Project description
Dancing to a different tune: sustainable and efficient catalytic methods
Synthetic chemists are sort of like choreographers, creating intricate and complex "dances" between molecules and molecular entities in which partners come together, change places, move away and often pass off their partners to another "dancer." Chemists are also matchmakers; many of these entities do not want to come together, and new ways must be found to reduce the "barriers" between them. At the heart of many of these dances are catalysts. The EU-funded HBPTC project is developing novel sustainable catalytic routes to high-value products such as pharmaceuticals and agrochemicals that are cost-effective and whose efficiencies rival those of less sustainable or more expensive processes.
Objective
The objective of the research described in this proposal is to develop a new mode of activation for catalysis leading to more sustainable catalytic processes using abundant feedstock materials. By merging hydrogen bonding and phase transfer catalysis, we propose that hydrogen bonding of an insoluble unreactive anionic nucleophile with a hydrogen bond donor catalyst will form a soluble and reactive entity now capable of carbon-nucleophile bond formation with concomitant release of the hydrogen bond donor catalyst. This activation mode is applicable to nucleophiles as simple as feedstock inorganic salts enabling challenging asymmetric bond-forming reactions in a general and predictable fashion. Inexpensive lost nucleophiles currently unusable due to poor solubility and reactivity will be reclaimed as effective reagents for asymmetric catalysis. Common inorganic salts such as sodium chloride or potassium fluoride will be transformed into high-value products such as complex pharmaceutical and agrochemical products applying operationally simple and cost effective protocols. Synergistic catalysis whereby hydrogen bonding phase transfer catalysis will work in concert with an additional catalytic cycle will be implemented to introduce new chemical transformations with these feedstock reagents, improve efficiency, and create catalytic enantioselectivity where stereocontrol is absent or challenging. This research will require the development of high performance catalysts and the understanding of catalytic mechanisms applying structural, kinetics, and computational studies. HBPTC is expected to expand the field of catalysis, and rival the efficiency of some of the most active metal, organocatalyst and biocatalyst known to date.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences inorganic chemistry alkali metals
- natural sciences chemical sciences catalysis biocatalysis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2018-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.