Impact of tissue injury induced by diagnostic biopsies and surgery on cancer metastasis

Informazioni relative al progetto

INJURMET

ID dell’accordo di sovvenzione: 834974

DOI

10.3030/834974

Progetto chiuso

Data della firma CE 23 Luglio 2019

Data di avvio 1 Agosto 2019

Data di completamento 31 Luglio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 499 985,00

Contributo UE

€ 2 499 985,00

Coordinato da

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (32)

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Autori: Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, S
Pubblicato in: Immunity, 2023, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

Autori: Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller,
Pubblicato in: EMBO Molecular Medicine, Numero 12/9, 2020, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911908

Circulating tumor cells and extracellular vesicles as liquid biopsy markers in neuro-oncology: prospects and limitations.

Autori: Westphal M, Pantel K, Ricklefs FL, Maire C, Riethdorf S, Mohme M, Wikman H, Lamszus K
Pubblicato in: Neurooncol Adv., 2022, ISSN 2632-2498
Editore: EANO
DOI: 10.1093/noajnl/vdac015

Metastatic Breast Cancer Recurrence after Bone Fractures

Autori: Nadia Obi; Stefan Werner; Frank Thelen; Heiko Becher; Klaus Pantel
Pubblicato in: Cancers, Numero 5, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030601

Possible Role of Circulating Tumour Cells for Prediction of Salvage Lymph Node Dissection Outcome in Patients with Early Prostate Cancer Recurrence

Autori: Sophie Knipper, Sabine Riethdorf, Stefan Werner, Derya Tilki, Markus Graefen, Klaus Pantel, Tobias Maurer
Pubblicato in: Eur Urol Open Sci, Numero 34, 2021, Pagina/e 55-58
Editore: Elsevier
DOI: 10.1016/j.euros.2021.09.017

Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts.

Autori: Heidrich I, Pantel K
Pubblicato in: EMBO Mol Med, 2022, ISSN 1757-4684
Editore: EMBOpress
DOI: 10.15252/emmm.202216326

Clinical applications of circulating tumor cells in patients with solid tumors

Autori: Smit DJ, Schneegans S, Pantel K.
Pubblicato in: Clin Exp Metastasis, 2024, ISSN 0262-0898
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10585-024-10267-5

Detection of Hypomethylation in Long-ctDNA

Autori: Joosse SA, Pantel K
Pubblicato in: Clin Chem, 2022, ISSN 0009-9147
Editore: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac108

Tumor-Associated Release of Prostatic Cells into the Blood after Transrectal Ultrasound-Guided Biopsy in Patients with Histologically Confirmed Prostate Cancer

Autori: Simon A Joosse, Burkhard Beyer, Christin Gasch, Paulina Nastały, Andra Kuske, Hendrik Isbarn, Ludwig J Horst, Claudia Hille, Tobias M Gorges, Laure Cayrefourcq, Catherine Alix-Panabières, Pierre Tennstedt, Sabine Riethdorf, Thorsten Schlomm, Klaus Pantel
Pubblicato in: Clinical Chemistry, Numero 66/1, 2019, Pagina/e 161-168, ISSN 0009-9147
Editore: American Association for Clinical Chemistry, Inc.
DOI: 10.1373/clinchem.2019.310912

Detection and Characterization of Estrogen Receptor α Expression of Circulating Tumor Cells as a Prognostic Marker

Autori: Retno Ningsi; Maha Elazezy; Luisa Stegat; Elena Laakmann; Sven Peine; Sabine Riethdorf; Volkmar Müller; Klaus Pantel; Simon A. Joosse
Pubblicato in: Cancers, Numero 1, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112621

Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2- Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2- Breast Cancer.

Autori: Sven Roßwag; Cristina L. Cotarelo; Klaus Pantel; Sabine Riethdorf; Jonathan P. Sleeman; Jonathan P. Sleeman; Marcus Schmidt; Sonja Thaler
Pubblicato in: Cancers, Numero 4, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081810

Multibiomarker panels in liquid biopsy for early detection of pancreatic cancer – a comprehensive review

Autori: Kim-Lea Reese, Klaus Pantel, Daniel J. Smit
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 43, 2024, ISSN 1756-9966
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s13046-024-03166-w

Circulating Tumor Cells: From Basic to Translational Research

Autori: Cortés-Hernández LE, Eslami-S Z, Pantel K, Alix-Panabières C
Pubblicato in: Clin Chem, 2024, ISSN 0009-9147
Editore: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvad142

Circulating tumor cells as liquid biopsy markers in cancer patients

Autori: Daniel J. Smit, Klaus Pantel
Pubblicato in: Molecular Aspects of Medicine, Numero 96, 2025, Pagina/e 101258, ISSN 0098-2997
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101258

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

Autori: Laura Keller, Yassine Belloum, Harriet Wikman, Klaus Pantel
Pubblicato in: British Journal of Cancer, Numero 124/2, 2021, Pagina/e 345-358, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-020-01047-5

Expression Patterns and Corepressor Function of Retinoic Acid-induced 2 in Prostate Cancer

Autori: Besler K, Węglarz A, Keller L, von Amsberg G, Bednarz-Knoll N, Offermann A, Stoupiec S, Eltze E, Semjonow A, Boettcher L, Schneegans S, Perner S, Hauch S, Todenhöfer T, Peine S, Pantel K, Wikman H, Werner S
Pubblicato in: Clin Chem, 2022, ISSN 0009-9147
Editore: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac073

PSMA-heterogeneity in metastatic castration-resistant prostate cancer: Circulating tumor cells, metastatic tumor burden, and response to targeted radioligand therapy

Autori: Derlin T, Riethdorf S, Schumacher U, Lafos M, Peine S, Coith C, Ross TL, Pantel K, Bengel FM
Pubblicato in: Prostate, 2023, ISSN 0270-4137
Editore: John Wiley & Sons Inc.
DOI: 10.1002/pros.24549

Crucial roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation

Autori: Pantel K, Alix-Panabières C
Pubblicato in: Immunother Cancer, 2022, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2022-005615

Circulating Cellular Communication Network Factor 1 Protein as a Sensitive Liquid Biopsy Marker for Early Detection of Breast Cancer

Autori: Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Maggie Banys-Paluchowski, Antje Andreas, Marcus Wurlitzer, Maria Geffken, Hannah Voß, Tanja Zeller, Stefan Blankenberg, Sven Peine, Simon A Joosse, Volkmar Müller, Hartmut Schlüter, Leticia Oliveira-Ferrer, Klaus Pantel
Pubblicato in: Clin Chem, Numero 68/2, 2021, Pagina/e 344–353, ISSN 1530-8561
Editore: Oxfor Academic
DOI: 10.1093/clinchem/hvab153

Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients

Autori: Kai Bartkowiak, Parinaz Mossahebi Mohammadi, Paula Nissen, Stefan Werner, David Agorku, Antje Andreas, Maria Geffken, Sven Peine, Karl Verpoort, Thomas M. Deutsch, Laura L. Michel, Andreas Schneeweiss, Verena Thewes, Andreas Trumpp, Olaf Hardt, Volkmar Müller, Sabine Riethdorf, Hartmut Schlüter, Klaus Pantel
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-87122-4

Liquid biopsies: Potential and challenges

Autori: Isabel Heidrich, Lucija Ačkar, Parinaz Mossahebi Mohammadi, Klaus Pantel
Pubblicato in: International Journal of Cancer, Numero 148/3, 2021, Pagina/e 528-545, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33217

Cysteine-Rich Angiogenic Inducer 61: Pro-Survival Function and Role as a Biomarker for Disseminating Breast Cancer Cells

Autori: Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Tobias M. Gorges, Antje Andreas, Maria Geffken, Karl Verpoort, Volkmar Müller, Hartmut Schlüter, Klaus Pantel
Pubblicato in: Cancers, Numero 13/3, 2021, Pagina/e 563, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030563

Circulating tumour cells for early detection of clinically relevant cancer

Autori: Lawrence R, Watters M, Davies CR, Pantel K, Lu YJ
Pubblicato in: Nat Rev Clin Oncol, 2023, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-023-00781-y

Minimal residual disease as a target for liquid biopsy in patients with solid tumours

Autori: Klaus Pantel, Catherine Alix-Panabières
Pubblicato in: Nature Reviews Clinical Oncology, Numero 22, 2024, Pagina/e 65-77, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-024-00967-y

Pre-Analytical and Analytical Variables of Label-Independent Enrichment and Automated Detection of Circulating Tumor Cells in Cancer Patients

Autori: Claudia Koch, Simon A. Joosse, Svenja Schneegans, Okka J. W. Wilken, Melanie Janning, Desiree Loreth, Volkmar Müller, Katharina Prieske, Malgorzata Banys-Paluchowski, Ludwig J. Horst, Sonja Loges, Sven Peine, Harriet Wikman, Tobias M. Gorges, Klaus Pantel
Pubblicato in: Cancers, Numero 12/2, 2020, Pagina/e 442, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12020442

Neoadjuvant Chemotherapy of Patients with Early Breast Cancer Is Associated with Increased Detection of Disseminated Tumor Cells in the Bone Marrow.

Autori: Léa Volmer; André Koch; Sabine Matovina; Dominik Dannehl; Martin Weiss; Ganna Welker; Markus Hahn; Tobias Engler; Markus Wallwiener; Christina Barbara Walter; Ernst Oberlechner; Sara Yvonne Brucker; Klaus Pantel; Andreas Hartkopf
Pubblicato in: Cancers, Numero 3, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030635

Functional analysis of circulating tumour cells: the KEY to understand thebiology of the metastatic cascade

Autori: Eslami-S Z, Cortés-Hernández LE, Thomas F, Pantel K, Alix-Panabières C.
Pubblicato in: Br J Cancer, 2022, ISSN 0007-0920
Editore: Nature Publishing Group
DOI: 10.1038/s41416-022-01819-1

Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels

Autori: Leong SP, Naxerova K, Keller L, Pantel K, Witte M.
Pubblicato in: Clin Exp Metastasis, 2022, ISSN 0262-0898
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10585-021-10120-z

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape

Autori: Malte Mohme, Cecile L. Maire, Simon Schliffke, Simon A. Joosse, Malik Alawi, Jakob Matschke, Ulrich Schüller, Judith Dierlamm, Tobias Martens, Klaus Pantel, Sabine Riethdorf, Katrin Lamszus, Manfred Westphal
Pubblicato in: Acta Neuropathologica Communications, Numero 8/1, 2020, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-020-00906-9

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma

Autori: Mark Sementsov, Leonie Ott, Julian Kött, Alexander Sartori, Amelie Lusque, Sarah Degenhardt, Bertille Segier, Isabel Heidrich, Beate Volkmer, Rüdiger Greinert, Peter Mohr, Ronald Simon, Julia-Christina Stadler, Darryl Irwin, Claudia Koch, Antje Andreas, Benjamin Deitert, Verena Thewes, Andreas Trumpp, Andreas Schneeweiss, Yassine Belloum, Sven Peine, Harriett Wikman, Sabine Riethdorf, Stefan W S
Pubblicato in: EMBO Molecular Medicine, Numero 16, 2024, Pagina/e 1560-1578, ISSN 1757-4684
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00082-6

Comparative analysis of circulating tumor cells in prostatic plexus and peripheral blood of patients undergoing prostatectomy

Autori: Gresa Emurlai, Randi M. Pose, Nikhil Kalra, Cornelia Coith, Sandra Lenz, Pierre Tennstedt, Markus Graefen, Stefan Werner, Sabine Riethdorf, Derya Tilki, Simon A. Joosse, Klaus Pantel
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 44, 2025, ISSN 1756-9966
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s13046-025-03397-5

MicroRNAs from Liquid Biopsy Derived Extracellular Vesicles: Recent Advances in Detection and Characterization Methods

Autori: Rares Drula, Leonie Florence Ott, Ioana Berindan-Neagoe, Klaus Pantel, George A. Calin
Pubblicato in: Cancers, Numero 12/8, 2020, Pagina/e 2009, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082009

Diritti di proprietà intellettuale

Patent (2)

METHOD OF DETECTING CANCER OR CANCER CELLS

Numero candidatura/pubblicazione: 17 157020
Data: 2017-02-20
Candidato/i: UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

METHOD OF DETECTING CANCER OR CANCER CELLS

Numero candidatura/pubblicazione: 20 18054052
Data: 2018-02-19
Candidato/i: UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF