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A woman's reproductive experience: Long-term implications for chronic disease and death

Project description

Studying the long-term effects of pregnancy complications on maternal health

Although preeclampsia, preterm birth and other pregnancy complications can affect maternal health, this connection has not yet been studied in depth. The EU-funded HealthierWomen project aims to study the various patterns of pregnancy complications that occur alone or in combination across pregnancies and analyse their association with cause-specific maternal mortality. The research will be conducted by linking significant data from women's reproductive histories as registered at the Medical Birth Registry of Norway to population-based death and cancer registries. In this way, HealthierWomen aspires to shed light on how pregnancy complications affect long-term maternal health and to contribute to the development of more effective chronic disease prevention strategies.

Objective

Pregnancy complications such as preeclampsia and preterm birth are known to affect infant health, but their influence on mothers long-term health is not well understood. Most previous studies are seriously limited by their reliance on information from the first pregnancy. Often they lack the data to study womens complete reproductive histories. Without a complete reproductive history, the relationship between pregnancy complications and womens long-term health cannot be reliably studied. The Medical Birth Registry of Norway, covering all births from 1967-, includes information on more than 3 million births and 1.5 million sibships. Linking this to population based death and cancer registries provides a worldwide unique source of population-based data which can be analysed to identify heterogeneities in risk by lifetime parity and the cumulative experience of pregnancy complications. Having worked in this field of research for many years, I see many erroneous conclusions in studies based on insufficient data. For instance, both after preeclampsia and after a stillbirth, the high risk of heart disease observed in one-child mothers is strongly attenuated in women with subsequent pregnancies. I will study different patterns of pregnancy complications that occur alone or in combination across pregnancies, and analyse their associations with cause specific maternal mortality. Using this unique methodology, I will challenge the idea that placental dysfunction is the origin of preeclampsia and test the hypothesis that pregnancy complications may cause direct long-term effects on maternal health. The findings of this research have the potential to advance our understanding of how pregnancy complications affect the long-term maternal health and help to develop more effective chronic disease prevention strategies.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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ERC-ADG - Advanced Grant

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Call for proposal

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(opens in new window) ERC-2018-ADG

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Host institution

UNIVERSITETET I BERGEN
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 500 000,00
Address
MUSEPLASSEN 1
5020 Bergen
Norway

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Region
Norge Vestlandet Vestland
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 500 000,00

Beneficiaries (1)

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