Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies

Informations projet

Immune-Image

N° de convention de subvention: 831514

DOI

10.3030/831514

Date de signature de la CE 26 Septembre 2019

Date de début 1 Octobre 2019

Date de fin 31 Mars 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 27 154 551,37

Contribution de l’UE

€ 15 000 000,00

Coordonné par

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (13)

Midterm recruitment report for task 6.4

For further details see WP6Task 64

Midterm recruitment report for task 6.3

For further details see WP6Task 63

Draft Data Management Plan for Immune-Imaging data storage and analysis infrastructure using FAIR as guiding principles

For further details see WP2Task 21

SOP to transfer new tracers to WP6

For further details see WP5/Task 5.1

68Ga-MMR liquid formulation

For further details see WP6Task 61

First study subject approvals package for task 6.3

For further details see WP6Task 63

First study subject approvals package for task 6.1

For further details see WP6Task 61

SOP/CoA to transfer new tracers to WP4

For further details see WP3/Task 3.1,3.2,3.3,3.4,3.6

SOP for data collection and storage

For further details see WP2/Task 2.3

Report on the feasibility of harmonising preclinical systems and prototype harmonising system performance standards with WP3,4,5

For further details see WP2Task 27

First study subject approvals package for task 6.4

For further details see WP6Task 64

Completed clinical imaging protocols and setup/design of imaging system accreditation programme for clinical studies in WP6

For further details see WP2Task 2227

First study subject approvals package for task 6.6

For further details see WP6Task 66

Websites, patent fillings, videos etc. (1)

Public web site in place

For further details see WP1/Task 1.6

Other (1)

Immune-Image biosample meta-data catalogue available online and loaded with first sample data

For further details see WP2/Task 2.4

Publications

Peer reviewed articles (24)

Imaging temozolomide-induced changes in the myeloid glioma microenvironment

Auteurs: Claudia Foray, Silvia Valtorta, Cristina Barca, Alexandra Winkeler, Wolfgang Roll, Michael Müther, Stefan Wagner, Miranda L. Gardner, Sven Hermann, Michael Schäfers, Oliver Martin Grauer, Rosa Maria Moresco, Bastian Zinnhardt, Andreas H. Jacobs
Publié dans: Theranostics, Numéro 11/5, 2021, Page(s) 2020-2033, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.47269

Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI

Auteurs: Foray, Claudia; Barca, Cristina; Winkeler, Alexandra; Wagner, Stefan; Hermann, Sven; Schäfers, Michael; Grauer, Oliver Martin; Zinnhardt, Bastian; Jacobs, Andreas H.
Publié dans: Journal of Nuclear Medicine, Numéro 2159662X, 2022, Page(s) 1386-1393, ISSN 2159-662X
Éditeur: Society of Nuclear Medicine and Molecular Imaging
DOI: 10.2967/jnumed.121.263318

Characterization of the inflammatory post-ischemic tissue by full volumetric analysis of a multimodal imaging dataset

Auteurs: Cristina Barca, Claudia Foray, Sven Hermann, Christian Döring, Michael Schäfers, Andreas H. Jacobs, Bastian Zinnhardt
Publié dans: NeuroImage, Numéro 222, 2020, Page(s) 117217, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2020.117217

Concerning the photophysics of fluorophores towards tailoredbioimaging compounds: a case study involving S100A9 inflammationmarkers

Auteurs: Simon T. Steiner,Iván Maisuls, Anna Junker, Günter Fritz, Andreas Faust, Cristian A. Strassert
Publié dans: Photochemical & Photobiological Sciences, 2023, ISSN 1474-905X
Éditeur: Royal Society of Chemistry
DOI: 10.1007/s43630-023-00432-2

Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors

Auteurs: Macarena Román Alonso, Ariadna Grinyó-Escuer, Santiago Duro-Sánchez, Irene Rius-Ruiz, Marta Bort-Brusca, Marta Escorihuela, Susana Maqueda-Marcos, Sandra Pérez-Ramos, Judit Gago, Vanesa Nogales, Martín Espinosa-Bravo, Vicente Peg, Santiago Escrivá-de-Romaní, Laia Foradada, Laura Soucek, Irene Braña, Vladimir Galvao, Silvia Martín-Lluesma, Ekkehard Moessner, Christian Klein, Elena Garralda
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-53265-7

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes

Auteurs: Cristina Barca, Maximilian Wiesmann, Jesús Calahorra, Lydia Wachsmuth, Christian Döring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Ángeles Peinado, Eva Siles, Cornelius Faber, Michael Schäfers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Zinnhardt
Publié dans: Theranostics, Numéro 11/9, 2021, Page(s) 4030-4049, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.48110

Radiomic Signatures Associated with CD8+ Tumour-Infiltrating Lymphocytes: A Systematic Review and Quality Assessment Study 

Auteurs: Syafiq Ramlee, David Hulse, Kinga Bernatowicz, Raquel Pérez-López, Evis Sala, Luigi Aloj 
Publié dans: Cancers, Numéro 20726694, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153656

Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study

Auteurs: Wijngaarden, Jessica E.; Huisman, Marc C.; Pouw, Johanna E. E.; Menke-van der Houven van Oordt, C. Willemien; Jauw, Yvonne W. S.; Boelaard, Ronald
Publié dans: EJNMMI Research, Numéro 2191219X, 2022, ISSN 2191-219X
Éditeur: Springer Berlin
DOI: 10.1186/s13550-022-00927-6

Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β

Auteurs: Timo W.M. De Groof, Yoline Lauwers, Tessa De Pauw, Mohit Saxena, Cécile Vincke, Jolien Van Craenenbroeck, Catherine Chapon, Roger Le Grand, Geert Raes, Thibaut Naninck, Jo A. Van Ginderachter, Nick Devoogdt
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, 2024, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-024-06896-3

Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Auteurs: Gondry, Odrade; Xavier, Catarina; Raes, Laurens; Heemskerk, Johannes; Devoogdt, Nick; Everaert, Hendrik; Breckpot, Karine; Lecocq, Quentin; Decoster, Lore; Fontaine, Christel; Schallier, Denis; Aspeslagh, Sandrine; Vaneycken, Ilse; Raes, Geert; Van Ginderachter, Jo A.; Lahoutte, Tony; Cavaliers, Vicky; Keyaerts, Marleen
Publié dans: Journal of Nuclear Medicine, Numéro 5, 2023, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.122.264853

How to obtain the image‑derived blood concentration from 89Zr‑immuno‑PET scans

Auteurs: Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke‑van der Houven van Oordt, Marc C. Huisman
Publié dans: EJNMMI Physics, 2024, ISSN 1619-7089
Éditeur: Springer Science+Business Media
DOI: 10.1186/s40658-024-00621-7

Navigating the landscape of PD-1/PD-L1 imaging tracers: from challenges to opportunities

Auteurs: Melinda Badenhorst, Albert D. Windhorst, Wissam Beaino
Publié dans: Frontiers in Medicine, 2024, ISSN 2296-858X
Éditeur: Frontiers Media
DOI: 10.3389/fmed.2024.1401515

A novel 18 F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo

Auteurs: Dominic Alexej Depke, Christian Paul Konken, Lukas Rösner, Sven Hermann, Michael Schäfers, Andrea Rentmeister
Publié dans: Chemical Communications, Numéro 57/77, 2021, Page(s) 9850-9853, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1cc03871k

Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake

Auteurs: Wiijngaarden, Jessica E; Huisman, Marc C; Jauw, Yvonne W S; van Dongen, Guus A M S; Greuter, Henri N J M; Schuit, Robert C; Cleceland, Matthew; Gootjes, Elske C; Vugts, Danielle J; Menke-van der Houven van Oordt, C Willemien; Boellaard, Ronald
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, Numéro 1, 2023, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-023-06151-1

Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica

Auteurs: van der Geest, Kornelis S.M.; Sandovici, Maria; Nienhues, Peter H.; Slart, Riemer H.J.A.; Heeringa, Peter; Brouwer, Elisabeth; Jiemy, William
Publié dans: Frontiers in Medicine, Numéro 2, 2022, ISSN 2296-858X
Éditeur: Frontiers Media
DOI: 10.3389/fmed.2022.902155

89Zr-Immuno-PET with Immune Checkpoint Inhibitors: Measuring Target Engagement in Healthy Organs

Auteurs: Iris H. C. Miedema, Jessica E. Wijngaarden, Johanna E. E. Pouw, Gerben J. C. Zwezerijnen, Hylke J. Sebus, Egbert Smit, Adrianus J. de Langen, Idris Bahce, Andrea Thiele, Daniëlle J. Vugts, Ronald Boellaard, Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt
Publié dans: Cancers, Numéro 6, 2023, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15235546

Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

Auteurs: Arnouk, Sana; De Groof, Timo; Van Ginderachter, Jo
Publié dans: Advanced Drug Delivery Review, Numéro 184, 2022, Page(s) 114239, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2022.114239

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD81 T cells in giant cell arteritis

Auteurs: Reitsema, Rosanne D.; van der Geest, Kornelis S. M.; Sandovici, Maria; Jiemy, William F.; Graver, Jacoba C.; Abdulahad, Wayel H.; Boots, Annemieke M.H.; Herringa, Peter; Brouwer, Elisabeth
Publié dans: The Journal of Rheuatology, Numéro 6, 2022, ISSN 0315-162X
Éditeur: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.1093/rheumatology/keac250

TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma

Auteurs: Bastian Zinnhardt, Michael Müther, Wolfgang Roll, Philipp Backhaus, Astrid Jeibmann, Claudia Foray, Cristina Barca, Christian Döring, Bertrand Tavitian, Frédéric Dollé, Matthias Weckesser, Alexandra Winkeler, Sven Hermann, Stefan Wagner, Heinz Wiendl, Walter Stummer, Andreas H Jacobs, Michael Schäfers, Oliver M Grauer
Publié dans: Neuro-Oncology, Numéro 22/7, 2020, Page(s) 1030-1043, ISSN 1522-8517
Éditeur: Duke University Press
DOI: 10.1093/neuonc/noaa023

In-depth cross-validation of human and mouse CD4-specific minibodies for noninvasive PET imaging of CD4+ cells and response prediction to cancer immunotherapy

Auteurs: Pezzana, Stefania; Blaess, Simone; Kortendieck, Jule; Hemmer, Nicole; Tako, Bredi; Pietura, Claudia; Ruoff, Lara; Riel, Simone; Schaller, Martin; Gonzalez-Menendez, Irene; Quintanilla-Martinez, Leticia; Mascioni, Alessandro; Aivazian, Argin; Wilson, Ian; Maurer, Andreas; Pichler, Bernd J.; Kneilling, Manfred; Sonanini, Dominik
Publié dans: Theranostics, Numéro 5, 2024, Page(s) 4582-4597, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.95173

Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET

Auteurs: Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt & Marc C. Huisman
Publié dans: EJNMMI Research, 2024, ISSN 2191-219X
Éditeur: Springer Berlin
DOI: 10.1186/s13550-024-01079-5

Expanding Theranostic Radiopharmaceuticals for TumorDiagnosis and Therapy

Auteurs: Cristina Barca, Christoph M. Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D. Windhorst, Nick Devoogdt, Kevin M. Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H. Jacobs
Publié dans: Pharmaceuticals, Numéro 15, 2021, Page(s) 13, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15010013

The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)

Auteurs: Barca, Cristina; Foray, Claudia; Hermann, Sven; Herrlinger, Ulrich; Remory, Isabel; Laoui, Damya; Schäfers, Michael; Grauer, Oliver; Zinnhardt, Bastian; Jacbos, Andreas H.
Publié dans: Frontiers in Immunology, Numéro 12, 2021, Page(s) 787307, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.787307

Fluorescently labelled vedolizumab to visualise drug distribution and mucosal target cells in inflammatory bowel disease

Auteurs: Ruben Y Gabriëls, Anne M van der Waaij, Matthijs D Linssen, Michael Dobosz, Pia Volkmer, Sumreen Jalal, Dominic Robinson, Marcela A Hermoso, Marjolijn N Lub- de Hooge, Eleonora A M Festen, Gursah Kats- Ugurlu, Gerard Dijkstra, Wouter B Nagengast
Publié dans: Gut, 2024, ISSN 0017-5749
Éditeur: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331696

Droits de propriété intellectuelle

Patent (6)

CD163-BINDING CONJUGATES

Numéro de demande/publication: 20 24051945
Date: 2024-01-26
Demandeur(s): VIB VZW

CD8b-BINDING POLYPEPTIDES

Numéro de demande/publication: 20 24051929
Date: 2024-01-26
Demandeur(s): VIB VZW

CD8b-BINDING POLYPEPTIDES

Numéro de demande/publication: 20 24051929
Date: 2024-01-26
Demandeur(s): VRIJE UNIVERSITEIT BRUSSEL

AUTOMATED IMAGE INFERENCE FROM WHOLE-BODY MEDICAL IMAGES

Numéro de demande/publication: 20 23064597
Date: 2023-05-31
Demandeur(s): ANTAROS MEDICAL AB

BENZO[D]IMIDAZO[1,2-A]IMIDAZOLES AND THEIR USE IN DIAGNOSIS

Numéro de demande/publication: 20 23061215
Date: 2023-04-28
Demandeur(s): UNIVERSITAET MUENSTER

CD163-BINDING CONJUGATES

Numéro de demande/publication: 20 24051945
Date: 2024-01-26
Demandeur(s): VRIJE UNIVERSITEIT BRUSSEL