Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies

Leistungen

Midterm recruitment report for task 6.4

For further details see WP6Task 64

Midterm recruitment report for task 6.3

For further details see WP6Task 63

Draft Data Management Plan for Immune-Imaging data storage and analysis infrastructure using FAIR as guiding principles

For further details see WP2Task 21

SOP to transfer new tracers to WP6

For further details see WP5/Task 5.1

68Ga-MMR liquid formulation

For further details see WP6Task 61

First study subject approvals package for task 6.3

For further details see WP6Task 63

First study subject approvals package for task 6.1

For further details see WP6Task 61

SOP/CoA to transfer new tracers to WP4

For further details see WP3/Task 3.1,3.2,3.3,3.4,3.6

SOP for data collection and storage

For further details see WP2/Task 2.3

Report on the feasibility of harmonising preclinical systems and prototype harmonising system performance standards with WP3,4,5

For further details see WP2Task 27

First study subject approvals package for task 6.4

For further details see WP6Task 64

Completed clinical imaging protocols and setup/design of imaging system accreditation programme for clinical studies in WP6

For further details see WP2Task 2227

First study subject approvals package for task 6.6

For further details see WP6Task 66

Public web site in place

For further details see WP1/Task 1.6

Immune-Image biosample meta-data catalogue available online and loaded with first sample data

For further details see WP2/Task 2.4

Veröffentlichungen

Imaging temozolomide-induced changes in the myeloid glioma microenvironment

Autoren: Claudia Foray, Silvia Valtorta, Cristina Barca, Alexandra Winkeler, Wolfgang Roll, Michael Müther, Stefan Wagner, Miranda L. Gardner, Sven Hermann, Michael Schäfers, Oliver Martin Grauer, Rosa Maria Moresco, Bastian Zinnhardt, Andreas H. Jacobs
Veröffentlicht in: Theranostics, Ausgabe 11/5, 2021, Seite(n) 2020-2033, ISSN 1838-7640
Herausgeber: Ivyspring International Publisher
DOI: 10.7150/thno.47269

Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI

Autoren: Foray, Claudia; Barca, Cristina; Winkeler, Alexandra; Wagner, Stefan; Hermann, Sven; Schäfers, Michael; Grauer, Oliver Martin; Zinnhardt, Bastian; Jacobs, Andreas H.
Veröffentlicht in: Journal of Nuclear Medicine, Ausgabe 2159662X, 2022, Seite(n) 1386-1393, ISSN 2159-662X
Herausgeber: Society of Nuclear Medicine and Molecular Imaging
DOI: 10.2967/jnumed.121.263318

Characterization of the inflammatory post-ischemic tissue by full volumetric analysis of a multimodal imaging dataset

Autoren: Cristina Barca, Claudia Foray, Sven Hermann, Christian Döring, Michael Schäfers, Andreas H. Jacobs, Bastian Zinnhardt
Veröffentlicht in: NeuroImage, Ausgabe 222, 2020, Seite(n) 117217, ISSN 1053-8119
Herausgeber: Academic Press
DOI: 10.1016/j.neuroimage.2020.117217

Concerning the photophysics of fluorophores towards tailoredbioimaging compounds: a case study involving S100A9 inflammationmarkers

Autoren: Simon T. Steiner,Iván Maisuls, Anna Junker, Günter Fritz, Andreas Faust, Cristian A. Strassert
Veröffentlicht in: Photochemical & Photobiological Sciences, 2023, ISSN 1474-905X
Herausgeber: Royal Society of Chemistry
DOI: 10.1007/s43630-023-00432-2

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes

Autoren: Cristina Barca, Maximilian Wiesmann, Jesús Calahorra, Lydia Wachsmuth, Christian Döring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Ángeles Peinado, Eva Siles, Cornelius Faber, Michael Schäfers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Zinnhardt
Veröffentlicht in: Theranostics, Ausgabe 11/9, 2021, Seite(n) 4030-4049, ISSN 1838-7640
Herausgeber: Ivyspring International Publisher
DOI: 10.7150/thno.48110

Radiomic Signatures Associated with CD8+ Tumour-Infiltrating Lymphocytes: A Systematic Review and Quality Assessment Study

Autoren: Syafiq Ramlee, David Hulse, Kinga Bernatowicz, Raquel Pérez-López, Evis Sala, Luigi Aloj
Veröffentlicht in: Cancers, Ausgabe 20726694, 2022, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14153656

Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study

Autoren: Wijngaarden, Jessica E.; Huisman, Marc C.; Pouw, Johanna E. E.; Menke-van der Houven van Oordt, C. Willemien; Jauw, Yvonne W. S.; Boelaard, Ronald
Veröffentlicht in: EJNMMI Research, Ausgabe 2191219X, 2022, ISSN 2191-219X
Herausgeber: Springer Berlin
DOI: 10.1186/s13550-022-00927-6

Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I)

Autoren: Gondry, Odrade; Xavier, Catarina; Raes, Laurens; Heemskerk, Johannes; Devoogdt, Nick; Everaert, Hendrik; Breckpot, Karine; Lecocq, Quentin; Decoster, Lore; Fontaine, Christel; Schallier, Denis; Aspeslagh, Sandrine; Vaneycken, Ilse; Raes, Geert; Van Ginderachter, Jo A.; Lahoutte, Tony; Cavaliers, Vicky; Keyaerts, Marleen
Veröffentlicht in: Journal of Nuclear Medicine, Ausgabe 5, 2023, ISSN 0161-5505
Herausgeber: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.122.264853

How to obtain the image‑derived blood concentration from 89Zr‑immuno‑PET scans

Autoren: Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke‑van der Houven van Oordt, Marc C. Huisman
Veröffentlicht in: EJNMMI Physics, 2024, ISSN 1619-7089
Herausgeber: Springer Science+Business Media
DOI: 10.1186/s40658-024-00621-7

A novel 18 F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PET in vivo

Autoren: Dominic Alexej Depke, Christian Paul Konken, Lukas Rösner, Sven Hermann, Michael Schäfers, Andrea Rentmeister
Veröffentlicht in: Chemical Communications, Ausgabe 57/77, 2021, Seite(n) 9850-9853, ISSN 1359-7345
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d1cc03871k

Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake

Autoren: Wiijngaarden, Jessica E; Huisman, Marc C; Jauw, Yvonne W S; van Dongen, Guus A M S; Greuter, Henri N J M; Schuit, Robert C; Cleceland, Matthew; Gootjes, Elske C; Vugts, Danielle J; Menke-van der Houven van Oordt, C Willemien; Boellaard, Ronald
Veröffentlicht in: European Journal of Nuclear Medicine and Molecular Imaging, Ausgabe 1, 2023, ISSN 1619-7070
Herausgeber: Springer Verlag
DOI: 10.1007/s00259-023-06151-1

Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica

Autoren: van der Geest, Kornelis S.M.; Sandovici, Maria; Nienhues, Peter H.; Slart, Riemer H.J.A.; Heeringa, Peter; Brouwer, Elisabeth; Jiemy, William
Veröffentlicht in: Frontiers in Medicine, Ausgabe 2, 2022, ISSN 2296-858X
Herausgeber: Frontiers Media
DOI: 10.3389/fmed.2022.902155

89Zr-Immuno-PET with Immune Checkpoint Inhibitors: Measuring Target Engagement in Healthy Organs

Autoren: Iris H. C. Miedema, Jessica E. Wijngaarden, Johanna E. E. Pouw, Gerben J. C. Zwezerijnen, Hylke J. Sebus, Egbert Smit, Adrianus J. de Langen, Idris Bahce, Andrea Thiele, Daniëlle J. Vugts, Ronald Boellaard, Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt
Veröffentlicht in: Cancers, Ausgabe 6, 2023, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15235546

Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

Autoren: Arnouk, Sana; De Groof, Timo; Van Ginderachter, Jo
Veröffentlicht in: Advanced Drug Delivery Review, Ausgabe 184, 2022, Seite(n) 114239, ISSN 0169-409X
Herausgeber: Elsevier BV
DOI: 10.1016/j.addr.2022.114239

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD81 T cells in giant cell arteritis

Autoren: Reitsema, Rosanne D.; van der Geest, Kornelis S. M.; Sandovici, Maria; Jiemy, William F.; Graver, Jacoba C.; Abdulahad, Wayel H.; Boots, Annemieke M.H.; Herringa, Peter; Brouwer, Elisabeth
Veröffentlicht in: The Journal of Rheuatology, Ausgabe 6, 2022, ISSN 0315-162X
Herausgeber: Journal of Rheumatology Publishing Co., Ltd.
DOI: 10.1093/rheumatology/keac250

TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma

Autoren: Bastian Zinnhardt, Michael Müther, Wolfgang Roll, Philipp Backhaus, Astrid Jeibmann, Claudia Foray, Cristina Barca, Christian Döring, Bertrand Tavitian, Frédéric Dollé, Matthias Weckesser, Alexandra Winkeler, Sven Hermann, Stefan Wagner, Heinz Wiendl, Walter Stummer, Andreas H Jacobs, Michael Schäfers, Oliver M Grauer
Veröffentlicht in: Neuro-Oncology, Ausgabe 22/7, 2020, Seite(n) 1030-1043, ISSN 1522-8517
Herausgeber: Duke University Press
DOI: 10.1093/neuonc/noaa023

Expanding Theranostic Radiopharmaceuticals for TumorDiagnosis and Therapy

Autoren: Cristina Barca, Christoph M. Griessinger, Andreas Faust, Dominic Depke, Markus Essler, Albert D. Windhorst, Nick Devoogdt, Kevin M. Brindle, Michael Schäfers, Bastian Zinnhardt, Andreas H. Jacobs
Veröffentlicht in: Pharmaceuticals, Ausgabe 15, 2021, Seite(n) 13, ISSN 1424-8247
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph15010013

The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)

Autoren: Barca, Cristina; Foray, Claudia; Hermann, Sven; Herrlinger, Ulrich; Remory, Isabel; Laoui, Damya; Schäfers, Michael; Grauer, Oliver; Zinnhardt, Bastian; Jacbos, Andreas H.
Veröffentlicht in: Frontiers in Immunology, Ausgabe 12, 2021, Seite(n) 787307, ISSN 1664-3224
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.787307

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