Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis

Project Information

Host-TB

Grant agreement ID: 832721

DOI 10.3030/832721

EC signature date 18 April 2019

Start date 1 June 2019

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 160 926,00

EU contribution € 2 160 926,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Publications

Peer reviewed articles (5)

Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9

Author(s): Aniek S. Meijers, Ran Troost, Roy Ummels, Janneke Maaskant, Alexander Speer, Sergey Nejentsev, Wilbert Bitter, Coenraad P. Kuijl
Published in: Tuberculosis, Issue 124, 2020, Page(s) 101983, ISSN 1472-9792
Publisher: Churchill Livingstone
DOI: 10.1016/j.tube.2020.101983

An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome

Author(s): Malcolm Begg, Augustin Amour, Emily Jarvis, Teresa Tang, Sara Santos Franco, Andrew Want, Misba Beerahee, Disala Fernando, Yakshitha Karkera, Clare Sander, Thomas Southworth, Dave Singh, Jonathan Clark, Sergey Nejentsev, Klaus Okkenhaug, Alison Condliffe, Anita Chandra, Anthony Cahn, Edward Banham Hall
Published in: Pulmonary pharmacology and therapeutics, 2023, ISSN 1094-5539
Publisher: Academic Press
DOI: 10.1016/j.pupt.2023.102201

IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn’s disease

Author(s): Jakob Benedict Seidelin, Simone Jensen, Morten Hansen, Mariana Rodrigues de Carvalho Bronze, Delphine Cuchet-Lourenco, Sergey Nejentsev, Eric Charles LaCasse, Ole Haagen Nielsen
Published in: Clinical and Experimental Immunology, 2023, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad092

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation

Author(s): Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton K, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Yeboa KA, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz B, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelha
Published in: J Crohns Colitis, 2021, ISSN 1873-9946
Publisher: Elsevier Science
DOI: 10.1093/ecco-jcc/jjab077

Topoisomerase 2β mutation impairs early B-cell development

Author(s): Papapietro O, Chandra A, Eletto D, Inglott S, Plagnol V, Curtis J, Maes M, Alisaac A, Albuquerque AS, Basseres E, Hermine O, Picard C, Fischer A, Durandy A, Kracker S, Burns S, Cuchet-Lourenco D, Okkenhaug K, Nejentsev S
Published in: Blood, 2020, Page(s) 135(17):1497-1501, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019003299