Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis

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Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9

Autoren: Aniek S. Meijers, Ran Troost, Roy Ummels, Janneke Maaskant, Alexander Speer, Sergey Nejentsev, Wilbert Bitter, Coenraad P. Kuijl
Veröffentlicht in: Tuberculosis, Ausgabe 124, 2020, Seite(n) 101983, ISSN 1472-9792
Herausgeber: Churchill Livingstone
DOI: 10.1016/j.tube.2020.101983

An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome

Autoren: Malcolm Begg, Augustin Amour, Emily Jarvis, Teresa Tang, Sara Santos Franco, Andrew Want, Misba Beerahee, Disala Fernando, Yakshitha Karkera, Clare Sander, Thomas Southworth, Dave Singh, Jonathan Clark, Sergey Nejentsev, Klaus Okkenhaug, Alison Condliffe, Anita Chandra, Anthony Cahn, Edward Banham Hall
Veröffentlicht in: Pulmonary pharmacology and therapeutics, 2023, ISSN 1094-5539
Herausgeber: Academic Press
DOI: 10.1016/j.pupt.2023.102201

IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn’s disease

Autoren: Jakob Benedict Seidelin, Simone Jensen, Morten Hansen, Mariana Rodrigues de Carvalho Bronze, Delphine Cuchet-Lourenco, Sergey Nejentsev, Eric Charles LaCasse, Ole Haagen Nielsen
Veröffentlicht in: Clinical and Experimental Immunology, 2023, ISSN 0009-9104
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad092

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation

Autoren: Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton K, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Yeboa KA, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz B, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelha
Veröffentlicht in: J Crohns Colitis, 2021, ISSN 1873-9946
Herausgeber: Elsevier Science
DOI: 10.1093/ecco-jcc/jjab077

Topoisomerase 2β mutation impairs early B-cell development

Autoren: Papapietro O, Chandra A, Eletto D, Inglott S, Plagnol V, Curtis J, Maes M, Alisaac A, Albuquerque AS, Basseres E, Hermine O, Picard C, Fischer A, Durandy A, Kracker S, Burns S, Cuchet-Lourenco D, Okkenhaug K, Nejentsev S
Veröffentlicht in: Blood, 2020, Seite(n) 135(17):1497-1501, ISSN 0006-4971
Herausgeber: American Society of Hematology
DOI: 10.1182/blood.2019003299

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