Impact of tissue injury induced by diagnostic biopsies and surgery on cancer metastasis

Información del proyecto

INJURMET

Identificador del acuerdo de subvención: 834974

DOI

10.3030/834974

Proyecto cerrado

Fecha de la firma de la CE 23 Julio 2019

Fecha de inicio 1 Agosto 2019

Fecha de finalización 31 Julio 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 499 985,00

Aportación de la UE

€ 2 499 985,00

Coordinado por

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (32)

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Autores: Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, S
Publicado en: Immunity, 2023, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

Autores: Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller,
Publicado en: EMBO Molecular Medicine, Edición 12/9, 2020, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911908

Circulating tumor cells and extracellular vesicles as liquid biopsy markers in neuro-oncology: prospects and limitations.

Autores: Westphal M, Pantel K, Ricklefs FL, Maire C, Riethdorf S, Mohme M, Wikman H, Lamszus K
Publicado en: Neurooncol Adv., 2022, ISSN 2632-2498
Editor: EANO
DOI: 10.1093/noajnl/vdac015

Metastatic Breast Cancer Recurrence after Bone Fractures

Autores: Nadia Obi; Stefan Werner; Frank Thelen; Heiko Becher; Klaus Pantel
Publicado en: Cancers, Edición 5, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030601

Possible Role of Circulating Tumour Cells for Prediction of Salvage Lymph Node Dissection Outcome in Patients with Early Prostate Cancer Recurrence

Autores: Sophie Knipper, Sabine Riethdorf, Stefan Werner, Derya Tilki, Markus Graefen, Klaus Pantel, Tobias Maurer
Publicado en: Eur Urol Open Sci, Edición 34, 2021, Página(s) 55-58
Editor: Elsevier
DOI: 10.1016/j.euros.2021.09.017

Liquid biopsy: blood-based analyses of circulating cell-free DNA in xenografts.

Autores: Heidrich I, Pantel K
Publicado en: EMBO Mol Med, 2022, ISSN 1757-4684
Editor: EMBOpress
DOI: 10.15252/emmm.202216326

Clinical applications of circulating tumor cells in patients with solid tumors

Autores: Smit DJ, Schneegans S, Pantel K.
Publicado en: Clin Exp Metastasis, 2024, ISSN 0262-0898
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10585-024-10267-5

Detection of Hypomethylation in Long-ctDNA

Autores: Joosse SA, Pantel K
Publicado en: Clin Chem, 2022, ISSN 0009-9147
Editor: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac108

Tumor-Associated Release of Prostatic Cells into the Blood after Transrectal Ultrasound-Guided Biopsy in Patients with Histologically Confirmed Prostate Cancer

Autores: Simon A Joosse, Burkhard Beyer, Christin Gasch, Paulina Nastały, Andra Kuske, Hendrik Isbarn, Ludwig J Horst, Claudia Hille, Tobias M Gorges, Laure Cayrefourcq, Catherine Alix-Panabières, Pierre Tennstedt, Sabine Riethdorf, Thorsten Schlomm, Klaus Pantel
Publicado en: Clinical Chemistry, Edición 66/1, 2019, Página(s) 161-168, ISSN 0009-9147
Editor: American Association for Clinical Chemistry, Inc.
DOI: 10.1373/clinchem.2019.310912

Detection and Characterization of Estrogen Receptor α Expression of Circulating Tumor Cells as a Prognostic Marker

Autores: Retno Ningsi; Maha Elazezy; Luisa Stegat; Elena Laakmann; Sven Peine; Sabine Riethdorf; Volkmar Müller; Klaus Pantel; Simon A. Joosse
Publicado en: Cancers, Edición 1, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14112621

Functional Characterization of Circulating Tumor Cells (CTCs) from Metastatic ER+/HER2- Breast Cancer Reveals Dependence on HER2 and FOXM1 for Endocrine Therapy Resistance and Tumor Cell Survival: Implications for Treatment of ER+/HER2- Breast Cancer.

Autores: Sven Roßwag; Cristina L. Cotarelo; Klaus Pantel; Sabine Riethdorf; Jonathan P. Sleeman; Jonathan P. Sleeman; Marcus Schmidt; Sonja Thaler
Publicado en: Cancers, Edición 4, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081810

Multibiomarker panels in liquid biopsy for early detection of pancreatic cancer – a comprehensive review

Autores: Kim-Lea Reese, Klaus Pantel, Daniel J. Smit
Publicado en: Journal of Experimental & Clinical Cancer Research, Edición 43, 2024, ISSN 1756-9966
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13046-024-03166-w

Circulating Tumor Cells: From Basic to Translational Research

Autores: Cortés-Hernández LE, Eslami-S Z, Pantel K, Alix-Panabières C
Publicado en: Clin Chem, 2024, ISSN 0009-9147
Editor: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvad142

Circulating tumor cells as liquid biopsy markers in cancer patients

Autores: Daniel J. Smit, Klaus Pantel
Publicado en: Molecular Aspects of Medicine, Edición 96, 2025, Página(s) 101258, ISSN 0098-2997
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.mam.2024.101258

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

Autores: Laura Keller, Yassine Belloum, Harriet Wikman, Klaus Pantel
Publicado en: British Journal of Cancer, Edición 124/2, 2021, Página(s) 345-358, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-020-01047-5

Expression Patterns and Corepressor Function of Retinoic Acid-induced 2 in Prostate Cancer

Autores: Besler K, Węglarz A, Keller L, von Amsberg G, Bednarz-Knoll N, Offermann A, Stoupiec S, Eltze E, Semjonow A, Boettcher L, Schneegans S, Perner S, Hauch S, Todenhöfer T, Peine S, Pantel K, Wikman H, Werner S
Publicado en: Clin Chem, 2022, ISSN 0009-9147
Editor: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvac073

PSMA-heterogeneity in metastatic castration-resistant prostate cancer: Circulating tumor cells, metastatic tumor burden, and response to targeted radioligand therapy

Autores: Derlin T, Riethdorf S, Schumacher U, Lafos M, Peine S, Coith C, Ross TL, Pantel K, Bengel FM
Publicado en: Prostate, 2023, ISSN 0270-4137
Editor: John Wiley & Sons Inc.
DOI: 10.1002/pros.24549

Crucial roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation

Autores: Pantel K, Alix-Panabières C
Publicado en: Immunother Cancer, 2022, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2022-005615

Circulating Cellular Communication Network Factor 1 Protein as a Sensitive Liquid Biopsy Marker for Early Detection of Breast Cancer

Autores: Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Maggie Banys-Paluchowski, Antje Andreas, Marcus Wurlitzer, Maria Geffken, Hannah Voß, Tanja Zeller, Stefan Blankenberg, Sven Peine, Simon A Joosse, Volkmar Müller, Hartmut Schlüter, Leticia Oliveira-Ferrer, Klaus Pantel
Publicado en: Clin Chem, Edición 68/2, 2021, Página(s) 344–353, ISSN 1530-8561
Editor: Oxfor Academic
DOI: 10.1093/clinchem/hvab153

Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients

Autores: Kai Bartkowiak, Parinaz Mossahebi Mohammadi, Paula Nissen, Stefan Werner, David Agorku, Antje Andreas, Maria Geffken, Sven Peine, Karl Verpoort, Thomas M. Deutsch, Laura L. Michel, Andreas Schneeweiss, Verena Thewes, Andreas Trumpp, Olaf Hardt, Volkmar Müller, Sabine Riethdorf, Hartmut Schlüter, Klaus Pantel
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-87122-4

Liquid biopsies: Potential and challenges

Autores: Isabel Heidrich, Lucija Ačkar, Parinaz Mossahebi Mohammadi, Klaus Pantel
Publicado en: International Journal of Cancer, Edición 148/3, 2021, Página(s) 528-545, ISSN 0020-7136
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33217

Cysteine-Rich Angiogenic Inducer 61: Pro-Survival Function and Role as a Biomarker for Disseminating Breast Cancer Cells

Autores: Kai Bartkowiak, Isabel Heidrich, Marcel Kwiatkowski, Tobias M. Gorges, Antje Andreas, Maria Geffken, Karl Verpoort, Volkmar Müller, Hartmut Schlüter, Klaus Pantel
Publicado en: Cancers, Edición 13/3, 2021, Página(s) 563, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030563

Circulating tumour cells for early detection of clinically relevant cancer

Autores: Lawrence R, Watters M, Davies CR, Pantel K, Lu YJ
Publicado en: Nat Rev Clin Oncol, 2023, ISSN 1759-4774
Editor: Nature Publishing Group
DOI: 10.1038/s41571-023-00781-y

Minimal residual disease as a target for liquid biopsy in patients with solid tumours

Autores: Klaus Pantel, Catherine Alix-Panabières
Publicado en: Nature Reviews Clinical Oncology, Edición 22, 2024, Página(s) 65-77, ISSN 1759-4774
Editor: Nature Publishing Group
DOI: 10.1038/s41571-024-00967-y

Pre-Analytical and Analytical Variables of Label-Independent Enrichment and Automated Detection of Circulating Tumor Cells in Cancer Patients

Autores: Claudia Koch, Simon A. Joosse, Svenja Schneegans, Okka J. W. Wilken, Melanie Janning, Desiree Loreth, Volkmar Müller, Katharina Prieske, Malgorzata Banys-Paluchowski, Ludwig J. Horst, Sonja Loges, Sven Peine, Harriet Wikman, Tobias M. Gorges, Klaus Pantel
Publicado en: Cancers, Edición 12/2, 2020, Página(s) 442, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12020442

Neoadjuvant Chemotherapy of Patients with Early Breast Cancer Is Associated with Increased Detection of Disseminated Tumor Cells in the Bone Marrow.

Autores: Léa Volmer; André Koch; Sabine Matovina; Dominik Dannehl; Martin Weiss; Ganna Welker; Markus Hahn; Tobias Engler; Markus Wallwiener; Christina Barbara Walter; Ernst Oberlechner; Sara Yvonne Brucker; Klaus Pantel; Andreas Hartkopf
Publicado en: Cancers, Edición 3, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030635

Functional analysis of circulating tumour cells: the KEY to understand thebiology of the metastatic cascade

Autores: Eslami-S Z, Cortés-Hernández LE, Thomas F, Pantel K, Alix-Panabières C.
Publicado en: Br J Cancer, 2022, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-022-01819-1

Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels

Autores: Leong SP, Naxerova K, Keller L, Pantel K, Witte M.
Publicado en: Clin Exp Metastasis, 2022, ISSN 0262-0898
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10585-021-10120-z

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape

Autores: Malte Mohme, Cecile L. Maire, Simon Schliffke, Simon A. Joosse, Malik Alawi, Jakob Matschke, Ulrich Schüller, Judith Dierlamm, Tobias Martens, Klaus Pantel, Sabine Riethdorf, Katrin Lamszus, Manfred Westphal
Publicado en: Acta Neuropathologica Communications, Edición 8/1, 2020, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-020-00906-9

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma

Autores: Mark Sementsov, Leonie Ott, Julian Kött, Alexander Sartori, Amelie Lusque, Sarah Degenhardt, Bertille Segier, Isabel Heidrich, Beate Volkmer, Rüdiger Greinert, Peter Mohr, Ronald Simon, Julia-Christina Stadler, Darryl Irwin, Claudia Koch, Antje Andreas, Benjamin Deitert, Verena Thewes, Andreas Trumpp, Andreas Schneeweiss, Yassine Belloum, Sven Peine, Harriett Wikman, Sabine Riethdorf, Stefan W S
Publicado en: EMBO Molecular Medicine, Edición 16, 2024, Página(s) 1560-1578, ISSN 1757-4684
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44321-024-00082-6

Comparative analysis of circulating tumor cells in prostatic plexus and peripheral blood of patients undergoing prostatectomy

Autores: Gresa Emurlai, Randi M. Pose, Nikhil Kalra, Cornelia Coith, Sandra Lenz, Pierre Tennstedt, Markus Graefen, Stefan Werner, Sabine Riethdorf, Derya Tilki, Simon A. Joosse, Klaus Pantel
Publicado en: Journal of Experimental & Clinical Cancer Research, Edición 44, 2025, ISSN 1756-9966
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13046-025-03397-5

MicroRNAs from Liquid Biopsy Derived Extracellular Vesicles: Recent Advances in Detection and Characterization Methods

Autores: Rares Drula, Leonie Florence Ott, Ioana Berindan-Neagoe, Klaus Pantel, George A. Calin
Publicado en: Cancers, Edición 12/8, 2020, Página(s) 2009, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082009

Derechos de propiedad intelectual

Patent (2)

METHOD OF DETECTING CANCER OR CANCER CELLS

Número de solicitud/publicación: 17 157020
Fecha: 2017-02-20
Solicitante(s): UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

METHOD OF DETECTING CANCER OR CANCER CELLS

Número de solicitud/publicación: 20 18054052
Fecha: 2018-02-19
Solicitante(s): UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF