Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies

Información del proyecto

Immune-Image

Identificador del acuerdo de subvención: 831514

DOI

10.3030/831514

Fecha de la firma de la CE 26 Septiembre 2019

Fecha de inicio 1 Octubre 2019

Fecha de finalización 31 Marzo 2026

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 27 154 551,37

Aportación de la UE

€ 15 000 000,00

Coordinado por

STICHTING AMSTERDAM UMC
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (13)

Midterm recruitment report for task 6.4

For further details see WP6Task 64

Midterm recruitment report for task 6.3

For further details see WP6Task 63

Draft Data Management Plan for Immune-Imaging data storage and analysis infrastructure using FAIR as guiding principles

For further details see WP2Task 21

SOP to transfer new tracers to WP6

For further details see WP5/Task 5.1

68Ga-MMR liquid formulation

For further details see WP6Task 61

First study subject approvals package for task 6.3

For further details see WP6Task 63

First study subject approvals package for task 6.1

For further details see WP6Task 61

SOP/CoA to transfer new tracers to WP4

For further details see WP3/Task 3.1,3.2,3.3,3.4,3.6

SOP for data collection and storage

For further details see WP2/Task 2.3

Report on the feasibility of harmonising preclinical systems and prototype harmonising system performance standards with WP3,4,5

For further details see WP2Task 27

First study subject approvals package for task 6.4

For further details see WP6Task 64

Completed clinical imaging protocols and setup/design of imaging system accreditation programme for clinical studies in WP6

For further details see WP2Task 2227

First study subject approvals package for task 6.6

For further details see WP6Task 66

Websites, patent fillings, videos etc. (1)

Public web site in place

For further details see WP1/Task 1.6

Other (1)

Immune-Image biosample meta-data catalogue available online and loaded with first sample data

For further details see WP2/Task 2.4

Publicaciones

Peer reviewed articles (24)

Imaging temozolomide-induced changes in the myeloid glioma microenvironment

Autores: Claudia Foray, Silvia Valtorta, Cristina Barca, Alexandra Winkeler, Wolfgang Roll, Michael Müther, Stefan Wagner, Miranda L. Gardner, Sven Hermann, Michael Schäfers, Oliver Martin Grauer, Rosa Maria Moresco, Bastian Zinnhardt, Andreas H. Jacobs
Publicado en: Theranostics, Edición 11/5, 2021, Página(s) 2020-2033, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.47269

Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI

Autores: Foray, Claudia; Barca, Cristina; Winkeler, Alexandra; Wagner, Stefan; Hermann, Sven; Schäfers, Michael; Grauer, Oliver Martin; Zinnhardt, Bastian; Jacobs, Andreas H.
Publicado en: Journal of Nuclear Medicine, Edición 2159662X, 2022, Página(s) 1386-1393, ISSN 2159-662X
Editor: Society of Nuclear Medicine and Molecular Imaging
DOI: 10.2967/jnumed.121.263318

Characterization of the inflammatory post-ischemic tissue by full volumetric analysis of a multimodal imaging dataset

Autores: Cristina Barca, Claudia Foray, Sven Hermann, Christian Döring, Michael Schäfers, Andreas H. Jacobs, Bastian Zinnhardt
Publicado en: NeuroImage, Edición 222, 2020, Página(s) 117217, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2020.117217

Concerning the photophysics of fluorophores towards tailoredbioimaging compounds: a case study involving S100A9 inflammationmarkers

Autores: Simon T. Steiner,Iván Maisuls, Anna Junker, Günter Fritz, Andreas Faust, Cristian A. Strassert
Publicado en: Photochemical & Photobiological Sciences, 2023, ISSN 1474-905X
Editor: Royal Society of Chemistry
DOI: 10.1007/s43630-023-00432-2

Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors

Autores: Macarena Román Alonso, Ariadna Grinyó-Escuer, Santiago Duro-Sánchez, Irene Rius-Ruiz, Marta Bort-Brusca, Marta Escorihuela, Susana Maqueda-Marcos, Sandra Pérez-Ramos, Judit Gago, Vanesa Nogales, Martín Espinosa-Bravo, Vicente Peg, Santiago Escrivá-de-Romaní, Laia Foradada, Laura Soucek, Irene Braña, Vladimir Galvao, Silvia Martín-Lluesma, Ekkehard Moessner, Christian Klein, Elena Garralda
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-53265-7

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes

Autores: Cristina Barca, Maximilian Wiesmann, Jesús Calahorra, Lydia Wachsmuth, Christian Döring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Ángeles Peinado, Eva Siles, Cornelius Faber, Michael Schäfers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Zinnhardt
Publicado en: Theranostics, Edición 11/9, 2021, Página(s) 4030-4049, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.48110

Radiomic Signatures Associated with CD8+ Tumour-Infiltrating Lymphocytes: A Systematic Review and Quality Assessment Study 

Autores: Syafiq Ramlee, David Hulse, Kinga Bernatowicz, Raquel Pérez-López, Evis Sala, Luigi Aloj 
Publicado en: Cancers, Edición 20726694, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153656

Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study

Autores: Wijngaarden, Jessica E.; Huisman, Marc C.; Pouw, Johanna E. E.; Menke-van der Houven van Oordt, C. Willemien; Jauw, Yvonne W. S.; Boelaard, Ronald
Publicado en: EJNMMI Research, Edición 2191219X, 2022, ISSN 2191-219X
Editor: Springer Berlin
DOI: 10.1186/s13550-022-00927-6

Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β

Autores: Timo W.M. De Groof, Yoline Lauwers, Tessa De Pauw, Mohit Saxena, Cécile Vincke, Jolien Van Craenenbroeck, Catherine Chapon, Roger Le Grand, Geert Raes, Thibaut Naninck, Jo A. Van Ginderachter, Nick Devoogdt
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, 2024, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1007/s00259-024-06896-3

Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Autores: Gondry, Odrade; Xavier, Catarina; Raes, Laurens; Heemskerk, Johannes; Devoogdt, Nick; Everaert, Hendrik; Breckpot, Karine; Lecocq, Quentin; Decoster, Lore; Fontaine, Christel; Schallier, Denis; Aspeslagh, Sandrine; Vaneycken, Ilse; Raes, Geert; Van Ginderachter, Jo A.; Lahoutte, Tony; Cavaliers, Vicky; Keyaerts, Marleen
Publicado en: Journal of Nuclear Medicine, Edición 5, 2023, ISSN 0161-5505
Editor: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.122.264853

How to obtain the image‑derived blood concentration from 89Zr‑immuno‑PET scans

Autores: Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke‑van der Houven van Oordt, Marc C. Huisman
Publicado en: EJNMMI Physics, 2024, ISSN 1619-7089
Editor: Springer Science+Business Media
DOI: 10.1186/s40658-024-00621-7

Navigating the landscape of PD-1/PD-L1 imaging tracers: from challenges to opportunities

Autores: Melinda Badenhorst, Albert D. Windhorst, Wissam Beaino
Publicado en: Frontiers in Medicine, 2024, ISSN 2296-858X
Editor: Frontiers Media
DOI: 10.3389/fmed.2024.1401515

A novel 18 F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo

Autores: Dominic Alexej Depke, Christian Paul Konken, Lukas Rösner, Sven Hermann, Michael Schäfers, Andrea Rentmeister
Publicado en: Chemical Communications, Edición 57/77, 2021, Página(s) 9850-9853, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cc03871k

Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake

Autores: Wiijngaarden, Jessica E; Huisman, Marc C; Jauw, Yvonne W S; van Dongen, Guus A M S; Greuter, Henri N J M; Schuit, Robert C; Cleceland, Matthew; Gootjes, Elske C; Vugts, Danielle J; Menke-van der Houven van Oordt, C Willemien; Boellaard, Ronald
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, Edición 1, 2023, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1007/s00259-023-06151-1

Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica

Autores: van der Geest, Kornelis S.M.; Sandovici, Maria; Nienhues, Peter H.; Slart, Riemer H.J.A.; Heeringa, Peter; Brouwer, Elisabeth; Jiemy, William
Publicado en: Frontiers in Medicine, Edición 2, 2022, ISSN 2296-858X
Editor: Frontiers Media
DOI: 10.3389/fmed.2022.902155

89Zr-Immuno-PET with Immune Checkpoint Inhibitors: Measuring Target Engagement in Healthy Organs

Autores: Iris H. C. Miedema, Jessica E. Wijngaarden, Johanna E. E. Pouw, Gerben J. C. Zwezerijnen, Hylke J. Sebus, Egbert Smit, Adrianus J. de Langen, Idris Bahce, Andrea Thiele, Daniëlle J. Vugts, Ronald Boellaard, Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt
Publicado en: Cancers, Edición 6, 2023, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15235546

Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

Autores: Arnouk, Sana; De Groof, Timo; Van Ginderachter, Jo
Publicado en: Advanced Drug Delivery Review, Edición 184, 2022, Página(s) 114239, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2022.114239

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD81 T cells in giant cell arteritis

Autores: Reitsema, Rosanne D.; van der Geest, Kornelis S. M.; Sandovici, Maria; Jiemy, William F.; Graver, Jacoba C.; Abdulahad, Wayel H.; Boots, Annemieke M.H.; Herringa, Peter; Brouwer, Elisabeth
Publicado en: The Journal of Rheuatology, Edición 6, 2022, ISSN 0315-162X
Editor: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.1093/rheumatology/keac250

TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma

Autores: Bastian Zinnhardt, Michael Müther, Wolfgang Roll, Philipp Backhaus, Astrid Jeibmann, Claudia Foray, Cristina Barca, Christian Döring, Bertrand Tavitian, Frédéric Dollé, Matthias Weckesser, Alexandra Winkeler, Sven Hermann, Stefan Wagner, Heinz Wiendl, Walter Stummer, Andreas H Jacobs, Michael Schäfers, Oliver M Grauer
Publicado en: Neuro-Oncology, Edición 22/7, 2020, Página(s) 1030-1043, ISSN 1522-8517
Editor: Duke University Press
DOI: 10.1093/neuonc/noaa023

In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy

Autores: Pezzana, Stefania; Blaess, Simone; Kortendieck, Jule; Hemmer, Nicole; Tako, Bredi; Pietura, Claudia; Ruoff, Lara; Riel, Simone; Schaller, Martin; Gonzalez-Menendez, Irene; Quintanilla-Martinez, Leticia; Mascioni, Alessandro; Aivazian, Argin; Wilson, Ian; Maurer, Andreas; Pichler, Bernd J.; Kneilling, Manfred; Sonanini, Dominik
Publicado en: Theranostics, Edición 5, 2024, Página(s) 4582-4597, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.95173

Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET

Autores: Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt & Marc C. Huisman
Publicado en: EJNMMI Research, 2024, ISSN 2191-219X
Editor: Springer Berlin
DOI: 10.1186/s13550-024-01079-5

Expanding Theranostic Radiopharmaceuticals for TumorDiagnosis and Therapy

Autores: Cristina Barca, Christoph M. Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D. Windhorst, Nick Devoogdt, Kevin M. Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H. Jacobs
Publicado en: Pharmaceuticals, Edición 15, 2021, Página(s) 13, ISSN 1424-8247
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15010013

The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)

Autores: Barca, Cristina; Foray, Claudia; Hermann, Sven; Herrlinger, Ulrich; Remory, Isabel; Laoui, Damya; Schäfers, Michael; Grauer, Oliver; Zinnhardt, Bastian; Jacbos, Andreas H.
Publicado en: Frontiers in Immunology, Edición 12, 2021, Página(s) 787307, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.787307

Fluorescently labelled vedolizumab to visualise drug distribution and mucosal target cells in inflammatory bowel disease

Autores: Ruben Y Gabriëls, Anne M van der Waaij, Matthijs D Linssen, Michael Dobosz, Pia Volkmer, Sumreen Jalal, Dominic Robinson, Marcela A Hermoso, Marjolijn N Lub- de Hooge, Eleonora A M Festen, Gursah Kats- Ugurlu, Gerard Dijkstra, Wouter B Nagengast
Publicado en: Gut, 2024, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331696

Derechos de propiedad intelectual

Patent (6)

CD163-BINDING CONJUGATES

Número de solicitud/publicación: 20 24051945
Fecha: 2024-01-26
Solicitante(s): VIB VZW

CD8b-BINDING POLYPEPTIDES

Número de solicitud/publicación: 20 24051929
Fecha: 2024-01-26
Solicitante(s): VIB VZW

CD8b-BINDING POLYPEPTIDES

Número de solicitud/publicación: 20 24051929
Fecha: 2024-01-26
Solicitante(s): VRIJE UNIVERSITEIT BRUSSEL

AUTOMATED IMAGE INFERENCE FROM WHOLE-BODY MEDICAL IMAGES

Número de solicitud/publicación: 20 23064597
Fecha: 2023-05-31
Solicitante(s): ANTAROS MEDICAL AB

BENZO[D]IMIDAZO[1,2-A]IMIDAZOLES AND THEIR USE IN DIAGNOSIS

Número de solicitud/publicación: 20 23061215
Fecha: 2023-04-28
Solicitante(s): UNIVERSITAET MUENSTER

CD163-BINDING CONJUGATES

Número de solicitud/publicación: 20 24051945
Fecha: 2024-01-26
Solicitante(s): VRIJE UNIVERSITEIT BRUSSEL