Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis

Informazioni relative al progetto

Host-TB

ID dell’accordo di sovvenzione: 832721

DOI 10.3030/832721

Data della firma CE 18 Aprile 2019

Data di avvio 1 Giugno 2019

Data di completamento 31 Agosto 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 160 926,00

Contributo UE € 2 160 926,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Pubblicazioni

Peer reviewed articles (5)

Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9

Autori: Aniek S. Meijers, Ran Troost, Roy Ummels, Janneke Maaskant, Alexander Speer, Sergey Nejentsev, Wilbert Bitter, Coenraad P. Kuijl
Pubblicato in: Tuberculosis, Numero 124, 2020, Pagina/e 101983, ISSN 1472-9792
Editore: Churchill Livingstone
DOI: 10.1016/j.tube.2020.101983

An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome

Autori: Malcolm Begg, Augustin Amour, Emily Jarvis, Teresa Tang, Sara Santos Franco, Andrew Want, Misba Beerahee, Disala Fernando, Yakshitha Karkera, Clare Sander, Thomas Southworth, Dave Singh, Jonathan Clark, Sergey Nejentsev, Klaus Okkenhaug, Alison Condliffe, Anita Chandra, Anthony Cahn, Edward Banham Hall
Pubblicato in: Pulmonary pharmacology and therapeutics, 2023, ISSN 1094-5539
Editore: Academic Press
DOI: 10.1016/j.pupt.2023.102201

IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn’s disease

Autori: Jakob Benedict Seidelin, Simone Jensen, Morten Hansen, Mariana Rodrigues de Carvalho Bronze, Delphine Cuchet-Lourenco, Sergey Nejentsev, Eric Charles LaCasse, Ole Haagen Nielsen
Pubblicato in: Clinical and Experimental Immunology, 2023, ISSN 0009-9104
Editore: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad092

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation

Autori: Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton K, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Yeboa KA, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz B, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelha
Pubblicato in: J Crohns Colitis, 2021, ISSN 1873-9946
Editore: Elsevier Science
DOI: 10.1093/ecco-jcc/jjab077

Topoisomerase 2β mutation impairs early B-cell development

Autori: Papapietro O, Chandra A, Eletto D, Inglott S, Plagnol V, Curtis J, Maes M, Alisaac A, Albuquerque AS, Basseres E, Hermine O, Picard C, Fischer A, Durandy A, Kracker S, Burns S, Cuchet-Lourenco D, Okkenhaug K, Nejentsev S
Pubblicato in: Blood, 2020, Pagina/e 135(17):1497-1501, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019003299