Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis

Información del proyecto

Host-TB

Identificador del acuerdo de subvención: 832721

DOI

10.3030/832721

Proyecto cerrado

Fecha de la firma de la CE 18 Abril 2019

Fecha de inicio 1 Junio 2019

Fecha de finalización 31 Mayo 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 160 926,00

Aportación de la UE

€ 2 160 926,00

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9

Autores: Aniek S. Meijers, Ran Troost, Roy Ummels, Janneke Maaskant, Alexander Speer, Sergey Nejentsev, Wilbert Bitter, Coenraad P. Kuijl
Publicado en: Tuberculosis, Edición 124, 2020, Página(s) 101983, ISSN 1472-9792
Editor: Churchill Livingstone
DOI: 10.1016/j.tube.2020.101983

An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome

Autores: Malcolm Begg, Augustin Amour, Emily Jarvis, Teresa Tang, Sara Santos Franco, Andrew Want, Misba Beerahee, Disala Fernando, Yakshitha Karkera, Clare Sander, Thomas Southworth, Dave Singh, Jonathan Clark, Sergey Nejentsev, Klaus Okkenhaug, Alison Condliffe, Anita Chandra, Anthony Cahn, Edward Banham Hall
Publicado en: Pulmonary pharmacology and therapeutics, 2023, ISSN 1094-5539
Editor: Academic Press
DOI: 10.1016/j.pupt.2023.102201

Topoisomerase 2β and DNA topology during B cell development

Autores: Olivier Papapietro, Sergey Nejentsev
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.982870

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy

Autores: Helka Göös, Christopher L. Fogarty, Biswajyoti Sahu, Vincent Plagnol, Kristiina Rajamäki, Katariina Nurmi, Xiaonan Liu, Elisabet Einarsdottir, Annukka Jouppila, Tom Pettersson, Helena Vihinen, Kaarel Krjutskov, Päivi Saavalainen, Asko Järvinen, Mari Muurinen, Dario Greco, Giovanni Scala, James Curtis, Dan Nordström, Robert Flaumenhaft, Outi Vaarala, Panu E. Kovanen, Salla Keskitalo, Annamari
Publicado en: Journal of Allergy and Clinical Immunology, Edición 144, 2025, Página(s) 1364-1376, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2019.06.003

Phosphoinositide 3-kinase δ activity in patients with systemic lupus erythematosus

Autores: Elham Sadat Mirfazeli, Shalmalee Kharkar, Michel W. P. Tsang-A-Sjoe, Olivier Papapietro, Izabella Niewczas, Agner R. Parra Sanchez, Anita Chandra, Klaus Okkenhaug, Irene E. M. Bultink, Reina E. Mebius, Jonathan Clark, Alexandre E. Voskuyl, Sergey Nejentsev
Publicado en: Frontiers in Immunology, Edición 17, 2026, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2026.1745692

Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations

Autores: Tiziana Lorenzini, Manfred Fliegauf, Nils Klammer, Natalie Frede, Michele Proietti, Alla Bulashevska, Nadezhda Camacho-Ordonez, Markku Varjosalo, Matias Kinnunen, Esther de Vries, Jos W.M. van der Meer, Rohan Ameratunga, Chaim M. Roifman, Yael D. Schejter, Robin Kobbe, Timo Hautala, Faranaz Atschekzei, Reinhold E. Schmidt, Claudia Schröder, Polina Stepensky, Bella Shadur, Luis A. Pedroza, Michiel
Publicado en: Journal of Allergy and Clinical Immunology, Edición 146, 2022, Página(s) 901-911, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2019.11.051

IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn’s disease

Autores: Jakob Benedict Seidelin, Simone Jensen, Morten Hansen, Mariana Rodrigues de Carvalho Bronze, Delphine Cuchet-Lourenco, Sergey Nejentsev, Eric Charles LaCasse, Ole Haagen Nielsen
Publicado en: Clinical and Experimental Immunology, 2023, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad092

Practical challenges for functional validation of <i>STAT1</i> gain of function genetic variants

Autores: Adriana S Albuquerque, Jesmeen Maimaris, Alexander J McKenna, Jonathan Lambourne, Fernando Moreira, Sarita Workman, Karyn Megy, Ilenia Simeoni, Hana Lango Allen, null null, Zoe Adhya, Hana Alachkar, Ariharan Anantharachagan, Richard Antrobus, Gururaj Arumugakani, Chiara Bacchelli, Helen Baxendale, Claire Bethune, Shahnaz Bibi, Barbara Boardman, Claire Booth, Michael Browning, Mary Brownlie, Siobha
Publicado en: Clinical and Experimental Immunology, Edición 212, 2023, Página(s) 166-169, ISSN 0009-9104
Editor: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad008

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation

Autores: Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton K, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Yeboa KA, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz B, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelha
Publicado en: J Crohns Colitis, 2021, ISSN 1873-9946
Editor: Elsevier Science
DOI: 10.1093/ecco-jcc/jjab077

Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma

Autores: Ekaterina Minskaia, Jesmeen Maimaris, Persephone Jenkins, Adriana S. Albuquerque, Ying Hong, Despina Eleftheriou, Kimberly C. Gilmour, Richard Grace, Fernando Moreira, Bodo Grimbacher, null null, Zoe Adhya, Hana Alachkar, Ariharan Anantharachagan, Richard Antrobus, Gururaj Arumugakani, Chiara Bacchelli, Helen Baxendale, Claire Bethune, Shahnaz Bibi, Barbara Boardman, Claire Booth, Michael Browning
Publicado en: Journal of Clinical Immunology, Edición 43, 2023, Página(s) 1611-1622, ISSN 0271-9142
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-023-01530-7

Topoisomerase 2β mutation impairs early B-cell development

Autores: Papapietro O, Chandra A, Eletto D, Inglott S, Plagnol V, Curtis J, Maes M, Alisaac A, Albuquerque AS, Basseres E, Hermine O, Picard C, Fischer A, Durandy A, Kracker S, Burns S, Cuchet-Lourenco D, Okkenhaug K, Nejentsev S
Publicado en: Blood, 2020, Página(s) 135(17):1497-1501, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019003299

A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis

Autores: Robin Lissner, Aaron Franklin, Samuel T. Benedict, Vicky Charitou, Alexander Speer, Jaco Knol, Connie Jimenez, Patrick J. Moynihan, Sergey Nejentsev, Coen Kuijl, Wilbert Bitter
Publicado en: mBio, Edición 17, 2026, ISSN 2150-7511
Editor: American Society for Microbiology
DOI: 10.1128/mbio.02119-25

Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

Autores: Laura Boekel, Eileen W Stalman, Luuk Wieske, Femke Hooijberg, Koos P J van Dam, Yaëlle R Besten, Laura Y L Kummer, Maurice Steenhuis, Zoé L E van Kempen, Joep Killestein, Adriaan G Volkers, Sander W Tas, Anneke J van der Kooi, Joost Raaphorst, Mark Löwenberg, R Bart Takkenberg, Geert R A M D'Haens, Phyllis I Spuls, Marcel W Bekkenk, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hil
Publicado en: The Lancet Rheumatology, Edición 4, 2025, Página(s) e417-e429, ISSN 2665-9913
Editor: Elsevier BV
DOI: 10.1016/s2665-9913(22)00102-3

Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians

Autores: Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R. León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Mercedes Becerra, Sergey Nejentsev, Peter A. Nigrovic, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri
Publicado en: Nature Communications, Edición 10, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-11664-1

Impact of COVID‐19 disease and vaccination on dermatological immune‐mediated inflammatory diseases atopic dermatitis, psoriasis, and vitiligo: a Target2B! substudy

Autores: Nicoline F. van Buchem‐Post, Wouter Ouwerkerk, Eileen W. Stalman, Koos P. J. van Dam, Luuk Wieske, Marcel W. Bekkenk, Albert Wolkerstorfer, Phyllis Spuls, Annelie H. Musters, Angela L. Bosma, Dirk‐Jan Hijnen, Filip Eftimov, Rosalie M. Luiten, null null, Zoé L. E. van Kempen, Eileen W. Stalman, Maurice Steenhuis, Laura Y. L. Kummer, Koos P. J. van Dam, Anja Ten Brinke, S. Marieke van Ham, Taco
Publicado en: The Journal of Dermatology, Edición 52, 2025, Página(s) 624-633, ISSN 0385-2407
Editor: Nihon Hifuka Gakkai/Japanese Dermatological Association
DOI: 10.1111/1346-8138.17664

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Autores: James E. D. Thaventhiran, Hana Lango Allen, Oliver S. Burren, William Rae, Daniel Greene, Emily Staples, Zinan Zhang, James H. R. Farmery, Ilenia Simeoni, Elizabeth Rivers, Jesmeen Maimaris, Christopher J. Penkett, Jonathan Stephens, Sri V. V. Deevi, Alba Sanchis-Juan, Nicholas S. Gleadall, Moira J. Thomas, Ravishankar B. Sargur, Pavels Gordins, Helen E. Baxendale, Matthew Brown, Paul Tuijnenburg,
Publicado en: Nature, Edición 583, 2023, Página(s) 90-95, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2265-1

Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study

Autores: Luuk Wieske, Koos P J van Dam, Maurice Steenhuis, Eileen W Stalman, Laura Y L Kummer, Zoé L E van Kempen, Joep Killestein, Adriaan G Volkers, Sander W Tas, Laura Boekel, Gerrit J Wolbink, Anneke J van der Kooi, Joost Raaphorst, Mark Löwenberg, R Bart Takkenberg, Geert R A M D'Haens, Phyllis I Spuls, Marcel W Bekkenk, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hilhorst, Yosta Vegt
Publicado en: The Lancet Rheumatology, Edición 4, 2026, Página(s) e338-e350, ISSN 2665-9913
Editor: Elsevier BV
DOI: 10.1016/s2665-9913(22)00034-0

Other (1)

<i>VCAM1</i> -expressing T cells and systemic autoimmunity in Regnase-1 deficiency

Autores: Delphine Cuchet-Lourenço, Matilde I. Conte, Sooyeon Chang, Nika Ten, Davide Eletto, Olivier Papapietro, Vincent Plagnol, Mike de Kok, Ilie Hashim, Lourdes Ceron-Gutierrez, Marlous van den Braber, James Curtis, Harriet C. T. Groom, Mailis Maes, Rainer Doffinger, Juan Garcia Vallejo, Cecilia Dominguez Conde, Joao Farela Neves, Sergey Nejentsev
Publicado en: medRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2025.01.21.25320127