Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis

Informazioni relative al progetto

Host-TB

ID dell’accordo di sovvenzione: 832721

DOI

10.3030/832721

Progetto chiuso

Data della firma CE 18 Aprile 2019

Data di avvio 1 Giugno 2019

Data di completamento 31 Maggio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 160 926,00

Contributo UE

€ 2 160 926,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Efficient genome editing in pathogenic mycobacteria using Streptococcus thermophilus CRISPR1-Cas9

Autori: Aniek S. Meijers, Ran Troost, Roy Ummels, Janneke Maaskant, Alexander Speer, Sergey Nejentsev, Wilbert Bitter, Coenraad P. Kuijl
Pubblicato in: Tuberculosis, Numero 124, 2020, Pagina/e 101983, ISSN 1472-9792
Editore: Churchill Livingstone
DOI: 10.1016/j.tube.2020.101983

An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome

Autori: Malcolm Begg, Augustin Amour, Emily Jarvis, Teresa Tang, Sara Santos Franco, Andrew Want, Misba Beerahee, Disala Fernando, Yakshitha Karkera, Clare Sander, Thomas Southworth, Dave Singh, Jonathan Clark, Sergey Nejentsev, Klaus Okkenhaug, Alison Condliffe, Anita Chandra, Anthony Cahn, Edward Banham Hall
Pubblicato in: Pulmonary pharmacology and therapeutics, 2023, ISSN 1094-5539
Editore: Academic Press
DOI: 10.1016/j.pupt.2023.102201

Topoisomerase 2β and DNA topology during B cell development

Autori: Olivier Papapietro, Sergey Nejentsev
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.982870

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy

Autori: Helka Göös, Christopher L. Fogarty, Biswajyoti Sahu, Vincent Plagnol, Kristiina Rajamäki, Katariina Nurmi, Xiaonan Liu, Elisabet Einarsdottir, Annukka Jouppila, Tom Pettersson, Helena Vihinen, Kaarel Krjutskov, Päivi Saavalainen, Asko Järvinen, Mari Muurinen, Dario Greco, Giovanni Scala, James Curtis, Dan Nordström, Robert Flaumenhaft, Outi Vaarala, Panu E. Kovanen, Salla Keskitalo, Annamari
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 144, 2025, Pagina/e 1364-1376, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2019.06.003

Phosphoinositide 3-kinase δ activity in patients with systemic lupus erythematosus

Autori: Elham Sadat Mirfazeli, Shalmalee Kharkar, Michel W. P. Tsang-A-Sjoe, Olivier Papapietro, Izabella Niewczas, Agner R. Parra Sanchez, Anita Chandra, Klaus Okkenhaug, Irene E. M. Bultink, Reina E. Mebius, Jonathan Clark, Alexandre E. Voskuyl, Sergey Nejentsev
Pubblicato in: Frontiers in Immunology, Numero 17, 2026, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2026.1745692

Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations

Autori: Tiziana Lorenzini, Manfred Fliegauf, Nils Klammer, Natalie Frede, Michele Proietti, Alla Bulashevska, Nadezhda Camacho-Ordonez, Markku Varjosalo, Matias Kinnunen, Esther de Vries, Jos W.M. van der Meer, Rohan Ameratunga, Chaim M. Roifman, Yael D. Schejter, Robin Kobbe, Timo Hautala, Faranaz Atschekzei, Reinhold E. Schmidt, Claudia Schröder, Polina Stepensky, Bella Shadur, Luis A. Pedroza, Michiel
Pubblicato in: Journal of Allergy and Clinical Immunology, Numero 146, 2022, Pagina/e 901-911, ISSN 0091-6749
Editore: Mosby Inc.
DOI: 10.1016/j.jaci.2019.11.051

IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn’s disease

Autori: Jakob Benedict Seidelin, Simone Jensen, Morten Hansen, Mariana Rodrigues de Carvalho Bronze, Delphine Cuchet-Lourenco, Sergey Nejentsev, Eric Charles LaCasse, Ole Haagen Nielsen
Pubblicato in: Clinical and Experimental Immunology, 2023, ISSN 0009-9104
Editore: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad092

Practical challenges for functional validation of <i>STAT1</i> gain of function genetic variants

Autori: Adriana S Albuquerque, Jesmeen Maimaris, Alexander J McKenna, Jonathan Lambourne, Fernando Moreira, Sarita Workman, Karyn Megy, Ilenia Simeoni, Hana Lango Allen, null null, Zoe Adhya, Hana Alachkar, Ariharan Anantharachagan, Richard Antrobus, Gururaj Arumugakani, Chiara Bacchelli, Helen Baxendale, Claire Bethune, Shahnaz Bibi, Barbara Boardman, Claire Booth, Michael Browning, Mary Brownlie, Siobha
Pubblicato in: Clinical and Experimental Immunology, Numero 212, 2023, Pagina/e 166-169, ISSN 0009-9104
Editore: Blackwell Publishing Inc.
DOI: 10.1093/cei/uxad008

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation

Autori: Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton K, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Yeboa KA, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz B, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelha
Pubblicato in: J Crohns Colitis, 2021, ISSN 1873-9946
Editore: Elsevier Science
DOI: 10.1093/ecco-jcc/jjab077

Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma

Autori: Ekaterina Minskaia, Jesmeen Maimaris, Persephone Jenkins, Adriana S. Albuquerque, Ying Hong, Despina Eleftheriou, Kimberly C. Gilmour, Richard Grace, Fernando Moreira, Bodo Grimbacher, null null, Zoe Adhya, Hana Alachkar, Ariharan Anantharachagan, Richard Antrobus, Gururaj Arumugakani, Chiara Bacchelli, Helen Baxendale, Claire Bethune, Shahnaz Bibi, Barbara Boardman, Claire Booth, Michael Browning
Pubblicato in: Journal of Clinical Immunology, Numero 43, 2023, Pagina/e 1611-1622, ISSN 0271-9142
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10875-023-01530-7

Topoisomerase 2β mutation impairs early B-cell development

Autori: Papapietro O, Chandra A, Eletto D, Inglott S, Plagnol V, Curtis J, Maes M, Alisaac A, Albuquerque AS, Basseres E, Hermine O, Picard C, Fischer A, Durandy A, Kracker S, Burns S, Cuchet-Lourenco D, Okkenhaug K, Nejentsev S
Pubblicato in: Blood, 2020, Pagina/e 135(17):1497-1501, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019003299

A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis

Autori: Robin Lissner, Aaron Franklin, Samuel T. Benedict, Vicky Charitou, Alexander Speer, Jaco Knol, Connie Jimenez, Patrick J. Moynihan, Sergey Nejentsev, Coen Kuijl, Wilbert Bitter
Pubblicato in: mBio, Numero 17, 2026, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/mbio.02119-25

Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies

Autori: Laura Boekel, Eileen W Stalman, Luuk Wieske, Femke Hooijberg, Koos P J van Dam, Yaëlle R Besten, Laura Y L Kummer, Maurice Steenhuis, Zoé L E van Kempen, Joep Killestein, Adriaan G Volkers, Sander W Tas, Anneke J van der Kooi, Joost Raaphorst, Mark Löwenberg, R Bart Takkenberg, Geert R A M D'Haens, Phyllis I Spuls, Marcel W Bekkenk, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hil
Pubblicato in: The Lancet Rheumatology, Numero 4, 2025, Pagina/e e417-e429, ISSN 2665-9913
Editore: Elsevier BV
DOI: 10.1016/s2665-9913(22)00102-3

Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians

Autori: Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R. León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Mercedes Becerra, Sergey Nejentsev, Peter A. Nigrovic, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri
Pubblicato in: Nature Communications, Numero 10, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11664-1

Impact of COVID‐19 disease and vaccination on dermatological immune‐mediated inflammatory diseases atopic dermatitis, psoriasis, and vitiligo: a Target2B! substudy

Autori: Nicoline F. van Buchem‐Post, Wouter Ouwerkerk, Eileen W. Stalman, Koos P. J. van Dam, Luuk Wieske, Marcel W. Bekkenk, Albert Wolkerstorfer, Phyllis Spuls, Annelie H. Musters, Angela L. Bosma, Dirk‐Jan Hijnen, Filip Eftimov, Rosalie M. Luiten, null null, Zoé L. E. van Kempen, Eileen W. Stalman, Maurice Steenhuis, Laura Y. L. Kummer, Koos P. J. van Dam, Anja Ten Brinke, S. Marieke van Ham, Taco
Pubblicato in: The Journal of Dermatology, Numero 52, 2025, Pagina/e 624-633, ISSN 0385-2407
Editore: Nihon Hifuka Gakkai/Japanese Dermatological Association
DOI: 10.1111/1346-8138.17664

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Autori: James E. D. Thaventhiran, Hana Lango Allen, Oliver S. Burren, William Rae, Daniel Greene, Emily Staples, Zinan Zhang, James H. R. Farmery, Ilenia Simeoni, Elizabeth Rivers, Jesmeen Maimaris, Christopher J. Penkett, Jonathan Stephens, Sri V. V. Deevi, Alba Sanchis-Juan, Nicholas S. Gleadall, Moira J. Thomas, Ravishankar B. Sargur, Pavels Gordins, Helen E. Baxendale, Matthew Brown, Paul Tuijnenburg,
Pubblicato in: Nature, Numero 583, 2023, Pagina/e 90-95, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-020-2265-1

Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study

Autori: Luuk Wieske, Koos P J van Dam, Maurice Steenhuis, Eileen W Stalman, Laura Y L Kummer, Zoé L E van Kempen, Joep Killestein, Adriaan G Volkers, Sander W Tas, Laura Boekel, Gerrit J Wolbink, Anneke J van der Kooi, Joost Raaphorst, Mark Löwenberg, R Bart Takkenberg, Geert R A M D'Haens, Phyllis I Spuls, Marcel W Bekkenk, Annelie H Musters, Nicoline F Post, Angela L Bosma, Marc L Hilhorst, Yosta Vegt
Pubblicato in: The Lancet Rheumatology, Numero 4, 2026, Pagina/e e338-e350, ISSN 2665-9913
Editore: Elsevier BV
DOI: 10.1016/s2665-9913(22)00034-0

Other (1)

<i>VCAM1</i> -expressing T cells and systemic autoimmunity in Regnase-1 deficiency

Autori: Delphine Cuchet-Lourenço, Matilde I. Conte, Sooyeon Chang, Nika Ten, Davide Eletto, Olivier Papapietro, Vincent Plagnol, Mike de Kok, Ilie Hashim, Lourdes Ceron-Gutierrez, Marlous van den Braber, James Curtis, Harriet C. T. Groom, Mailis Maes, Rainer Doffinger, Juan Garcia Vallejo, Cecilia Dominguez Conde, Joao Farela Neves, Sergey Nejentsev
Pubblicato in: medRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2025.01.21.25320127