Description du projet
Étudier de plus près la physiologie reproductive pour augmenter la fertilité
L’alimentation influence l’efficacité reproductive. Des études ont démontré que les acides gras polyinsaturés oméga-3 (AGPI n-3) peuvent s’avérer essentiels pour la physiologie reproductive. L’efficacité des AGPI n-3 pendant la période péri-implantatoire chez les mammifères est également à l’étude. Toutefois, il est nécessaire de poursuivre les recherches pour en tirer des conclusions. C’est pourquoi NUTREPHEALTH combinera des études morphologiques, des essais hormonaux, des procédures en protéomique et en génomique et des technologies de transfert ou de récupération des embryons pour évaluer les effets de ces AGPI n-3 pendant la période péri-implantatoire. Les résultats obtenus permettront d’améliorer la productivité dans les systèmes de production animale, influençant à la fois le domaine agricole et celui des sciences de la vie. Les connaissances acquises dans le cadre de cette proposition contribueront également à augmenter le taux de fertilité chez les femmes atteintes de problèmes de fertilité.
Objectif
It is well known, that an adequate fertility rates has important outcomes in different species of mammals (including human). However, despite the efforts to maintain outstanding reproductive performance, the reproductive failures are still considerable. This reproductive failure is related to a failure in maternal-embryo communication. In this sense, nutritional factor is one of the most important issues involved in the reproductive efficiency. Some studies have indicated that the use of polyunsatures fatty acids (PUFAS) like omega-3 have a positve effects on human and animal health. Nowadays, the effects of diets rich in PUFAS omega-3 (PUFASn-3) on reproductive physiology have been studied assensing the follicular function, ovulation rate and oocyte quality. In addition, there is scarce information about of the mechanism and/or effectiveness of PUFASn-3 during peri-implantational period in mammals. However the outcomes obtained have been controversiel and non-conclusive, justifying the necesity to perform futher studies. Thus, the combined use of morphologic studies, hormonal assays, genomics and proteomics procedures and embryo recover/transfer technologies could be suitable methodologies to evaluate the effects of PUFASn-3 during peri-implantational period. Also, these tools could evaluate the maternal/endometrial signal (e.g: receptors expression) and gene embryonic expressions during this period. In consequence, these studies could assess the effectiveness of PUFASn-3 on maternal and/or embryo’s level. The results obtained, will contribute to enhance the productivity in animal production system. Furthermore, the use of ovine species has been a classical experimental model in human medical studies. Thus, the awarness obtained in this proposal would contribute to increase the fertility rate in women with reproductive failure during this periodreinforcing the inter/multidisciplinary dimension of this proposal (impacting in life science and agricultural fields).
Champ scientifique
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
07100 Sassari
Italie