Neuro-Oncology, Issue 22/7, 2020, Page(s) 1030-1043, ISSN 1522-8517
Publisher: Duke University Press
DOI: 10.1093/neuonc/noaa023

In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy

Author(s): Pezzana, Stefania; Blaess, Simone; Kortendieck, Jule; Hemmer, Nicole; Tako, Bredi; Pietura, Claudia; Ruoff, Lara; Riel, Simone; Schaller, Martin; Gonzalez-Menendez, Irene; Quintanilla-Martinez, Leticia; Mascioni, Alessandro; Aivazian, Argin; Wilson, Ian; Maurer, Andreas; Pichler, Bernd J.; Kneilling, Manfred; Sonanini, Dominik
Published in: Theranostics, Issue 5, 2024, Page(s) 4582-4597, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.95173

Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET

Author(s): Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt & Marc C. Huisman
Published in: EJNMMI Research, 2024, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-024-01079-5

Expanding Theranostic Radiopharmaceuticals for TumorDiagnosis and Therapy

Author(s): Cristina Barca, Christoph M. Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D. Windhorst, Nick Devoogdt, Kevin M. Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H. Jacobs
Published in: Pharmaceuticals, Issue 15, 2021, Page(s) 13, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15010013

The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)

Author(s): Barca, Cristina; Foray, Claudia; Hermann, Sven; Herrlinger, Ulrich; Remory, Isabel; Laoui, Damya; Schäfers, Michael; Grauer, Oliver; Zinnhardt, Bastian; Jacbos, Andreas H.
Published in: Frontiers in Immunology, Issue 12, 2021, Page(s) 787307, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.787307

Fluorescently labelled vedolizumab to visualise drug distribution and mucosal target cells in inflammatory bowel disease

Author(s): Ruben Y Gabriëls, Anne M van der Waaij, Matthijs D Linssen, Michael Dobosz, Pia Volkmer, Sumreen Jalal, Dominic Robinson, Marcela A Hermoso, Marjolijn N Lub- de Hooge, Eleonora A M Festen, Gursah Kats- Ugurlu, Gerard Dijkstra, Wouter B Nagengast
Published in: Gut, 2024, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331696

Intellectual Property Rights

Patent (6)

CD163-BINDING CONJUGATES

Application/Publication number: 20 24051945
Date: 2024-01-26
Applicant(s): VIB VZW

CD8b-BINDING POLYPEPTIDES

Application/Publication number: 20 24051929
Date: 2024-01-26
Applicant(s): VIB VZW

CD8b-BINDING POLYPEPTIDES

Application/Publication number: 20 24051929
Date: 2024-01-26
Applicant(s): VRIJE UNIVERSITEIT BRUSSEL

AUTOMATED IMAGE INFERENCE FROM WHOLE-BODY MEDICAL IMAGES

Application/Publication number: 20 23064597
Date: 2023-05-31
Applicant(s): ANTAROS MEDICAL AB

BENZO[D]IMIDAZO[1,2-A]IMIDAZOLES AND THEIR USE IN DIAGNOSIS

Application/Publication number: 20 23061215
Date: 2023-04-28
Applicant(s): UNIVERSITAET MUENSTER

CD163-BINDING CONJUGATES

Application/Publication number: 20 24051945
Date: 2024-01-26
Applicant(s): VRIJE UNIVERSITEIT BRUSSEL