Impact of tissue injury induced by diagnostic biopsies and surgery on cancer metastasis

Project Information

INJURMET

Grant agreement ID: 834974

DOI 10.3030/834974

EC signature date 23 July 2019

Start date 1 August 2019

End date 31 July 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 499 985,00

EU contribution € 2 499 985,00

Coordinated by

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

Publications

Peer reviewed articles (26)

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Author(s): Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, S
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

Author(s): Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller,
Published in: EMBO Molecular Medicine, Issue 12/9, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911908

Circulating tumor cells and extracellular vesicles as liquid biopsy markers in neuro-oncology: prospects and limitations.

Author(s): Westphal M, Pantel K, Ricklefs FL, Maire C, Riethdorf S, Mohme M, Wikman H, Lamszus K
Published in: Neurooncol Adv., 2022, ISSN 2632-2498
Publisher: EANO
DOI: 10.1093/noajnl/vdac015

Metastatic Breast Cancer Recurrence after Bone Fractures

Author(s): Nadia Obi; Stefan Werner; Frank Thelen; Heiko Becher; Klaus Pantel
Published in: Cancers, Issue 5, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030601

Possible Role of Circulating Tumour Cells for Prediction of Salvage Lymph Node Dissection Outcome in Patients with Early Prostate Cancer Recurrence

Author(s): Sophie Knipper, Sabine Riethdorf, Stefan Werner, Derya Tilki, Markus Graefen, Klaus Pantel, Tobias Maurer
Published in: Eur Urol Open Sci, Issue 34, 2021, Page(s) 55-58
Publisher: Elsevier
DOI: 10.1016/j.euros.2021.09.017

Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts.

Author(s): Heidrich I, Pantel K
Published in: EMBO Mol Med, 2022, ISSN 1757-4684
Publisher: EMBOpress
DOI: 10.15252/emmm.202216326

Clinical applications of circulating tumor cells in patients with solid tumors

Author(s): Smit DJ, Schneegans S, Pantel K.
Published in: Clin Exp Metastasis, 2024, ISSN 0262-0898
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10585-024-10267-5

Detection of Hypomethylation in Long-ctDNA

Author(s): Joosse SA, Pantel K
Published in: Clin Chem, 2022, ISSN 0009-9147
Publisher: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac108

Tumor-Associated Release of Prostatic Cells into the Blood after Transrectal Ultrasound-Guided Biopsy in Patients with Histologically Confirmed Prostate Cancer

Author(s): Simon A Joosse, Burkhard Beyer, Christin Gasch, Paulina Nastały, Andra Kuske, Hendrik Isbarn, Ludwig J Horst, Claudia Hille, Tobias M Gorges, Laure Cayrefourcq, Catherine Alix-Panabières, Pierre Tennstedt, Sabine Riethdorf, Thorsten Schlomm, Klaus Pantel
Published in: Clinical Chemistry, Issue 66/1, 2019, Page(s) 161-168, ISSN 0009-9147
Publisher: American Association for Clinical Chemistry, Inc.
DOI: 10.1373/clinchem.2019.310912

Detection and Characterization of Estrogen Receptor α Expression of Circulating Tumor Cells as a Prognostic Marker

Author(s): Retno Ningsi; Maha Elazezy; Luisa Stegat; Elena Laakmann; Sven Peine; Sabine Riethdorf; Volkmar Müller; Klaus Pantel; Simon A. Joosse
Published in: Cancers, Issue 1, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112621

Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2- Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2- Breast Cancer.

Author(s): Sven Roßwag; Cristina L. Cotarelo; Klaus Pantel; Sabine Riethdorf; Jonathan P. Sleeman; Jonathan P. Sleeman; Marcus Schmidt; Sonja Thaler
Published in: Cancers, Issue 4, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081810

Circulating Tumor Cells: From Basic to Translational Research

Author(s): Cortés-Hernández LE, Eslami-S Z, Pantel K, Alix-Panabières C
Published in: Clin Chem, 2024, ISSN 0009-9147
Publisher: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvad142

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

Author(s): Laura Keller, Yassine Belloum, Harriet Wikman, Klaus Pantel
Published in: British Journal of Cancer, Issue 124/2, 2021, Page(s) 345-358, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-020-01047-5

Expression Patterns and Corepressor Function of Retinoic Acid-induced 2 in Prostate Cancer

Author(s): Besler K, Węglarz A, Keller L, von Amsberg G, Bednarz-Knoll N, Offermann A, Stoupiec S, Eltze E, Semjonow A, Boettcher L, Schneegans S, Perner S, Hauch S, Todenhöfer T, Peine S, Pantel K, Wikman H, Werner S
Published in: Clin Chem, 2022, ISSN 0009-9147
Publisher: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac073

PSMA-heterogeneity in metastatic castration-resistant prostate cancer: Circulating tumor cells, metastatic tumor burden, and response to targeted radioligand therapy

Author(s): Derlin T, Riethdorf S, Schumacher U, Lafos M, Peine S, Coith C, Ross TL, Pantel K, Bengel FM
Published in: Prostate, 2023, ISSN 0270-4137
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/pros.24549

Crucial roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation

Author(s): Pantel K, Alix-Panabières C
Published in: Immunother Cancer, 2022, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2022-005615

Circulating Cellular Communication Network Factor 1 Protein as a Sensitive Liquid Biopsy Marker for Early Detection of Breast Cancer

Author(s): Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Maggie Banys-Paluchowski, Antje Andreas, Marcus Wurlitzer, Maria Geffken, Hannah Voß, Tanja Zeller, Stefan Blankenberg, Sven Peine, Simon A Joosse, Volkmar Müller, Hartmut Schlüter, Leticia Oliveira-Ferrer, Klaus Pantel
Published in: Clin Chem, Issue 68/2, 2021, Page(s) 344–353, ISSN 1530-8561
Publisher: Oxfor Academic
DOI: 10.1093/clinchem/hvab153

Liquid biopsies: Potential and challenges

Author(s): Isabel Heidrich, Lucija Ačkar, Parinaz Mossahebi Mohammadi, Klaus Pantel
Published in: International Journal of Cancer, Issue 148/3, 2021, Page(s) 528-545, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33217

Cysteine-Rich Angiogenic Inducer 61: Pro-Survival Function and Role as a Biomarker for Disseminating Breast Cancer Cells

Author(s): Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Tobias M. Gorges, Antje Andreas, Maria Geffken, Karl Verpoort, Volkmar Müller, Hartmut Schlüter, Klaus Pantel
Published in: Cancers, Issue 13/3, 2021, Page(s) 563, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030563

Circulating tumour cells for early detection of clinically relevant cancer

Author(s): Lawrence R, Watters M, Davies CR, Pantel K, Lu YJ
Published in: Nat Rev Clin Oncol, 2023, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-023-00781-y

Pre-Analytical and Analytical Variables of Label-Independent Enrichment and Automated Detection of Circulating Tumor Cells in Cancer Patients

Author(s): Claudia Koch, Simon A. Joosse, Svenja Schneegans, Okka J. W. Wilken, Melanie Janning, Desiree Loreth, Volkmar Müller, Katharina Prieske, Malgorzata Banys-Paluchowski, Ludwig J. Horst, Sonja Loges, Sven Peine, Harriet Wikman, Tobias M. Gorges, Klaus Pantel
Published in: Cancers, Issue 12/2, 2020, Page(s) 442, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12020442

Neoadjuvant Chemotherapy of Patients with Early Breast Cancer Is Associated with Increased Detection of Disseminated Tumor Cells in the Bone Marrow.

Author(s): Léa Volmer; André Koch; Sabine Matovina; Dominik Dannehl; Martin Weiss; Ganna Welker; Markus Hahn; Tobias Engler; Markus Wallwiener; Christina Barbara Walter; Ernst Oberlechner; Sara Yvonne Brucker; Klaus Pantel; Andreas Hartkopf
Published in: Cancers, Issue 3, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030635

Functional analysis of circulating tumour cells: the KEY to understand thebiology of the metastatic cascade

Author(s): Eslami-S Z, Cortés-Hernández LE, Thomas F, Pantel K, Alix-Panabières C.
Published in: Br J Cancer, 2022, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-01819-1

Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels

Author(s): Leong SP, Naxerova K, Keller L, Pantel K, Witte M.
Published in: Clin Exp Metastasis, 2022, ISSN 0262-0898
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10585-021-10120-z

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape

Author(s): Malte Mohme, Cecile L. Maire, Simon Schliffke, Simon A. Joosse, Malik Alawi, Jakob Matschke, Ulrich Schüller, Judith Dierlamm, Tobias Martens, Klaus Pantel, Sabine Riethdorf, Katrin Lamszus, Manfred Westphal
Published in: Acta Neuropathologica Communications, Issue 8/1, 2020, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-020-00906-9

MicroRNAs from Liquid Biopsy Derived Extracellular Vesicles: Recent Advances in Detection and Characterization Methods

Author(s): Rares Drula, Leonie Florence Ott, Ioana Berindan-Neagoe, Klaus Pantel, George A. Calin
Published in: Cancers, Issue 12/8, 2020, Page(s) 2009, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082009

Intellectual Property Rights

Patent (2)

METHOD OF DETECTING CANCER OR CANCER CELLS

Application/Publication number: 20 18054052
Date: 2018-02-19
Applicant(s): UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

METHOD OF DETECTING CANCER OR CANCER CELLS

Application/Publication number: 17 157020
Date: 2017-02-20
Applicant(s): UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF