Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies

Deliverables

Documents, reports (6)

Draft Data Management Plan for Immune-Imaging data storage and analysis infrastructure using FAIR as guiding principles

For further details see WP2Task 21

SOP to transfer new tracers to WP6

For further details see WP5/Task 5.1

SOP/CoA to transfer new tracers to WP4

For further details see WP3/Task 3.1,3.2,3.3,3.4,3.6

SOP for data collection and storage

For further details see WP2/Task 2.3

Completed clinical imaging protocols and setup/design of imaging system accreditation programme for clinical studies in WP6

For further details see WP2Task 2227

First study subject approvals package for task 6.6

For further details see WP6Task 66

Websites, patent fillings, videos etc. (1)

Public web site in place

For further details see WP1/Task 1.6

Publications

Peer reviewed articles (10)

Imaging temozolomide-induced changes in the myeloid glioma microenvironment

Author(s): Claudia Foray, Silvia Valtorta, Cristina Barca, Alexandra Winkeler, Wolfgang Roll, Michael Müther, Stefan Wagner, Miranda L. Gardner, Sven Hermann, Michael Schäfers, Oliver Martin Grauer, Rosa Maria Moresco, Bastian Zinnhardt, Andreas H. Jacobs
Published in: Theranostics, 11/5, 2021, Page(s) 2020-2033, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.47269

Characterization of the inflammatory post-ischemic tissue by full volumetric analysis of a multimodal imaging dataset

Author(s): Cristina Barca, Claudia Foray, Sven Hermann, Christian Döring, Michael Schäfers, Andreas H. Jacobs, Bastian Zinnhardt
Published in: NeuroImage, 222, 2020, Page(s) 117217, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2020.117217

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes

Author(s): Cristina Barca, Maximilian Wiesmann, Jesús Calahorra, Lydia Wachsmuth, Christian Döring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Ángeles Peinado, Eva Siles, Cornelius Faber, Michael Schäfers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Zinnhardt
Published in: Theranostics, 11/9, 2021, Page(s) 4030-4049, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.48110

A novel 18 F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo

Author(s): Dominic Alexej Depke, Christian Paul Konken, Lukas Rösner, Sven Hermann, Michael Schäfers, Andrea Rentmeister
Published in: Chemical Communications, 57/77, 2021, Page(s) 9850-9853, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc03871k

Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica

Author(s): van der Geest, Kornelis S.M.; Sandovici, Maria; Nienhues, Peter H.; Slart, Riemer H.J.A.; Heeringa, Peter; Brouwer, Elisabeth; Jiemy, William
Published in: Frontiers in Medicine, 2, 2022, ISSN 2296-858X
Publisher: Frontiers Media
DOI: 10.3389/fmed.2022.902155

Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

Author(s): Arnouk, Sana; De Groof, Timo; Van Ginderachter, Jo
Published in: Advanced Drug Delivery Review, 184, 2022, Page(s) 114239, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114239

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD81 T cells in giant cell arteritis

Author(s): Reitsema, Rosanne D.; van der Geest, Kornelis S. M.; Sandovici, Maria; Jiemy, William F.; Graver, Jacoba C.; Abdulahad, Wayel H.; Boots, Annemieke M.H.; Herringa, Peter; Brouwer, Elisabeth
Published in: The Journal of Rheuatology, 6, 2022, ISSN 0315-162X
Publisher: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.1093/rheumatology/keac250

TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma

Author(s): Bastian Zinnhardt, Michael Müther, Wolfgang Roll, Philipp Backhaus, Astrid Jeibmann, Claudia Foray, Cristina Barca, Christian Döring, Bertrand Tavitian, Frédéric Dollé, Matthias Weckesser, Alexandra Winkeler, Sven Hermann, Stefan Wagner, Heinz Wiendl, Walter Stummer, Andreas H Jacobs, Michael Schäfers, Oliver M Grauer
Published in: Neuro-Oncology, 22/7, 2020, Page(s) 1030-1043, ISSN 1522-8517
Publisher: Duke University Press
DOI: 10.1093/neuonc/noaa023

Expanding Theranostic Radiopharmaceuticals for TumorDiagnosis and Therapy

Author(s): Cristina Barca, Christoph M. Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D. Windhorst, Nick Devoogdt, Kevin M. Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H. Jacobs
Published in: Pharmaceuticals, 15, 2021, Page(s) 13, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15010013

The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)

Author(s): Barca, Cristina; Foray, Claudia; Hermann, Sven; Herrlinger, Ulrich; Remory, Isabel; Laoui, Damya; Schäfers, Michael; Grauer, Oliver; Zinnhardt, Bastian; Jacbos, Andreas H.
Published in: Frontiers in Immunology, 12, 2021, Page(s) 787307, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.787307