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The Quest of the Argonautes - from Myth to Reality

Project description

The Argonautes take us on a new adventure in gene editing

Argonaute proteins are a ubiquitous and highly conserved family that silence gene expression in various ways and with wide-ranging effects. For example, some prokaryotic Argonaute proteins participate in host defence by DNA interference. Eukaryotic proteins control or modulate a wide range of processes through RNA interference. More recently, their role in alternative splicing and DNA double-strand break repair have been reported. Clearly, harnessing these super-molecules for targeted genome editing could have tremendous impact on fields from agriculture to medicine and beyond. The EU-funded ARGO project plans to characterise the structure and function of novel natural variants to engineer synthetic ones. The journey toward future application is beginning with ARGO.

Call for proposal

ERC-2018-ADG
See other projects for this call

Funding Scheme

ERC-ADG - Advanced Grant

Host institution

WAGENINGEN UNIVERSITY
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 177 157,50

Beneficiaries (1)

WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 2 177 157,50
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments